Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 47469-47475

  Lents, Nathan H ^a   Keenan, Susan M ^a,b   Bellone, Clifford ^a   Baldassare, Joseph J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; ENZYMES; PHOSPHATES;

EUKARYOTIC CELL CYCLE;

BIOCHEMISTRY;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; THREONINE;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EUKARYOTIC CELL; INHIBITION KINETICS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BLOTTING, WESTERN; BUTADIENES; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; CRICETINAE; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MODELS, GENETIC; NITRILES; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; THREONINE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

ANIMALIA; EUKARYOTA;

EID: 0037033035     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207425200     Document Type: Article

References (57)

1. Sherr, C. J. (1996) Science 274, 1672-1677
2. Sherr, C. J. (1994) Cell 79, 551-555
3. Ohtsubo, M., and Roberts, J. M. (1993) Science 259, 1908-1912
4. Sherr, C. J. (1993) Cell 73, 1059-1065
5. Matsushime, H., Ewen, M. E., Strom, D. K., Kato, J. Y., Hanks, S. K., Roussel, M. F., and Sherr, C. J. (1992) Cell 71, 323-334
6. Meyerson, M., and Harlow, E. (1994) Mol. Cell. Biol. 14, 2077-2086
7. Bates, S., Bonetta, L., MacAllan, D., Parry, D., Holder, A., Dickson, C., and Peters, G. (1994) Oncogene 9, 71-79
8. Tam, S. W., Theodoras, A. M., Shay, J. W., Draetta, G. F., and Pagano, M. (1994) Oncogene 9, 2663-2674
9. Phillips-Mason, P. J., Raben, D. M., and Baldassare, J. J. (2000) J. Biol. Chem. 275, 18046-18053
10. Weber, J. D., Raben, D. M., Phillips, P. J., and Baldassare, J. J. (1997) Biochem. J. 326, 61-68
11. Donjerkovic, D., and Scott, D. W. (2000) Cell Res. 10, 1-16
12. Pardee, A. B. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 1286-1290
13. Dou, Q. P., Levin, A. H., Zhao, S., and Pardee, A. B. (1993) Cancer Res. 53, 1493-1497
14. Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J. (1993) Genes Dev. 7, 331-342
15. Geng, Y., Whoriskey, W., Park, M. Y., Bronson, R. T., Medema, R. H., Li, T., Weinberg, R. A., and Sicinski, P. (1999) Cell 97, 767-777
16. Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M., and Roberts, J. M. (1991) Cell 66, 1217-1228
17. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J. W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R., and Roberts, J. M. (1992) Science 257, 1689-1694
18. Winey, M. (1999) Curr. Biol. 9, R449-R452
19. Zhao, J., Dynlacht, B., Imai, T., Hori, T., and Harlow, E. (1998) Genes Dev. 12, 456-461
20. Dynlacht, B. D., Flores, O., Lees, J. A., and Harlow, E. (1994) Genes Dev. 8, 1772-1786
21. Knoblich, J. A., Sauer, K., Jones, L., Richardson, H., Saint, R., and Lehner, C. F. (1994) Cell 77, 107-120
22. Tsai, L. H., Lees, E., Faha, B., Harlow, E., and Riabowol, K. (1993) Oncogene 8, 1593-1602
23. Keenan, S. M., Bellone, C., and Baldassare, J. J. (2001) J. Biol. Chem. 276, 22404-22409
24. Blanchard, D. A., Mouhamad, S., Auffredou, M. T., Pesty, A., Bertoglio, J., Leca, G., and Vazquez, A. (2000) Oncogene 19, 4184-4189
25. Dietrich, C., Wallenfang, K., Oesch, F., and Wieser, R. (1997) Exp. Cell Res. 232, 72-78
26. Russo, A. A., Jeffrey, P. D., and Pavletich, N. P. (1996) Nat. Struct. Biol. 3, 696-700
27. Jeffrey, P. D., Russo, A. A., Polyak, K., Gibbs, E., Hurwitz, J., Massague, J., and Pavletich, N. P. (1995) Nature 376, 313-320
28. Larochelle, S., Pandur, J., Fisher, R. P., Salz, H. K., and Suter, B. (1998) Genes Dev. 12, 370-381
29. Harper, J. W., and Elledge, S. J. (1998) Genes Dev. 12, 285-289
30. Yankulov, K. Y., and Bentley, D. L. (1997) EMBO J. 16, 1638-1646
31. Fisher, R. P., and Morgan, D. O. (1994) Cell 78, 713-724
32. Sebastian, B., Kakizuka, A., and Hunter, T. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 3521-3524
33. Tsakraklides, V., and Solomon, M. J. (2002) J. Biol. Chem.
34. Sexl, V., Diehl, J. A., Sherr, C. J., Ashmun, R., Beach, D., and Roussel, M. F. (1999) Oncogene 18, 573-582
35. Blomberg, I., and Hoffmann, I. (1999) Mol. Cell. Biol. 19, 6183-6194
36. Boulton, T. G., Yancopoulos, G. D., Gregory, J. S., Slaughter, C., Moomaw, C., Hsu, J., and Cobb, M. H. (1990) Science 249, 64-67
37. Dent, P., Reardon, D. B., Morrison, D. K., and Sturgill, T. W. (1995) Mol. Cell. Biol. 15, 4125-4135
38. Leng, X., Connell-Crowley, L., Goodrich, D., and Harper, J. W. (1997) Curr. Biol. 7, 709-712
39. Kaldis, P., and Solomon, M. J. (2000) Eur. J. Biochem. 267, 4213-4221
40. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) Cell 75, 805-816
41. Polyak, K., Lee, M. H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., and Massague, J. (1994) Cell 78, 59-66
42. Weber, J. D., Hu, W., Jefcoat, S. C., Jr., Raben, D. M., and Baldassare, J. J. (1997) J. Biol. Chem. 272, 32966-32971
43. Toyoshima, H., and Hunter, T. (1994) Cell 78, 67-74
44. Hu, W., Bellone, C. J., and Baldassare, J. J. (1999) J. Biol. Chem. 274, 3396-3401
45. Goel, R., Phillips-Mason, P. J., Raben, D. M., and Baldassare, J. J. (2002) J. Biol. Chem. 277, 18640-18648
46. Kyriakis, J. M., App, H., Zhang, X. F., Banerjee, P., Brautigan, D. L., Rapp, U. R., and Avruch, J. (1992) Nature 358, 417-421
47. Macdonald, S. G., Crews, C. M., Wu, L., Driller, J., Clark, R., Erikson, R. L., and McCormick, F. (1993) Mol. Cell. Biol. 13, 6615-6620
48. Kolch, W. (2000) Biochem. J. 351, 289-305
49. Harbour, J. W., Luo, R. X., Dei, S. A., Postigo, A. A., and Dean, D. C. (1999) Cell 98, 859-869
50. Chow, K. N., Starostik, P., and Dean, D. C. (1996) Mol. Cell. Biol. 16, 7173-7181
51. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., and Livingston, D. M. (1993) Cell 73, 487-497
52. Chiariello, M., Gomez, E., and Gutkind, J. S. (2000) Biochem. J. 349, 869-876
53. Devault, A., Martinez, A. M., Fesquet, D., Labbe, J. C., Morin, N., Tassan, J. P., Nigg, E. A., Cavadore, J. C., and Doree, M. (1995) EMBO J. 14, 5027-5036
54. Martinez, A. M., Afshar, M., Martin, F., Cavadore, J. C., Labbe, J. C., and Doree, M. (1997) EMBO J. 16, 343-354
55. Rossignol, M., Kolb-Cheynel, I., and Egly, J. M. (1997) EMBO J. 16, 1628-1637
56. Nagahara, H., Ezhevsky, S. A., Vocero-Akbani, A. M., Kaldis, P., Solomon, M. J., and Dowdy, S. F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 14961-14966
57. Espinoza, F. H., Farrell, A., Erdjument-Bromage, H., Tempst, P., and Morgan, D. O. (1996) Science 273, 1714-1717