Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs

Cell Death and Disease

Volumn 6, Issue 4, 2015, Pages

  Mei, H ^a   Sun, S ^a   Bai, Y ^b   Chen, Y ^a   Chai, R ^c   Li, H ^a  

^a FUDAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CISPLATIN; DOXORUBICIN; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; ANTINEOPLASTIC AGENT; SMALL INTERFERING RNA;

A549 CELL LINE; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION; HEP 2 CELL LINE; HNE2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; TUMOR CELL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; DOWN-REGULATION; DOXORUBICIN; HUMANS; NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84989837528     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.78     Document Type: Article

References (31)

1. Bogenhagen D, Clayton DA. Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell 1977; 11: 719-727.
2. Kai Y, Takamatsu C, Tokuda K, Okamoto M, Irita K, Takahashi S. Rapid and random turnover of mitochondrial DNA in rat hepatocytes of primary culture. Mitochondrion 2006; 6: 299-304.
3. Shadel GS, Clayton DA. Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem 1997; 66: 409-435.
4. Clay Montier LL, Deng JJ, Bai Y. Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 2009; 36: 125-131.
5. Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K et al. Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet 2004; 13: 935-944.
6. Pohjoismaki JL, Wanrooij S, Hyvarinen AK, Goffart S, Holt IJ, Spelbrink JN et al. Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Res 2006; 34: 5815-5828.
7. Lu B, Lee J, Nie X, Li M, Morozov Yaroslav I, Venkatesh S et al. Phosphorylation of Human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Molecular Cell 2013; 49: 121-132.
8. Wen SL, Zhang F, Feng S. Decreased copy number of mitochondrial DNA: a potential diagnostic criterion for gastric cancer. Oncol Lett 2013; 6(4): 1098-1102.
9. Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M et al. Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients. Diagn Pathol 2014; 9: 28.
10. Cerritelli SM, Frolova EG, Feng C, Grinberg A, Love PE, Crouch RJ. Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol Cell 2003; 11: 807-815.
11. Wang J, Silva JP, Gustafsson CM, Rustin P, Larsson N-G. Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci 2001; 98: 4038-4043.
12. Mondal R, Ghosh SK, Choudhury JH, Seram A, Sinha K, Hussain M et al. Mitochondrial DNA Copy number and risk of oral cancer: a report from Northeast India. PLoS One 2013; 8: e57771.
13. Paull D, Emmanuele V, Weiss KA, Treff N, Stewart L, Hua H et al. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature 2013; 493: 632-637.
14. Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RD, McKenzie M et al. The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 2013; 20: 1644-1653.
15. Ferguson LR, von Borstel RC. Induction of the cytoplasmic 'petite' mutation by chemical and physical agents in Saccharomyces cerevisiae. Mutat Res 1992; 265: 103-148.
16. Roy Chowdhury A, Bakshi R, Wang J, Yildirir G, Liu B, Pappas-Brown V et al. The Killing of African Trypanosomes by Ethidium Bromide. PLoS Pathog 2010; 6: e1001226.
17. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303: 1010-1014.
18. Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HLA et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998; 281: 2027-2031.
19. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CYJ et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410: 549-554.
20. Murgia M, Pizzo P, Sandoná D, Zanovello P, Rizzuto R, Di Virgilio F. Mitochondrial DNA is not fragmented during apoptosis. J Biol Chem 1992; 267: 10939-10941.
21. Mizumachi T, Suzuki S, Naito A, Carcel-Trullols J, Evans TT, Spring PM et al. Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells. Oncogene 27: 831-838.
22. Zorov DB, Filburn CR, Klotz L-O, Zweier JL, Sollott SJ. Reactive oxygen species (Ros-Induced) Ros release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exper Med 2000; 192: 1001-1014.
23. Guo J, Zheng L, Liu W, Wang X, Wang Z, Wang Z et al. Frequent truncating mutation of TFAM induces mitochondrial dna depletion and apoptotic resistance in microsatelliteunstable colorectal cancer. Cancer Res 2011; 71: 2978-2987.
24. Rantanen A, Gaspari M, Falkenberg M, Gustafsson CM, Larsson N-G. Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Mamm Genome 14: 1-6.
25. Di Re M, Sembongi H, He J, Reyes A, Yasukawa T, Martinsson P et al. The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells. Nucleic Acids Res 2009; 37: 5701-5713.
26. Maniura-Weber K, Goffart S, Garstka HL, Montoya J, Wiesner RJ. Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. Nucleic Acids Res 2004; 32: 6015-6027.
27. Veatch JR, McMurray MA, Nelson ZW, Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137: 1247-1258.
28. Klamt F, Zdanov S, Levine RL, Pariser A, Zhang Y, Zhang B et al. Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nat Cell Biol 2009; 11: 1241-1246.
29. Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG et al. AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. J Biol Chem 2010; 285: 36199-36206.
30. Kanzok SM, Fechner A, Bauer H, Ulschmid JK, Müller H-M, Botella-Munoz J et al. Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science 2001; 291: 643-646.
31. Saeed U, Durgadoss L, Valli RK, Joshi DC, Joshi PG, Ravindranath V. Knockdown of cytosolic glutaredoxin 1 leads to loss of mitochondrial membrane potential: implication in neurodegenerative diseases. PLoS One 2008; 3: e2459.