Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension

Hypertension

Volumn 61, Issue 3, 2013, Pages 585-592

  Crosswhite, Patrick ^a   Sun, Zhongjie ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

blood pressure; macrophage infiltration; NADPH oxidase; pulmonary artery; remodeling; right ventricle; smooth muscle cell proliferation; superoxide

Indexed keywords

8 ISOBUTYL METHYL XANTHINE; ALPHA SMOOTH MUSCLE ACTIN; APOCYNIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; COLD EXPOSURE; COLD INDUCED PULMONARY HYPERTERNSION; CONTROLLED STUDY; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; ROOM TEMPERATURE; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WEIGHT GAIN;

1-METHYL-3-ISOBUTYLXANTHINE; ACETOPHENONES; ANIMALS; COLD TEMPERATURE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; ENZYME INHIBITORS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG DISEASES; MACROPHAGES; MALE; NADPH OXIDASE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 84874366022     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.00676     Document Type: Article

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