A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 1185-1192

  Robbins, Paul F ^a   El Gamil, Mona ^a   Li, Yong F ^a   Kawakami, Yutaka ^a   Loftus, Douglas ^a   Appella, Ettore ^a   Rosenberg, Steven A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; TUMOR ANTIGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; CELL ADHESION; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

AMINO ACID SEQUENCE; BASE SEQUENCE; BETA CATENIN; CADHERINS; CELL LINE; CLONING, MOLECULAR; CYTOSKELETAL PROTEINS; DNA PRIMERS; DNA, COMPLEMENTARY; GENE LIBRARY; HUMANS; KIDNEY; LYMPHOCYTES, TUMOR-INFILTRATING; MELANOMA; MOLECULAR SEQUENCE DATA; MUTAGENESIS; ORGAN SPECIFICITY; PEPTIDES; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; T-LYMPHOCYTES; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0029669950     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.1185     Document Type: Article

References (28)

1. - mutation P35B generates the MHC-binding site of a new antigenic peptide. Immunogenetics. 37:135-138.
2. d by cytolytic T cells. Cell. 58:293-303.
3. Van Den Eynde, B., B. Lethé, A. Van Pel, E. De Plaen, and T Boon. 1991. The gene coding for a major tumor rejection antigen of rumor P815 is identical to the normal gene of syngeneic DBA/2 mice. J. Exp. Med. 173:1373-1384.
4. Van der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. DePlaen, B. Van Den Eynde, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science (Wash. DC). 254: 1643-1647.
5. Gaugler, B., B. Van Den Eynde, P. Van der Bruggen, P. Romero, J.J. Gaforio, E. DePlaen, B. Lethe, F. Brasseur, and T Boon. 1994. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J. Exp. Med. 179:921-930.
6. Boel, P., C. Wildmann, M.L. Sensi, R. Brasseir. J.-C. Remuld, P. Coulie, T. Boon, and P. Van der Bruggen. 1995. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity. 2: 167-175.
7. Van Den Eynde, B., O. Peeters, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new family ot genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. Exp. Med. 182:689-698.
8. Brichard, V., A. Van Pel, T. Wolfel, C. Wolfel, E. DePlaen, B. Lethe, P. Coulie, and T. Boon. 1993. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178:489-495.
9. Robbins, P.F., M. El-Gamil, Y. Kawakami, and S.A. Rosenberg. 1994. Recognition of tyrosinase by tumor infiltrating lymphocytes from a patient responding to immunotherapy. Cancer Res. 54:3124-3126.
10. Kawakami, Y., S. Eliyahu, C.H. Delgaldo, P.F. Robbins, L. Rivoltini, S.L. Topalian, T. Miki, and S.A. Rosenberg. 1994. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA. 91:3515-3519.
11. Kawakami, Y., S. Eliyahu, C.H. Delgado, P.F. Robbins, K. Sakaguchi, E. Appella, J.R. Yannelli, T. Miki, and S.A. Rosenberg. 1994. Identification of a human melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. USA. 91: 6458-6462.
12. Wang. R.F., P.F. Robbins, Y. Kawakami, X.Q. Kang, and S.A. Rosenberg. 1995. Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J. Exp. Med. 181:799-804.
13. Coulie, P.G., F. Lehmann, B. Lethe, J. Herman, C. Lurquin, M. Andrawiss, and T. Boon. 1995. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. Natl. Acad. Sci. USA. 92:7976-7980.
14. Wolfel, T., M. Hauer, J. Schneider, M. Serrano, C. Wolfel, E. Klehmann-Hieb, E. De Plaen, T. Hankeln, K.-H. Meyer zum Buschenfelde, and D. Beach. 1995. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (Wash. DC). 269:1281-1284.
15. Robbins, P.F., M. El-Gamil, Y.F. Li, S.L. Topalian, L. Rivoltini, K. Sakaguchi, E. Appella, Y. Kawakami, and S.A. Rosenberg. 1995. Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24 restricted tumor-infiltrating lymphocytes. J. Immunol. 154:5944-5950.
16. Grunwald, G.B. 1993. The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules. Curr. Opin. Cell Biol. 5:797-805.
17. Rosenberg, S.A., B.S. Packard, P.M. Aebersold, D. Solomon, S.L. Topalian, S.T. Toy, P. Simon, M.T. Lotze, J.C. Yang, C.A. Seipp et al. 1988. Use of tumor infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. Preliminary report. N. Engl. J. Med. 319:1676-1680.
18. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
19. Del Guercio, M.F., J. Sidney, G. Hermason, C. Perez, H.M. Grey, Kubo, R.T., and A. Sette. 1995. Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype. J. Immunol. 154:685-693.
20. Kondo, A., J. Sidney, S. Southwood, M.-F. del Guercio, E. Appella, H. Sakamoto, and E. Celis. 1995. Prominent roles of secondary anchor residues in peptide binding to HLA-A*2401 human class I molecules. J. Immunol 155:4307-4312.
21. Kubo, R.T., A. Sette, H.M. Grey, E. Appella, K. Sakaguchi, N-Z. Zhu, and D. Arnott, N. Sherman, J. Shabanowitz, H. Michel, W.M. Bodnar, T.A. Davis, and D.F. Hunt. 1994. Definition of specific peptide motifs for four major HLA-A alleles. J. Immunol. 152:3913-3924.
22. Brash, D.E., J.A. Rudolph, J.A. Simon, A. Lin, G.J. McKenna, H.P. Baden, A.J. Halperin, and J. Ponten. 1991. A role of sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA. 88:10124-10128.
23. Becker, K.-F., M.J. Atkinson, U. Reich, I. Becker, H. Nekarda, J.R. Siewert, and H. Hofler. 1994. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 54:3845-3852.
24. Vleminckx, K., L. Vakaet Jr., M. Mareel, W. Fiers, and F. Van Roy. 1991. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 66:107-119.
25. Kawanishi, J., J. Kato, K. Sasaki, S. Fujii, N. Watanabe, and Y. Niitsu. 1995. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39. Mol. Cell Biol. 15:1175-1181.
26. Oda, T., Y. Kanai, Y. Shimoyama, A. Nagafuchi, S. Tsukita, and S. Hirohashi. 1993. Cloning of the human α-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem. Biophys. Res. Comm. 193:897-904.
27. Su, L.-K., B. Vogelstein, and K.W. Kinzler. 1993. Association of the APC tumor suppressor protein with catenins. Science (Wash. DC). 262:1734-1737.
28. Hoschuetzky, H., H. Aberle, and R. Kemler. 1994. β-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127: 1375-1380.