Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis

Toxicological sciences : an official journal of the Society of Toxicology

Volumn 143, Issue 1, 2015, Pages 81-96

  Zhou, Qian ^a   Liu, Chunxiao ^a   Liu, Wen ^a   Zhang, Hai ^a   Zhang, Ruijie ^a   Liu, Jia ^a   Zhang, Jinfei ^a   Xu, Chong ^a   Liu, Lei ^a   Huang, Shile ^a   Chen, Long ^a  

^a NANJING NORMAL UNIVERSITY   (China)

Author keywords

apoptosis; hydrogen peroxide; mammalian target of rapamycin; neuronal cells; Parkinson s disease; rotenone

Indexed keywords

ANTIOXIDANT; CARRIER PROTEIN; CASPASE INHIBITOR; EIF4E PROTEIN, MOUSE; EIF4EBP1 PROTEIN, MOUSE; EIF4EBP1 PROTEIN, RAT; HYDROGEN PEROXIDE; INITIATION FACTOR 4E; MTOR PROTEIN, MOUSE; MTOR PROTEIN, RAT; PHOSPHOPROTEIN; ROTENONE; RPS6KA1 PROTEIN, MOUSE; S6 KINASE; S6K1 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ANIMAL; APOPTOSIS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PC12 CELL LINE; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARRIER PROTEINS; CASPASE INHIBITORS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-4E; HYDROGEN PEROXIDE; MICE; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PHOSPHOPROTEINS; RATS; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RNA INTERFERENCE; ROTENONE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSFECTION; UP-REGULATION;

EID: 85017301895     PISSN: None     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu211     Document Type: Article

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