-
1
-
-
4143141823
-
The immunobiology of cancer immunosurveillance and immunoediting
-
Dunn, G. P., Old, L. J. and Schreiber, R. D. 2004. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21:137.
-
(2004)
Immunity
, vol.21
, pp. 137
-
-
Dunn, G.P.1
Old, L.J.2
Schreiber, R.D.3
-
2
-
-
0036852241
-
Cancer immunoediting: from immunosurveillance to tumor escape
-
Dunn G. P., Bruce A. T., Ikeda H. et al. 2002. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3:991.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 991
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
-
5
-
-
84855957129
-
How the TCR balances sensitivity and specificity for the recognition of self and pathogens
-
Morris, G. P. and Allen, P. M. 2012. How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat. Immunol. 13:121.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 121
-
-
Morris, G.P.1
Allen, P.M.2
-
6
-
-
82255164138
-
Towards a systems understanding of MHC class I and MHC class II antigen presentation
-
Neefjes J., Jongsma M. L., Paul P. et al. 2011. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat. Rev. Immunol. 11:823.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 823
-
-
Neefjes, J.1
Jongsma, M.L.2
Paul, P.3
-
7
-
-
0028675006
-
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
-
Linsley P. S., Greene J. L., Brady W. et al. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
-
(1994)
Immunity
, vol.1
, pp. 793
-
-
Linsley, P.S.1
Greene, J.L.2
Brady, W.3
-
8
-
-
0023270567
-
A new member of the immunoglobulin superfamily-CTLA-4
-
Brunet, J. F., Denizot, F., Luciani, M. F. et al. 1987. A new member of the immunoglobulin superfamily-CTLA-4. Nature 328:267.
-
(1987)
Nature
, vol.328
, pp. 267
-
-
Brunet, J.F.1
Denizot, F.2
Luciani, M.F.3
-
9
-
-
0026486220
-
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
-
Linsley, P. S., Greene, J. L., Tan, P. et al. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595.
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1595
-
-
Linsley, P.S.1
Greene, J.L.2
Tan, P.3
-
10
-
-
0027057908
-
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production
-
Freeman, G. J., Lombard, D. B., Gimmi, C. D. et al. 1992. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J. Immunol. 149:3795.
-
(1992)
J. Immunol.
, vol.149
, pp. 3795
-
-
Freeman, G.J.1
Lombard, D.B.2
Gimmi, C.D.3
-
11
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach, D. R., Krummel, M. F. and Allison, J. P. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734.
-
(1996)
Science
, vol.271
, pp. 1734
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
12
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F. S., O'Day, S. J., McDermott, D. F. et al. 2010. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363:711.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 711
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
13
-
-
84928917822
-
Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
-
Schadendorf, D., Hodi, F. S., Robert, C. et al. 2015. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J. Clin. Oncol. 33:1889.
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 1889
-
-
Schadendorf, D.1
Hodi, F.S.2
Robert, C.3
-
14
-
-
84933678156
-
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
-
Eggermont, A. M., Chiarion-Sileni, V., Grob, J. J. et al. 2015. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol. 16:522.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 522
-
-
Eggermont, A.M.1
Chiarion-Sileni, V.2
Grob, J.J.3
-
15
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman, G. J., Long, A. J., Iwai, Y. et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1027
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
16
-
-
18544380239
-
Tumorassociated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
-
Dong, H., Strome, S. E., Salomao, D. R. et al. 2002. Tumorassociated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8:793.
-
(2002)
Nat. Med.
, vol.8
, pp. 793
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
17
-
-
44349150012
-
Inhibitory B7-family molecules in the tumour microenvironment
-
Zou, W. and Chen, L. 2008. Inhibitory B7-family molecules in the tumour microenvironment. Nat. Rev. Immunol. 8:467.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 467
-
-
Zou, W.1
Chen, L.2
-
18
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
-
Weber, J. S., D'Angelo, S. P., Minor, D. et al. 2015. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 16:375.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 375
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
-
19
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C., Long G. V., Brady B. et al. 2015. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372:320.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 320
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
20
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
-
Ribas, A., Puzanov, I., Dummer, R. et al. 2015. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 16:908.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 908
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
-
21
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Herbst, R. S., Baas, P., Kim, D. W. et al. 2015. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387:1540.
-
(2015)
Lancet
, vol.387
, pp. 1540
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
22
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei, H., Paz-Ares, L., Horn, L. et al. 2015. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N. Engl. J. Med. 373:1627.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 1627
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
23
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer, R. J., Escudier, B., McDermott, D. F. et al. 2015. Nivolumab versus everolimus in advanced renal-cell carcinoma. N. Engl. J. Med. 373:1803.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 1803
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
24
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin, J., Chiarion-Sileni, V., Gonzalez, R. et al. 2015. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373:23.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 23
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
-
25
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow, M. A., Chesney, J., Pavlick, A. C. et al. 2015. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372:2006.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2006
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
-
26
-
-
84960498096
-
Safety and antitumour activity of durvalumab plus tremelimumab in nonsmall cell lung cancer: a multicentre, phase 1b study
-
Antonia, S., Goldberg, S. B., Balmanoukian, A. et al. 2016. Safety and antitumour activity of durvalumab plus tremelimumab in nonsmall cell lung cancer: a multicentre, phase 1b study. Lancet Oncol. 17:299.
-
(2016)
Lancet Oncol.
, vol.17
, pp. 299
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.3
-
27
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano, F., Kaneko, K., Tamura, H. et al. 2005. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65:1089.
-
(2005)
Cancer Res.
, vol.65
, pp. 1089
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
-
28
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer, J. R., Tykodi, S. S., Chow, L. Q. et al. 2012. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366:2455.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2455
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
29
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst, R. S., Soria, J. C., Kowanetz, M. et al. 2014. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515:563.
-
(2014)
Nature
, vol.515
, pp. 563
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
30
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh, P. C., Harview, C. L., Yearley, J. H. et al. 2014. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515:568.
-
(2014)
Nature
, vol.515
, pp. 568
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
-
31
-
-
0027979962
-
Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand
-
Huard, B., Gaulard, P., Faure, F. et al. 1994. Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. Immunogenetics 39:213.
-
(1994)
Immunogenetics
, vol.39
, pp. 213
-
-
Huard, B.1
Gaulard, P.2
Faure, F.3
-
32
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
Woo, S. R., Turnis, M. E., Goldberg, M. V. et al. 2012. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 72:917.
-
(2012)
Cancer Res.
, vol.72
, pp. 917
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
-
33
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore antitumor immunity
-
Sakuishi, K., Apetoh, L., Sullivan, J. M. et al. 2010. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore antitumor immunity. J. Exp. Med. 207:2187.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2187
-
-
Sakuishi, K.1
Apetoh, L.2
Sullivan, J.M.3
-
34
-
-
70449193189
-
Immunity to methylcho, lanthrene-induced sarcomas
-
Prehn, R. T. and Main, J. M. 1957. Immunity to methylcho, lanthrene-induced sarcomas. J. Natl Cancer Inst. 18:769.
-
(1957)
J. Natl Cancer Inst.
, vol.18
, pp. 769
-
-
Prehn, R.T.1
Main, J.M.2
-
35
-
-
0016173689
-
Antigenicity of murine skin tumors induced by ultraviolet light
-
Kripke, M. L. 1974. Antigenicity of murine skin tumors induced by ultraviolet light. J. Natl Cancer Inst. 53:1333.
-
(1974)
J. Natl Cancer Inst.
, vol.53
, pp. 1333
-
-
Kripke, M.L.1
-
36
-
-
33749023052
-
Unique tumor antigens: evidence for immune control of genome integrity and immunogenic targets for T cell-mediated patient-specific immunotherapy
-
Sensi, M. and Anichini, A. 2006. Unique tumor antigens: evidence for immune control of genome integrity and immunogenic targets for T cell-mediated patient-specific immunotherapy. Clin. Cancer Res. 12:5023.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5023
-
-
Sensi, M.1
Anichini, A.2
-
37
-
-
84894559188
-
Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
-
Coulie, P. G., Van den Eynde, B. J., van der Bruggen, P. et al. 2014. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nat. Rev. Cancer 14:135.
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 135
-
-
Coulie, P.G.1
Van den Eynde, B.J.2
van der Bruggen, P.3
-
38
-
-
23144464171
-
Cancer/testis antigens, gametogenesis and cancer
-
Simpson, A. J., Caballero, O. L., Jungbluth, A. et al. 2005. Cancer/testis antigens, gametogenesis and cancer. Nat. Rev. Cancer 5:615.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 615
-
-
Simpson, A.J.1
Caballero, O.L.2
Jungbluth, A.3
-
39
-
-
0028302028
-
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
-
Kawakami, Y., Eliyahu, S., Sakaguchi, K. et al. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J. Exp. Med. 180:347.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 347
-
-
Kawakami, Y.1
Eliyahu, S.2
Sakaguchi, K.3
-
40
-
-
0028303166
-
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
-
Coulie, P. G., Brichard, V., Van Pel, A. et al. 1994. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 180:35.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 35
-
-
Coulie, P.G.1
Brichard, V.2
Van Pel, A.3
-
41
-
-
0028347940
-
Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes
-
Wölfel, T., Van Pel, A., Brichard, V. et al. 1994. Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur. J. Immunol. 24:759.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 759
-
-
Wölfel, T.1
Van Pel, A.2
Brichard, V.3
-
42
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher, T. N. and Schreiber, R. D. 2015. Neoantigens in cancer immunotherapy. Science 348:69.
-
(2015)
Science
, vol.348
, pp. 69
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
43
-
-
0028326766
-
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma
-
Mandelboim, O., Berke, G., Fridkin, M. et al. 1994. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature 369:67.
-
(1994)
Nature
, vol.369
, pp. 67
-
-
Mandelboim, O.1
Berke, G.2
Fridkin, M.3
-
44
-
-
0028884728
-
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides
-
Mandelboim, O., Vadai, E., Fridkin, M. et al. 1995. Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides. Nat. Med. 1:1179.
-
(1995)
Nat. Med.
, vol.1
, pp. 1179
-
-
Mandelboim, O.1
Vadai, E.2
Fridkin, M.3
-
45
-
-
0029125899
-
A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
-
Coulie, P. G., Lehmann, F., Lethé, B. et al. 1995. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. Natl Acad. Sci. USA 92:7976.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7976
-
-
Coulie, P.G.1
Lehmann, F.2
Lethé, B.3
-
46
-
-
0028978274
-
A p16INK4ainsensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
-
Wölfel, T., Hauer, M., Schneider, J. et al. 1995. A p16INK4ainsensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269:1281.
-
(1995)
Science
, vol.269
, pp. 1281
-
-
Wölfel, T.1
Hauer, M.2
Schneider, J.3
-
47
-
-
0029669950
-
A mutated betacatenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
-
Robbins, P. F., El-Gamil, M., Li, Y. F. et al. 1996. A mutated betacatenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J. Exp. Med. 183:1185.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1185
-
-
Robbins, P.F.1
El-Gamil, M.2
Li, Y.F.3
-
48
-
-
27644534576
-
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
-
Lennerz, V., Fatho, M., Gentilini, C. et al. 2005. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Proc. Natl Acad. Sci. USA 102:16013.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 16013
-
-
Lennerz, V.1
Fatho, M.2
Gentilini, C.3
-
49
-
-
11344251911
-
Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy
-
Zhou, J., Dudley, M. E., Rosenberg, S. A. et al. 2005. Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy. J. Immunother. 28:53.
-
(2005)
J. Immunother.
, vol.28
, pp. 53
-
-
Zhou, J.1
Dudley, M.E.2
Rosenberg, S.A.3
-
50
-
-
84862776855
-
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
-
Matsushita, H., Vesely, M. D., Koboldt, D. C. et al. 2012. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 482:400.
-
(2012)
Nature
, vol.482
, pp. 400
-
-
Matsushita, H.1
Vesely, M.D.2
Koboldt, D.C.3
-
51
-
-
84857118418
-
Expression of tumour-specific antigens underlies cancer immunoediting
-
DuPage, M., Mazumdar, C., Schmidt, L. M. et al. 2012. Expression of tumour-specific antigens underlies cancer immunoediting. Nature 482:405.
-
(2012)
Nature
, vol.482
, pp. 405
-
-
DuPage, M.1
Mazumdar, C.2
Schmidt, L.M.3
-
52
-
-
79953151458
-
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
-
Schreiber, R. D., Old, L. J. and Smyth, M. J. 2011. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331:1565.
-
(2011)
Science
, vol.331
, pp. 1565
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
53
-
-
0035503698
-
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer
-
Liu, T., Yan, H., Kuismanen, S. et al. 2001. The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. Cancer Res. 61:7798.
-
(2001)
Cancer Res.
, vol.61
, pp. 7798
-
-
Liu, T.1
Yan, H.2
Kuismanen, S.3
-
55
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder, A., Makarov, V., Merghoub, T. et al. 2014. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371:2189.
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2189
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
56
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N. A., Hellmann, M. D., Snyder, A. et al. 2015. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348:124.
-
(2015)
Science
, vol.348
, pp. 124
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
57
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C. et al. 2013. Signatures of mutational processes in human cancer. Nature 500:415.
-
(2013)
Nature
, vol.500
, pp. 415
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
-
58
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence, M. S., Stojanov, P., Polak, P. et al. 2013. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499:214.
-
(2013)
Nature
, vol.499
, pp. 214
-
-
Lawrence, M.S.1
Stojanov, P.2
Polak, P.3
-
59
-
-
84920962202
-
Molecular and genetic properties of tumors associated with local immune cytolytic activity
-
Rooney, M. S., Shukla, S. A,. Wu, C. J. et al. 2015. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160:48.
-
(2015)
Cell
, vol.160
, pp. 48
-
-
Rooney, M.S.1
Shukla, S.A.2
Wu, C.J.3
-
60
-
-
84899836282
-
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
-
Brown, S. D., Warren, R. L., Gibb, E. A. et al. 2014. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res. 24:743.
-
(2014)
Genome Res.
, vol.24
, pp. 743
-
-
Brown, S.D.1
Warren, R.L.2
Gibb, E.A.3
-
61
-
-
84935009372
-
Genomic classification of cutaneous melanoma
-
Cancer Genome Atlas Network. 2015. Genomic classification of cutaneous melanoma. Cell 161:1681.
-
(2015)
Cell
, vol.161
, pp. 1681
-
-
-
62
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan, R., Ding, L., Griffith, M. et al. 2012. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150:1121.
-
(2012)
Cell
, vol.150
, pp. 1121
-
-
Govindan, R.1
Ding, L.2
Griffith, M.3
-
63
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network. 2014. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511:543.
-
(2014)
Nature
, vol.511
, pp. 543
-
-
-
64
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le, D. T., Uram, J. N., Wang, H. et al. 2015. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372:2509.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2509
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
65
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network. 2012. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330.
-
(2012)
Nature
, vol.487
, pp. 330
-
-
-
66
-
-
84919743846
-
Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
-
Shinbrot, E., Henninger, E. E., Weinhold, N. et al. 2014. Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res. 24:1740.
-
(2014)
Genome Res.
, vol.24
, pp. 1740
-
-
Shinbrot, E.1
Henninger, E.E.2
Weinhold, N.3
-
67
-
-
84887924524
-
The landscape of microsatellite instability in colorectal and endometrial cancer genomes
-
Kim, T. M., Laird, P. W. and Park, P. J. 2013. The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell 155:858.
-
(2013)
Cell
, vol.155
, pp. 858
-
-
Kim, T.M.1
Laird, P.W.2
Park, P.J.3
-
68
-
-
0035818515
-
Frameshiftmutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer
-
Saeterdal, I., Bjørheim, J., Lislerud, K. et al. 2001. Frameshiftmutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer. Proc. Natl Acad. Sci. USA 98:13255.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 13255
-
-
Saeterdal, I.1
Bjørheim, J.2
Lislerud, K.3
-
69
-
-
0035399602
-
Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens
-
Linnebacher, M., Gebert, J., Rudy, W. et al. 2001. Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens. Int. J. Cancer 93:6.
-
(2001)
Int. J. Cancer
, vol.93
, pp. 6
-
-
Linnebacher, M.1
Gebert, J.2
Rudy, W.3
-
70
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger, M., Rowan, A. J., Horswell, S. et al. 2012. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366:883.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 883
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
71
-
-
84964240053
-
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
-
McGranahan, N. and Swanton, C. 2015. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell 27:15.
-
(2015)
Cancer Cell
, vol.27
, pp. 15
-
-
McGranahan, N.1
Swanton, C.2
-
72
-
-
84961572813
-
Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival
-
Morris, L. G., Riaz, N., Desrichard, A. et al. 2016 Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival. Oncotarget 7:10051.
-
(2016)
Oncotarget
, vol.7
, pp. 10051
-
-
Morris, L.G.1
Riaz, N.2
Desrichard, A.3
-
73
-
-
84954242823
-
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
-
Andor, N., Graham, T. A., Jansen, M. et al. 2016. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat. Med. 22:105.
-
(2016)
Nat. Med.
, vol.22
, pp. 105
-
-
Andor, N.1
Graham, T.A.2
Jansen, M.3
-
74
-
-
84962301577
-
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
-
McGranahan, N., Furness, A. J., Rosenthal, R. et al. 2016. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351:1463.
-
(2016)
Science
, vol.351
, pp. 1463
-
-
McGranahan, N.1
Furness, A.J.2
Rosenthal, R.3
-
75
-
-
84920921528
-
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
-
Gubin, M. M., Zhang, X., Schuster, H. et al. 2014. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515:577.
-
(2014)
Nature
, vol.515
, pp. 577
-
-
Gubin, M.M.1
Zhang, X.2
Schuster, H.3
-
76
-
-
38849151665
-
Epitope landscape in breast and colorectal cancer
-
Segal, N. H., Parsons, D. W., Peggs, K. S. et al. 2008. Epitope landscape in breast and colorectal cancer. Cancer Res. 68:889.
-
(2008)
Cancer Res.
, vol.68
, pp. 889
-
-
Segal, N.H.1
Parsons, D.W.2
Peggs, K.S.3
-
77
-
-
84920895589
-
Immunogenic peptide discovery in cancer genomes
-
Snyder, A. and Chan, T. A. 2015. Immunogenic peptide discovery in cancer genomes. Curr. Opin. Genet. Dev. 30:7.
-
(2015)
Curr. Opin. Genet. Dev.
, vol.30
, pp. 7
-
-
Snyder, A.1
Chan, T.A.2
-
78
-
-
84949564442
-
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
-
Alioto, T. S., Buchhalter, I., Derdak, S. et al. 2015. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat. Commun. 6:10001.
-
(2015)
Nat. Commun.
, vol.6
, pp. 10001
-
-
Alioto, T.S.1
Buchhalter, I.2
Derdak, S.3
-
79
-
-
84897403748
-
Comparison of somatic mutation calling methods in amplicon and whole exome sequence data
-
Xu, H., DiCarlo, J., Satya, R. V. et al. 2014. Comparison of somatic mutation calling methods in amplicon and whole exome sequence data. BMC Genomics 15:244.
-
(2014)
BMC Genomics
, vol.15
, pp. 244
-
-
Xu, H.1
DiCarlo, J.2
Satya, R.V.3
-
80
-
-
84943516465
-
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
-
Van Allen, E. M., Miao, D., Schilling, B. et al. 2015. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350:207.
-
(2015)
Science
, vol.350
, pp. 207
-
-
Van Allen, E.M.1
Miao, D.2
Schilling, B.3
-
81
-
-
17844385106
-
The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage
-
Nielsen, M., Lundegaard, C., Lund, O. et al. 2005. The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage. Immunogenetics 57:33.
-
(2005)
Immunogenetics
, vol.57
, pp. 33
-
-
Nielsen, M.1
Lundegaard, C.2
Lund, O.3
-
82
-
-
38049169092
-
Largescale validation of methods for cytotoxic T-lymphocyte epitope prediction
-
Larsen, M. V., Lundegaard, C., Lamberth, K. et al. 2007. Largescale validation of methods for cytotoxic T-lymphocyte epitope prediction. BMC Bioinformatics 8:424.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 424
-
-
Larsen, M.V.1
Lundegaard, C.2
Lamberth, K.3
-
83
-
-
0037407113
-
Reliable prediction of T-cell epitopes using neural networks with novel sequence representations
-
Nielsen, M., Lundegaard, C., Worning, P. et al. 2003. Reliable prediction of T-cell epitopes using neural networks with novel sequence representations. Protein Sci. 12:1007.
-
(2003)
Protein Sci.
, vol.12
, pp. 1007
-
-
Nielsen, M.1
Lundegaard, C.2
Worning, P.3
-
84
-
-
84936751041
-
Automated benchmarking of peptide-MHC class I binding predictions
-
Trolle, T., Metushi, I. G., Greenbaum, J. A. et al. 2015. Automated benchmarking of peptide-MHC class I binding predictions. Bioinformatics 31:2174.
-
(2015)
Bioinformatics
, vol.31
, pp. 2174
-
-
Trolle, T.1
Metushi, I.G.2
Greenbaum, J.A.3
-
85
-
-
84959881509
-
Gapped sequence alignment using artificial neural networks: application to the MHC class I system
-
Andreatta, M. and Nielsen, M. 2016. Gapped sequence alignment using artificial neural networks: application to the MHC class I system. Bioinformatics 32:511.
-
(2016)
Bioinformatics
, vol.32
, pp. 511
-
-
Andreatta, M.1
Nielsen, M.2
-
86
-
-
39549084433
-
NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and-B locus protein of known sequence
-
Nielsen, M., Lundegaard, C., Blicher, T. et al. 2007. NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and-B locus protein of known sequence. PLoS One 2:e796.
-
(2007)
PLoS One
, vol.2
-
-
Nielsen, M.1
Lundegaard, C.2
Blicher, T.3
-
87
-
-
84961221351
-
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
-
Hugo, W., Zaretsky, J. M., Sun, L. et al. 2016. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165:35.
-
(2016)
Cell
, vol.165
, pp. 35
-
-
Hugo, W.1
Zaretsky, J.M.2
Sun, L.3
-
88
-
-
84943329717
-
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
-
Cohen, C. J., Gartner, J. J., Horovitz-Fried, M. et al. 2015. Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes. J. Clin. Invest. 125:3981.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3981
-
-
Cohen, C.J.1
Gartner, J.J.2
Horovitz-Fried, M.3
-
89
-
-
84887277467
-
Properties of MHC class I presented peptides that enhance immunogenicity
-
Calis, J. J., Maybeno, M., Greenbaum, J. A. et al. 2013. Properties of MHC class I presented peptides that enhance immunogenicity. PLoS Comput. Biol. 9:e1003266.
-
(2013)
PLoS Comput. Biol.
, vol.9
-
-
Calis, J.J.1
Maybeno, M.2
Greenbaum, J.A.3
-
90
-
-
77953520516
-
MHC class II epitope predictive algorithms
-
Nielsen, M., Lund, O., Buus, S. et al. 2010. MHC class II epitope predictive algorithms. Immunology 130:319.
-
(2010)
Immunology
, vol.130
, pp. 319
-
-
Nielsen, M.1
Lund, O.2
Buus, S.3
-
91
-
-
84947042013
-
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification
-
Andreatta, M., Karosiene, E., Rasmussen, M. et al. 2015. Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification. Immunogenetics 67:641.
-
(2015)
Immunogenetics
, vol.67
, pp. 641
-
-
Andreatta, M.1
Karosiene, E.2
Rasmussen, M.3
-
92
-
-
84928811341
-
Mutant MHC class II epitopes drive therapeutic immune responses to cancer
-
Kreiter, S., Vormehr, M., van de Roemer, N. et al. 2015. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 520:692.
-
(2015)
Nature
, vol.520
, pp. 692
-
-
Kreiter, S.1
Vormehr, M.2
van de Roemer, N.3
-
93
-
-
84900301377
-
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
-
Tran, E., Turcotte, S., Gros, A. et al. 2014. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344:641.
-
(2014)
Science
, vol.344
, pp. 641
-
-
Tran, E.1
Turcotte, S.2
Gros, A.3
-
94
-
-
84961323160
-
Highthroughput epitope discovery reveals frequent recognition of neoantigens by CD4+ T cells in human melanoma
-
Linnemann, C., van Buuren, M. M., Bies, L. et al. 2015. Highthroughput epitope discovery reveals frequent recognition of neoantigens by CD4+ T cells in human melanoma. Nat. Med. 21:81.
-
(2015)
Nat. Med.
, vol.21
, pp. 81
-
-
Linnemann, C.1
van Buuren, M.M.2
Bies, L.3
-
95
-
-
84872841412
-
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
-
van Rooij, N., van Buuren, M. M., Philips, D. et al. 2013. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J. Clin. Oncol. 31:e439.
-
(2013)
J. Clin. Oncol.
, vol.31
-
-
van Rooij, N.1
van Buuren, M.M.2
Philips, D.3
-
96
-
-
84880276438
-
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
-
Robbins, P. F., Lu, Y. C., El-Gamil, M. et al. 2013. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat. Med. 19:747.
-
(2013)
Nat. Med.
, vol.19
, pp. 747
-
-
Robbins, P.F.1
Lu, Y.C.2
El-Gamil, M.3
-
97
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
-
Sivan, A., Corrales, L., Hubert, N. et al. 2015. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350:1084.
-
(2015)
Science
, vol.350
, pp. 1084
-
-
Sivan, A.1
Corrales, L.2
Hubert, N.3
-
98
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vétizou, M., Pitt, J. M., Daillère, R. et al. 2015. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350:1079.
-
(2015)
Science
, vol.350
, pp. 1079
-
-
Vétizou, M.1
Pitt, J.M.2
Daillère, R.3
-
99
-
-
84880145306
-
Database of T cell-defined tumor antigens: the 2013 update
-
Vigneron, N., Stroobant, V., Van den Eynde, B. J. and van der Bruggen, P. 2013. Database of T cell-defined tumor antigens: the 2013 update. Cancer Immun. 13:15.
-
(2013)
Cancer Immun.
, vol.13
, pp. 15
-
-
Vigneron, N.1
Stroobant, V.2
Van den Eynde, B.J.3
van der Bruggen, P.4
-
100
-
-
84988962330
-
Virus-specific CD8+ T cells infiltrate melanoma lesions and retain function despite high PD-1 expression
-
November 4-8, 2015, National Harbor, MD, USA: Oral Abstract
-
Erkes, D. A., Mohgbeli, T. and Snyder, C. M. 2015. Virus-specific CD8+ T cells infiltrate melanoma lesions and retain function despite high PD-1 expression. Society for Immunotherapy of Cancer Meeting (SITC 2015), November 4-8, 2015, National Harbor, MD, USA: Oral Abstract.
-
(2015)
Society for Immunotherapy of Cancer Meeting (SITC 2015)
-
-
Erkes, D.A.1
Mohgbeli, T.2
Snyder, C.M.3
-
101
-
-
84901295133
-
Deconstructing the peptide-MHC specificity of T cell recognition
-
Birnbaum, M. E., Mendoza, J. L., Sethi, D. K. et al. 2014. Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157:1073.
-
(2014)
Cell
, vol.157
, pp. 1073
-
-
Birnbaum, M.E.1
Mendoza, J.L.2
Sethi, D.K.3
|