Haplodeficiency of klotho gene causes arterial stiffening via upregulation of scleraxis expression and induction of autophagy

Hypertension

Volumn 66, Issue 5, 2015, Pages 1006-1013

  Chen, Kai ^a   Zhou, Xiaoli ^a,b   Sun, Zhongjie ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

autophagy; Becn1 protein, mouse; collagen; elastin; myofibroblasts; Scx protein, mouse; vascular stiffness

Indexed keywords

ALDOSTERONE; ALDOSTERONE RECEPTOR; BECLIN 1; COLLAGEN; COLLAGEN TYPE 1; ELASTIN; EPLERENONE; GELATINASE A; GELATINASE B; KLOTHO PROTEIN; SCLERAXIS; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BECN1 PROTEIN, MOUSE; BETA GLUCURONIDASE; SCX PROTEIN, MOUSE;

ALDOSTERONE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL STIFFNESS; ARTICLE; AUTOPHAGY; CELL DIFFERENTIATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HETEROZYGOTE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PULSE WAVE; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WILD TYPE; ANIMAL; BLOOD; DEFICIENCY; DISEASE MODEL; GENETICS; HAPLOIDY; HAPLOINSUFFICIENCY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ALDOSTERONE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BECLIN-1; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; ELASTIN; GLUCURONIDASE; HAPLOIDY; HAPLOINSUFFICIENCY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; VASCULAR STIFFNESS;

EID: 84943378123     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06033     Document Type: Article

References (46)

1. Kuro-o M, Matsumura Y, Aizawa H, Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997 390 45 51. doi: 10.1038/36285
2. Kuro-o M., Klotho and aging. Biochim Biophys. Acta 2009 1790 1049 1058
3. Xu Y, Sun Z., Molecular basis of klotho: from gene to function in aging. Endocr Rev 2015 36 174 193. doi: 10.1210/er.2013-1079
4. Wang Y, Sun Z., Current understanding of klotho. Ageing Res Rev 2009 8 43 51. doi: 10.1016/j.arr.2008.10.002
5. Kurosu H, Yamamoto M, Clark JD, Suppression of aging in mice by the hormone Klotho. Science 2005 309 1829 1833. doi: 10.1126/science.1112766
6. Safar ME., Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens 2001 10 257 261
7. Sun Z., Aging, arterial stiffness, and hypertension. Hypertension 2015 65 252 256. doi: 10.1161/HYPERTENSIONAHA.114.03617
8. Cavalcante JL, Lima JA, Redheuil A, Al-Mallah MH., Aortic stiffness: current understanding and future directions. J Am Coll Cardiol 2011 57 1511 1522. doi: 10.1016/j.jacc.2010.12.017
9. Ward MR, Pasterkamp G, Yeung AC, Borst C., Arterial remodeling. Mechanisms and clinical implications. Circulation 2000 102 1186 1191
10. Pasterkamp G, De Kleijn DP, Borst C., Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications. Cardiovasc Res 2000 45 843 852
11. Wagenseil JE, Mecham RP., Elastin in large artery stiffness and hypertension. J Cardiovasc Transl Res 2012 5 264 273. doi: 10.1007/s12265-012-9349-8
12. Collier SR, Sandberg K, Moody AM, Frechette V, Curry CD, Ji H, Gowdar R, Chaudhuri D, Meucci M., Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise. J Hum Hypertens 2015 29 53 57. doi: 10.1038/jhh.2014.33
13. Kamide K., Role of renin-angiotensin-aldosterone system in metabolic syndrome and obesity-related hypertension. Curr Hypertens Rev 2014 9 238 245
14. Aroor AR, Demarco VG, Jia G, Sun Z, Nistala R, Meininger GA, Sowers JR., The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol (Lausanne) 2013 4 161. doi: 10.3389/fendo.2013.00161
15. Park S, Kim JB, Shim CY, Ko YG, Choi D, Jang Y, Chung N., The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients. J Hypertens 2007 25 1279 1283. doi: 10.1097/HJH.0b013e3280f31b6e.
16. Leibovitz E, Ebrahimian T, Paradis P, Schiffrin EL., Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction. J Hypertens 2009 27 2192 2200. doi: 10.1097/HJH.0b013e328330a963
17. Xiao NM, Zhang YM, Zheng Q, Gu J., Klotho is a serum factor related to human aging. Chin Med J (Engl) 2004 117 742 747
18. Kotsis V, Stabouli S., Arterial stiffness, vascular aging, and intracranial large artery disease. Am J Hypertens 2011 24 252. doi: 10.1038/ajh.2010.251
19. Kitagawa M, Sugiyama H, Morinaga H, Inoue T, Takiue K, Ogawa A, Yamanari T, Kikumoto Y, Uchida HA, Kitamura S, Maeshima Y, Nakamura K, Ito H, Makino H., A decreased level of serum soluble klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One 2013 8 e56695. doi: 10.1371/journal.pone.0056695
20. Zhou X, Wang Y, Lei H, Sun Z., Mutation of anti-aging gene klotho causes hypertension via upregulation of adrenal CYP11B2 expression and aldosterone synthesis. Circulation 2014 130 A17793. (Abstract)
21. Lin Y, Sun Z., In vivo pancreatic β-cell-specific expression of antiaging gene klotho: A novel approach for preserving β-cells in type 2 diabetes. Diabetes 2015 64 1444 1458. doi: 10.2337/db14-0632
22. Crosswhite P, Chen K, Sun Z., AAV delivery of tumor necrosis factor-α short hairpin RNA attenuates cold-induced pulmonary hypertension and pulmonary arterial remodeling. Hypertension 2014 64 1141 1150. doi: 10.1161/HYPERTENSIONAHA.114.03791
23. Wang Y, Sun Z., Antiaging gene klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J Hypertens 2014 32 1629 36; discussion 1636. doi: 10.1097/HJH.0000000000000233
24. Wang X, Skelley L, Wang B, Mejia A, Sapozhnikov V, Sun Z., AAV-based RNAi silencing of NADPH oxidase gp91(phox) attenuates cold-induced cardiovascular dysfunction. Hum Gene Ther 2012 23 1016 1026. doi: 10.1089/hum.2012.078
25. Lin Y, Kuro-o M, Sun Z., Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology 2013 154 3855 3863. doi: 10.1210/en.2013-1053
26. Léjard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl MH, Noda M, Duprez D, Houillier P, Rossert J., Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem 2007 282 17665 17675. doi: 10.1074/jbc.M610113200
27. Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R., Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 2007 134 2697 2708. doi: 10.1242/dev.001933
28. Georgianos PI, Sarafidis PA, Lasaridis AN., Arterial stiffness: A novel cardiovascular risk factor in kidney disease patients. Curr Vasc Pharmacol 2015 13 229 238
29. Van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, Van der Kuip DA, Hofman A, Witteman JC., Association between arterial stiffness and atherosclerosis: The Rotterdam study. Stroke 2001 32 454 460
30. Scuteri A, Brancati AM, Gianni W, Assisi A, Volpe M., Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: A pilot study. J Hypertens 2005 23 1211 1216
31. Liao J, Farmer J., Arterial stiffness as a risk factor for coronary artery disease. Curr Atheroscler Rep 2014 16 387. doi: 10.1007/s11883-013-0387-8
32. Matsubara T, Miyaki A, Akazawa N, Choi Y, Ra SG, Tanahashi K, Kumagai H, Oikawa S, Maeda S., Aerobic exercise training increases plasma klotho levels and reduces arterial stiffness in postmenopausal women. Am J Physiol Heart Circ Physiol 2014 306 H348 H355. doi: 10.1152/ajpheart.00429.2013
33. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS, Mitchell GF., Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 2012 308 875 881. doi: 10.1001/2012.jama.10503
34. Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M, Heiss G., Arterial stiffness and the development of hypertension. The ARIC study. Hypertension 1999 34 201 206
35. Najjar SS, Scuteri A, Shetty V, Wright JG, Muller DC, Fleg JL, Spurgeon HP, Ferrucci L, Lakatta EG., Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol 2008 51 1377 1383. doi: 10.1016/j.jacc.2007.10.065
36. Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F., Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension 2013 62 1105 1110. doi: 10.1161/HYPERTENSIONAHA.113.01744
37. Fischer SS, Kempe DS, Leibrock CB, Rexhepaj R, Siraskar B, Boini KM, Ackermann TF, Föller M, Hocher B, Rosenblatt KP, Kuro-O M, Lang F., Hyperaldosteronism in klotho-deficient mice. Am J Physiol Renal Physiol 2010 299 F1171 F1177. doi: 10.1152/ajprenal.00233.2010
38. Cserjesi P, Brown D, Ligon KL, Lyons GE, Copeland NG, Gilbert DJ, Jenkins NA, Olson EN., Scleraxis: A basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 1995 121 1099 1110
39. Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ., Analysis of the tendon cell fate using scleraxis, a specific marker for tendons and ligaments. Development 2001 128 3855 3866
40. Brent AE, Schweitzer R, Tabin CJ., A somitic compartment of tendon progenitors. Cell 2003 113 235 248
41. Espira L, Lamoureux L, Jones SC, Gerard RD, Dixon IM, Czubryt MP., The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. J Mol Cell Cardiol 2009 47 188 195. doi: 10.1016/j.yjmcc.2009.03.024
42. Bagchi RA, Czubryt MP., Synergistic roles of scleraxis and Smads in the regulation of collagen 1α2 gene expression. Biochim Biophys Acta 2012 1823 1936 1944. doi: 10.1016/j.bbamcr.2012.07.002
43. Huett A, Goel G, Xavier RJ., A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 2010 26 302 309. doi: 10.1097/MOG.0b013e32833ae2ed.
44. Kobayashi S, Liang Q., Autophagy and mitophagy in diabetic cardiomyopathy. Biochim Biophys Acta 2015 1852 252 261. doi: 10.1016/j.bbadis.2014.05.020
45. Mao N, Cheng Y, Shi XL, Wang L, Wen J, Zhang Q, Hu QD, Fan JM., Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro. Acta Pharmacol Sin 2014 35 513 522. doi: 10.1038/aps.2013.187
46. Garcia AG, Wilson RM, Heo J, Murthy NR, Baid S, Ouchi N, Sam F., Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure. Am J Physiol Heart Circ Physiol 2012 303 H587 H596. doi: 10.1152/ajpheart.00298.2012