New mimetic peptides inhibitors of β aggregation. Molecular guidance for rational drug design

European Journal of Medicinal Chemistry

Volumn 95, Issue , 2015, Pages 136-152

  Barrera Guisasola, Exequiel E ^a,b   Andujar, Sebastián A ^a,b   Hubin, Ellen ^c,d,e   Broersen, Kerensa ^c   Kraan, Ivonne M ^c   Méndez, Luciana ^f   Delpiccolo, Carina M L ^f   Masman, Marcelo F ^g   Rodríguez, Ana M ^a,b   Enriz, Ricardo D ^a,b  

^a UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c UNIVERSITY OF TWENTE   (Netherlands)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f Universidad Nacional de Rosario   (Argentina)

^g UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Aggregation modulating effect; Amyloid protein; Mimetic peptides; Molecular dynamics simulations; Molecular modelling

Indexed keywords

6 BENZYLOXYCARBONYLAMINO 2 (4 METHYLAMINO BENZOYLAMINO) HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 (4 METHYLAMINO BENZOYLAMINO) HEXANOIC ACID BENZYL ESTER; BENZYL DERIVATIVE; HEXANOIC ACID DERIVATIVE; OLIGOMER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; PEPTIDE FRAGMENT; PEPTIDOMIMETIC AGENT; WATER;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANTIBODY DETECTION; ARTICLE; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; PROTEIN CONFORMATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; DRUG DESIGN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PEPTIDOMIMETICS; PROTEIN CONFORMATION; WATER;

EID: 84925596313     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.03.042     Document Type: Article

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