메뉴 건너뛰기




Volumn 7, Issue 7, 2015, Pages 1189-1202

Plant-derived neuroprotective agents in Parkinson’s disease

Author keywords

Chinese herbs; Curcumin; Ginsenoside; Neuroprotection; Parkinson s disease; Resveratrol

Indexed keywords

C REACTIVE PROTEIN; CASPASE 3; CURCUMIN; CYCLOOXYGENASE 2; GINSENOSIDE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOLIPASE A2; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RESVERATROL; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNINDEXED DRUG;

EID: 84939556767     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (102)

References (94)
  • 1
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson’s disease: Mechanisms and models
    • [1] Dauer W and Przedborski S. Parkinson’s disease: mechanisms and models. Neuron 2003; 39: 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 2
    • 84887935315 scopus 로고    scopus 로고
    • Neural metabolite changes in corpus striatum after rat multipotent mesenchymal stem cells transplanted in hemiparkinsonian rats by magnetic resonance spectroscopy
    • [2] Fu W, Zheng Z, Zhuang W, Chen D, Wang X, Sun X and Wang X. Neural metabolite changes in corpus striatum after rat multipotent mesenchymal stem cells transplanted in hemiparkinsonian rats by magnetic resonance spectroscopy. Int J Neurosci 2013; 123: 883-891.
    • (2013) Int J Neurosci , vol.123 , pp. 883-891
    • Fu, W.1    Zheng, Z.2    Zhuang, W.3    Chen, D.4    Wang, X.5    Sun, X.6    Wang, X.7
  • 4
    • 84885330430 scopus 로고    scopus 로고
    • Food, nutrigenomics, and neurodegeneration--neuroprotection by what you eat!
    • [4] Virmani A, Pinto L, Binienda Z and Ali S. Food, nutrigenomics, and neurodegeneration--neuroprotection by what you eat! Mol Neurobiol 2013; 48: 353-362.
    • (2013) Mol Neurobiol , vol.48 , pp. 353-362
    • Virmani, A.1    Pinto, L.2    Binienda, Z.3    Ali, S.4
  • 5
    • 84899516945 scopus 로고    scopus 로고
    • Curcumin and its derivatives: Their application in neuropharmacology and neuroscience in the 21st century
    • [5] Lee WH, Loo CY, Bebawy M, Luk F, Mason RS and Rohanizadeh R. Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol 2013; 11: 338-378.
    • (2013) Curr Neuropharmacol , vol.11 , pp. 338-378
    • Lee, W.H.1    Loo, C.Y.2    Bebawy, M.3    Luk, F.4    Mason, R.S.5    Rohanizadeh, R.6
  • 6
    • 84872242871 scopus 로고    scopus 로고
    • A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system
    • [6] Kim HJ, Kim P and Shin CY. A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J Ginseng Res 2013; 37: 8-29.
    • (2013) J Ginseng Res , vol.37 , pp. 8-29
    • Kim, H.J.1    Kim, P.2    Shin, C.Y.3
  • 7
    • 77955088481 scopus 로고    scopus 로고
    • Resveratrol as a therapeutic agent for neurodegenerative diseases
    • [7] Sun AY, Wang Q, Simonyi A and Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol 2010; 41: 375-383.
    • (2010) Mol Neurobiol , vol.41 , pp. 375-383
    • Sun, A.Y.1    Wang, Q.2    Simonyi, A.3    Sun, G.Y.4
  • 8
    • 34547762666 scopus 로고    scopus 로고
    • Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson’s disease
    • [8] Chen LW, Wang YQ, Wei LC, Shi M and Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson’s disease. CNS Neurol Disord Drug Targets 2007; 6: 273-281.
    • (2007) CNS Neurol Disord Drug Targets , vol.6 , pp. 273-281
    • Chen, L.W.1    Wang, Y.Q.2    Wei, L.C.3    Shi, M.4    Chan, Y.S.5
  • 9
    • 77956242222 scopus 로고    scopus 로고
    • Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions
    • [9] Zhang F, Shi JS, Zhou H, Wilson B, Hong JS and Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol 2010; 78: 466-477.
    • (2010) Mol Pharmacol , vol.78 , pp. 466-477
    • Zhang, F.1    Shi, J.S.2    Zhou, H.3    Wilson, B.4    Hong, J.S.5    Gao, H.M.6
  • 11
    • 84871840817 scopus 로고    scopus 로고
    • Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
    • [11] Zhang F, Wang YY, Liu H, Lu YF, Wu Q, Liu J and Shi JS. Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release. Evid Based Complement Alternat Med 2012; 2012: 937605.
    • (2012) Evid Based Complement Alternat Med 2012
    • Zhang, F.1    Wang, Y.Y.2    Liu, H.3    Lu, Y.F.4    Wu, Q.5    Liu, J.6    Shi, J.S.7
  • 12
    • 84891837932 scopus 로고    scopus 로고
    • Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: Effect on p53 and GRP75 localization
    • [12] Renaud J, Bournival J, Zottig X and Martinoli MG. Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization. Neurotox Res 2014; 25: 110-123.
    • (2014) Neurotox Res , vol.25 , pp. 110-123
    • Renaud, J.1    Bournival, J.2    Zottig, X.3    Martinoli, M.G.4
  • 13
    • 51549098145 scopus 로고    scopus 로고
    • Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity
    • [13] Chao J, Yu MS, Ho YS, Wang M and Chang RC. Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radic Biol Med 2008; 45: 1019-1026.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1019-1026
    • Chao, J.1    Yu, M.S.2    Ho, Y.S.3    Wang, M.4    Chang, R.C.5
  • 14
    • 84900017196 scopus 로고    scopus 로고
    • Immune responses in Parkinson’s disease: Interplay between central and peripheral immune systems
    • [14] Su X and Federoff HJ. Immune responses in Parkinson’s disease: interplay between central and peripheral immune systems. Biomed Res 2014; 2014: 275178.
    • (2014) Biomed Res 2014
    • Su, X.1    Federoff, H.J.2
  • 15
    • 84904595928 scopus 로고    scopus 로고
    • SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway
    • [15] Liu L, Arun A, Ellis L, Peritore C and Donmez G. SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Front Aging Neurosci 2014; 6: 184.
    • (2014) Front Aging Neurosci , vol.6 , pp. 184
    • Liu, L.1    Arun, A.2    Ellis, L.3    Peritore, C.4    Donmez, G.5
  • 16
    • 84912571285 scopus 로고    scopus 로고
    • Apoptosis and oxidative stress in neurodegenerative diseases
    • [16] Radi E, Formichi P, Battisti C and Federico A. Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimers Dis 2014; 42 Suppl 3: S125-152.
    • (2014) J Alzheimers Dis , vol.42 , pp. S125-S152
    • Radi, E.1    Formichi, P.2    Battisti, C.3    Federico, A.4
  • 17
    • 0032806379 scopus 로고    scopus 로고
    • Cysteamine pretreatment of the astroglial substratum (Mitochondrial iron sequestration) enhances PC12 cell vulnerability to oxidative injury
    • [17] Frankel D and Schipper HM. Cysteamine pretreatment of the astroglial substratum (mitochondrial iron sequestration) enhances PC12 cell vulnerability to oxidative injury. Exp Neurol 1999; 160: 376-385.
    • (1999) Exp Neurol , vol.160 , pp. 376-385
    • Frankel, D.1    Schipper, H.M.2
  • 18
    • 38849203188 scopus 로고    scopus 로고
    • Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation
    • [18] Bureau G, Longpre F and Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res 2008; 86: 403-410.
    • (2008) J Neurosci Res , vol.86 , pp. 403-410
    • Bureau, G.1    Longpre, F.2    Martinoli, M.G.3
  • 19
    • 56149119401 scopus 로고    scopus 로고
    • Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson’s disease in rats
    • [19] Jin F, Wu Q, Lu YF, Gong QH and Shi JS. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson’s disease in rats. Eur J Pharmacol 2008; 600: 78-82.
    • (2008) Eur J Pharmacol , vol.600 , pp. 78-82
    • Jin, F.1    Wu, Q.2    Lu, Y.F.3    Gong, Q.H.4    Shi, J.S.5
  • 20
    • 84898986648 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s-like disease: Possible role of SOCS-1 in reducing pro-inflammatory responses
    • [20] Lofrumento DD, Nicolardi G, Cianciulli A, De Nuccio F, La Pesa V, Carofiglio V, Dragone T, Calvello R and Panaro MA. Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses. Innate Immun 2014; 20: 249-260.
    • (2014) Innate Immun , vol.20 , pp. 249-260
    • Lofrumento, D.D.1    Nicolardi, G.2    Cianciulli, A.3    De Nuccio, F.4    La Pesa, V.5    Carofiglio, V.6    Dragone, T.7    Calvello, R.8    Panaro, M.A.9
  • 21
    • 84875970786 scopus 로고    scopus 로고
    • Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells
    • [21] Chang CY, Choi DK, Lee DK, Hong YJ and Park EJ. Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells. PLoS One 2013; 8: e60654.
    • (2013) Plos One , vol.8
    • Chang, C.Y.1    Choi, D.K.2    Lee, D.K.3    Hong, Y.J.4    Park, E.J.5
  • 22
    • 84884368396 scopus 로고    scopus 로고
    • Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
    • [22] Ye J, Liu Z, Wei J, Lu L, Huang Y, Luo L and Xie H. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neurosci Lett 2013; 553: 72-77.
    • (2013) Neurosci Lett , vol.553 , pp. 72-77
    • Ye, J.1    Liu, Z.2    Wei, J.3    Lu, L.4    Huang, Y.5    Luo, L.6    Xie, H.7
  • 24
    • 77952882393 scopus 로고    scopus 로고
    • Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SHSY5Y cells
    • [24] Chao J, Li H, Cheng KW, Yu MS, Chang RC and Wang M. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SHSY5Y cells. J Nutr Biochem 2010; 21: 482-489.
    • (2010) J Nutr Biochem , vol.21 , pp. 482-489
    • Chao, J.1    Li, H.2    Cheng, K.W.3    Yu, M.S.4    Chang, R.C.5    Wang, M.6
  • 26
    • 84892734212 scopus 로고    scopus 로고
    • Studies on sensitivity of zebrafish as a model organism for Parkinson’s disease: Comparison with rat model
    • [26] Makhija DT and Jagtap AG. Studies on sensitivity of zebrafish as a model organism for Parkinson’s disease: Comparison with rat model. J Pharmacol Pharmacother 2014; 5: 39-46.
    • (2014) J Pharmacol Pharmacother , vol.5 , pp. 39-46
    • Makhija, D.T.1    Jagtap, A.G.2
  • 27
    • 77049122576 scopus 로고    scopus 로고
    • Protective effects of resveratrol and quercetin against MPP+-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons
    • [27] Bournival J, Quessy P and Martinoli MG. Protective effects of resveratrol and quercetin against MPP+-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol Neurobiol 2009; 29: 1169-1180.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 1169-1180
    • Bournival, J.1    Quessy, P.2    Martinoli, M.G.3
  • 28
    • 35548982587 scopus 로고    scopus 로고
    • SIRT1/PGC-1: A neuroprotective axis?
    • Rasouri S, Lagouge M and Auwerx J. [SIRT1/PGC-1: a neuroprotective axis?]. Med Sci (Paris) 2007; 23: 840-844.
    • (2007) Med Sci (Paris) , vol.23 , pp. 840-844
    • Rasouri, S.1    Lagouge, M.2    Auwerx, J.3
  • 30
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • [30] Baur JA and Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5: 493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 31
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • [31] Dasgupta B and Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A 2007; 104: 7217-7222.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 32
    • 37549060702 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    • [32] Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC and Bronfman M. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem 2007; 282: 37006-37015.
    • (2007) J Biol Chem , vol.282 , pp. 37006-37015
    • Fuenzalida, K.1    Quintanilla, R.2    Ramos, P.3    Piderit, D.4    Fuentealba, R.A.5    Martinez, G.6    Inestrosa, N.C.7    Bronfman, M.8
  • 34
    • 42949125477 scopus 로고    scopus 로고
    • SIRT1 and neuronal diseases
    • [34] Tang BL and Chua CE. SIRT1 and neuronal diseases. Mol Aspects Med 2008, 29: 187-200.
    • (2008) Mol Aspects Med , vol.29 , pp. 187-200
    • Tang, B.L.1    Chua, C.E.2
  • 35
    • 80052359850 scopus 로고    scopus 로고
    • Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease
    • [35] Wu Y, Li X, Zhu JX, Xie W, Le W, Fan Z, Jankovic J and Pan T. Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease. Neurosignals 2011; 19: 163-174.
    • (2011) Neurosignals , vol.19 , pp. 163-174
    • Wu, Y.1    Li, X.2    Zhu, J.X.3    Xie, W.4    Le, W.5    Fan, Z.6    Jankovic, J.7    Pan, T.8
  • 37
    • 70450285045 scopus 로고    scopus 로고
    • Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model
    • [37] Long J, Gao H, Sun L, Liu J and Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model. Rejuvenation Res 2009; 12: 321-331.
    • (2009) Rejuvenation Res , vol.12 , pp. 321-331
    • Long, J.1    Gao, H.2    Sun, L.3    Liu, J.4    Zhao-Wilson, X.5
  • 39
    • 79960811118 scopus 로고    scopus 로고
    • Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson’s disease
    • [39] Zahid M, Saeed M, Yang L, Beseler C, Rogan E and Cavalieri EL. Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson’s disease. IUBMB Life 2011; 63: 1087-1093.
    • (2011) IUBMB Life , vol.63 , pp. 1087-1093
    • Zahid, M.1    Saeed, M.2    Yang, L.3    Beseler, C.4    Rogan, E.5    Cavalieri, E.L.6
  • 40
    • 79953321373 scopus 로고    scopus 로고
    • Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats
    • [40] Wang Y, Xu H, Fu Q, Ma R and Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats. J Neurol Sci 2011; 304: 29-34.
    • (2011) J Neurol Sci , vol.304 , pp. 29-34
    • Wang, Y.1    Xu, H.2    Fu, Q.3    Ma, R.4    Xiang, J.5
  • 41
    • 84878014110 scopus 로고    scopus 로고
    • Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins
    • [41] Wu PF, Xie N, Zhang JJ, Guan XL, Zhou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F and Chen JG. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem 2013; 24: 1070-1077.
    • (2013) J Nutr Biochem , vol.24 , pp. 1070-1077
    • Wu, P.F.1    Xie, N.2    Zhang, J.J.3    Guan, X.L.4    Zhou, J.5    Long, L.H.6    Li, Y.L.7    Xiong, Q.J.8    Zeng, J.H.9    Wang, F.10    Chen, J.G.11
  • 42
    • 48749085399 scopus 로고    scopus 로고
    • Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
    • [42] Rubiolo JA, Mithieux G and Vega FV. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Euro J Pharmacol 2008; 591: 66-72.
    • (2008) Euro J Pharmacol , vol.591 , pp. 66-72
    • Rubiolo, J.A.1    Mithieux, G.2    Vega, F.V.3
  • 47
    • 84857932521 scopus 로고    scopus 로고
    • Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb-and paraquat-induced parkinsonism in the mouse
    • [47] Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O and Singh MP. Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb-and paraquat-induced parkinsonism in the mouse. Free Radic Biol Med 2012; 52: 1294-1306.
    • (2012) Free Radic Biol Med , vol.52 , pp. 1294-1306
    • Srivastava, G.1    Dixit, A.2    Yadav, S.3    Patel, D.K.4    Prakash, O.5    Singh, M.P.6
  • 48
    • 65649105139 scopus 로고    scopus 로고
    • Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factorkappa B modulation in MES23.5 cells
    • [48] Wang J, Du XX, Jiang H and Xie JX. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factorkappa B modulation in MES23.5 cells. Biochem Pharmacol 2009; 78: 178-183.
    • (2009) Biochem Pharmacol , vol.78 , pp. 178-183
    • Wang, J.1    Du, X.X.2    Jiang, H.3    Xie, J.X.4
  • 49
    • 51749116969 scopus 로고    scopus 로고
    • Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    • [49] Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M and Hong JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res 2008; 33: 2044-2053.
    • (2008) Neurochem Res , vol.33 , pp. 2044-2053
    • Yang, S.1    Zhang, D.2    Yang, Z.3    Hu, X.4    Qian, S.5    Liu, J.6    Wilson, B.7    Block, M.8    Hong, J.S.9
  • 50
    • 84866057219 scopus 로고    scopus 로고
    • Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease
    • [50] Ojha RP, Rastogi M, Devi BP, Agrawal A and Dubey GP. Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease. J Neuroimmune Pharmacol 2012; 7: 609-618.
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 609-618
    • Ojha, R.P.1    Rastogi, M.2    Devi, B.P.3    Agrawal, A.4    Dubey, G.P.5
  • 51
    • 84878621998 scopus 로고    scopus 로고
    • Ameliorating effects of curcumin on 6-OHDAinduced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice
    • [51] Tripanichkul W and Jaroensuppaperch EO. Ameliorating effects of curcumin on 6-OHDAinduced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice. Eur Rev Med Pharmacol Sci 2013; 17: 1360-1368.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 1360-1368
    • Tripanichkul, W.1    Jaroensuppaperch, E.O.2
  • 53
    • 33745056543 scopus 로고    scopus 로고
    • Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway
    • [53] Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, Sun SN, Feng JQ and Chen PX. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis 2006; 11: 943-953.
    • (2006) Apoptosis , vol.11 , pp. 943-953
    • Chen, J.1    Tang, X.Q.2    Zhi, J.L.3    Cui, Y.4    Yu, H.M.5    Tang, E.H.6    Sun, S.N.7    Feng, J.Q.8    Chen, P.X.9
  • 54
    • 77951557863 scopus 로고    scopus 로고
    • Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson’s disease cell model
    • [54] Wang MS, Boddapati S, Emadi S and Sierks MR. Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson’s disease cell model. BMC Neurosci 2010; 11: 57.
    • (2010) BMC Neurosci , vol.11 , pp. 57
    • Wang, M.S.1    Boddapati, S.2    Emadi, S.3    Sierks, M.R.4
  • 55
    • 84874663567 scopus 로고    scopus 로고
    • Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction
    • [55] Pan J, Li H, Ma JF, Tan YY, Xiao Q, Ding JQ and Chen SD. Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction. Transl Neurodegener 2012; 1: 16.
    • (2012) Transl Neurodegener , vol.1 , pp. 16
    • Pan, J.1    Li, H.2    Ma, J.F.3    Tan, Y.Y.4    Xiao, Q.5    Ding, J.Q.6    Chen, S.D.7
  • 56
    • 84921832523 scopus 로고    scopus 로고
    • Liposomal-formulated curcumin [Lipocurc] targeting HDAC (Histone deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: Implications for epigenetics-based nanotechnology-driven drug platform
    • Chiu S, Terpstra KJ, Bureau Y, Hou J, Raheb H, Cernvosky Z, Badmeav V, Copen J, Husni M and Woodbury-Farina M. Liposomal-formulated curcumin [Lipocurc] targeting HDAC (histone deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platform. J Complement Integr Med 2013; 10.
    • (2013) J Complement Integr Med , pp. 10
    • Chiu, S.1    Terpstra, K.J.2    Bureau, Y.3    Hou, J.4    Raheb, H.5    Cernvosky, Z.6    Badmeav, V.7    Copen, J.8    Husni, M.9    Woodbury-Farina, M.10
  • 58
    • 20744452215 scopus 로고    scopus 로고
    • Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus
    • [58] Kim HT, Qiang W, Liu N, Scofield VL, Wong PK and Stoica G. Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus. J Neurovirol 2005; 11: 166-179.
    • (2005) J Neurovirol , vol.11 , pp. 166-179
    • Kim, H.T.1    Qiang, W.2    Liu, N.3    Scofield, V.L.4    Wong, P.K.5    Stoica, G.6
  • 60
    • 84874645362 scopus 로고    scopus 로고
    • Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson’s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy
    • [60] Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ and Chen SD. Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson’s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy. J Neuroimmune Pharmacol 2013; 8: 356-369.
    • (2013) J Neuroimmune Pharmacol , vol.8 , pp. 356-369
    • Jiang, T.F.1    Zhang, Y.J.2    Zhou, H.Y.3    Wang, H.M.4    Tian, L.P.5    Liu, J.6    Ding, J.Q.7    Chen, S.D.8
  • 61
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson’s disease
    • [61] Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI and Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson’s disease. Free Radic Res 2005; 39: 1119-1125.
    • (2005) Free Radic Res , vol.39 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 62
    • 39149124146 scopus 로고    scopus 로고
    • Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson’s disease explained via in silico studies
    • [62] Jagatha B, Mythri RB, Vali S and Bharath MM. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson’s disease explained via in silico studies. Free Radic Biol Med 2008; 44: 907-917.
    • (2008) Free Radic Biol Med , vol.44 , pp. 907-917
    • Jagatha, B.1    Mythri, R.B.2    Vali, S.3    Bharath, M.M.4
  • 63
    • 77950296916 scopus 로고    scopus 로고
    • Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease
    • [63] Harish G, Venkateshappa C, Mythri RB, Dubey SK, Mishra K, Singh N, Vali S and Bharath MM. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease. Bioorg Med Chem 2010; 18: 2631-2638.
    • (2010) Bioorg Med Chem , vol.18 , pp. 2631-2638
    • Harish, G.1    Venkateshappa, C.2    Mythri, R.B.3    Dubey, S.K.4    Mishra, K.5    Singh, N.6    Vali, S.7    Bharath, M.M.8
  • 64
    • 84866262431 scopus 로고    scopus 로고
    • Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson’s Disease in Albino Wistar Rats
    • [64] Agrawal SS, Gullaiya S, Dubey V, Singh V, Kumar A, Nagar A and Tiwari P. Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson’s Disease in Albino Wistar Rats. Cardiovasc Psychiatry Neurol 2012; 2012: 942981.
    • (2012) Cardiovasc Psychiatry Neurol 2012
    • Agrawal, S.S.1    Gullaiya, S.2    Dubey, V.3    Singh, V.4    Kumar, A.5    Nagar, A.6    Tiwari, P.7
  • 65
    • 84898011829 scopus 로고    scopus 로고
    • Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells
    • [65] Meesarapee B, Thampithak A, Jaisin Y, Sanvarinda P, Suksamrarn A, Tuchinda P, Morales NP and Sanvarinda Y. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytother Res 2014; 28: 611-616.
    • (2014) Phytother Res , vol.28 , pp. 611-616
    • Meesarapee, B.1    Thampithak, A.2    Jaisin, Y.3    Sanvarinda, P.4    Suksamrarn, A.5    Tuchinda, P.6    Morales, N.P.7    Sanvarinda, Y.8
  • 66
    • 84885958457 scopus 로고    scopus 로고
    • Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson’s disease
    • [66] Jayaraj RL, Tamilselvam K, Manivasagam T and Elangovan N. Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson’s disease. J Mol Neurosci 2013; 51: 863-870.
    • (2013) J Mol Neurosci , vol.51 , pp. 863-870
    • Jayaraj, R.L.1    Tamilselvam, K.2    Manivasagam, T.3    Elangovan, N.4
  • 67
    • 78651280379 scopus 로고    scopus 로고
    • Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: Implications for Parkinson’s disease
    • [67] Mythri RB, Harish G, Dubey SK, Misra K and Bharath MM. Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson’s disease. Mol Cell Biochem 2011; 347: 135-143.
    • (2011) Mol Cell Biochem , vol.347 , pp. 135-143
    • Mythri, R.B.1    Harish, G.2    Dubey, S.K.3    Misra, K.4    Bharath, M.M.5
  • 68
    • 79955478926 scopus 로고    scopus 로고
    • Curcumin protects against A53T alpha-synucleininduced toxicity in a PC12 inducible cell model for Parkinsonism
    • [68] Liu Z, Yu Y, Li X, Ross CA and Smith WW. Curcumin protects against A53T alpha-synucleininduced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res 2011; 63: 439-444.
    • (2011) Pharmacol Res , vol.63 , pp. 439-444
    • Liu, Z.1    Yu, Y.2    Li, X.3    Ross, C.A.4    Smith, W.W.5
  • 69
    • 71849091967 scopus 로고    scopus 로고
    • Therapeutic approaches to mitochondrial dysfunction in Parkinson’s disease
    • [69] Beal MF. Therapeutic approaches to mitochondrial dysfunction in Parkinson’s disease. Parkinsonism Relat Disord 2009; 15 Suppl 3: S189-194.
    • (2009) Parkinsonism Relat Disord , vol.15 , pp. S189-S194
    • Beal, M.F.1
  • 70
    • 84864658369 scopus 로고    scopus 로고
    • Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson’s disease
    • [70] Du XX, Xu HM, Jiang H, Song N, Wang J and Xie JX. Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson’s disease. Neurosci Bull 2012; 28: 253-258.
    • (2012) Neurosci Bull , vol.28 , pp. 253-258
    • Du, X.X.1    Xu, H.M.2    Jiang, H.3    Song, N.4    Wang, J.5    Xie, J.X.6
  • 71
    • 84921896144 scopus 로고    scopus 로고
    • The multiple pharmaceutical potential of curcumin in Parkinson’s disease
    • [71] Ji HF, Shen L. The multiple pharmaceutical potential of curcumin in Parkinson’s disease. CNS Neurol Disord Drug Targets 2014; 13: 369-373.
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , pp. 369-373
    • Ji, H.F.1    Shen, L.2
  • 72
    • 59649087536 scopus 로고    scopus 로고
    • Alpha-synuclein assembly as a therapeutic target of Parkinson’s disease and related disorders
    • [72] Ono K, Hirohata M and Yamada M. Alpha-synuclein assembly as a therapeutic target of Parkinson’s disease and related disorders. Curr Pharm Des 2008; 14: 3247-3266.
    • (2008) Curr Pharm Des , vol.14 , pp. 3247-3266
    • Ono, K.1    Hirohata, M.2    Yamada, M.3
  • 73
    • 84855849474 scopus 로고    scopus 로고
    • Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits alpha-synuclein oligomer formation: Relevance to Parkinson’s disease
    • [73] Gadad BS, Subramanya PK, Pullabhatla S, Shantharam IS and Rao KS. Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits alpha-synuclein oligomer formation: relevance to Parkinson’s disease. Curr Pharm Des 2012; 18: 76-84.
    • (2012) Curr Pharm Des , vol.18 , pp. 76-84
    • Gadad, B.S.1    Subramanya, P.K.2    Pullabhatla, S.3    Shantharam, I.S.4    Rao, K.S.5
  • 75
    • 84903742654 scopus 로고    scopus 로고
    • β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: A case study with alpha-synuclein
    • [75] Gautam S, Karmakar S, Bose A and Chowdhury PK. β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with alpha-synuclein. Biochemistry 2014; 53: 4081-4083.
    • (2014) Biochemistry , vol.53 , pp. 4081-4083
    • Gautam, S.1    Karmakar, S.2    Bose, A.3    Chowdhury, P.K.4
  • 76
    • 42049109707 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice
    • [76] Rajeswari A and Sabesan M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice. Inflammopharmacology 2008; 16: 96-99.
    • (2008) Inflammopharmacology , vol.16 , pp. 96-99
    • Rajeswari, A.1    Sabesan, M.2
  • 77
    • 84864715450 scopus 로고    scopus 로고
    • Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex
    • [77] Verma M, Sharma A, Naidu S, Bhadra AK, Kukreti R and Taneja V. Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex. PLoS One 2012; 7: e42923.
    • (2012) Plos One , vol.7
    • Verma, M.1    Sharma, A.2    Naidu, S.3    Bhadra, A.K.4    Kukreti, R.5    Taneja, V.6
  • 79
    • 84862308648 scopus 로고    scopus 로고
    • LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin
    • [79] Yang D, Li T, Liu Z, Arbez N, Yan J, Moran TH, Ross CA and Smith WW. LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin. Neurobiol Dis 2012; 47: 385-392.
    • (2012) Neurobiol Dis , vol.47 , pp. 385-392
    • Yang, D.1    Li, T.2    Liu, Z.3    Arbez, N.4    Yan, J.5    Moran, T.H.6    Ross, C.A.7    Smith, W.W.8
  • 80
    • 84867826588 scopus 로고    scopus 로고
    • Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells
    • [80] Lee KW, Jung SY, Choi SM and Yang EJ. Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Complement Altern Med 2012; 12: 196.
    • (2012) BMC Complement Altern Med , vol.12 , pp. 196
    • Lee, K.W.1    Jung, S.Y.2    Choi, S.M.3    Yang, E.J.4
  • 81
    • 34548490504 scopus 로고    scopus 로고
    • Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control
    • [81] Kim SN, Ha YW, Shin H, Son SH, Wu SJ and Kim YS. Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J Pharm Biomed Anal 2007; 45: 164-170.
    • (2007) J Pharm Biomed Anal , vol.45 , pp. 164-170
    • Kim, S.N.1    Ha, Y.W.2    Shin, H.3    Son, S.H.4    Wu, S.J.5    Kim, Y.S.6
  • 82
    • 84877699705 scopus 로고    scopus 로고
    • Anti-Inflammatory Effect of Ginsenoside Rg5 in Lipopolysaccharide-Stimulated BV2 Microglial Cells
    • [82] Lee YY, Park JS, Jung JS, Kim DH and Kim HS. Anti-Inflammatory Effect of Ginsenoside Rg5 in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Int J Mol Sci 2013; 14: 9820-9833.
    • (2013) Int J Mol Sci , vol.14 , pp. 9820-9833
    • Lee, Y.Y.1    Park, J.S.2    Jung, J.S.3    Kim, D.H.4    Kim, H.S.5
  • 83
    • 84871748170 scopus 로고    scopus 로고
    • Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signaling
    • [83] Kim KH, Song K, Yoon SH, Shehzad O, Kim YS and Son JH. Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signaling. J Biol Chem 2012; 287: 44109-44120.
    • (2012) J Biol Chem , vol.287 , pp. 44109-44120
    • Kim, K.H.1    Song, K.2    Yoon, S.H.3    Shehzad, O.4    Kim, Y.S.5    Son, J.H.6
  • 84
    • 78650415275 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation
    • [84] Liu Q, Kou JP and Yu BY. Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation. Neurochem Int 2011; 58: 119-125.
    • (2011) Neurochem Int , vol.58 , pp. 119-125
    • Liu, Q.1    Kou, J.P.2    Yu, B.Y.3
  • 85
    • 38449083961 scopus 로고    scopus 로고
    • Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture
    • [85] Lin WM, Zhang YM, Moldzio R and Rausch WD. Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture. J Neural Transm Suppl 2007; 72: 105-112.
    • (2007) J Neural Transm Suppl , vol.72 , pp. 105-112
    • Lin, W.M.1    Zhang, Y.M.2    Moldzio, R.3    Rausch, W.D.4
  • 86
    • 84866039246 scopus 로고    scopus 로고
    • Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice
    • [86] Park SM, Choi MS, Sohn NW and Shin JW. Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice. Biol Pharm Bull 2012; 35: 1546-1552.
    • (2012) Biol Pharm Bull , vol.35 , pp. 1546-1552
    • Park, S.M.1    Choi, M.S.2    Sohn, N.W.3    Shin, J.W.4
  • 88
    • 33846890205 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    • [88] Leung KW, Yung KK, Mak NK, Chan YS, Fan TP and Wong RN. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 2007; 52: 827-835.
    • (2007) Neuropharmacology , vol.52 , pp. 827-835
    • Leung, K.W.1    Yung, K.K.2    Mak, N.K.3    Chan, Y.S.4    Fan, T.P.5    Wong, R.N.6
  • 89
    • 12344336324 scopus 로고    scopus 로고
    • Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson’s disease mouse model
    • [89] Xu BB, Liu CQ, Gao X, Zhang WQ, Wang SW and Cao YL. Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson’s disease mouse model. J Asian Nat Prod Res 2005; 7: 215-224.
    • (2005) J Asian Nat Prod Res , vol.7 , pp. 215-224
    • Xu, B.B.1    Liu, C.Q.2    Gao, X.3    Zhang, W.Q.4    Wang, S.W.5    Cao, Y.L.6
  • 90
    • 78649782421 scopus 로고    scopus 로고
    • Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells
    • [90] Xu H, Jiang H, Wang J and Xie J. Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells. J Cell Biochem 2010; 111: 1537-1545.
    • (2010) J Cell Biochem , vol.111 , pp. 1537-1545
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 91
    • 72049117894 scopus 로고    scopus 로고
    • Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake
    • [91] Xu H, Jiang H, Wang J and Xie J. Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology 2010; 58: 488-494.
    • (2010) Neuropharmacology , vol.58 , pp. 488-494
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 92
    • 0034868729 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1)
    • [92] Rudakewich M, Ba F and Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med 2001; 67: 533-537.
    • (2001) Planta Med , vol.67 , pp. 533-537
    • Rudakewich, M.1    Ba, F.2    Benishin, C.G.3
  • 93
    • 84894386559 scopus 로고    scopus 로고
    • Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: Some uses and the establishment and biological basis of medical efficacy
    • [93] Witkin JM and Li X. Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy. CNS Neurol Disord Drug Targets 2013; 12: 487-497.
    • (2013) CNS Neurol Disord Drug Targets , vol.12 , pp. 487-497
    • Witkin, J.M.1    Li, X.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.