메뉴 건너뛰기




Volumn 42, Issue 19, 2014, Pages 12070-12081

Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5' splice site selection

Author keywords

[No Author keywords available]

Indexed keywords

POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN BCL X; PROTEIN PTBP1; RNA; UNCLASSIFIED DRUG; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; NUCLEAR PROTEIN; PTBP1 PROTEIN, HUMAN; RNA BINDING PROTEIN; RNA SPLICING; SERINE-ARGININE-RICH SPLICING PROTEINS;

EID: 84925283590     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku922     Document Type: Article
Times cited : (66)

References (53)
  • 2
  • 3
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black, D.L. (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem., 72, 291-336.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 291-336
    • Black, D.L.1
  • 4
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl, M.C., Will, C.L. and Lührmann, R. (2009) The spliceosome: Design principles of a dynamic RNP machine. Cell, 136, 701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Lührmann, R.3
  • 5
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen, M. and Manley, J.L. (2009) Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches. Nat. Rev. Mol. Cell Biol., 10, 741-754.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 6
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan, Q., Shai, O., Lee, L.J., Frey, B.J. and Blencowe, B.J. (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet., 40, 1413-1415.
    • (2008) Nat. Genet. , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 8
    • 80053027909 scopus 로고    scopus 로고
    • Functional consequences of developmentally regulated alternative splicing
    • Kalsotra, A. and Cooper, T.A. (2011) Functional consequences of developmentally regulated alternative splicing. Nat. Rev. Genet., 12, 715-729.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 715-729
    • Kalsotra, A.1    Cooper, T.A.2
  • 10
    • 84867900147 scopus 로고    scopus 로고
    • The role of RNA structure in posttranscriptional regulation of gene expression
    • Jacobs, E., Mills, J.D. and Janitz, M. (2012) The role of RNA structure in posttranscriptional regulation of gene expression. J. Genet. Genomics, 39, 535-543.
    • (2012) J. Genet. Genomics , vol.39 , pp. 535-543
    • Jacobs, E.1    Mills, J.D.2    Janitz, M.3
  • 11
    • 0029055472 scopus 로고
    • Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
    • Singh, R., Valcárcel, J. and Green, M.R. (1995) Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science, 268, 1173-1176.
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcárcel, J.2    Green, M.R.3
  • 12
    • 84896524463 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point
    • Zheng, X., Cho, S., Moon, H., Loh, T.J., Oh, H.K., Green, M.R. and Shen, H. (2014) Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point. RNA, 20, 440-446.
    • (2014) RNA , vol.20 , pp. 440-446
    • Zheng, X.1    Cho, S.2    Moon, H.3    Loh, T.J.4    Oh, H.K.5    Green, M.R.6    Shen, H.7
  • 13
    • 79951996054 scopus 로고    scopus 로고
    • U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression
    • Sharma, S., Maris, C., Allain, F.H. and Black, D.L. (2011) U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression. Mol. Cell, 41, 579-588.
    • (2011) Mol. Cell , vol.41 , pp. 579-588
    • Sharma, S.1    Maris, C.2    Allain, F.H.3    Black, D.L.4
  • 15
    • 59649107040 scopus 로고    scopus 로고
    • An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
    • Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X.D. and Gage, F.H. (2009) An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat. Struct. Mol. Biol., 16, 130-137.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 130-137
    • Yeo, G.W.1    Coufal, N.G.2    Liang, T.Y.3    Peng, G.E.4    Fu, X.D.5    Gage, F.H.6
  • 16
    • 72149117411 scopus 로고    scopus 로고
    • Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping
    • Xue, Y., Zhou, Y., Wu, T., Zhu, T., Ji, X., Kwon, Y.S., Zhang, C., Yeo, G., Black, D.L., Sun, H. et al. (2009) Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol. Cell, 36, 996-1006.
    • (2009) Mol. Cell , vol.36 , pp. 996-1006
    • Xue, Y.1    Zhou, Y.2    Wu, T.3    Zhu, T.4    Ji, X.5    Kwon, Y.S.6    Zhang, C.7    Yeo, G.8    Black, D.L.9    Sun, H.10
  • 18
    • 60149093432 scopus 로고    scopus 로고
    • RNA and desease
    • Cooper, TA., Wan, L. and Dreyfuss, G. (2009) RNA and desease. Cell, 136, 777-793.
    • (2009) Cell , vol.136 , pp. 777-793
    • Cooper, T.A.1    Wan, L.2    Dreyfuss, G.3
  • 19
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • Schwerk, C. and Schulze-Osthoff, K. (2005) Regulation of apoptosis by alternative pre-mRNA splicing. Mol. Cell, 19, 1-13.
    • (2005) Mol. Cell , vol.19 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 20
    • 84875794702 scopus 로고    scopus 로고
    • Live or let die: Posttranscriptional gene regulation in cell stress and cell death
    • Thomas, M.P. and Lieberman, J. (2013) Live or let die: Posttranscriptional gene regulation in cell stress and cell death. Immunol. Rev., 253, 237-252.
    • (2013) Immunol. Rev. , vol.253 , pp. 237-252
    • Thomas, M.P.1    Lieberman, J.2
  • 22
    • 77955662560 scopus 로고    scopus 로고
    • An alternative splicing network links cell-cycle control to apoptosis
    • Moore, M.J., Wang, Q., Kennedy, C.J. and Silver, P.A. (2010) An alternative splicing network links cell-cycle control to apoptosis. Cell, 142, 625-636.
    • (2010) Cell , vol.142 , pp. 625-636
    • Moore, M.J.1    Wang, Q.2    Kennedy, C.J.3    Silver, P.A.4
  • 23
    • 0030805125 scopus 로고    scopus 로고
    • Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases
    • Olopade, O.I., Adeyanju, M.O., Safa, A.R., Hagos, F., Mick, R., Thompson, C.B. and Recant, W.M. (1997) Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J. Sci. Am., 3, 230-237.
    • (1997) Cancer J. Sci. Am. , vol.3 , pp. 230-237
    • Olopade, O.I.1    Adeyanju, M.O.2    Safa, A.R.3    Hagos, F.4    Mick, R.5    Thompson, C.B.6    Recant, W.M.7
  • 24
    • 0034950640 scopus 로고    scopus 로고
    • Expression and role of Bcl-xL in human hepatocellular carcinomas
    • Takehara, T., Liu, X., Fujimoto, J., Friedman, S.L. and Takahashi, H. (2001) Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology, 34, 55-61.
    • (2001) Hepatology , vol.34 , pp. 55-61
    • Takehara, T.1    Liu, X.2    Fujimoto, J.3    Friedman, S.L.4    Takahashi, H.5
  • 25
    • 0345829926 scopus 로고    scopus 로고
    • Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents
    • Mercatante, D.R., Mohler, J.L. and Kole, R. (2002) Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents. J. Biol. Chem., 277, 49374-49782.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49374-49782
    • Mercatante, D.R.1    Mohler, J.L.2    Kole, R.3
  • 26
    • 20744450092 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x
    • Garneau, D., Revil, T., Fisette, J.F. and Chabot, B. (2005) Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x. J. Biol. Chem., 280, 22641-22650.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22641-22650
    • Garneau, D.1    Revil, T.2    Fisette, J.F.3    Chabot, B.4
  • 27
    • 33947712084 scopus 로고    scopus 로고
    • The RNA-binding protein SAM68 modulates the alternative splicing of Bcl-x
    • Paronetto, M.P., Achsel, T., Massiello, A., Chalfant, C.E. and Sette, C. (2007) The RNA-binding protein SAM68 modulates the alternative splicing of Bcl-x. J. Cell Biol., 176, 929-939.
    • (2007) J. Cell Biol. , vol.176 , pp. 929-939
    • Paronetto, M.P.1    Achsel, T.2    Massiello, A.3    Chalfant, C.E.4    Sette, C.5
  • 28
    • 52049094582 scopus 로고    scopus 로고
    • Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x
    • Cloutier, P., Toutant, J., Shkreta, L., Goekjian, S., Revil, T. and Chabot, B. (2008) Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x. J. Biol. Chem., 283, 21315-21324.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21315-21324
    • Cloutier, P.1    Toutant, J.2    Shkreta, L.3    Goekjian, S.4    Revil, T.5    Chabot, B.6
  • 29
    • 69249087295 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform
    • Revil, T., Pelletier, J., Toutant, J., Cloutier, A. and Chabot, B. (2009) Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform. J. Biol. Chem., 284, 21458-21467.
    • (2009) J. Biol. Chem. , vol.284 , pp. 21458-21467
    • Revil, T.1    Pelletier, J.2    Toutant, J.3    Cloutier, A.4    Chabot, B.5
  • 30
    • 84856945928 scopus 로고    scopus 로고
    • The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator
    • Pedrotti, S., Busà, R., Compagnucci, C. and Sette, C. (2012) The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res., 40, 1021-1032.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 1021-1032
    • Pedrotti, S.1    Busà, R.2    Compagnucci, C.3    Sette, C.4
  • 33
    • 84898632029 scopus 로고    scopus 로고
    • The transcription factor FBI-1 modulates SAM68-mediated BCL-X alternative splicing and apoptosis
    • Bielli, P., Busà, R., Di Stasi, S.M., Munoz, M.J., Botti, F., Kornblihtt, A.R. and Sette, C. (2014) The transcription factor FBI-1 modulates SAM68-mediated BCL-X alternative splicing and apoptosis. EMBO Rep., 15, 419-427.
    • (2014) EMBO Rep. , vol.15 , pp. 419-427
    • Bielli, P.1    Busà, R.2    Di Stasi, S.M.3    Munoz, M.J.4    Botti, F.5    Kornblihtt, A.R.6    Sette, C.7
  • 35
    • 78650440393 scopus 로고    scopus 로고
    • Anti-tumor activity of splice-switching oligonucleotides
    • Bauman, J.A., Li, S.D., Yang, A., Huang, L. and Kole, R. (2010) Anti-tumor activity of splice-switching oligonucleotides. Nucleic Acids Res., 38, 8348-8356.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 8348-8356
    • Bauman, J.A.1    Li, S.D.2    Yang, A.3    Huang, L.4    Kole, R.5
  • 36
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
    • Kole, R., Krainer, A.R. and Altman, S. (2012) RNA therapeutics: Beyond RNA interference and antisense oligonucleotides. Nat. Rev. Drug Discov., 11, 125-140.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 37
    • 1942533609 scopus 로고    scopus 로고
    • Identification of two RNA cis-elements that function to regulate the 5' SS selection of Bcl-x premRNA in response to ceramide
    • Massiello, A., Salas, A., Pinkerman, R.L., Roddy, P., Roesser, J.R. and Chalfant, C.E. (2004) Identification of two RNA cis-elements that function to regulate the 5' SS selection of Bcl-x premRNA in response to ceramide. J. Biol. Chem., 279, 15799-15804.
    • (2004) J. Biol. Chem. , vol.279 , pp. 15799-15804
    • Massiello, A.1    Salas, A.2    Pinkerman, R.L.3    Roddy, P.4    Roesser, J.R.5    Chalfant, C.E.6
  • 38
    • 0029682322 scopus 로고    scopus 로고
    • Site-directed mutagenesis in vitro by megaprimer PCR
    • Barik, S. (1996) Site-directed mutagenesis in vitro by megaprimer PCR. Methods Mol. Biol., 57, 203-215.
    • (1996) Methods Mol. Biol. , vol.57 , pp. 203-215
    • Barik, S.1
  • 39
    • 77950524790 scopus 로고    scopus 로고
    • The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
    • Pedrotti, S., Bielli, P., Paronetto, M.P., Ciccosanti, F., Fimia, G.M., Stamm, S., Manley, J.L. and Sette, C. (2010) The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J., 29, 1235-1247.
    • (2010) EMBO J. , vol.29 , pp. 1235-1247
    • Pedrotti, S.1    Bielli, P.2    Paronetto, M.P.3    Ciccosanti, F.4    Fimia, G.M.5    Stamm, S.6    Manley, J.L.7    Sette, C.8
  • 40
    • 67649840910 scopus 로고    scopus 로고
    • CLIP: Construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivo
    • Wang, Z., Tollervey, J., Briese, M., Turner, D. and Ule, J. (2009) CLIP: Construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivo. Methods, 48, 287-293.
    • (2009) Methods , vol.48 , pp. 287-293
    • Wang, Z.1    Tollervey, J.2    Briese, M.3    Turner, D.4    Ule, J.5
  • 42
  • 43
    • 0034163539 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors
    • Jin, W., McCutcheon, I.E., Fuller, G.N., Huang, E.S. and Cote, G.J. (2000) Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. Cancer Res., 60, 1221-1224.
    • (2000) Cancer Res. , vol.60 , pp. 1221-1224
    • Jin, W.1    McCutcheon, I.E.2    Fuller, G.N.3    Huang, E.S.4    Cote, G.J.5
  • 44
    • 76649102764 scopus 로고    scopus 로고
    • The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
    • Clower, C.V., Chatterjee, D., Wang, Z., Cantley, L.C., Vander-Heiden, M.G. and Krainer, A.R. (2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc. Natl. Acad. Sci. U.S.A., 107, 1894-1899.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1894-1899
    • Clower, C.V.1    Chatterjee, D.2    Wang, Z.3    Cantley, L.C.4    Vander-Heiden, M.G.5    Krainer, A.R.6
  • 45
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David, C.J., Chen, M., Assanah, M., Canoll, P. and Manley, J.L. (2010) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature, 463, 364-368.
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 48
    • 84871401549 scopus 로고    scopus 로고
    • Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms
    • Erkelenz, S., Mueller, W.F., Evans, M.S., Busch, A., Schöneweis, K., Hertel, K.J. and Schaal, H. (2013) Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA, 19, 96-102.
    • (2013) RNA , vol.19 , pp. 96-102
    • Erkelenz, S.1    Mueller, W.F.2    Evans, M.S.3    Busch, A.4    Schöneweis, K.5    Hertel, K.J.6    Schaal, H.7
  • 49
    • 84867900618 scopus 로고    scopus 로고
    • PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis
    • Izaguirre, D.I., Zhu, W., Hai, T., Cheung, H.C., Krahe, R. and Cote, G.J. (2012) PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol. Carcinog., 51, 895-906.
    • (2012) Mol. Carcinog. , vol.51 , pp. 895-906
    • Izaguirre, D.I.1    Zhu, W.2    Hai, T.3    Cheung, H.C.4    Krahe, R.5    Cote, G.J.6
  • 50
    • 84869106125 scopus 로고    scopus 로고
    • Antisense-based therapy for the treatment of spinal muscular atrophy
    • Rigo, F., Hua, Y., Krainer, A.R. and Bennett, C.F. (2012) Antisense-based therapy for the treatment of spinal muscular atrophy. J. Cell Biol., 199, 21-25.
    • (2012) J. Cell Biol. , vol.199 , pp. 21-25
    • Rigo, F.1    Hua, Y.2    Krainer, A.R.3    Bennett, C.F.4
  • 51
    • 84877872340 scopus 로고    scopus 로고
    • Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy
    • Koo, T. and Wood, M.J. (2013) Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy. Hum. Gene Ther., 24, 479-488.
    • (2013) Hum. Gene Ther. , vol.24 , pp. 479-488
    • Koo, T.1    Wood, M.J.2
  • 52
    • 84907263928 scopus 로고    scopus 로고
    • Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer
    • Das, S. and Krainer, A.R. (2014) Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Mol. Cancer Res., 12, 1195-1204.
    • (2014) Mol. Cancer Res. , vol.12 , pp. 1195-1204
    • Das, S.1    Krainer, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.