Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways

BMC Cancer

Volumn 16, Issue 1, 2016, Pages

  Wang, Yu ^a   Nie, Hao ^a   Zhao, Xin ^a   Qin, Yong ^a   Gong, Xingguo ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

AKT; Autophagy; Bicyclol; Cell cycle; ERK; HepG2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4,4' DIMETHOXY 5,6,5',6' BIS(DIMETHYLENE DIOXY) 2 HYDROXYMETHYL 2' METHOXY CARBONYL BIPHENYL; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BICYCLOL; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; GREEN FLUORESCENT PROTEIN; LIVER PROTECTIVE AGENT; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; RED FLUORESCENT PROTEIN; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; SORAFENIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE ASSAY; CELL PROLIFERATION ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 84988487412     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-016-2767-2     Document Type: Article

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