Effect of bicyclol on acetaminophen-induced hepatotoxicity: energetic metabolism and mitochondrial injury in acetaminophen-intoxicated mice

Yaoxue Xuebao

Volumn 36, Issue 10, 2001, Pages 723-726

  Li, Ye ^a   Dai, Guo Wei ^a   Li, Yan ^a   Liu, Geng Tao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetaminophen; Bicyclol; Energetic metabolism; Magnetic resonance spectroscopy; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BICYCLOL; BIPHENYL DERIVATIVE; PARACETAMOL;

ANIMAL; ARTICLE; DRUG EFFECT; ENERGY METABOLISM; ENZYMOLOGY; LIVER MITOCHONDRION; MALE; MEMBRANE FLUIDITY; METABOLISM; MOUSE; PATHOLOGY; RANDOMIZATION; TOXIC HEPATITIS;

ACETAMINOPHEN; ADENOSINETRIPHOSPHATASE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIPHENYL COMPOUNDS; ENERGY METABOLISM; ENGLISH ABSTRACT; HEPATITIS, TOXIC; MALE; MEMBRANE FLUIDITY; MICE; MITOCHONDRIA, LIVER; RANDOM ALLOCATION;

EID: 0001012455     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Geoffrion Y, Rydzy M. The use of immobilized ferrite to enhance the depth selectivity of in vivo surface coil NMR spectroscopy [J]. NMR Biomed, 1988, 1(3):107-112.
2. 31P-NMR spectra of the liver and kidney [J]. J Magn Resonance, 1992,96:181-184.
3. 31P-NMR spectroscopy [J]. Biochim Biophys Acta, 1986,885:1-11.
4. Berson A, Renault S, Letteron P. et al. Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction [J]. Gastroenterlogy, 1996,110: 1878-1890.
5. Watanabe H, Kobayashi A, Yamamoto T, et al. Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium [J]. Fre Rad Biol Med, 1990,8: 507-511.
6. Parmar DV, Ahmed G, Khandkar MA, et al. Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity [J]. Eur J Pharmacol, 1995,293:225-229.
7. 31P NMR study in rats [J]. Hepatology, 1990,11(1):65-73.
8. Meyers LL, Beierschmitt WP, Khairallah EA, et al. Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice [J]. Toxicol App Pharamcol, 1988,93: 378-388.
9. Katyare SS, Satav JG. Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat [J]. Br J Pharmacol, 1989,96:51 -58.