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Volumn 34, Issue 4, 2016, Pages 281-299

Stevioside and rebaudioside a - Predominant ent-kaurene diterpene glycosides of terapeutic potential: A review

Author keywords

Secondary metabolites; Stevia rebaudiana; Sweetener; Therapeutic applications

Indexed keywords

BEVERAGES; DIETARY SUPPLEMENTS; FOOD ADDITIVES; METABOLITES; PATHOGENS; PLANTS (BOTANY); SUGAR INDUSTRY; SUGAR SUBSTITUTES; SUGARS;

EID: 84985962880     PISSN: 12121800     EISSN: None     Source Type: Journal    
DOI: 10.17221/335/2015-CJFS     Document Type: Review
Times cited : (27)

References (125)
  • 2
    • 84986006925 scopus 로고    scopus 로고
    • A review on natural sweetener plant - Stevia having medicinal and commercial importance
    • Ahmed B., Hossain M., Islam R., Kumar Saha A., Mandal A. (2011): A review on natural sweetener plant - stevia having medicinal and commercial importance. Agronomski glasnik, 73: 75-91.
    • (2011) Agronomski Glasnik , vol.73 , pp. 75-91
    • Ahmed, B.1    Hossain, M.2    Islam, R.3    Kumar Saha, A.4    Mandal, A.5
  • 3
    • 55649120019 scopus 로고    scopus 로고
    • Evaluation of supplementary stevia (Stevia rebaudiana bertoni) leaves and stevioside in broiler diets: Effects on feed intake, nutrient metabolism, blood parameters and growth performance
    • Atteh J., Onagbesan O., Tona K., Decuypere E., Geuns J., Buyse J. (2008): Evaluation of supplementary Stevia (Stevia rebaudiana Bertoni) leaves and stevioside in broiler diets: Effects on feed intake, nutrient metabolism, blood parameters and growth performance. Journal of Animal Physiology and Animal Nutrition, 92: 640-649.
    • (2008) Journal of Animal Physiology and Animal Nutrition , vol.92 , pp. 640-649
    • Atteh, J.1    Onagbesan, O.2    Tona, K.3    Decuypere, E.4    Geuns, J.5    Buyse, J.6
  • 4
    • 79960718911 scopus 로고    scopus 로고
    • Longterm feeding effect of stevioside sweetener on some toxicological parameters of growing male rats
    • Awney H.A., Massoud M.I., El-Maghrabi S. (2011): Longterm feeding effect of stevioside sweetener on some toxicological parameters of growing male rats. Journal of Applied Toxicology, 31: 431-438.
    • (2011) Journal of Applied Toxicology , vol.31 , pp. 431-438
    • Awney, H.A.1    Massoud, M.I.2    El-Maghrabi, S.3
  • 6
    • 43749120034 scopus 로고    scopus 로고
    • Apparent lack of pharmacological efect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in type 1 and type 2 diabetics
    • Barriocanal L.A., Palacios M., Benitez G., Benitez S., Jimenez J.T., Jimenez N. (2008): Apparent lack of pharmacological efect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Regulatory Toxicology and Pharmacology, 51: 37-41.
    • (2008) Regulatory Toxicology and Pharmacology , vol.51 , pp. 37-41
    • Barriocanal, L.A.1    Palacios, M.2    Benitez, G.3    Benitez, S.4    Jimenez, J.T.5    Jimenez, N.6
  • 10
    • 34447101720 scopus 로고    scopus 로고
    • Steviol glycoside biosynthesis
    • Brandle B.E., Telmer P.G. (2007): Steviol glycoside biosynthesis. Phytochemistry, 68: 1855-1863.
    • (2007) Phytochemistry , vol.68 , pp. 1855-1863
    • Brandle, B.E.1    Telmer, P.G.2
  • 11
    • 0036836919 scopus 로고    scopus 로고
    • Leaf ESTs from stevia rebaudiana: A resource for gene discovery in diterpene synthesis
    • Brandle J.E., Richman A., Swanson A.K., Chapman B.P. (2002): Leaf ESTs from Stevia rebaudiana: a resource for gene discovery in diterpene synthesis. Plant Molecular Biology, 50: 613-622.
    • (2002) Plant Molecular Biology , vol.50 , pp. 613-622
    • Brandle, J.E.1    Richman, A.2    Swanson, A.K.3    Chapman, B.P.4
  • 12
    • 45949093346 scopus 로고    scopus 로고
    • A critical review of the genotoxicity of steviol and steviol glycosides
    • Brusick D. (2008): A critical review of the genotoxicity of steviol and steviol glycosides. Food and Chemical Toxicology, 7: S83-S91.
    • (2008) Food and Chemical Toxicology , vol.7 , pp. S83-S91
    • Brusick, D.1
  • 13
    • 45949100030 scopus 로고    scopus 로고
    • Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages
    • Carakostas M.C., Curry L.L., Boilea A.C., Brusick D. (2008): Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food and Chemical Toxicology, 46: S1-S10.
    • (2008) Food and Chemical Toxicology , vol.46 , pp. S1-S10
    • Carakostas, M.C.1    Curry, L.L.2    Boilea, A.C.3    Brusick, D.4
  • 14
    • 0033818478 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension
    • Chan P., Tomlinson B., Chen Y.J., Liu J.C., Hsieh M.H., Cheng J.T. (2000): A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. British Journal of Clinical Pharmacology, 50: 215-220.
    • (2000) British Journal of Clinical Pharmacology , vol.50 , pp. 215-220
    • Chan, P.1    Tomlinson, B.2    Chen, Y.J.3    Liu, J.C.4    Hsieh, M.H.5    Cheng, J.T.6
  • 15
    • 57749106147 scopus 로고    scopus 로고
    • Stevioside and related compounds: Therapeutic benefits beyond sweetness
    • Chatsudthipong V., Muanprasat C. (2009): Stevioside and related compounds: therapeutic benefits beyond sweetness. Pharmacology and Therapeutics, 121: 41-54.
    • (2009) Pharmacology and Therapeutics , vol.121 , pp. 41-54
    • Chatsudthipong, V.1    Muanprasat, C.2
  • 16
    • 57749092287 scopus 로고
    • Effect and mechanism of stevioside on rat renal function
    • Chatsudthipong V., Thongouppakarn P. (1995): Effect and mechanism of stevioside on rat renal function. The FASEB Journal, 9: A917-A917.
    • (1995) The FASEB Journal , vol.9 , pp. A917-A917
    • Chatsudthipong, V.1    Thongouppakarn, P.2
  • 18
    • 14944361919 scopus 로고    scopus 로고
    • Mechanism of the hypoglycemic effect of stevioside, a glycoside of stevia rebaudiana
    • Chen T.H., Chen S.C., Chan P., Chu Y.L., Yang H.Y., Cheng J.T. (2005): Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Medica, 71: 108-113.
    • (2005) Planta Medica , vol.71 , pp. 108-113
    • Chen, T.H.1    Chen, S.C.2    Chan, P.3    Chu, Y.L.4    Yang, H.Y.5    Cheng, J.T.6
  • 19
    • 84870185472 scopus 로고    scopus 로고
    • Simultaneous quantification of stevioside and rebaudioside A in different samples collected from the Indian subcontinent
    • Chester K., Tamboli E., Singh M., Ahmad S. (2012): Simultaneous quantification of stevioside and rebaudioside A in different samples collected from the Indian subcontinent. Journal of Pharmacy and Bioallied Sciences, 4: 276-281.
    • (2012) Journal of Pharmacy and Bioallied Sciences , vol.4 , pp. 276-281
    • Chester, K.1    Tamboli, E.2    Singh, M.3    Ahmad, S.4
  • 20
    • 45949085901 scopus 로고    scopus 로고
    • Rebaudioside A: Two-generation reproductive toxicity study in rats
    • Curry L., Roberts A., Brown N. (2008): Rebaudioside A: two-generation reproductive toxicity study in rats. Food and Chemical Toxicology, 46: S21-S30.
    • (2008) Food and Chemical Toxicology , vol.46 , pp. S21-S30
    • Curry, L.1    Roberts, A.2    Brown, N.3
  • 21
    • 24944574340 scopus 로고    scopus 로고
    • Sweet diterpenic glycosides balance of a new cultivar of stevia rebaudiana (Bert.) bertoni: Isolation and quantitative distribution by chromatographic, spectroscopic, and electrophoretic methods
    • Dacome A.S., Da Silva C.C, Da Costa C.E.M., Fontana J.D., Adelmann J., Da Costa S.C. (2005): Sweet diterpenic glycosides balance of a new cultivar of Stevia rebaudiana (Bert.) Bertoni: Isolation and quantitative distribution by chromatographic, spectroscopic, and electrophoretic methods. Process Biochemistry, 40: 3587-3594.
    • (2005) Process Biochemistry , vol.40 , pp. 3587-3594
    • Dacome, A.S.1    Da Silva, C.C.2    Da Costa, C.E.M.3    Fontana, J.D.4    Adelmann, J.5    Da Costa, S.C.6
  • 23
    • 0027024527 scopus 로고
    • Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A
    • Das S., Das A.K., Murphy R.A., Punwani I.C., Nasution M.P, Kinghorn A.D. (1992): Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. Caries Research, 26: 363-366.
    • (1992) Caries Research , vol.26 , pp. 363-366
    • Das, S.1    Das, A.K.2    Murphy, R.A.3    Punwani, I.C.4    Nasution, M.P.5    Kinghorn, A.D.6
  • 24
    • 84959376605 scopus 로고    scopus 로고
    • Isolation, purification and characterization of sweetners from stevia rebaudiana (Bertoni) for their anticancerous activity against colon cancer
    • Deshmukh S.R., Kedari V.R. (2014): Isolation, purification and characterization of sweetners from Stevia rebaudiana (Bertoni) for their anticancerous activity against colon cancer. World Journal of Pharmacy and Pharmaceutical Sciences, 3: 1394-1410.
    • (2014) World Journal of Pharmacy and Pharmaceutical Sciences , vol.3 , pp. 1394-1410
    • Deshmukh, S.R.1    Kedari, V.R.2
  • 25
    • 0142147418 scopus 로고
    • Estudo da viabilidade dos frutos de stevia rebaudiana bert
    • (in Portuguese, English abstract)
    • Felippe G.M., Lucas N.M.C. (1971): Estudo da viabilidade dos frutos de Stevia rebaudiana Bert. Hoehnea 1: 95-105. (in Portuguese, English abstract)
    • (1971) Hoehnea , vol.1 , pp. 95-105
    • Felippe, G.M.1    Lucas, N.M.C.2
  • 26
    • 0005224217 scopus 로고    scopus 로고
    • Food and Drug Administration to Hain Celestial Group Inc., Washington, DC. Aug 17, 2007
    • FDA (2007): Letter Department of Health and Human Services. Food and Drug Administration to Hain Celestial Group Inc., Washington, DC. Aug 17, 2007. Available at www.fda.gov/foi/warning-letters/s6500c.htm
    • (2007) Letter Department of Health and Human Services
  • 27
    • 75349110006 scopus 로고    scopus 로고
    • Evaluation of steviol and its glycosides in stevia rebaudiana leaves and commercial sweetener by ultra high performance liquid chromatography-mass spectrometry
    • Gardana C., Scaglianti M., Simonetti P. (2010): Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra high performance liquid chromatography-mass spectrometry. Journal of Chromatography A, 1217: 1463-1470.
    • (2010) Journal of Chromatography A , vol.1217 , pp. 1463-1470
    • Gardana, C.1    Scaglianti, M.2    Simonetti, P.3
  • 28
    • 77949541015 scopus 로고    scopus 로고
    • Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice
    • Geeraert B., Crombe F., Hulsmans M., Benhabiles N., Geuns J.M., Holvoet P. (2010): Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. International Journal of Obesity, 34: 569-577.
    • (2010) International Journal of Obesity , vol.34 , pp. 569-577
    • Geeraert, B.1    Crombe, F.2    Hulsmans, M.3    Benhabiles, N.4    Geuns, J.M.5    Holvoet, P.6
  • 32
    • 0021150803 scopus 로고
    • Effects of the three sweeteners on rats urinary bladder carcinogenesis initiated by n-butyl-n-(4-hydroxybutyl)-nitrosamine
    • Hagiwara A., Fukushima S., Kitaori M., Shibata M., Ito N. (1984): Effects of the three sweeteners on rats urinary bladder carcinogenesis initiated by n-butyl-n-(4-hydroxybutyl)-nitrosamine. Gann Japanese Journal of Cancer Research, 75: 763-768.
    • (1984) Gann Japanese Journal of Cancer Research , vol.75 , pp. 763-768
    • Hagiwara, A.1    Fukushima, S.2    Kitaori, M.3    Shibata, M.4    Ito, N.5
  • 33
    • 0344514685 scopus 로고
    • Studies in terpenoid biosynthesis. II: The biosynthesis of steviol
    • Hanson J.R., White A.F. (1968): Studies in terpenoid biosynthesis. II: The biosynthesis of steviol. Phytochemistry, 7: 595-597.
    • (1968) Phytochemistry , vol.7 , pp. 595-597
    • Hanson, J.R.1    White, A.F.2
  • 34
    • 84985935727 scopus 로고    scopus 로고
    • The effect of rebadioside A on attenuation of oxidative stress in kidney of mice under acetaminophen toxicity
    • Hashemi S.A., Allameh A., Daraei B., Peynevandi K.M., Pashazadeh R. (2014): The effect of rebadioside A on attenuation of oxidative stress in kidney of mice under acetaminophen toxicity. Iranian Journal of Toxicology, 7: 944-951.
    • (2014) Iranian Journal of Toxicology , vol.7 , pp. 944-951
    • Hashemi, S.A.1    Allameh, A.2    Daraei, B.3    Peynevandi, K.M.4    Pashazadeh, R.5
  • 35
    • 61849121304 scopus 로고    scopus 로고
    • Determining levels of steviol glycosides in the leaves of stevia rebaudiana by near infrared reflectance spectroscopy
    • Hearn L.K., Subedi P.P. (2009): Determining levels of steviol glycosides in the leaves of Stevia rebaudiana by near infrared reflectance spectroscopy. Journal of Food Composition and Analysis, 22: 165-168.
    • (2009) Journal of Food Composition and Analysis , vol.22 , pp. 165-168
    • Hearn, L.K.1    Subedi, P.P.2
  • 36
    • 0033080412 scopus 로고    scopus 로고
    • Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis
    • Helliwell CA, Poole A., Peacock W.J., Dennis E.S. (1999): Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis. Plant Physiology, 119: 507-510.
    • (1999) Plant Physiology , vol.119 , pp. 507-510
    • Helliwell, C.A.1    Poole, A.2    Peacock, W.J.3    Dennis, E.S.4
  • 37
    • 84921044411 scopus 로고    scopus 로고
    • Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: A transcriptomic and metabolomics study
    • Holvoet P., Rull A., Heredia A.G., López-Sanromà S., Geeraert B., Joven J., Camps J. (2015): Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: A transcriptomic and metabolomics study. Food and Chemical Toxicology, 77: 22-33.
    • (2015) Food and Chemical Toxicology , vol.77 , pp. 22-33
    • Holvoet, P.1    Rull, A.2    Heredia, A.G.3    López-Sanromà, S.4    Geeraert, B.5    Joven, J.6    Camps, J.7
  • 39
    • 0344664552 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral stevioside in patients with mild essential hypertension, a two-year, randomized, placebo-controlled study
    • Hsieh M.H., Chan P., Sue Y.M., Liu J.C., Liang T.H., Huang T.Y, Tomlinson B., Chow M.S., Kao P.F., Chen Y.J. (2003): Efficacy and tolerability of oral stevioside in patients with mild essential hypertension, a two-year, randomized, placebo-controlled study. Clinical Therapeutics, 25: 2797-2808.
    • (2003) Clinical Therapeutics , vol.25 , pp. 2797-2808
    • Hsieh, M.H.1    Chan, P.2    Sue, Y.M.3    Liu, J.C.4    Liang, T.H.5    Huang, T.Y.6    Tomlinson, B.7    Chow, M.S.8    Kao, P.F.9    Chen, Y.J.10
  • 40
    • 0000738059 scopus 로고
    • Efeito do edulcorante natural (stevioside) e sinte'tico (sacarina) sobre oritmo cardiac em ratos
    • Humbolt G., Boech E.M. (1977): Efeito do edulcorante natural (stevioside) e sinte'tico (sacarina) sobre oritmo cardiac em ratos. Arquios Brasileirosde Cardiologia, 30: 257-277.
    • (1977) Arquios Brasileirosde Cardiologia , vol.30 , pp. 257-277
    • Humbolt, G.1    Boech, E.M.2
  • 41
    • 33745189198 scopus 로고    scopus 로고
    • Spatial organisation of four enzymes from stevia rebaudiana that are involved in steviol glycoside synthesis
    • Humphrey TV, Richman A.S., Menassa R., Brandle J.E. (2006): Spatial organisation of four enzymes from Stevia rebaudiana that are involved in steviol glycoside synthesis. Plant Molecular Biology, 61: 47-62.
    • (2006) Plant Molecular Biology , vol.61 , pp. 47-62
    • Humphrey, T.V.1    Richman, A.S.2    Menassa, R.3    Brandle, J.E.4
  • 43
    • 65349193313 scopus 로고    scopus 로고
    • Direct analysis of stevia leaves for diterpene glycosides by desorption electrospray ionisation mass spectrometry
    • Jackson A.U., Tata A., Wu C, Perry R.H., Haas G., West L., Cooks R.G. (2009): Direct analysis of Stevia leaves for diterpene glycosides by desorption electrospray ionisation mass spectrometry. Analyst, 134: 867-874.
    • (2009) Analyst , vol.134 , pp. 867-874
    • Jackson, A.U.1    Tata, A.2    Wu, C.3    Perry, R.H.4    Haas, G.5    West, L.6    Cooks, R.G.7
  • 44
    • 0042552607 scopus 로고    scopus 로고
    • st meeting joint FAO/WHO expert committee on food additives (JECFA). World health organization, geneva, Switzerland
    • st Meeting Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization, Geneva, Switzerland. WHO Food Additive Series, 42: 119-143. Available at http://www.inchem.org/documents/jecfa/jecmono
    • (1999) WHO Food Additive Series , vol.42 , pp. 119-143
    • JECFA1
  • 45
    • 84155181357 scopus 로고    scopus 로고
    • Steviol glycosides
    • Geneva: World Health Organization (WHO), Geneva, Switzerland, WHO Technical Report Series 928 and 138
    • rd Meeting of the Joint FAO/WHO Expert Committee on Food Additives, Geneva: World Health Organization (WHO), Geneva, Switzerland, WHO Technical Report Series 928: 34-39 and 138. Available at http://whqlibdoc.who.int/trs/WHO-TRS-928.pdf
    • (2005) rd Meeting of the Joint FAO/WHO Expert Committee on Food Additives , pp. 34-39
    • JECFA1
  • 46
    • 0003391968 scopus 로고    scopus 로고
    • World Health Organization (WHO), Geneva, Switzerland. WHO Technical Report Series No. 947
    • th Report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization (WHO), Geneva, Switzerland. WHO Technical Report Series No. 947: 50-54. Available at http://whqlibdoc.who.int/trs/WHO-TRS-947.pdf
    • (2007) th Report of the Joint FAO/WHO Expert Committee on Food Additives , pp. 50-54
    • JECFA1
  • 49
    • 0036190439 scopus 로고    scopus 로고
    • Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic efects in vivo: Studies in the diabetic goto-kakizaki (GK) rats
    • Jeppesen P.B., Gregersen S., Alstrup K.K., Hermansen K. (2002): Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic efects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine, 9: 9-14.
    • (2002) Phytomedicine , vol.9 , pp. 9-14
    • Jeppesen, P.B.1    Gregersen, S.2    Alstrup, K.K.3    Hermansen, K.4
  • 51
    • 0042552607 scopus 로고    scopus 로고
    • Toxicological evaluation of certain food additives
    • Joint FAO/WHO Expert Committee on Food Additives (1999): Toxicological evaluation of certain food additives. Geneva, WHO Food Additives Series, No. 10: 119-143.
    • (1999) Geneva, WHO Food Additives Series , Issue.10 , pp. 119-143
  • 53
    • 0030586753 scopus 로고    scopus 로고
    • Hydroxylation of entkaurenoic acid to steviol in stevia rebaudiana bertoni - Purification and partial characterization of the enzyme
    • Kim K.K., Sawa Y., Shibata H. (1996): Hydroxylation of entkaurenoic acid to steviol in Stevia rebaudiana Bertoni - purification and partial characterization of the enzyme. Archives of Biochemistry and Biophysics, 332: 223-230.
    • (1996) Archives of Biochemistry and Biophysics , vol.332 , pp. 223-230
    • Kim, K.K.1    Sawa, Y.2    Shibata, H.3
  • 54
    • 0001856330 scopus 로고
    • Current status of stevioside as a sweetening agent for human use
    • Wagner H., Hikino H., Farnsworth N.R. (eds) London, Academic Press
    • Kinghorn A.D., Soejarto D.D. (1985): Current status of stevioside as a sweetening agent for human use. In: Wagner H., Hikino H., Farnsworth N.R. (eds): Economics and Medicinal Plant Research. Vol. 1. London, Academic Press: 1-52.
    • (1985) Economics and Medicinal Plant Research , vol.1 , pp. 1-52
    • Kinghorn, A.D.1    Soejarto, D.D.2
  • 56
    • 0036664745 scopus 로고    scopus 로고
    • Cancer-chemopreventive effects of natural sweeteners and related compounds
    • Konoshima T., Takasaki M. (2002): Cancer-chemopreventive effects of natural sweeteners and related compounds. Pure and Applied Chemistry, 74: 1309-1316.
    • (2002) Pure and Applied Chemistry , vol.74 , pp. 1309-1316
    • Konoshima, T.1    Takasaki, M.2
  • 58
    • 0037333120 scopus 로고    scopus 로고
    • In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora
    • Koyama E., Kitazawa K., Ohori Y., Izawa O., Kakegawa K., Fujino A., Ui M. (2003): in vitro metabolism of the glycosidic sweeteners, Stevia mixture and enzymatically modified Stevia in human intestinal microflora. Food and Chemical Toxicology, 41: 359-374.
    • (2003) Food and Chemical Toxicology , vol.41 , pp. 359-374
    • Koyama, E.1    Kitazawa, K.2    Ohori, Y.3    Izawa, O.4    Kakegawa, K.5    Fujino, A.6    Ui, M.7
  • 59
    • 77956975964 scopus 로고    scopus 로고
    • Antidiabetic activity and phytochemical screening of crude extract of stevia rebaudiana in alloxan-induced diabetic rats
    • Kujur R.S., Singh V., Ram M., Yadava H.N., Singh K.K., Kumari S., Roy B.K. (2010): Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacognosy Research, 2: 258-263.
    • (2010) Pharmacognosy Research , vol.2 , pp. 258-263
    • Kujur, R.S.1    Singh, V.2    Ram, M.3    Yadava, H.N.4    Singh, K.K.5    Kumari, S.6    Roy, B.K.7
  • 61
    • 0035672675 scopus 로고    scopus 로고
    • Inhibitory effect of stevioside on calcium influx to produce antihypertension
    • Lee C.N., Wong K.L., Liu J.C., Chen Y.J., Cheng J.T, Chan P. (2001): Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Medica, 67: 796-799.
    • (2001) Planta Medica , vol.67 , pp. 796-799
    • Lee, C.N.1    Wong, K.L.2    Liu, J.C.3    Chen, Y.J.4    Cheng, J.T.5    Chan, P.6
  • 62
    • 84856221678 scopus 로고    scopus 로고
    • Stevia rebaudiana bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects
    • Lemus-Mondaca R., Vega-Galvez A., Zura-Bravo L., AhHen K. (2012): Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: a comprehensive review on the biochemical, nutritional and functional aspects. Food Chemistry, 132: 1121-1132.
    • (2012) Food Chemistry , vol.132 , pp. 1121-1132
    • Lemus-Mondaca, R.1    Vega-Galvez, A.2    Zura-Bravo, L.3    AhHen, K.4
  • 63
    • 84874048204 scopus 로고    scopus 로고
    • HPTLC method for simultaneous analysis of stevioside and rebaudioside-A in stevia rebaudiana
    • Londhe S.V., Nanaware S.M. (2013): HPTLC method for simultaneous analysis of stevioside and rebaudioside-A in Stevia rebaudiana. Journal of AOAC International, 96: 24-26.
    • (2013) Journal of AOAC International , vol.96 , pp. 24-26
    • Londhe, S.V.1    Nanaware, S.M.2
  • 66
    • 0029873741 scopus 로고    scopus 로고
    • Analysis of stevia glycosides by capillary electrophoresis
    • Mauri P., Catalano G., Gardana C., Pietta P. (1996): Analysis of Stevia glycosides by capillary electrophoresis. Electrophoresis, 17: 367-371.
    • (1996) Electrophoresis , vol.17 , pp. 367-371
    • Mauri, P.1    Catalano, G.2    Gardana, C.3    Pietta, P.4
  • 68
    • 0026650515 scopus 로고
    • Stevioside effect on renal function of normal and hypertensive rats
    • Melis M.S. (1992): Stevioside effect on renal function of normal and hypertensive rats. Journal of Ethnopharmacology, 36: 213-217.
    • (1992) Journal of Ethnopharmacology , vol.36 , pp. 213-217
    • Melis, M.S.1
  • 69
    • 0022351354 scopus 로고
    • Effects of indomethacin on the action of stevioside on mean arterial pressure and renal function in rats
    • Melis M.S., Maciel R.E., Sainati A.R. (1985): Effects of indomethacin on the action of stevioside on mean arterial pressure and renal function in rats. IRCS Medical Science-Biochemistry, 13: 1230-1231.
    • (1985) IRCS Medical Science-Biochemistry , vol.13 , pp. 1230-1231
    • Melis, M.S.1    Maciel, R.E.2    Sainati, A.R.3
  • 70
    • 0025783380 scopus 로고
    • Effect of calcium and verapamil on renal function of rats during treatment with stevioside
    • Melis M.S., Sainati A.R. (1991): Effect of calcium and verapamil on renal function of rats during treatment with stevioside. Journal of Ethnopharmacology, 33: 257-262.
    • (1991) Journal of Ethnopharmacology , vol.33 , pp. 257-262
    • Melis, M.S.1    Sainati, A.R.2
  • 75
    • 84982358134 scopus 로고
    • A revised medium of rapid growth and essays within tobacco tissue culture
    • Murashige T., Skoog F. (1962): A revised medium of rapid growth and essays within tobacco tissue culture. Physiologia Plantarum, 15: 473-497.
    • (1962) Physiologia Plantarum , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 76
    • 0033934335 scopus 로고    scopus 로고
    • Tryptophan as a precursor for melatonin and serotonin biosynthesis in in-vitro regenerated st. John's ort (hypericum perforatum cv. Anthos) plants
    • Murch S.J., Krishna R.S., Saxena P.K. (2000): Tryptophan as a precursor for melatonin and serotonin biosynthesis in in-vitro regenerated St. John's ort (hypericum perforatum cv. Anthos) plants. Plant Cell Reports, 19: 698-704.
    • (2000) Plant Cell Reports , vol.19 , pp. 698-704
    • Murch, S.J.1    Krishna, R.S.2    Saxena, P.K.3
  • 77
    • 84870495654 scopus 로고    scopus 로고
    • Test Number 5001 (079-085). Unpublished report of a study conducted at the Biosafety Research Center, Japan. Submitted to WHO by Ministry of Health and Welfare, Japan. Cited in: JECFA 2005
    • Nakajima (2000a): Chromosome aberration assay of Rebaudioside A in cultured mammalian cells. Test Number 5001 (079-085). Unpublished report of a study conducted at the Biosafety Research Center, Japan. Submitted to WHO by Ministry of Health and Welfare, Japan. Cited in: JECFA 2005.
    • (2000) Chromosome Aberration Assay of Rebaudioside a in Cultured Mammalian Cells
    • Nakajima1
  • 78
    • 84870527695 scopus 로고    scopus 로고
    • Test Number 5002 (079-086). Unpublished report of a study conducted at the Biosafety Research Center, Japan. Submitted to WHO by Ministry of Health and Welfare, Japan. Cited in: JECFA 2005
    • Nakajima (2000b): Micronucleus test of Rebaudioside A in mice. Test Number 5002 (079-086). Unpublished report of a study conducted at the Biosafety Research Center, Japan. Submitted to WHO by Ministry of Health and Welfare, Japan. Cited in: JECFA 2005.
    • (2000) Micronucleus Test of Rebaudioside a in Mice
    • Nakajima1
  • 79
    • 0029153758 scopus 로고
    • Suppression of syntheses of high molecular weight nonmuscle tropomyosins in macrophages
    • Nakamura Y., Sakiyama S., Takenaga K. (1995): Suppression of syntheses of high molecular weight nonmuscle tropomyosins in macrophages. Cell Motility and the Cytoskeleton, 31: 273-282.
    • (1995) Cell Motility and the Cytoskeleton , vol.31 , pp. 273-282
    • Nakamura, Y.1    Sakiyama, S.2    Takenaga, K.3
  • 80
    • 84867790336 scopus 로고    scopus 로고
    • Stevioside induced ROS-mediated apoptosis through mitochondrial pathway in human breast cancer cell line MCF-7
    • Paul S., Sengupta S., Bandyopadhyay T.K., Bhattacharyya A. (2012): Stevioside induced ROS-mediated apoptosis through mitochondrial pathway in human breast cancer cell line MCF-7. Nutrition and Cancer, 64: 1087-1094.
    • (2012) Nutrition and Cancer , vol.64 , pp. 1087-1094
    • Paul, S.1    Sengupta, S.2    Bandyopadhyay, T.K.3    Bhattacharyya, A.4
  • 82
    • 0036011085 scopus 로고    scopus 로고
    • The formation and function of plant volatiles: Perfumes for pollinator attraction and defense
    • Pichersky E., Gershenzon J. (2002): The formation and function of plant volatiles: perfumes for pollinator attraction and defense. Current Opinion in Plant Biology, 5: 237-243.
    • (2002) Current Opinion in Plant Biology , vol.5 , pp. 237-243
    • Pichersky, E.1    Gershenzon, J.2
  • 83
    • 85045228549 scopus 로고
    • Contraceptive properties of stevia rebaudiana
    • Planas G.M., Kuc J. (1968): Contraceptive properties of Stevia rebaudiana. Science, 162: 1007.
    • (1968) Science , vol.162 , pp. 1007
    • Planas, G.M.1    Kuc, J.2
  • 84
    • 34247595371 scopus 로고    scopus 로고
    • Characterization of stevia rebaudiana by comprehensive two-dimensional liquid chromatography time-of-flight mass spectrometry
    • Pól J., Hohnová B., Hyötyläinen T. (2007): Characterization of Stevia rebaudiana by comprehensive two-dimensional liquid chromatography time-of-flight mass spectrometry. Journal of Chromatography A, 1150: 85-92.
    • (2007) Journal of Chromatography A , vol.1150 , pp. 85-92
    • Pól, J.1    Hohnová, B.2    Hyötyläinen, T.3
  • 87
    • 0033180217 scopus 로고    scopus 로고
    • Diterpene synthesis in stevia rebaudiana: Recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway
    • Richman A.S., Gijzen M., Starratt A.N., Yang Z., Brandle J.E. (1999): Diterpene synthesis in Stevia rebaudiana: recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway. Plant Journal, 19: 411-421.
    • (1999) Plant Journal , vol.19 , pp. 411-421
    • Richman, A.S.1    Gijzen, M.2    Starratt, A.N.3    Yang, Z.4    Brandle, J.E.5
  • 88
    • 45949088674 scopus 로고    scopus 로고
    • Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats
    • Roberts A., Renwick A.G. (2008): Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats. Food and Chemical Toxicology, 46: S31-S39.
    • (2008) Food and Chemical Toxicology , vol.46 , pp. S31-S39
    • Roberts, A.1    Renwick, A.G.2
  • 89
    • 0002961793 scopus 로고
    • Japanese researches on stevia rebaudiana (Bert.) bertoni and stevioside
    • Sakaguchi M., Kan T. (1982): Japanese researches on Stevia rebaudiana (Bert.) Bertoni and stevioside. Ci Cult, 34: 235-248.
    • (1982) Ci Cult , vol.34 , pp. 235-248
    • Sakaguchi, M.1    Kan, T.2
  • 90
    • 84985923960 scopus 로고    scopus 로고
    • Study of stevia (Stevia rebaudiana bertoni) as a natural sweetener and its use in health benefit
    • Salvador R.R., Sotelo M.H., Paucar L.M. (2014): Study of Stevia (Stevia rebaudiana Bertoni) as a natural sweetener and its use in health benefit. Scientia Agropecuaria, 5: 157-163.
    • (2014) Scientia Agropecuaria , vol.5 , pp. 157-163
    • Salvador, R.R.1    Sotelo, M.H.2    Paucar, L.M.3
  • 91
    • 84879515053 scopus 로고    scopus 로고
    • Modulating efficacy of rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats
    • Saravanan R., Ramachandran V. (2013): Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats. Environmental Toxicology and Pharmacology, 36: 472-483.
    • (2013) Environmental Toxicology and Pharmacology , vol.36 , pp. 472-483
    • Saravanan, R.1    Ramachandran, V.2
  • 92
    • 84985932810 scopus 로고
    • Food Science and Techniques. Commission of the European Communities (EEC), Health and Consumer Protection DirectorateGeneral, Brussels, Belgium
    • th Series (Opinion Expressed 14 September 1984). In: Food Science and Techniques. Commission of the European Communities (EEC), Health and Consumer Protection DirectorateGeneral, Brussels, Belgium. Available at http://www.europa.eu.int/comm/food/fs/sc/scf/reports/scf-reports-16.pdf
    • (1985) th Series (Opinion Expressed 14 September 1984)
    • SCF1
  • 96
    • 0001411179 scopus 로고
    • Glucosylation of steviol and steviol-glycosides in extracts from stevia rebaudiana bertoni
    • Shibata H., Sonoke S., Ochiai H., Nishihashi H., Yamada M. (1991): Glucosylation of steviol and steviol-glycosides in extracts from Stevia rebaudiana Bertoni. Plant Physiology, 95: 152-156.
    • (1991) Plant Physiology , vol.95 , pp. 152-156
    • Shibata, H.1    Sonoke, S.2    Ochiai, H.3    Nishihashi, H.4    Yamada, M.5
  • 97
    • 0028978210 scopus 로고
    • Steviol and steviol-glycosides: Gluco syltranferase activities in stevia rebaudiana bertoni: Purification and partial characterization
    • Shibata H., Sawa Y., Oka T., Sonoke S., Kim K.K., Yoshioka M. (1995): Steviol and steviol-glycosides: gluco syltranferase activities in Stevia rebaudiana Bertoni: Purification and partial characterization. Archives of Biochemistry and Biophysics, 321: 390-396.
    • (1995) Archives of Biochemistry and Biophysics , vol.321 , pp. 390-396
    • Shibata, H.1    Sawa, Y.2    Oka, T.3    Sonoke, S.4    Kim, K.K.5    Yoshioka, M.6
  • 99
    • 0000931448 scopus 로고
    • Shanidar IV, a neanderthal flower burial in Northern Iraq
    • Solecki R.S. (1975): Shanidar IV, a Neanderthal flower burial in northern Iraq. Science, 190: 880-881.
    • (1975) Science , vol.190 , pp. 880-881
    • Solecki, R.S.1
  • 100
    • 71549125880 scopus 로고    scopus 로고
    • NMR studies of the conformation of the natural sweetener rebaudioside A
    • Steinmetz W.E., Lin A. (2009): NMR studies of the conformation of the natural sweetener rebaudioside A. Carbohydrate Research, 344: 2533-2538.
    • (2009) Carbohydrate Research , vol.344 , pp. 2533-2538
    • Steinmetz, W.E.1    Lin, A.2
  • 105
    • 84986004595 scopus 로고
    • A teratological study of stevioside administered orally to rats
    • National Institute of Hygienic Sciences, Japan. Submitted to WHO by Ministry of Health and Welfare, Food Chemistry Division, Japan
    • Takanaka T., Kawashima K., Usami M., Sakami K. (1991): A teratological study of stevioside administered orally to rats. Unpublished report from Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Sciences, Japan. Submitted to WHO by Ministry of Health and Welfare, Food Chemistry Division, Japan.
    • (1991) Unpublished Report from Department of Pharmacology, Biological Safety Research Center
    • Takanaka, T.1    Kawashima, K.2    Usami, M.3    Sakami, K.4
  • 108
    • 77956677070 scopus 로고    scopus 로고
    • Hypotensive action of naturally occurring diterpenes: A therapeutic promise for the treatment of hypertension
    • Tirapelli C.R., Ambrosio S.R., De Oliveira A.M, Tostes R.C. (2010): Hypotensive action of naturally occurring diterpenes: A therapeutic promise for the treatment of hypertension. Fitoterapia, 81: 690-702.
    • (2010) Fitoterapia , vol.81 , pp. 690-702
    • Tirapelli, C.R.1    Ambrosio, S.R.2    De Oliveira, A.M.3    Tostes, R.C.4
  • 112
  • 114
    • 0347419112 scopus 로고    scopus 로고
    • Sensitive highperformance liquid chromatography/mass spectrometry method for determination of steviol in rat plasma
    • Wang L., Goh B., Fan L., Lee H. (2004): Sensitive highperformance liquid chromatography/mass spectrometry method for determination of steviol in rat plasma. Rapid Communications in Mass Spectrometry, 18: 83-86.
    • (2004) Rapid Communications in Mass Spectrometry , vol.18 , pp. 83-86
    • Wang, L.1    Goh, B.2    Fan, L.3    Lee, H.4
  • 115
    • 0035753787 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis via 1-deoxy-d-xylulose 5-phosphate/2-C-methyl-d-erythritol 4-phosphate (DOXP/MEP) pathway
    • Wanke M., Tudek K.S., Swiezewska E. (2001): Isoprenoid biosynthesis via 1-deoxy-d-xylulose 5-phosphate/2-C-methyl-d-erythritol 4-phosphate (DOXP/MEP) pathway. Acta Biochimca Polonica, 48: 663-672.
    • (2001) Acta Biochimca Polonica , vol.48 , pp. 663-672
    • Wanke, M.1    Tudek, K.S.2    Swiezewska, E.3
  • 116
    • 68649088290 scopus 로고    scopus 로고
    • Genotoxicity studies on a high purity rebaudioside A preparation
    • Williams L.D., Burdock G.A. (2009): Genotoxicity studies on a high purity rebaudioside A preparation. Food and Chemical Toxicology, 47: 1831-1836.
    • (2009) Food and Chemical Toxicology , vol.47 , pp. 1831-1836
    • Williams, L.D.1    Burdock, G.A.2
  • 117
    • 0019303433 scopus 로고
    • Intestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside A
    • Wingard R., Brown J., Enderlin F., Dale J., Hale R., Seitz C. (1980): Intestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside A. Experientia, 36: 519-520.
    • (1980) Experientia , vol.36 , pp. 519-520
    • Wingard, R.1    Brown, J.2    Enderlin, F.3    Dale, J.4    Hale, R.5    Seitz, C.6
  • 118
    • 77954533178 scopus 로고    scopus 로고
    • Improved HPLC method for the evaluation of the major steviol glycosides in leaves of stevia rebaudiana
    • Woelwer-Rieck U., Lankes C., Wawrzun A., Wüst M. (2010): Improved HPLC method for the evaluation of the major steviol glycosides in leaves of Stevia rebaudiana. European Food Research and Technology, 231: 581-588.
    • (2010) European Food Research and Technology , vol.231 , pp. 581-588
    • Woelwer-Rieck, U.1    Lankes, C.2    Wawrzun, A.3    Wüst, M.4
  • 120
    • 84864695654 scopus 로고    scopus 로고
    • Steviol glycosides from stevia: Biosynthesis pathway review and their application in foods and medicine
    • Yadav S.K., Guleria P. (2012): Steviol glycosides from Stevia: biosynthesis pathway review and their application in foods and medicine. Critical Reviews in Food Science and Nutrition, 52: 988-998.
    • (2012) Critical Reviews in Food Science and Nutrition , vol.52 , pp. 988-998
    • Yadav, S.K.1    Guleria, P.2
  • 122
    • 0043053467 scopus 로고    scopus 로고
    • Inhibitory effect of stevioside on tumor promotion by 12-O-tetrade-canoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
    • Yasukawa K., Kitanaka S., Seo S. (2002): Inhibitory effect of stevioside on tumor promotion by 12-O-tetrade-canoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biological and Pharmaceutical Bulletin, 25: 1488-1490.
    • (2002) Biological and Pharmaceutical Bulletin , vol.25 , pp. 1488-1490
    • Yasukawa, K.1    Kitanaka, S.2    Seo, S.3
  • 124
    • 0026089997 scopus 로고
    • Effect of stevioside on growth and reproduction
    • Yodyingyuad V., Bunyawong S. (1991): Effect of stevioside on growth and reproduction. Human Reproduction, 6: 158-165.
    • (1991) Human Reproduction , vol.6 , pp. 158-165
    • Yodyingyuad, V.1    Bunyawong, S.2
  • 125


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