Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme

European Journal of Medicinal Chemistry

Volumn 124, Issue , 2016, Pages 361-371

  Ramshini, Hassan ^a   Mannini, Benedetta ^b,e   Khodayari, Kaveh ^a   Ebrahim Habibi, Azadeh ^c   Moghaddasi, Azam Sadat ^a   Tayebee, Reza ^d   Chiti, Fabrizio ^e  

^a PAYAME NOOR UNIVERSITY   (Iran)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d HAKIM SABZEVARI UNIVERSITY   (Iran)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Amyloid aggregation inhibitors; Aromatic compounds; Drug discovery; Indolyl methanes; Protein misfolding

Indexed keywords

AMYLOID; BIS(INDOLYL) 2 CHLOROPHENYLMETHANE; BIS(INDOLYL) 2 METHYLPHENYLMETHANE; BIS(INDOLYL) 3 METHOXYLPHENYLMETHANE; BIS(INDOLYL) 3 NITROPHENYLMETHANE; BIS(INDOLYL)PHENYLMETHANE; BIS(INDOLYL)PHENYLMETHANE DERIVATIVE; CYTOTOXIC AGENT; EGG WHITE; INDOLE DERIVATIVE; LYSOZYME; PROTEIN INHIBITOR; THIOFLAVINE; TOLUENE; TRYPAN BLUE; UNCLASSIFIED DRUG; HEN EGG LYSOZYME; PROTEIN AGGREGATE;

AMYLOIDOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; INFRARED SPECTROSCOPY; MCF 7 CELL LINE; MTT ASSAY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; KINETICS; MCF-7 CELL LINE;

AMYLOID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; KINETICS; MCF-7 CELLS; MURAMIDASE; PROTEIN AGGREGATES;

EID: 84984680182     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.08.056     Document Type: Article

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