Activation of SIRT1 attenuates klotho deficiency-induced arterial stiffness and hypertension by enhancing AMP-activated protein kinase activity

Hypertension

Volumn 68, Issue 5, 2016, Pages 1191-1199

  Gao, Diansa ^a,b   Zuo, Zhong ^a   Tian, Jing ^a   Ali, Quaisar ^b   Lin, Yi ^b   Lei, Han ^a   Sun, Zhongjie ^a,b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

angiotensin II; arteries; blood pressure; elastin; hypertension

Indexed keywords

AMP ACTIVATED PROTEIN KINASE ALPHA; COLLAGEN TYPE 1; ELASTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KLOTHO PROTEIN; N [2 [3 (1 PIPERAZINYLMETHYL)IMIDAZO[2,1 B]THIAZOL 6 YL]PHENYL] 2 QUINOXALINECARBOXAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIRTUIN 1; SUPEROXIDE; UNCLASSIFIED DRUG; ANGIOTENSIN II; BETA GLUCURONIDASE; FUSED HETEROCYCLIC RINGS; SIRT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; AORTIC ENDOTHELIAL CELL; ARTERIAL STIFFNESS; ARTERY DISEASE; ARTERY MEDIA; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; HUMAN; HYPERTENSION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULSE WAVE; SMOOTH MUSCLE CELL; AGING; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANGIOTENSIN II; ANIMALS; AORTA; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GLUCURONIDASE; HETEROCYCLIC COMPOUNDS, 4 OR MORE RINGS; HUMANS; HYPERTENSION; MALE; MICE; MICE, KNOCKOUT; PROSPECTIVE STUDIES; PULSE WAVE ANALYSIS; SIRTUIN 1; VASCULAR STIFFNESS;

EID: 84987624171     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07709     Document Type: Article

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