Transcription factor Runx2 promotes aortic fibrosis and stiffness in type 2 diabetes mellitus

Circulation Research

Volumn 117, Issue 6, 2015, Pages 513-524

  Raaz, Uwe ^a,b,c   Schellinger, Isabel N ^a,b   Chernogubova, Ekaterina ^d   Warnecke, Christina ^e   Kayama, Yosuke ^a,b   Penov, Kiril ^a   Hennigs, Jan K ^a   Salomons, Florian ^a,d   Eken, Suzanne ^d   Emrich, Fabian C ^g   Zheng, Wei H ^a,b   Adam, Matti ^a,b   Jagger, Ann ^a,b   Nakagami, Futoshi ^a   Toh, Ryuji ^a   Toyama, Kensuke ^a,b   Deng, Alicia ^a,b   Buerke, Michael ^f   Maegdefessel, Lars ^d   Hasenfuß, Gerd ^c   Spin, Joshua M ^a,b   Tsao, Philip S ^a,b   more..

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f St Mary's Hospital Siegen   (Germany)

^g NONE

Author keywords

arterial stiffness; diabetes mellitus; extracellular matrix; oxidative stress; smooth muscle cell

Indexed keywords

COLLAGEN 1A1; COLLAGEN 1A2; COLLAGEN TYPE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TEMPOL; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; RUNX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA DISEASE; AORTIC FIBROSIS; ARTERIAL STIFFNESS; ARTICLE; BLOOD VESSEL CALCIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDIATOR; MIDDLE AGED; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR FIBROSIS; VASCULAR SMOOTH MUSCLE CELL; AGED; ANIMAL; AORTA; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; FEMALE; FIBROSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AGED; ANIMALS; AORTA; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DIABETES MELLITUS, TYPE 2; FEMALE; FIBROSIS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; TRANSCRIPTION FACTORS; VASCULAR STIFFNESS;

EID: 84940484398     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306341     Document Type: Article

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