Inhibiting mitochondrial DNA ligase IIIα activates caspase 1-dependent apoptosis in cancer cells

Cancer Research

Volumn 76, Issue 18, 2016, Pages 5431-5441

  Sallmyr, Annahita ^a   Matsumoto, Yoshihiro ^a   Roginskaya, Vera ^b   Van Houten, Bennett ^b   Tomkinson, Alan E ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BETA GALACTOSIDASE; CHECKPOINT KINASE 2; DNA LIGASE; DNA LIGASE IIIALPHA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOCHONDRIAL DNA; PRILOCAINE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG; DNA LIGASE III ALPHA PROTEIN, XENOPUS; ENZYME INHIBITOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA METABOLISM; ENZYME INHIBITION; GENE DOSAGE; GLYCOLYSIS; HUMAN; HUMAN CELL; IC50; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ENZYMOLOGY; FLOW CYTOMETRY; IMMUNOBLOTTING; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CASPASE 1; CELL LINE, TUMOR; DNA LIGASES; DNA, MITOCHONDRIAL; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; NEOPLASMS;

EID: 84988966141     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-3243     Document Type: Article

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