Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H: Quinone oxidoreductase 1

Toxicology Letters

Volumn 219, Issue 1, 2013, Pages 35-41

  Yeo, Seung Hoon ^a,b   Noh, Jung Ran ^a   Kim, Yong Hoon ^a   Gang, Gil Tae ^a   Kim, Sang Woo ^a   Kim, Kyoung Shim ^a   Hwang, Jung Hwan ^a   Shong, Minho ^c   Lee, Chul Ho ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

cell; Apoptosis; Diabetes; Mice; NQO1; Streptozotocin

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; GLUCOSE; INSULIN; NADPH QUINONE OXIDOREDUCTASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; ENZYME DEFICIENCY; ENZYME DEGRADATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; WEIGHT REDUCTION; WILD TYPE;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; IMMUNOBLOTTING; IN SITU NICK-END LABELING; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NAD(P)H DEHYDROGENASE (QUINONE); REACTIVE OXYGEN SPECIES; STREPTOZOCIN;

EID: 84875245083     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.02.013     Document Type: Article

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