Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3741-3754

  Stark, Michal ^a   Bram, Eran E ^a   Akerman, Martin ^a,b   Mandel Gutfreund, Yael ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; ANGIOGENESIS; ANTICANCER DRUG; BIOACTIVATION; BREAST CANCER; CAPECITABINE; CHEMORESISTANCE; CHEMOTHERAPEUTIC DRUGS; COLORECTAL CANCER; CYTOTOXIC DRUGS; DRUG RESISTANCE; HUMAN MALIGNANCIES; IMMUNOPRECIPITATIONS; MICROVESSEL DENSITY; MOLECULAR MECHANISM; NUCLEAR LOCALIZATION; NUCLEAR RIBONUCLEOPROTEIN; NUCLEAR RNA; OVER-EXPRESSION; PARENTAL CELLS; PRE-MRNA; PRODRUGS; RESISTANT CELLS; RIBONUCLEOPROTEINS; SPLICING FACTORS; STRONG BINDING; THYMIDINE PHOSPHORYLASE; TUMOR CELLS;

BIOINFORMATICS; DISEASES; PHOSPHORYLATION; RNA; TUMORS;

NUCLEIC ACIDS;

5' DEOXYFLUOROURIDINE; ANTINEOPLASTIC AGENT; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H2; MESSENGER RNA PRECURSOR; NUCLEAR RNA; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; CAPECITABINE; DEOXYCYTIDINE; DRUG DERIVATIVE; FLUOROURACIL; HNRNPH2 PROTEIN, HUMAN; PRODRUG; RNA PRECURSOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOINFORMATICS; CANCER RESISTANCE; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; RNA SPLICING; DRUG EFFECT; DRUG RESISTANCE; GENETICS; METABOLISM; PROTEIN PROCESSING; TUMOR CELL LINE;

CELL LINE, TUMOR; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP F-H; HUMANS; PRODRUGS; PROTEIN SPLICING; RNA PRECURSORS; THYMIDINE PHOSPHORYLASE;

EID: 79952813023     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.163444     Document Type: Article

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