Diterpene synthesis in Stevia rebaudiana: Recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway

Plant Journal

Volumn 19, Issue 4, 1999, Pages 411-421

  Richman, Alex S ^a   Gijzen, Mark ^a   Starratt, Al N ^a   Yang, Zhiyi ^a   Brandle, Jim E ^a  

^a AGRICULTURE AND AGRI FOOD CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COPALYLDIPHOSPHATE SYNTHASE; CYCLIZATION; DITERPENE; GERANYLGERANYL DIPHOSPHATE; GIBBERELLIC ACID; KAURENE SYNTHASE; PLANT PRODUCT; SECONDARY METABOLITE;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ASTERACEAE; CATALYSIS; CLONING, MOLECULAR; DITERPENES; GENE EXPRESSION REGULATION, PLANT; GENES, DUPLICATE; GENES, PLANT; GENOME, PLANT; GIBBERELLINS; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLANT LEAVES; PLANT PROTEINS; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; UP-REGULATION;

STEVIA REBAUDIANA;

EID: 0033180217     PISSN: 09607412     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-313X.1999.00531.x     Document Type: Article

References (38)

1. Ait-Ali, T., Swain, S.M., Reid, J.B., Sun, T. and Kamiya, Y. (1997) The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A. Plant J. 11, 443-454.
2. 20 in Stevia rebaudiana and its significance for the biological activity of steviol. Plant Cell Physiol. 20, 123-130.
3. Bennett, R.D., Lieber, E.R. and Heftmann, E. (1967) Biosynthesis of steviol from (-)-kaurene. Phytochemistry, 6, 1107-1110.
4. Bensen, R.J., Johal, G.S., Crane, V.C., Tossberg, J.T., Schnable, P.S., Meeley, R.B. and Briggs, S.P. (1995) Cloning and characterization of the maize An1 gene. Plant Cell, 7, 75-84.
5. Boado, R.J. and Pardridge, W.M. (1997) The 5′-untranslated region of GLUT1 glucose transporter mRNA causes differential regulation of the translation rate in plant and animal systems. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 118, 309-312.
6. Bohlmann, J., Steele, C.L. and Croteau, R. (1997) Monoterpene syntheses from grand fir (Abies grandis) J. Biol. Chem. 272, 21784-21792.
7. Bohlmann, J., Meyer-Gauen, G. and Croteau, R. (1998) Plant terpenoid syntheses: molecular biology and phylogenetic analysis. Proc. Natl Acad. Sci. USA, 95, 4126-4133.
8. Brandle, J.E. and Rosa, N. (1992) Heritability for yield, leaf:stem ratio and stevioside content estimated from a landrace cultivar of Stevia rebaudiana. Can. J. Plant Sci. 72, 1263-1266.
9. Brandle, J.E., Starratt, A.N. and Gijzen, M. (1998) Stevia rebaudiana: its agricultural, biological and chemical properties. Can. J. Plant Sci. 78, 527-536.
10. Cai, X.-L., Wang, Z.-Y., Xing, Y.-Y., Zhang, J.-L. and Hong, M.-M. (1998) Aberrant splicing of intron 1 leads to heterogenous 5′ UTR and decreased expression of waxy gene in rice cultivars of intermediate amylose content. Plant J. 14, 459-465.
11. Chen, X.-Y., Chen, Y., Heinstein, P. and Davisson, V.J. (1995) Cloning, expression and characterization of (+)-δ-candinene synthase: a catalyst for cotton phytoalexin synthesis. Arch. Biochem. Biophys, 324, 255-266.
12. Clegg, M.T., Cummings, M.P. and Durbin, M.L. (1997) The evolution of plant nuclear genes. Proc. Natl Acad. Sci. USA, 94, 7791-7798.
13. Dellaporta, S.L., Wood, J. and Hicks, J.B. (1983) A plant DNA minipreparation - version II. Plant Mol. Biol. Rep. 1, 19-21.
14. Dornleas, M.C., Lejeune, B., Dron, M. and Kreis, M. (1998) The Arabidopsis SHAGGY-related protein kinase (ASK) gene family: structure, organization and evolution. Gene, 212, 249-257.
15. 32P-based hybridizations. Anal. Biochem. 210, 235-244.
16. Facchini, P.J. and Chappell, J. (1992) Gene family for an elicitor-induced sesquiterpene cyclase in tobacco. Proc. Natl Acad. Sci. USA, 89, 11088-11092.
17. Hanson, J.R. and White, A.F. (1968) Studies in terpenoid biosynthesis - II. The biosynthesis of steviol. Phytochemistry, 7, 595-597.
18. Hedden, P. and Kamiya, Y. (1997) Gibberellin biosynthesis: enzymes, genes and their regulation. Annu. Rev. Plant Physiol. Plant Mol. Biol. 48, 431-460.
19. Helliwell, C.A., Sheldon, C.C., Olive, M.R., Walker, A.R., Zeevaart, J.A.D., Peacock, W.J. and Dennis, E.S. (1998) Cloning the Arabidopsis ent-kaurene oxidase gene GA3. Proc. Natl Acad. Sci. USA, 95, 9019-9024.
20. Johansen, D.A. (1940) Plant Microtechnique. New York: McGraw-Hill.
21. Kawaide, H., Imai, R., Sassa, T. and Kamiya, Y. (1997) Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis. J. Biol. Chem. 272, 21706-21712.
22. Kim, K.K., Sawa, Y. and Shibata, H. (1996) Hydroxylation of (-)-kaurenoic acid to steviol in Stevia rebaudiana Bertoni - purification and partial characterization of the enzyme. Arch. Biochem. Biophys. 332, 223-230.
23. Kinghorn, A.D. and Soejarto, D.D. (1985) Current status of stevioside as a sweetening agent for human use. In Economic and Medicinal Plant Research (Wagner, H., Hikino, H. and Farnsworth, N.R., eds). London: Academic Press, pp. 1-52.
24. Kinghorn, A.D., Soejarto, D.D., Nanayakkara, N.P.O., Compadre, C.M., Makapugay, H.C., Hovanec-Brown, J.M., Medon, P.J. and Kamath, S.K. (1984) A phytochemical screening procedure for sweet ent-kaurene glycosides in the genus Stevia. J. Nat. Prod. 47, 439-444.
25. Langdale, J.A. (1994) In situ hybrization. In The Maize Handbook (Freeling, M. and Walbot, V., eds). New York: Springer Verlag, pp. 165-180.
26. McCaskill, D. and Croteau, R. (1999) Strategies for bioengineering the development and metabolism of glandular tissues in plants. Nature Biotechnol. 17, 31-35.
27. Nanayakkara, N.P.D., Klocke, J.A., Compadre, C.M., Hussain, R.A., Pezzuto, J.M. and Kinghorn, A.D. (1987) Characterization and feeding deterrent effects on the aphid, Schizaphis graminum, of some derivatives of the sweet compounds, stevioside and rebaudioside A. J. Nat. Prod. 50, 434-441.
28. Ohtani, K., Aikawa, Y., Kasai, R., Chou, W.-H., Yamasaki, K. and Tanaka, O. (1992) Minor diterpene glycosides from sweet leaves of Rubus sauvissimus. Phytochemistry, 31, 1553-1559.
29. Phillips, K.C. (1987) Stevia: steps to developing a new sweetener. In Developments in Sweeteners Volume 3 (Grenby, T.H., ed.). London: Elsevier Applied Science, pp. 1-43.
30. Silverstone, A.L., Chang, C.-W., Krol, E. and Sun, T.P. (1997) Developmental regulation of the gibberellin biosynthetic enzyme GA1 of Arabidopsis thaliana. Plant J. 12, 9-19.
31. Smith, M.W., Yamaguchi, S., Ait-Ali, T. and Kamiya, Y. (1998) The first step of gibberellin biosynthesis in pumpkin is catalyzed by a least two coplyl diphosphate syntheses encoded by differentially regulated genes. Plant Physiol. 118, 1411-1419.
32. Starks, C.M., Back, K., Chappell, J. and Noel, J.P. (1997) Structural basis for cyclic terpene biosynthesis by tobacco 5-epiaristilochene synthase. Science, 277, 1815-1819.
33. Sun, T.-P. and Kamiya, Y. (1994) The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Plant Cell, 6, 1509-1518.
34. Sun, T.-P., Goodman, H.M. and Ausabel, P.M. (1992) Cloning the Arabidopsis GA1 locus by genomic subtraction. Plant Cell, 4, 119-128.
35. Vogel, B.S., Wildung, M.R. and Croteau, R. (1996) Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. J. Biol. Chem. 271, 23262-23268.
36. Wendt, K.U., Poralla, K. and Schulz, G.E. (1997) Structure and function of a squalene cyclase. Science, 277, 1811-1815.
37. Yamaguchi, S., Saito, T., Abe, H., Yamane, H., Murofishi, N. and Kamiya, Y. (1996) Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme enfkaurene synthase B from pumpkin (Cucurbita maxima). Plant J. 10, 203-213.
38. Yamaguchi, S., Sun, T.-P., Kawaide, H. and Kamiya, Y. (1998) The GA2 locus of Arabidopsis thaliana encodes ent-kaurene synthase of gibberellin biosynthesis. Plant Physiol. 116, 1271-1278.