메뉴 건너뛰기




Volumn 15, Issue 9, 2016, Pages 2924-2938

Oncogenic KRAS and BRAF drive metabolic reprogramming in colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTAMINE; LACTIC ACID; PHOSPHOSERINE; PROTEOME; B RAF KINASE; BRAF PROTEIN, HUMAN; RAS PROTEIN;

EID: 84989179928     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M116.058925     Document Type: Article
Times cited : (89)

References (66)
  • 1
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg, O., Wind, F., and Negelein, E. (1927) The metabolism of tumors in the body. J. Gen. Physiol. 8, 519-530
    • (1927) J. Gen. Physiol. , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C., and Thompson, C. B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 5
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu, P. P., and Sabatini, D. M. (2008) Cancer cell metabolism: Warburg and beyond. Cell 134, 703-707
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 15
    • 84929464865 scopus 로고    scopus 로고
    • Correlation of BRAFV600E mutation and glucose metabolism in thyroid cancer patients: An18 F-FDG PET study
    • Nagarajah, J., Ho, A. L., Tuttle, R. M., Weber, W. A., and Grewal, R. K. (2015) Correlation of BRAFV600E mutation and glucose metabolism in thyroid cancer patients: An18 F-FDG PET study. J. Nucl. Med. 56, 662-667
    • (2015) J. Nucl. Med. , vol.56 , pp. 662-667
    • Nagarajah, J.1    Ho, A.L.2    Tuttle, R.M.3    Weber, W.A.4    Grewal, R.K.5
  • 16
    • 84885357137 scopus 로고    scopus 로고
    • Exploiting the bad eating habits of Ras-driven cancers
    • White, E. (2013) Exploiting the bad eating habits of Ras-driven cancers. Genes Dev. 27, 2065-2071
    • (2013) Genes Dev. , vol.27 , pp. 2065-2071
    • White, E.1
  • 17
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert, S., Shannon, K., and Bollag, G. (2007) Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 7, 295-308
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 18
    • 84929077789 scopus 로고    scopus 로고
    • Regulation of RAF protein kinases in ERK signaling
    • Lavoie, H., and Therrien, M. (2015) Regulation of RAF protein kinases in ERK signaling. Nat. Rev. Mol. Cell Biol. 16, 281-298
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 281-298
    • Lavoie, H.1    Therrien, M.2
  • 19
    • 79955751512 scopus 로고    scopus 로고
    • BRAFV600E: Implications for carcinogenesis and molecular therapy
    • Cantwell-Dorris, E. R., O'Leary, J. J., and Sheils, O. M. (2011) BRAFV600E: implications for carcinogenesis and molecular therapy. Mol. Cancer Ther 10, 385-394
    • (2011) Mol. Cancer Ther , vol.10 , pp. 385-394
    • Cantwell-Dorris, E.R.1    O'Leary, J.J.2    Sheils, O.M.3
  • 21
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Shirasawa, S., Furuse, M., Yokoyama, N., and Sasazuki, T. (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260, 85- 88
    • (1993) Science , vol.260 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 22
    • 0020316263 scopus 로고
    • Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
    • Chang, E. H., Furth, M. E., Scolnick, E. M., and Lowy, D. R. (1982) Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 297, 479-483
    • (1982) Nature , vol.297 , pp. 479-483
    • Chang, E.H.1    Furth, M.E.2    Scolnick, E.M.3    Lowy, D.R.4
  • 27
    • 84930468950 scopus 로고    scopus 로고
    • Large-scale targeted proteomics using internal standard triggered-parallel reaction monitoring (IS-PRM)
    • Gallien, S., Kim, S. Y., and Domon, B. (2015) Large-Scale Targeted Proteomics Using Internal Standard Triggered-Parallel Reaction Monitoring (IS-PRM). Mol. Cell. Proteomics 14, 1630-1644
    • (2015) Mol. Cell. Proteomics , vol.14 , pp. 1630-1644
    • Gallien, S.1    Kim, S.Y.2    Domon, B.3
  • 28
    • 84863611387 scopus 로고    scopus 로고
    • GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples
    • Halvey, P. J., Ferrone, C. R., and Liebler, D. C. (2012) GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples. J. Proteome Res. 11, 3908-3913
    • (2012) J. Proteome Res. , vol.11 , pp. 3908-3913
    • Halvey, P.J.1    Ferrone, C.R.2    Liebler, D.C.3
  • 30
    • 8844233567 scopus 로고    scopus 로고
    • Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)
    • Anderson, N. L., Anderson, N. G., Haines, L. R., Hardie, D. B., Olafson, R. W., and Pearson, T. W. (2004) Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA). J. Proteome Res. 3, 235-244
    • (2004) J. Proteome Res. , vol.3 , pp. 235-244
    • Anderson, N.L.1    Anderson, N.G.2    Haines, L.R.3    Hardie, D.B.4    Olafson, R.W.5    Pearson, T.W.6
  • 31
    • 84869233177 scopus 로고    scopus 로고
    • Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics
    • Peterson, A. C., Russell, J. D., Bailey, D. J., Westphall, M. S., and Coon, J. J. (2012) Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics. Mol. Cell. Proteomics 11, 1475-1488
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 1475-1488
    • Peterson, A.C.1    Russell, J.D.2    Bailey, D.J.3    Westphall, M.S.4    Coon, J.J.5
  • 32
    • 84945257948 scopus 로고    scopus 로고
    • Multiplexed, scheduled, high-resolution parallel reaction monitoring on a full scan QqTOF instrument with integrated data-dependent and targeted mass spectrometric workflows
    • Schilling, B., MacLean, B., Held, J. M., Sahu, A. K., Rardin, M. J., Sorensen, D. J., Peters, T., Wolfe, A. J., Hunter, C. L., MacCoss, M. J., and Gibson, B. W. (2015) Multiplexed, scheduled, high-resolution parallel reaction monitoring on a full scan QqTOF instrument with integrated data-dependent and targeted mass spectrometric workflows. Anal. Chem. 87, 10222-10229
    • (2015) Anal. Chem. , vol.87 , pp. 10222-10229
    • Schilling, B.1    MacLean, B.2    Held, J.M.3    Sahu, A.K.4    Rardin, M.J.5    Sorensen, D.J.6    Peters, T.7    Wolfe, A.J.8    Hunter, C.L.9    MacCoss, M.J.10    Gibson, B.W.11
  • 33
    • 84946887938 scopus 로고    scopus 로고
    • Using peptide-level proteomics data for detecting differentially expressed proteins
    • Suomi, T., Corthals, G. L., Nevalainen, O. S., and Elo, L. L. (2015) Using peptide-level proteomics data for detecting differentially expressed proteins. J. Proteome Res. 14, 4564-4570
    • (2015) J. Proteome Res. , vol.14 , pp. 4564-4570
    • Suomi, T.1    Corthals, G.L.2    Nevalainen, O.S.3    Elo, L.L.4
  • 35
    • 77955456065 scopus 로고    scopus 로고
    • Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry
    • Chen, Y., Gruidl, M., Remily-Wood, E., Liu, R. Z., Eschrich, S., Lloyd, M., Nasir, A., Bui, M. M., Huang, E., Shibata, D., Yeatman, T., and Koomen, J. M. (2010) Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry. J. Proteome Res. 9, 4215- 4227
    • (2010) J. Proteome Res. , vol.9 , pp. 4215-4227
    • Chen, Y.1    Gruidl, M.2    Remily-Wood, E.3    Liu, R.Z.4    Eschrich, S.5    Lloyd, M.6    Nasir, A.7    Bui, M.M.8    Huang, E.9    Shibata, D.10    Yeatman, T.11    Koomen, J.M.12
  • 37
    • 84856710193 scopus 로고    scopus 로고
    • Protein expression signatures for inhibition of epidermal growth factor receptormediated signaling
    • M111.015222
    • Myers, M. V., Manning, H. C., Coffey, R. J., and Liebler, D. C. (2012) Protein expression signatures for inhibition of epidermal growth factor receptormediated signaling. Mol. Cell. Proteomics 11, M111.015222
    • (2012) Mol. Cell. Proteomics , vol.11
    • Myers, M.V.1    Manning, H.C.2    Coffey, R.J.3    Liebler, D.C.4
  • 38
    • 77950395166 scopus 로고    scopus 로고
    • Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring
    • Schmidt, C., Lenz, C., Grote, M., Lührmann, R., and Urlaub, H. (2010) Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Anal. Chem. 82, 2784-2796
    • (2010) Anal. Chem. , vol.82 , pp. 2784-2796
    • Schmidt, C.1    Lenz, C.2    Grote, M.3    Lührmann, R.4    Urlaub, H.5
  • 39
    • 34250722602 scopus 로고    scopus 로고
    • Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
    • Wolf-Yadlin, A., Hautaniemi, S., Lauffenburger, D. A., and White, F. M. (2007) Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc. Natl. Acad. Sci. U.S.A. 104, 5860-5865
    • (2007) Proc. Natl. Acad. Sci. U. S. A , vol.104 , pp. 5860-5865
    • Wolf-Yadlin, A.1    Hautaniemi, S.2    Lauffenburger, D.A.3    White, F.M.4
  • 40
    • 84863628292 scopus 로고    scopus 로고
    • Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by selected reaction monitoring assay
    • Drabovich, A. P., Pavlou, M. P., Dimitromanolakis, A., and Diamandis, E. P. (2012) Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by selected reaction monitoring assay. Mol. Cell. Proteomics 11, 422-434
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 422-434
    • Drabovich, A.P.1    Pavlou, M.P.2    Dimitromanolakis, A.3    Diamandis, E.P.4
  • 42
    • 54949129419 scopus 로고    scopus 로고
    • ProteoWizard: Open source software for rapid proteomics tools development
    • Kessner, D., Chambers, M., Burke, R., Agus, D., and Mallick, P. (2008) ProteoWizard: open source software for rapid proteomics tools development. Bioinformatics 24, 2534-2536
    • (2008) Bioinformatics , vol.24 , pp. 2534-2536
    • Kessner, D.1    Chambers, M.2    Burke, R.3    Agus, D.4    Mallick, P.5
  • 43
    • 33847401893 scopus 로고    scopus 로고
    • MyriMatch: Highly accurate tandem mass spectral peptide identification by multivariate hypergeometric analysis
    • Tabb, D. L., Fernando, C. G., and Chambers, M. C. (2007) MyriMatch: highly accurate tandem mass spectral peptide identification by multivariate hypergeometric analysis. J. Proteome Res. 6, 654- 661
    • (2007) J. Proteome Res. , vol.6 , pp. 654-661
    • Tabb, D.L.1    Fernando, C.G.2    Chambers, M.C.3
  • 44
    • 84923247212 scopus 로고    scopus 로고
    • MS-GF+makes progress towards a universal database search tool for proteomics
    • Kim, S., and Pevzner, P. A. (2014) MS-GF+makes progress towards a universal database search tool for proteomics. Nat. Commun. 5, 5277
    • (2014) Nat. Commun. , vol.5 , pp. 5277
    • Kim, S.1    Pevzner, P.A.2
  • 45
    • 34948874252 scopus 로고    scopus 로고
    • Proteomic parsimony through bipartite graph analysis improves accuracy and transparency
    • Zhang, B., Chambers, M. C., and Tabb, D. L. (2007) Proteomic parsimony through bipartite graph analysis improves accuracy and transparency. J. Proteome Res. 6, 3549-3557
    • (2007) J. Proteome Res. , vol.6 , pp. 3549-3557
    • Zhang, B.1    Chambers, M.C.2    Tabb, D.L.3
  • 47
    • 84880617636 scopus 로고    scopus 로고
    • WEB-based GEne set analysis toolkit (WebGestalt): Update 2013
    • Wang, J., Duncan, D., Shi, Z., and Zhang, B. (2013) WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res. 41, W77-W83
    • (2013) Nucleic Acids Res. , vol.41 , pp. W77-W83
    • Wang, J.1    Duncan, D.2    Shi, Z.3    Zhang, B.4
  • 50
    • 84875604405 scopus 로고    scopus 로고
    • Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomics
    • Mani, D. R., Abbatiello, S. E., and Carr, S. A. (2012) Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomics. BMC Bioinformatics 13, S9
    • (2012) BMC Bioinformatics , vol.13 , pp. S9
    • Mani, D.R.1    Abbatiello, S.E.2    Carr, S.A.3
  • 54
    • 84944456728 scopus 로고    scopus 로고
    • Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression
    • Xu, X., Li, J., Sun, X., Guo, Y., Chu, D., Wei, L., Li, X., Yang, G., Liu, X., Yao, L., Zhang, J., and Shen, L. (2015) Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. Oncotarget 6, 26161-26176
    • (2015) Oncotarget , vol.6 , pp. 26161-26176
    • Xu, X.1    Li, J.2    Sun, X.3    Guo, Y.4    Chu, D.5    Wei, L.6    Li, X.7    Yang, G.8    Liu, X.9    Yao, L.10    Zhang, J.11    Shen, L.12
  • 58
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337
    • (2012) Nature , vol.487 , pp. 330-337
  • 61
    • 84872853570 scopus 로고    scopus 로고
    • Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
    • Young, A., Lou, D., and McCormick, F. (2013) Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 3, 112-123
    • (2013) Cancer Discov. , vol.3 , pp. 112-123
    • Young, A.1    Lou, D.2    McCormick, F.3
  • 63
    • 0141863388 scopus 로고    scopus 로고
    • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
    • Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., and Thompson, C. B. (2003) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23, 7315-7328
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7315-7328
    • Rathmell, J.C.1    Fox, C.J.2    Plas, D.R.3    Hammerman, P.S.4    Cinalli, R.M.5    Thompson, C.B.6
  • 64
    • 33646823663 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts
    • Riley, J. K., Carayannopoulos, M. O., Wyman, A. H., Chi, M., and Moley, K. H. (2006) Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. J. Biol. Chem. 281, 6010-6019
    • (2006) J. Biol. Chem. , vol.281 , pp. 6010-6019
    • Riley, J.K.1    Carayannopoulos, M.O.2    Wyman, A.H.3    Chi, M.4    Moley, K.H.5
  • 65
    • 84960154307 scopus 로고    scopus 로고
    • Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
    • Kerr, E. M., Gaude, E., Turrell, F. K., Frezza, C., and Martins, C. P. (2016) Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities. Nature 531, 110-113
    • (2016) Nature , vol.531 , pp. 110-113
    • Kerr, E.M.1    Gaude, E.2    Turrell, F.K.3    Frezza, C.4    Martins, C.P.5
  • 66
    • 71049141298 scopus 로고    scopus 로고
    • Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis
    • Sprung, R. W., Brock, J. W., Tanksley, J. P., Li, M., Washington, M. K., Slebos, R. J., and Liebler, D. C. (2009) Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol. Cell. Proteomics 8, 1988-1998
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 1988-1998
    • Sprung, R.W.1    Brock, J.W.2    Tanksley, J.P.3    Li, M.4    Washington, M.K.5    Slebos, R.J.6    Liebler, D.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.