Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats

Environmental Toxicology and Pharmacology

Volumn 36, Issue 2, 2013, Pages 472-483

  Saravanan, Ramalingam ^a   Ramachandran, Vinayagam ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Diabetes; Lipid profile; Oxidative stress; Rebaudioside A; Streptozotocin

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; DITERPENOID; FATTY ACID; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROPEROXIDE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; REBAUDIOSIDE A; STREPTOZOCIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG STRUCTURE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; LIVER HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

DIABETES; LIPID PROFILE; OXIDATIVE STRESS; REBAUDIOSIDE A; STREPTOZOTOCIN;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CATALASE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DITERPENES, KAURANE; DNA DAMAGE; FATTY ACIDS, NONESTERIFIED; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; KIDNEY; LIPID PEROXIDATION; LIPID PEROXIDES; LIPIDS; LIVER; MALE; OXIDATIVE STRESS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIGLYCERIDES; VITAMIN E;

RATTUS; RATTUS NORVEGICUS;

EID: 84879515053     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2013.05.009     Document Type: Article

References (53)

1. + channels. Diabetes Obes. Metab. 2008, 11:74-85.
2. Baker H., Frankel O., De Angelis B., Feingold S. Plasma α-tocopherol in man at various time intervals after ingesting free or acetylated tocopherol. Nutr. Rep. Int. 1980, 21:531-536.
3. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 1991, 40:405-412.
4. Blasiak J., Kowalik J. Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate. Acta Biochim. Pol. 2001, 48:233-240.
5. Bonnefont-Rousselot D., Beaudeux J.L., Therond P., Peynet J., Legrand A., Delattre J. Diabetes mellitus, oxidative stress and advanced glycation endproducts. Ann. Pharm. Fr. 2004, 62:147-157.
6. Brown B.G., Zhao X.Q., Sacco D.E., Albers J.J. Lipid lowering and plaque regression: newinsights into prevention of plaque disruption and clinical events in coronary disease. Circulation 1993, 87:1781-1791.
7. Budin S.B., Othman F., Louis S.R., Bakar M.A., Das S., Mohamed J. The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clinics (Sao Paulo) 2009, 64:235-244.
8. Burgi W., Briner M., Franken N., Kessler A.C.H. One step sandwich enzyme immunoassay for insulin using monoclonal antibodies. Clin. Biochem. 1988, 21:311-314.
9. Cekic V., Vasovic V., Jakovljevic V., Mikov M., Sabo A. Hypoglycaemic action of stevioside and a barley and brewer's yeast based preparation in the experimental model on mice. Bosnian J. Basic Med. Sci. 2011, 11:11-16.
10. Chan P., Xu D.Y., Liu J.C., Chan Y.J., Tomlinson B., Huang W.P., Cheng J.T. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. 1998, 63:1679-1684.
11. Coskun O., Kanter M., Korkmaz A., Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and b-cell damage in rat pancreas. Pharmacol. Res. 2005, 51:117-123.
12. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Armstrong D., Nicotera T. Oxidative damage to DNA in diabetes. Lancet 1996, 347:444-445.
13. Dmitriev L.F., Titov V.N. Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases. Ageing Res. Rev. 2010, 9:200-210.
14. Ellman G.L. Tissue sulfhydrl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
15. Elmai E., Altan N., Bukan N. Effect of sulphorylurea glibenclamide on liver and kidney antioxidant enzymes in streptozotozin induced diabetic rats. Drugs R. D. 2004, 5:203-208.
16. Falholt K., Falholt W., Lund B. An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clin. Chim. Acta 1973, 46:105-111.
17. Fenercioglu A.K., Saler T., Genc E., Sabuncu H., Altuntas Y. The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications. J. Endocrinol. Invest. 2010, 33:118-124.
18. Foster L.B., Dunn R.T. Stable reagents for determination of serum triglycerides by colorimetric hantzsch condensation method. Clin. Chem. 1973, 19:338-340.
19. Friedwald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of LDL-C in plasma without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18:449-502.
20. Gylling H., Miettinen T.A. Cholesterol absorption, synthesis and low and high density lipoprotein metabolism in non insulin dependent diabetes mellitus. Diabetes Care 1997, 20:90-95.
21. Halliwell B., Gutteridge J.M.C. Free radicals and toxicology. Free Radicals in Biology and Medicine 1997, 1-27. Clarendon Press, Oxford.
22. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 1999, Oxford University Press, Oxford. 3rd ed.
23. Heidari Z., Harati M., Mahmoudzadeh-Sagheb H.R., Moudi B. Beta cell protective effects of sodium tungstate in streptozotocin-induced diabetic rats: glycemic control, blockage of oxidative stress and beta cell histochemistry. Iran. Biomed. J. 2008, 12:143-152.
24. Hodgson E.K., Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry 1975, 14:5294-5299.
25. Jain S.K. Glutathione and glucose-6-phosphate dehydrogenase deficiency can increase protein glycation. Free Radic. Biol. Med. 1998, 24:197-201.
26. Jiang Z.Y., Hunt J.V., Wolff S.P. Detection of lipid hydroperoxides using the Fox method. Anal. Biochem. 1992, 202:384-389.
27. Kakkar P., Das B., Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 1978, 21:130-132.
28. Loven D., Schedl H., Wilson H., Daabees T.T., Stegink L.D., Diekus M. Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin induced diabetes. Diabetes 1986, 35:503-507.
29. Melis M.S. Stevioside effect on renal function of normal and hypertensive rats. J. Ethnopharmacol. 1992, 36:213-217.
30. Nichaus W.G., Samuelson B. Formation of MDA from phospholipids arachidonate during microsomal lipid peroxidation. Eur. J. Biochem. 1968, 6:126-130.
31. Noda Y., Kneyuki T., Packer L. Antioxidant activity of nasunin. Toxicology 2000, 148:119-123.
32. Opara E.C. Oxidative stress, micronutrients, diabetes mellitus and its complications. J. R. Soc. Promot. Health 2002, 122:28-34.
33. Opoka-Winiarska V. Impaired metabolism and effects of vitamin C supplementation on diabetes. Diabetol. Pol. 2001, 7:208-211.
34. Punithavathi V.R., Anuthama R., Prince P.S. Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. J. Appl. Toxicol. 2008, 28:806-813.
35. Rains J.L., Jain S.K. Oxidative stress, insulin signaling, and diabetes. Free Radic. Biol. Med. 2011, 50:567-575.
36. Roe J.H., Kuether C.A. Detection of ascorbic acid in whole blood and urine through 2,4-DNPH derivative of dehydroascorbic acid. J. Biol. Chem. 1943, 147:399-407.
37. Rotruck J.J., Pope A.L., Ganther H.E., Swanson A.B. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
38. Saravanan R., Vengatash babu K., Ramachandran V. Effect of Rebaudioside A, a diterpenoid on glucose homeostasis in STZ-induced diabetic rats. J. Physiol. Biochem. 2012, 68:421-431.
39. Schmatz R., Perreira L.B., Stefanello N., Mazzanti C., Spanevello R., Gutierres J., Bagatini M., Martins C.C., Abdalla F.H., Serres J.D.S., Zanini D., Vieira J.M., Cardoso A.M., Schetinge M.R., Morsch V.M. Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Biochimie 2011, 94:374-383.
40. Schuster D.P., Duvuuri V. Diabetes mellitus. Clin. Podiatr. Med. Surg. 2002, 19:79-107.
41. Shao J., Qiao L., Janssen R.C., Pagliassotti M., Friedman J.E. Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio. Diabetes 2005, 54:976-984.
42. Shih K.C., Kwak C.F., Hwa C.M. Acipimox attenuates hypertriglyceredemia in dislipidemic non-insulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control. Diabetes Res. Clin. Pract. 1997, 36:113-119.
43. Siedel J., Hagele E.O., Ziegenhorn J., Wahlefeld A.W. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin. Chem. 1983, 29:1075-1080.
44. Sindhu R.K., Koo J.R., Roberts C.K., Vaziri N.D. Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes response to insulin and antioxidant therapies. Clin. Exp. Hypertens. 2004, 26:43-53.
45. Singh S.K., Rai P.K., Jaiswal D., Watal G. Evidence-based critical evaluation of glycemic potential of Cynodon dactylon. eCAM 2008, 5:415-420.
46. Sinha K.A. Colorimetric assay of catalase. Anal. Biochem. 1972, 47:389-394.
47. Sklavos M.M., Bertera S., Tse H.M., Bottino R., He J., Beilke J.N., Coulombe M.G., Gill R.G., Crapo J.D., Trucco M., Piganelli J.D. Redox modulation protects islets from transplant-related injury. Diabetes 2010, 59:1731-1738.
48. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 1969, 6:24.
49. Winterbourn C.C. Concerted antioxidant activity of glutathione and superoxide dismutase. Biothiols in Health and Disease 1995, 117-134. Marcel Dekker Inc., New York. L. Packer, J. Fuchs (Eds.).
50. Wohaieb S.A., Godin D.V. Alterations in free radical tissue defense mechanisms in streptozotocin-induced diabetes in rat: effect of insulin treatment. Diabetes 1987, 36:1014-1018.
51. Wu H., Guo H., Zhao R. Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi. 2006, 126:365-371.
52. Xing F.Z., Tan B.W. Antihyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats. Clin. Exp. Pharmacol. Physiol. 2000, 27:358-363.
53. Zilversmit D.B., Davis A.K. Micro determination of phospholipids by TCA precipitation. J. Lab. Clin. Med. 1950, 35:155-159.