The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

EMBO Reports

Volumn 15, Issue 4, 2014, Pages 419-427

  Bielli, Pamela ^a,b   Busà, Roberta ^a,b   Di Stasi, Savino M ^a   Munoz, Manuel J ^c   Botti, Flavia ^a   Kornblihtt, Alberto R ^c   Sette, Claudio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c INSTITUTO DE FISIOLOGÍA   (Argentina)

Author keywords

alternative splicing; apoptosis; BCL X; FBI 1; SAM68

Indexed keywords

HISTONE DEACETYLASE; MESSENGER RNA; PROTEIN BCL X; PROTEIN BCL XL; PROTEIN SAM68; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FBI 1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HDAC1 PROTEIN, HUMAN; HISTONE DEACETYLASE 1; KHDRBS1 PROTEIN, HUMAN; PROTEIN BINDING; RNA BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ZBTB7A PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN INTERACTION; ALTERNATIVE RNA SPLICING; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; TUMOR CELL LINE; TWO HYBRID SYSTEM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALTERNATIVE SPLICING; APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; DNA-BINDING PROTEINS; HEK293 CELLS; HISTONE DEACETYLASE 1; HUMANS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84898632029     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1002/embr.201338241     Document Type: Article

References (26)

1. Chen M, Manley JL, (2009) Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 10: 741-754
2. Kalsotra A, Cooper TA, (2011) Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet 12: 715-729
3. Wahl MC, Will CL, Lührmann R, (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701-718
4. Black DL, (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336 (Pubitemid 36930448)
5. Schwerk C, Schulze-Osthoff K, (2005) Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 19: 1-13 (Pubitemid 40884653)
6. Boise LH, Gonzáles-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB, (1993) bcl-x, a bcl-2-related gene that function as a dominant regulator of apoptotic cell death. Cell 74: 507-608
7. Bauman JA, Li SD, Yang A, Huang L, Kole R, (2010) Anti-tumor activity of splice-switching oligonucleotides. Nucleic Acids Res 38: 8348-8356
8. Paronetto MP, Achsel T, Massiellom A, Chalfant CE, Sette C, (2007) The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol 176: 929-939 (Pubitemid 46506967)
9. Lukong KE, Richard S, (2003) Sam68, the KH domain-containing superSTAR. Biochim Biophys Acta 653: 73-86 (Pubitemid 37487649)
10. Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelici DF, Attisani F, Vespasiani G, Sette C, (2007) The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 26: 4372-4382 (Pubitemid 47014462)
11. Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP, (2007) Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 11: 860-866 (Pubitemid 46764272)
12. Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP, (2005) Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 433: 278-285
13. Aggarwal A, Hunter WJ III, Aggarwal H, Silva ED, Davey MS, Murphy RF, Agrawal DK, (2010) Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers. Exp Mol Pathol 89: 140-148
14. Bielli P, Busà R, Paronetto MP, Sette C, (2011) The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer 18: R91-R102
15. Taylor SJ, Resnick RJ, Shalloway D, (2004) Sam68 exerts separable effects on cell cycle progression and apoptosis. BMC Cell Biol 5: 5
16. Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss MJ, Pandolfi PP, (2009) LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Dev Cell 17: 527-540
17. Jeon BN, Yoo JY, Choi WI, Lee CE, Yoon HG, Hur MW, (2008) Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors. J Biol Chem 283: 33199-33210
18. Choi WI, Jeon BN, Yun CO, Kim PH, Kim SE, Choi KY, Kim SH, Hur MW, (2009) Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1. J Biol Chem 284: 12633-12644
19. Lukong KE, Larocque D, Tyner AL, Richard S, (2005) Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J Biol Chem 280: 38639-38647 (Pubitemid 43853766)
20. Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S, Manley JL, Sette C, (2010) The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J 29: 1235-1247
21. Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C, Hyslop T, Knudsen KE, Sette C, (2010) Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res 70: 229-239
22. Laudes M, Bilkovski R, Oberhauser F, Droste A, Gomolka M, Leeser U, Udelhoven M, Krone W, (2008) Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. J Mol Med (Berl) 86: 597-608
23. Hnilicová J, Hozeifi S, Dušková E, Icha J, Tománková T, Staněk D, (2011) Histone deacetylase activity modulates alternative splicing. PLoS ONE 6: e16727
24. Prince HM, Bishton MJ, Johnstone RW, (2009) Clinical studies of histone deacetylase inhibitors. Future Oncol 5: 601-612
25. Paronetto MP, Messina V, Barchi M, Geremia R, Richard S, Sette C, (2011) Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells. Nucleic Acids Res 39: 4961-4974
26. Wang Z, Tollervey J, Briese M, Turner D, Ule J, (2009) CLIP: construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivo. Methods 48: 287-293