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Volumn 23, Issue 12, 2016, Pages 1919-1929

Alternative splicing and cell survival: From tissue homeostasis to disease

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; FAS ANTIGEN; PROTEIN BCL XL;

EID: 84989244139     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2016.91     Document Type: Review
Times cited : (138)

References (111)
  • 1
    • 78649901091 scopus 로고    scopus 로고
    • Alternative cell death mechanisms in development and beyond
    • Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev 2010; 24: 2592-2602.
    • (2010) Genes Dev , vol.24 , pp. 2592-2602
    • Yuan, J.1    Kroemer, G.2
  • 2
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011; 333: 1109-1112.
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 3
    • 84907212907 scopus 로고    scopus 로고
    • Cell biology. Metabolic control of cell death
    • Green DR, Galluzzi L, Kroemer G. Cell biology. Metabolic control of cell death. Science 2014; 345: 1250256.
    • (2014) Science , vol.345 , pp. 1250256
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 4
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: The roads to ruin
    • Green DR. Apoptotic pathways: the roads to ruin. Cell 1998; 94: 695-698.
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 5
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim RW. Cell death during development of the nervous system. Annu Rev Neurosci 1991; 14: 453-501.
    • (1991) Annu Rev Neurosci , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 6
    • 0029834669 scopus 로고    scopus 로고
    • Mitogen-activated protein kinaseindependent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival
    • Creedon DJ, Johnson EM Jr, Lawrence JC Jr. Mitogen-activated protein kinaseindependent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 1996; 271: 20713-20718.
    • (1996) J Biol Chem , vol.271 , pp. 20713-20718
    • Creedon, D.J.1    Johnson, E.M.2    Lawrence, J.C.3
  • 7
    • 0023736226 scopus 로고
    • Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system
    • Purves D, Snider WD, Voyvodic JT. Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system. Nature 1988; 336: 123-128.
    • (1988) Nature , vol.336 , pp. 123-128
    • Purves, D.1    Snider, W.D.2    Voyvodic, J.T.3
  • 8
    • 84859118348 scopus 로고    scopus 로고
    • Follicular growth and atresia in mammalian ovaries: Regulation by survival and death of granulosa cells
    • Matsuda F, Inoue N, Manabe N, Ohkura S. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells. J Reprod Dev 2012; 58: 44-50.
    • (2012) J Reprod Dev , vol.58 , pp. 44-50
    • Matsuda, F.1    Inoue, N.2    Manabe, N.3    Ohkura, S.4
  • 9
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • Schwerk C, Schulze-Osthoff K. Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 2005; 19: 1-13.
    • (2005) Mol Cell , vol.19 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 10
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Lührmann R. The spliceosome: design principles of a dynamic RNP machine. Cell 2009; 136: 701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Lührmann, R.3
  • 11
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black DL. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 2003; 72: 291-336.
    • (2003) Annu Rev Biochem , vol.72 , pp. 291-336
    • Black, D.L.1
  • 12
    • 84922255144 scopus 로고    scopus 로고
    • Context-dependent control of alternative splicing by RNA-binding proteins
    • Fu XD, Ares M Jr. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet 2014; 15: 689-701.
    • (2014) Nat Rev Genet , vol.15 , pp. 689-701
    • Fu, X.D.1    Ares, M.2
  • 13
    • 0027282044 scopus 로고
    • Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    • Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608.
    • (1993) Cell , vol.74 , pp. 597-608
    • Boise, L.H.1    Gonzalez-Garcia, M.2    Postema, C.E.3    Ding, L.4    Lindsten, T.5    Turka, L.A.6
  • 14
    • 0034672298 scopus 로고    scopus 로고
    • A comparison of the expression and properties of Apaf-1 and Apaf-1 L
    • Walke DW, Morgan JI. A comparison of the expression and properties of Apaf-1 and Apaf-1 L. Brain Res 2000; 886: 73-81.
    • (2000) Brain Res , vol.886 , pp. 73-81
    • Walke, D.W.1    Morgan, J.I.2
  • 15
    • 0028168593 scopus 로고
    • Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
    • Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 1994; 78: 739-750.
    • (1994) Cell , vol.78 , pp. 739-750
    • Wang, L.1    Miura, M.2    Bergeron, L.3    Zhu, H.4    Yuan, J.5
  • 16
    • 0346725958 scopus 로고    scopus 로고
    • DeltaNp73beta is active in transactivation and growth suppression
    • Liu G, Nozell S, Xiao H, Chen X. DeltaNp73beta is active in transactivation and growth suppression. Mol Cell Biol 2004; 24: 487-501.
    • (2004) Mol Cell Biol , vol.24 , pp. 487-501
    • Liu, G.1    Nozell, S.2    Xiao, H.3    Chen, X.4
  • 18
    • 0034641898 scopus 로고    scopus 로고
    • CD95's deadly mission in the immune system
    • Krammer PH. CD95's deadly mission in the immune system. Nature 2000; 407: 789-795.
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 19
    • 33645784245 scopus 로고    scopus 로고
    • Genetic disorders of programmed cell death in the immune system
    • Bidere N, Su HC, Lenardo MJ. Genetic disorders of programmed cell death in the immune system. Annu Rev Immunol 2006; 24: 321-352.
    • (2006) Annu Rev Immunol , vol.24 , pp. 321-352
    • Bidere, N.1    Su, H.C.2    Lenardo, M.J.3
  • 20
    • 0030063193 scopus 로고    scopus 로고
    • Fas/Apo-1/CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis
    • Cascino I, Papoff G, De Maria R, Testi R, Ruberti G. Fas/Apo-1/CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. J Immunol 1996; 156: 13-17.
    • (1996) J Immunol , vol.156 , pp. 13-17
    • Cascino, I.1    Papoff, G.2    De Maria, R.3    Testi, R.4    Ruberti, G.5
  • 21
    • 0033636996 scopus 로고    scopus 로고
    • The apoptosispromoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
    • Förch P, Puig O, Kedersha N, Martínez C, Granneman S, Séraphin B et al. The apoptosispromoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Mol Cell 2000; 6: 1089-1098.
    • (2000) Mol Cell , vol.6 , pp. 1089-1098
    • Förch, P.1    Puig, O.2    Kedersha, N.3    Martínez, C.4    Granneman, S.5    Séraphin, B.6
  • 23
    • 0037121924 scopus 로고    scopus 로고
    • The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites
    • Förch P, Puig O, Martínez C, Séraphin B, Valcárcel J. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. EMBO J 2002; 21: 6882-6892.
    • (2002) EMBO J , vol.21 , pp. 6882-6892
    • Förch, P.1    Puig, O.2    Martínez, C.3    Séraphin, B.4    Valcárcel, J.5
  • 24
    • 0034637482 scopus 로고    scopus 로고
    • The splicing factor U1C represses EWS/FLI-mediated transactivation
    • Knoop LL, Baker SJ. The splicing factor U1C represses EWS/FLI-mediated transactivation. J Biol Chem 2000; 275: 24865-24871.
    • (2000) J Biol Chem , vol.275 , pp. 24865-24871
    • Knoop, L.L.1    Baker, S.J.2
  • 25
    • 23744492690 scopus 로고    scopus 로고
    • Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition
    • Izquierdo JM, Majós N, Bonnal S, Martínez C, Castelo R, Guigó R et al. Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol Cell 2005; 19: 475-484.
    • (2005) Mol Cell , vol.19 , pp. 475-484
    • Izquierdo, J.M.1    Majós, N.2    Bonnal, S.3    Martínez, C.4    Castelo, R.5    Guigó, R.6
  • 26
    • 33847308702 scopus 로고    scopus 로고
    • Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
    • Izquierdo JM, Valcárcel J. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. J Biol Chem 2007; 282: 1539-1543.
    • (2007) J Biol Chem , vol.282 , pp. 1539-1543
    • Izquierdo, J.M.1    Valcárcel, J.2
  • 27
    • 49649128843 scopus 로고    scopus 로고
    • Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
    • Izquierdo JM. Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition. J Biol Chem 2008; 283: 19077-19084.
    • (2008) J Biol Chem , vol.283 , pp. 19077-19084
    • Izquierdo, J.M.1
  • 28
    • 53149145051 scopus 로고    scopus 로고
    • RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition
    • Bonnal S, Martínez C, Förch P, Bachi A, Wilm M, Valcárcel J. RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol Cell 2008; 32: 81-95.
    • (2008) Mol Cell , vol.32 , pp. 81-95
    • Bonnal, S.1    Martínez, C.2    Förch, P.3    Bachi, A.4    Wilm, M.5    Valcárcel, J.6
  • 29
    • 84922380590 scopus 로고    scopus 로고
    • FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma
    • Sehgal L, Mathur R, Braun FK, Wise JF, Berkova Z, Neelapu S et al. FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma. Leukemia 2014; 28: 2376-2387.
    • (2014) Leukemia , vol.28 , pp. 2376-2387
    • Sehgal, L.1    Mathur, R.2    Braun, F.K.3    Wise, J.F.4    Berkova, Z.5    Neelapu, S.6
  • 30
    • 84920376732 scopus 로고    scopus 로고
    • Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis
    • Tejedor JR, Papasaikas P, Valcárcel J. Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis. Mol Cell 2015; 57: 23-38.
    • (2015) Mol Cell , vol.57 , pp. 23-38
    • Tejedor, J.R.1    Papasaikas, P.2    Valcárcel, J.3
  • 31
    • 0029069295 scopus 로고
    • ICE-like proteases in apoptosis
    • Kumar S. ICE-like proteases in apoptosis. Trends Biochem Sci 1995; 20: 198-202.
    • (1995) Trends Biochem Sci , vol.20 , pp. 198-202
    • Kumar, S.1
  • 32
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281: 1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 33
    • 0033573020 scopus 로고    scopus 로고
    • Caspase-9 and APAF-1 form an active holoenzyme
    • Rodriguez J, Lazebnik Y. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev 1999; 13: 3179-3184.
    • (1999) Genes Dev , vol.13 , pp. 3179-3184
    • Rodriguez, J.1    Lazebnik, Y.2
  • 34
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9
    • Kuida K, Haydar TF, Kuan C-Y, Gu Y, Taya C, Karasuyama H et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9. Cell 94: 325-3371998.
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1    Haydar, T.F.2    Kuan, C.-Y.3    Gu, Y.4    Taya, C.5    Karasuyama, H.6
  • 35
    • 0033593201 scopus 로고    scopus 로고
    • A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
    • Seol DW, Billiar TR. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem 1999; 274: 2072-2076.
    • (1999) J Biol Chem , vol.274 , pp. 2072-2076
    • Seol, D.W.1    Billiar, T.R.2
  • 36
    • 79960681326 scopus 로고    scopus 로고
    • SRSF1 regulates the alternative splicing of caspase-9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells
    • Shultz JC, Goehe RW, Murudkar CS, Wijesinghe DS, Mayton EK, Massiello A et al. SRSF1 regulates the alternative splicing of caspase-9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells. Mol Cancer Res 2011; 9: 889-900.
    • (2011) Mol Cancer Res , vol.9 , pp. 889-900
    • Shultz, J.C.1    Goehe, R.W.2    Murudkar, C.S.3    Wijesinghe, D.S.4    Mayton, E.K.5    Massiello, A.6
  • 37
    • 78049448047 scopus 로고    scopus 로고
    • HnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 premRNA processing
    • Goehe RW, Shultz JC, Murudkar C, Usanovic S, Lamour NF, Massey DH et al. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 premRNA processing. J Clin Invest 2010; 120: 3923-3939.
    • (2010) J Clin Invest , vol.120 , pp. 3923-3939
    • Goehe, R.W.1    Shultz, J.C.2    Murudkar, C.3    Usanovic, S.4    Lamour, N.F.5    Massey, D.H.6
  • 38
    • 84875428613 scopus 로고    scopus 로고
    • HnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L
    • Vu NT, Park MA, Shultz JC, Goehe RW, Hoeferlin LA, Shultz MD et al. hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L. J Biol Chem 2013; 288: 8575-8584.
    • (2013) J Biol Chem , vol.288 , pp. 8575-8584
    • Vu, N.T.1    Park, M.A.2    Shultz, J.C.3    Goehe, R.W.4    Hoeferlin, L.A.5    Shultz, M.D.6
  • 39
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice
    • Motoyama N, Wang F, Roth KA, Sawa H, Nakayama KI, Nakayama K et al. Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice. Science 1995; 267: 1506-1510.
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.I.5    Nakayama, K.6
  • 40
    • 84925283590 scopus 로고    scopus 로고
    • Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection
    • Bielli P, Bordi M, Biasio VD, Sette C. Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection. Nucleic Acids Res 2014; 42: 12070-12081.
    • (2014) Nucleic Acids Res , vol.42 , pp. 12070-12081
    • Bielli, P.1    Bordi, M.2    Biasio, V.D.3    Sette, C.4
  • 41
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994; 369: 321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 42
    • 0028152659 scopus 로고
    • Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes
    • Fang W, Rivard JJ, Mueller DL, Behrens TW. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J Immunol 1994; 153: 4388-4398.
    • (1994) J Immunol , vol.153 , pp. 4388-4398
    • Fang, W.1    Rivard, J.J.2    Mueller, D.L.3    Behrens, T.W.4
  • 43
    • 17544368001 scopus 로고    scopus 로고
    • An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells
    • Shiraiwa N, Inohara N, Okada S, Yuzaki M, Shoji S, Ohta S. An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J Biol Chem 1996; 271: 13258-13265.
    • (1996) J Biol Chem , vol.271 , pp. 13258-13265
    • Shiraiwa, N.1    Inohara, N.2    Okada, S.3    Yuzaki, M.4    Shoji, S.5    Ohta, S.6
  • 44
    • 0036645280 scopus 로고    scopus 로고
    • T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: Analysis of Bcl-xgammadeficient mice
    • Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH et al. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgammadeficient mice. J Exp Med 2002; 196: 87-95.
    • (2002) J Exp Med , vol.196 , pp. 87-95
    • Ye, Q.1    Press, B.2    Kissler, S.3    Yang, X.F.4    Lu, L.5    Bassing, C.H.6
  • 45
    • 20744450092 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x
    • Garneau D, Revil T, Fisette JF, Chabot B. Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x. J Biol Chem 2005; 280: 22641-22650.
    • (2005) J Biol Chem , vol.280 , pp. 22641-22650
    • Garneau, D.1    Revil, T.2    Fisette, J.F.3    Chabot, B.4
  • 46
  • 47
    • 84856945928 scopus 로고    scopus 로고
    • The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator
    • Pedrotti S, Busà R, Compagnucci C, Sette C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res 2012; 40: 1021-1032.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1021-1032
    • Pedrotti, S.1    Busà, R.2    Compagnucci, C.3    Sette, C.4
  • 48
    • 52649127884 scopus 로고    scopus 로고
    • Novel splicing factor RBM25 modulates Bclx Pre-mRNA 5' splice site selection
    • Zhou A, Ou AC, Cho A, Benz EJ Jr, Huang SC. Novel splicing factor RBM25 modulates Bclx Pre-mRNA 5' splice site selection. Mol Cell Biol 2008; 28: 5924-5936.
    • (2008) Mol Cell Biol , vol.28 , pp. 5924-5936
    • Zhou, A.1    Ou, A.C.2    Cho, A.3    Benz, E.J.4    Huang, S.C.5
  • 49
    • 33845715579 scopus 로고    scopus 로고
    • SAP155 Binds to ceramide-responsive RNA ciselement 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA
    • Massiello A, Roesser JR, Chalfant CE. SAP155 Binds to ceramide-responsive RNA ciselement 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA. FASEB J 2006; 20: 1680-1682.
    • (2006) FASEB J , vol.20 , pp. 1680-1682
    • Massiello, A.1    Roesser, J.R.2    Chalfant, C.E.3
  • 50
    • 52049094582 scopus 로고    scopus 로고
    • Antagonistic effects of the SRp30c protein and cryptic 5′ splice sites on the alternative splicing of the apoptotic regulator Bcl-x
    • Cloutier P, Toutant J, Shkreta L, Goekjian S, Revil T, Chabot B. Antagonistic effects of the SRp30c protein and cryptic 5′ splice sites on the alternative splicing of the apoptotic regulator Bcl-x. J Biol Chem 2008; 283: 21315-21324.
    • (2008) J Biol Chem , vol.283 , pp. 21315-21324
    • Cloutier, P.1    Toutant, J.2    Shkreta, L.3    Goekjian, S.4    Revil, T.5    Chabot, B.6
  • 51
    • 69249087295 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform
    • Revil T, Pelletier J, Toutant J, Cloutier A, Chabot B. Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform. J Biol Chem 2009; 284: 21458-21467.
    • (2009) J Biol Chem , vol.284 , pp. 21458-21467
    • Revil, T.1    Pelletier, J.2    Toutant, J.3    Cloutier, A.4    Chabot, B.5
  • 52
    • 77955662560 scopus 로고    scopus 로고
    • An alternative splicing network links cell-cycle control to apoptosis
    • Moore MJ, Wang Q, Kennedy CJ, Silver PA. An alternative splicing network links cell-cycle control to apoptosis. Cell 2010; 142: 625-636.
    • (2010) Cell , vol.142 , pp. 625-636
    • Moore, M.J.1    Wang, Q.2    Kennedy, C.J.3    Silver, P.A.4
  • 53
    • 77954384049 scopus 로고    scopus 로고
    • Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs
    • Dominguez C, Fisette JF, Chabot B, Allain FH. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nat Struct Mol Biol 2010; 17: 853-861.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 853-861
    • Dominguez, C.1    Fisette, J.F.2    Chabot, B.3    Allain, F.H.4
  • 54
    • 0035977067 scopus 로고    scopus 로고
    • FAS activation induces dephosphorylation of SR proteins; Dependence on the de novo generation of ceramide and activation of protein phosphatase 1
    • Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem 2001; 276: 44848-44855.
    • (2001) J Biol Chem , vol.276 , pp. 44848-44855
    • Chalfant, C.E.1    Ogretmen, B.2    Galadari, S.3    Kroesen, B.J.4    Pettus, B.J.5    Hannun, Y.A.6
  • 55
    • 0037066727 scopus 로고    scopus 로고
    • De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1
    • Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 2002; 277: 12587-12595.
    • (2002) J Biol Chem , vol.277 , pp. 12587-12595
    • Chalfant, C.E.1    Rathman, K.2    Pinkerman, R.L.3    Wood, R.E.4    Obeid, L.M.5    Ogretmen, B.6
  • 58
    • 84898632029 scopus 로고    scopus 로고
    • The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
    • Bielli P, Busà R, Di Stasi SM, Munoz MJ, Botti F, Kornblihtt AR et al. The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis. EMBO Rep 2014; 15: 419-427.
    • (2014) EMBO Rep , vol.15 , pp. 419-427
    • Bielli, P.1    Busà, R.2    Di Stasi, S.M.3    Munoz, M.J.4    Botti, F.5    Kornblihtt, A.R.6
  • 61
    • 84887460995 scopus 로고    scopus 로고
    • Misregulation of pre-mRNA alternative splicing in cancer
    • Zhang J, Manley JL. Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discov 2013; 3: 1228-1237.
    • (2013) Cancer Discov , vol.3 , pp. 1228-1237
    • Zhang, J.1    Manley, J.L.2
  • 62
    • 84925286546 scopus 로고    scopus 로고
    • Alternative splicing in cancer: Implications for biology and therapy
    • Chen J, Weiss WA. Alternative splicing in cancer: implications for biology and therapy. Oncogene 2015; 34: 1-14.
    • (2015) Oncogene , vol.34 , pp. 1-14
    • Chen, J.1    Weiss, W.A.2
  • 63
    • 84940094221 scopus 로고    scopus 로고
    • Aberrant RNA splicing in cancer; Expression changes and driver mutations of splicing factor genes
    • Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI. Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes. Oncogene 2015; 35: 2413-2427.
    • (2015) Oncogene , vol.35 , pp. 2413-2427
    • Sveen, A.1    Kilpinen, S.2    Ruusulehto, A.3    Lothe, R.A.4    Skotheim, R.I.5
  • 64
    • 84939192606 scopus 로고    scopus 로고
    • Splicing regulation: A molecular device to enhance cancer cell adaptation
    • Pagliarini V, Naro C, Sette C. Splicing regulation: a molecular device to enhance cancer cell adaptation. Biomed Res Int 20152015: 543067.
    • (2015) Biomed Res Int , vol.2015 , pp. 543067
    • Pagliarini, V.1    Naro, C.2    Sette, C.3
  • 65
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: Growing ever more complex
    • Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009; 9: 749-758.
    • (2009) Nat Rev Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 67
    • 0345829926 scopus 로고    scopus 로고
    • Cellular response to an antisense-mediated shift of Bclx pre-mRNA splicing and antineoplastic agents
    • Mercatante DR, Mohler JL, Kole R. Cellular response to an antisense-mediated shift of Bclx pre-mRNA splicing and antineoplastic agents. J Biol Chem 2002; 277: 49374-49382.
    • (2002) J Biol Chem , vol.277 , pp. 49374-49382
    • Mercatante, D.R.1    Mohler, J.L.2    Kole, R.3
  • 69
    • 84872373803 scopus 로고    scopus 로고
    • NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
    • Zhou W, Yang Y, Xia J, Wang H, Salama ME, Xiong W et al. NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell 2013; 23: 48-62.
    • (2013) Cancer Cell , vol.23 , pp. 48-62
    • Zhou, W.1    Yang, Y.2    Xia, J.3    Wang, H.4    Salama, M.E.5    Xiong, W.6
  • 70
    • 84908686543 scopus 로고    scopus 로고
    • The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression
    • Wang Y, Chen D, Qian H, Tsai YS, Shao S, Liu Q et al. The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression. Cancer Cell 2014; 26: 374-389.
    • (2014) Cancer Cell , vol.26 , pp. 374-389
    • Wang, Y.1    Chen, D.2    Qian, H.3    Tsai, Y.S.4    Shao, S.5    Liu, Q.6
  • 73
    • 84858003339 scopus 로고    scopus 로고
    • Regulation of chemoresistance via alternative messenger RNA splicing
    • Eblen ST. Regulation of chemoresistance via alternative messenger RNA splicing. Biochem Pharmacol 2012; 83: 1063-1072.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1063-1072
    • Eblen, S.T.1
  • 74
    • 85012081784 scopus 로고    scopus 로고
    • The RNA splicing response to DNA damage
    • Shkreta L, Chabot B. The RNA splicing response to DNA damage. Biomolecules 2015; 5: 2935-2977.
    • (2015) Biomolecules , vol.5 , pp. 2935-2977
    • Shkreta, L.1    Chabot, B.2
  • 75
  • 78
    • 84945582553 scopus 로고    scopus 로고
    • Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9
    • Fidaleo M, Svetoni F, Volpe E, Miñana B, Caporossi D, Paronetto MP. Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget 2015; 6: 31740-31757.
    • (2015) Oncotarget , vol.6 , pp. 31740-31757
    • Fidaleo, M.1    Svetoni, F.2    Volpe, E.3    Miñana, B.4    Caporossi, D.5    Paronetto, M.P.6
  • 79
    • 84879415211 scopus 로고    scopus 로고
    • Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway
    • Adesso L, Calabretta S, Barbagallo F, Capurso G, Pilozzi E, Geremia R et al. Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. Oncogene 2013; 32: 2848-2857.
    • (2013) Oncogene , vol.32 , pp. 2848-2857
    • Adesso, L.1    Calabretta, S.2    Barbagallo, F.3    Capurso, G.4    Pilozzi, E.5    Geremia, R.6
  • 80
    • 84938629534 scopus 로고    scopus 로고
    • Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
    • Calabretta S, Bielli P, Passacantilli I, Pilozzi E, Fendrich V, Capurso G et al. Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells. Oncogene 2016; 35: 2031-2039.
    • (2016) Oncogene , vol.35 , pp. 2031-2039
    • Calabretta, S.1    Bielli, P.2    Passacantilli, I.3    Pilozzi, E.4    Fendrich, V.5    Capurso, G.6
  • 81
  • 82
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010; 463: 364-368.
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 83
    • 79952813023 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein H1/H2dependent unsplicing of thymidinephosphorylase results in anticancer drug resistance
    • Stark M, Bram EE, Akerman M, Mandel-Gutfreund Y, Assaraf YG. Heterogeneous nuclear ribonucleoprotein H1/H2dependent unsplicing of thymidinephosphorylase results in anticancer drug resistance. J Biol Chem 2011; 286: 3741-3754.
    • (2011) J Biol Chem , vol.286 , pp. 3741-3754
    • Stark, M.1    Bram, E.E.2    Akerman, M.3    Mandel-Gutfreund, Y.4    Assaraf, Y.G.5
  • 84
    • 34347348168 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells
    • Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF et al. The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 2007; 26: 4372-4382.
    • (2007) Oncogene , vol.26 , pp. 4372-4382
    • Busà, R.1    Paronetto, M.P.2    Farini, D.3    Pierantozzi, E.4    Botti, F.5    Angelini, D.F.6
  • 85
    • 80051951015 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 is a multifunctional player in human cancer
    • Bielli P, Busà R, Paronetto MP, Sette C. The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer 2011; 18: R91-R102.
    • (2011) Endocr Relat Cancer , vol.18 , pp. R91-R102
    • Bielli, P.1    Busà, R.2    Paronetto, M.P.3    Sette, C.4
  • 86
    • 0037069651 scopus 로고    scopus 로고
    • Signal-dependent regulation of splicing via phosphorylation of Sam68
    • Matter N, Herrlich P, König H. Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature 2002; 420: 691-695.
    • (2002) Nature , vol.420 , pp. 691-695
    • Matter, N.1    Herrlich, P.2    König, H.3
  • 87
    • 75149187424 scopus 로고    scopus 로고
    • Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68
    • Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C et al. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res 2010; 70: 229-239.
    • (2010) Cancer Res , vol.70 , pp. 229-239
    • Paronetto, M.P.1    Cappellari, M.2    Busà, R.3    Pedrotti, S.4    Vitali, R.5    Comstock, C.6
  • 88
    • 84940416602 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    • Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J et al. The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7. Sci Rep 2015; 5: 13426.
    • (2015) Sci Rep , vol.5 , pp. 13426
    • Stockley, J.1    Markert, E.2    Zhou, Y.3    Robson, C.N.4    Elliott, D.J.5    Lindberg, J.6
  • 89
    • 77953252238 scopus 로고    scopus 로고
    • Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin
    • Busà R, Geremia R, Sette C. Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin. Nucleic Acids Res 2010; 38: 3005-3018.
    • (2010) Nucleic Acids Res , vol.38 , pp. 3005-3018
    • Busà, R.1    Geremia, R.2    Sette, C.3
  • 90
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997; 275: 967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6
  • 91
    • 84867264063 scopus 로고    scopus 로고
    • BaxDelta2 is a novel bax isoform unique to microsatellite unstable tumors
    • Haferkamp B, Zhang H, Lin Y, Yeap X, Bunce A, Sharpe J et al. BaxDelta2 is a novel bax isoform unique to microsatellite unstable tumors. J Biol Chem 2012; 287: 34722-34729.
    • (2012) J Biol Chem , vol.287 , pp. 34722-34729
    • Haferkamp, B.1    Zhang, H.2    Lin, Y.3    Yeap, X.4    Bunce, A.5    Sharpe, J.6
  • 92
    • 84907274821 scopus 로고    scopus 로고
    • BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite unstable colon cancer
    • Zhang H, Lin Y, Mañas A, Zhao Y, Denning MF, Ma L et al. BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite unstable colon cancer. Mol. Cancer Res 2014; 12: 1225-1232.
    • (2014) Mol. Cancer Res , vol.12 , pp. 1225-1232
    • Zhang, H.1    Lin, Y.2    Mañas, A.3    Zhao, Y.4    Denning, M.F.5    Ma, L.6
  • 94
    • 33845394286 scopus 로고    scopus 로고
    • The cyclin D1b splice variant: An old oncogene learns new tricks
    • Knudsen KE. The cyclin D1b splice variant: an old oncogene learns new tricks. Cell Div 2006; 1: 15.
    • (2006) Cell Div , vol.1 , pp. 15
    • Knudsen, K.E.1
  • 95
    • 65049089363 scopus 로고    scopus 로고
    • Cyclin D1 splice variants: Polymorphism, risk, and isoform-specific regulation in prostate cancer
    • Comstock CE, Augello MA, Benito RP, Karch J, Tran TH, Utama FE et al. Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer. Clin Cancer Res 2009; 15: 5338-5349.
    • (2009) Clin Cancer Res , vol.15 , pp. 5338-5349
    • Comstock, C.E.1    Augello, M.A.2    Benito, R.P.3    Karch, J.4    Tran, T.H.5    Utama, F.E.6
  • 97
    • 77952796886 scopus 로고    scopus 로고
    • Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene
    • Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, Sette C et al. Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. Cancer Res 2010; 70: 3975-3984.
    • (2010) Cancer Res , vol.70 , pp. 3975-3984
    • Olshavsky, N.A.1    Comstock, C.E.2    Schiewer, M.J.3    Augello, M.A.4    Hyslop, T.5    Sette, C.6
  • 99
    • 68849092790 scopus 로고    scopus 로고
    • An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
    • Mitra D, Brumlik MJ, Okamgba SU, Zhu Y, Duplessis TT, Parvani JG et al. An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance. Mol Cancer Ther 2009; 8: 2152-2162.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2152-2162
    • Mitra, D.1    Brumlik, M.J.2    Okamgba, S.U.3    Zhu, Y.4    Duplessis, T.T.5    Parvani, J.G.6
  • 100
    • 0027468645 scopus 로고
    • A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells
    • Scott GK, Robles R, Park JW, Montgomery PA, Daniel J, Holmes WE et al. A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells. Mol Cell Biol 1993; 13: 2247-2257.
    • (1993) Mol Cell Biol , vol.13 , pp. 2247-2257
    • Scott, G.K.1    Robles, R.2    Park, J.W.3    Montgomery, P.A.4    Daniel, J.5    Holmes, W.E.6
  • 102
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147: 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 104
    • 84876812269 scopus 로고    scopus 로고
    • Signals from the lysosome: A control centre for cellular clearance and energy metabolism
    • Settembre C, Fraldi A, Medina DL, Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013; 14: 283-296.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 283-296
    • Settembre, C.1    Fraldi, A.2    Medina, D.L.3    Ballabio, A.4
  • 105
    • 84964294905 scopus 로고    scopus 로고
    • BECN1s, a short splice variant of BECN1, functions in mitophagy
    • Cheng B, Xu A, Qiao M, Wu Q, Wang W, Mei Y et al. BECN1s, a short splice variant of BECN1, functions in mitophagy. Autophagy 2015; 11: 2048-2056.
    • (2015) Autophagy , vol.11 , pp. 2048-2056
    • Cheng, B.1    Xu, A.2    Qiao, M.3    Wu, Q.4    Wang, W.5    Mei, Y.6
  • 106
    • 84878263360 scopus 로고    scopus 로고
    • Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins
    • Liu C, Ma H, Wu J, Huang Q, Liu JO, Yu L. Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. BMC Cell Biol 2013; 14: 27.
    • (2013) BMC Cell Biol , vol.14 , pp. 27
    • Liu, C.1    Ma, H.2    Wu, J.3    Huang, Q.4    Liu, J.O.5    Yu, L.6
  • 107
    • 84872178548 scopus 로고    scopus 로고
    • Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5
    • Ouyang DY, Xu LH, He XH, Zhang YT, Zeng LH, Cai JY et al. Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5. Autophagy 2013; 9: 20-32.
    • (2013) Autophagy , vol.9 , pp. 20-32
    • Ouyang, D.Y.1    Xu, L.H.2    He, X.H.3    Zhang, Y.T.4    Zeng, L.H.5    Cai, J.Y.6
  • 108
    • 84966660727 scopus 로고    scopus 로고
    • U2AF35(S34F) promotes transformation by directing aberrant ATG7 pre-mRNA 3' end Formation
    • Park SM, Ou J, Chamberlain L, Simone TM, Yang H, Virbasius CM et al. U2AF35(S34F) promotes transformation by directing aberrant ATG7 pre-mRNA 3' end Formation. Mol Cell 2016; 62: 479-490.
    • (2016) Mol Cell , vol.62 , pp. 479-490
    • Park, S.M.1    Ou, J.2    Chamberlain, L.3    Simone, T.M.4    Yang, H.5    Virbasius, C.M.6
  • 109
    • 80053902729 scopus 로고    scopus 로고
    • Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model
    • Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF et al. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature 2011; 478: 123-126.
    • (2011) Nature , vol.478 , pp. 123-126
    • Hua, Y.1    Sahashi, K.2    Rigo, F.3    Hung, G.4    Horev, G.5    Bennett, C.F.6
  • 110
    • 84869106125 scopus 로고    scopus 로고
    • Antisense-based therapy for the treatment of spinal muscular atrophy
    • Rigo F, Hua Y, Krainer AR, Bennett CF. Antisense-based therapy for the treatment of spinal muscular atrophy. J Cell Biol 2012; 199: 21-25.
    • (2012) J Cell Biol , vol.199 , pp. 21-25
    • Rigo, F.1    Hua, Y.2    Krainer, A.R.3    Bennett, C.F.4


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