α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 454-468

  Harischandra, Dilshan S ^a   Jin, Huajun ^a   Anantharam, Vellareddy ^a   Kanthasamy, Arthi ^a   Kanthasamy, Anumantha G ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Metals; Neuroprotection; Neurotoxicity; Parkinson's disease; Protein aggregation; synuclein

Indexed keywords

ALPHA SYNUCLEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; MANGANESE; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; CHLORIDE; DOPAMINE; MANGANESE CHLORIDE; MANGANESE DERIVATIVE; PROTEIN BINDING;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOSOL; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; EXPOSURE; MASS SPECTROMETRY; MESENCEPHALON; METAL BINDING; MITOCHONDRION; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; WILD TYPE; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; BIOLOGICAL MODEL; CELL LINE; CELL SURVIVAL; COMPLICATION; CULTURE TECHNIQUE; DNA FRAGMENTATION; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HUMAN; MANGANESE POISONING; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CHLORIDES; DNA FRAGMENTATION; DOPAMINE; DOPAMINERGIC NEURONS; HUMANS; MANGANESE COMPOUNDS; MANGANESE POISONING; MESENCEPHALON; MODELS, NEUROLOGICAL; PARKINSON DISEASE; PROTEIN BINDING; RATS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, ATOMIC; TRANSFECTION;

EID: 84924658110     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu247     Document Type: Article

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