Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for MTDNA maintenance

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26594-26605

  Shokolenko, Inna N ^a   Fayzulin, Rafik Z ^a   Katyal, Sachin ^b   McKinnon, Peter J ^b   Wilson, Glenn L ^a   Alexeyev, Mikhail F ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULTURED CELL; KNOCK OUTS; MITOCHONDRIAL DNA;

BIOCHEMISTRY; BIOLOGY;

DNA;

MITOCHONDRIAL DNA; MITOCHONDRIAL DNA LIGASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRUVIC ACID; UNCLASSIFIED DRUG; URIDINE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL GROWTH; CELL POPULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; FIBROBLAST; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

DNA DAMAGE; DNA REPAIR; DNA REPLICATION; MITOCHONDRIA; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA DEGRADATION; REACTIVE OXYGEN SPECIES; RESPIRATION; RHO-0 CELLS;

ALLELES; ANIMALS; CROSSES, GENETIC; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DNA, MITOCHONDRIAL; FIBROBLASTS; GENOTYPE; HELA CELLS; HUMANS; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OLIGONUCLEOTIDES; OXIDATIVE STRESS; PHENOTYPE;

EID: 84884175360     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.472977     Document Type: Article

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