T cell costimulation through CD28 depends on induction of the Bcl-xγ isoform: Analysis of Bcl-xγ-deficient mice

Journal of Experimental Medicine

Volumn 196, Issue 1, 2002, Pages 87-95

  Ye, Qunrui ^a   Press, Barry ^a   Kissler, Stephan ^a   Yang, Xiao Feng ^a   Lu, Linrong ^a   Bassing, Craig H ^b   Sleckman, Barry P ^b   Jansson, Marianne ^a   Panoutsakopoulou, Vily ^a   Trimble, Linda A ^a   Alt, Frederick W ^b   Cantor, Harvey ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Bcl x ; CD28; Costimulation; EAE; T cell

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; INTERLEUKIN 2; PROTEIN BCL X; PROTEIN BCL XGAMMA; PROTEOLIPID PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SUSPENSION; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE INDUCTION; GENE OVEREXPRESSION; IMMUNOLOGICAL MEMORY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; APOPTOSIS; AUTOIMMUNITY; BCL-X PROTEIN; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; CHIMERA; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; GENE TARGETING; INTERLEUKIN-2; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES;

EID: 0036645280     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20012084     Document Type: Article

References (31)

1. CD28-mediated signalling costimulates murine T-cells and prevents induction of anergy in T-cell clones
2. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
3. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
4. Bcl-x, a Bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
5. Bcl-XL and Bcl-2 repress a common pathway of cell death
6. Bcl-xL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
7. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
8. Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes
9. Cutting edge: Distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-xL
10. A point mutation in CD28 distinguishes proliferative signals from survival signals
11. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells
12. Functional dissection of the lck proximal promoter
13. Simplified mammalian DNA isolation procedure
14. Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-xγ expression after CD28-dependent costimulation
15. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
16. T cells: A proliferation of costimulatory molecules
17. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response
18. CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression
19. CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes
20. Co-stimulation lowers the threshold for activation of naive T cells by bacterial superantigens
21. Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice
22. CD28 costimulation is crucial for the development of spontaneous autoinunune encephalomyelitis
23. Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis
24. Distinct phenotypes associated with increasing dosage of the PLP gene: Implications for CMT1A due to PMP22 gene duplication
25. Costimulatory regulation of T-cell function
26. Differential T cell costimulatory requirements in CD28-deficient mice
27. A Jun-binding protein related to a putative tumor suppressor
28. Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
29. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
30. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells
31. Caspase activation is required for T cell proliferation