Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: A model-based analysis

FEBS Journal

Volumn 280, Issue 20, 2013, Pages 5080-5093

  Berndt, Nikolaus ^a   Holzhütter, Herrmann Georg ^a   Bulik, Sascha ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

complex I inhibition; KGDHC inhibition; kinetic model; mitochondrial energy metabolism; neuronal metabolism; Parkinson's disease; ROS

Indexed keywords

ADENOSINE TRIPHOSPHATE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; COMPLEX FORMATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; ENERGY YIELD; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME METABOLISM; ENZYME SYNTHESIS; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

COMPLEX I INHIBITION; KGDHC INHIBITION; KINETIC MODEL; MITOCHONDRIAL ENERGY METABOLISM; NEURONAL METABOLISM; PARKINSON'S DISEASE; ROS;

ADENOSINE TRIPHOSPHATE; ANIMALS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; ENERGY METABOLISM; KETOGLUTARATE DEHYDROGENASE COMPLEX; MITOCHONDRIA; NEURONS; PARKINSON DISEASE; RATS; REACTIVE OXYGEN SPECIES; ROTENONE;

EID: 84885292221     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12480     Document Type: Article

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