deconstructSigs: Delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  Rosenthal, Rachel ^a,b   McGranahan, Nicholas ^a,b,c   Herrero, Javier ^a   Taylor, Barry S ^d   Swanton, Charles ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

APOBEC; Esophageal carcinoma; Mutational signatures; Single samples

Indexed keywords

ARTICLE; CANCER GROWTH; DATA ANALYSIS; DNA REPAIR; ENVIRONMENTAL EXPOSURE; ESOPHAGEAL ADENOCARCINOMA; FRAMESHIFT MUTATION; GENE SEQUENCE; METASTASIS; MUTATIONAL ANALYSIS; PRIMARY TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR GENE; ADENOCARCINOMA; DISORDERS OF DNA SYNTHESIS AND REPAIR; DNA MUTATIONAL ANALYSIS; ESOPHAGUS TUMOR; GENETICS; HUMAN; HUMAN GENOME; MUTATION; PATHOLOGY;

CYTIDINE DEAMINASE;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; CYTIDINE DEAMINASE; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA REPAIR-DEFICIENCY DISORDERS; ESOPHAGEAL NEOPLASMS; GENOME, HUMAN; HUMANS; MUTATION;

EID: 84959467752     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-0893-4     Document Type: Article

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