-
1
-
-
0020964586
-
Biology of disease amyloidosis: A familiar problem in light of current pathogenic developments
-
Kisilevsky, R. Biology of disease amyloidosis: a familiar problem in light of current pathogenic developments. Lab. Inv. 49, 381-390 (1983).
-
(1983)
Lab. Inv.
, vol.49
, pp. 381-390
-
-
Kisilevsky, R.1
-
2
-
-
0342822601
-
-
(ed. Samter, M.) (Little, Brown and Co., Boston/Toronto)
-
Pepys, M. B. in Immunological Diseases (ed. Samter, M.) 631-674 (Little, Brown and Co., Boston/Toronto, 1988).
-
(1988)
Immunological Diseases
, pp. 631-674
-
-
Pepys, M.B.1
-
3
-
-
0034001502
-
Immunoglobulin light chains, glycosaminoglycans, and amyloid
-
Stevens, F. J. & Kisilevsky, R. Immunoglobulin light chains, glycosaminoglycans, and amyloid. Cell. Mol. Life Sci. 57, 441-449 (2000).
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 441-449
-
-
Stevens, F.J.1
Kisilevsky, R.2
-
7
-
-
0002696182
-
-
(eds. Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D.) (McGraw Hill, New York)
-
Benson, M. D. & Wallace, M. R. in The Metabolic Basis of Inherited Disease (eds. Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D.) 2439 (McGraw Hill, New York, 1989).
-
(1989)
The Metabolic Basis of Inherited Disease
, pp. 2439
-
-
Benson, M.D.1
Wallace, M.R.2
-
8
-
-
0024503518
-
Familial amyloidotic polyneuropathy
-
Benson, M. D. Familial amyloidotic polyneuropathy. Trends Biochem. Sci. 12, 88-92 (1989).
-
(1989)
Trends Biochem. Sci.
, vol.12
, pp. 88-92
-
-
Benson, M.D.1
-
9
-
-
0029981197
-
Alternative conformations of amyloidogenic proteins govern their behavior
-
Kelly, J. W. Alternative conformations of amyloidogenic proteins govern their behavior Curr. Opin. Struct. Biol. 6, 11-17 (1996).
-
(1996)
Curr. Opin. Struct. Biol.
, vol.6
, pp. 11-17
-
-
Kelly, J.W.1
-
10
-
-
0031932169
-
Protein aggregation: Folding aggregates, inclusion bodies and amyloid
-
Fink, A. L. Protein aggregation: folding aggregates, inclusion bodies and amyloid. Fold. Des. 3, R9-R23 (1998).
-
(1998)
Fold. Des.
, vol.3
-
-
Fink, A.L.1
-
11
-
-
0034028197
-
Serum amyloid A. From fibril to function. Current status
-
Sipe, J. D. Serum amyloid A. From fibril to function. Current status. Amyloid 7, 10-12 (2000).
-
(2000)
Amyloid
, vol.7
, pp. 10-12
-
-
Sipe, J.D.1
-
12
-
-
0027506498
-
Human lysozyme gene mutation causes hereditary systemic amyloidosis
-
Pepys, M. B. & Hawkins, P. N. Human lysozyme gene mutation causes hereditary systemic amyloidosis. Nature 362, 553-557 (1993).
-
(1993)
Nature
, vol.362
, pp. 553-557
-
-
Pepys, M.B.1
Hawkins, P.N.2
-
13
-
-
0026539090
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
-
Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J. & Younkin, S. G. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730 (1992).
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
14
-
-
0026760261
-
Production of the Alzheimer amyloid β-protein by normal proteolytic processing
-
Shoji, M. et al. Production of the Alzheimer amyloid β-protein by normal proteolytic processing. Science 258, 126-129 (1992).
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
-
15
-
-
0033595706
-
β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R. et al. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 (1999).
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
-
16
-
-
0000792598
-
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
-
Kimberly, W. T., Xia, W., Rahmati, T., Wolfe, M. S. & Selkoe, D. J. The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation. J. Biol. Chem. 275, 3173-3178 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3173-3178
-
-
Kimberly, W.T.1
Xia, W.2
Rahmati, T.3
Wolfe, M.S.4
Selkoe, D.J.5
-
17
-
-
0035890055
-
2+ stabilization
-
2+ stabilization. EMBO J. 20, 6277-6287 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6277-6287
-
-
Chen, C.D.1
-
18
-
-
0027949973
-
A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation
-
Kelly, J. W. & Lansbury, P. T. J. A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation. Amyloid: Int. J. Exp. Clin. Invest. 1, 186-205 (1994).
-
(1994)
Amyloid: Int. J. Exp. Clin. Invest.
, vol.1
, pp. 186-205
-
-
Kelly, J.W.1
Lansbury, P.T.J.2
-
19
-
-
0242326155
-
A new frontier in pharmacology: The endoplasmic reticulum as a regulated export pathway in health and disease
-
Moyer, B. D. & Balch, W. E. A new frontier in pharmacology: the endoplasmic reticulum as a regulated export pathway in health and disease. Emerging Therap. Targets 5, 165-176 (2001).
-
(2001)
Emerging Therap. Targets
, vol.5
, pp. 165-176
-
-
Moyer, B.D.1
Balch, W.E.2
-
20
-
-
0031570336
-
Amyloid fibril formation and protein misassembly: A structural quest for insights into amyloid and prion diseases
-
Kelly, J. W. Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases. Structure 5, 595-600 (1997).
-
(1997)
Structure
, vol.5
, pp. 595-600
-
-
Kelly, J.W.1
-
21
-
-
0032477873
-
The environmental dependency of protein folding best explains prion and amyloid diseases
-
Kelly, J. W. The environmental dependency of protein folding best explains prion and amyloid diseases. Proc. Natl Acad. Sci. USA 95, 930-932 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 930-932
-
-
Kelly, J.W.1
-
22
-
-
0025278448
-
Fibril in senile systemic amyloidosis is derived from normal transthyretin
-
Westermark, P., Sletten, K., Johansson, B. & Cornwell, G. G. Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc. Natl Acad. Sci. USA 87, 2843-2845 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 2843-2845
-
-
Westermark, P.1
Sletten, K.2
Johansson, B.3
Cornwell, G.G.4
-
23
-
-
0021266985
-
Amyloid fibril protein in familial polyneuropathy, Portugese type: Definition of molecular abnormality in transthyretin (prealbumin)
-
Saravia, M. J. M., Birken, S., Costa, P. & Goodman, D. S. Amyloid fibril protein in familial polyneuropathy, Portugese type: definition of molecular abnormality in transthyretin (prealbumin). J. Clin. Inv. 74, 104-119 (1984).
-
(1984)
J. Clin. Inv.
, vol.74
, pp. 104-119
-
-
Saravia, M.J.M.1
Birken, S.2
Costa, P.3
Goodman, D.S.4
-
24
-
-
0031038918
-
Alzheimer's disease: Genotypes, phenotype and treatments
-
Selkoe, D. J. Alzheimer's disease: genotypes, phenotype and treatments. Science 275, 630-631 (1997).
-
(1997)
Science
, vol.275
, pp. 630-631
-
-
Selkoe, D.J.1
-
25
-
-
0032012657
-
Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide
-
Kiuru, S. Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide. Amyloid 5, 55-66 (1998).
-
(1998)
Amyloid
, vol.5
, pp. 55-66
-
-
Kiuru, S.1
-
26
-
-
0028305304
-
A role for destabilizing amino acid replacements in light chain amyloidosis
-
Hurle, M. R., Helms, L. R., Li, L., Chan, W. & Wetzel, R. A role for destabilizing amino acid replacements in light chain amyloidosis. Proc. Natl Acad. Sci. USA 91, 5446-5450 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5446-5450
-
-
Hurle, M.R.1
Helms, L.R.2
Li, L.3
Chan, W.4
Wetzel, R.5
-
27
-
-
0035957228
-
Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates
-
Khurana, R. et al. Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates. Biochemistry 40, 3525-3535 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 3525-3535
-
-
Khurana, R.1
-
28
-
-
0033798660
-
Protein aggregation in Huntington's and Parkinson's disease: Implications for therapy
-
Wanker, E. E. Protein aggregation in Huntington's and Parkinson's disease: implications for therapy. Mol. Med. Today 6, 387-391 (2000).
-
(2000)
Mol. Med. Today
, vol.6
, pp. 387-391
-
-
Wanker, E.E.1
-
29
-
-
0033791230
-
Protein aggregation and pathogenesis of Huntington's disease: Mechanisms and correlations
-
Wanker, E. E. Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations. Biol. Chem. 381, 937-942 (2000).
-
(2000)
Biol. Chem.
, vol.381
, pp. 937-942
-
-
Wanker, E.E.1
-
30
-
-
0033551063
-
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington's disease pathology
-
Scherzinger, E. et al. Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology. Proc. Natl Acad. Sci. USA 96, 4604-4609 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4604-4609
-
-
Scherzinger, E.1
-
31
-
-
0034646391
-
Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
-
Conway, K. A., Harper, J. D. & Lansbury, P. T. Jr. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39, 2552-2563 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 2552-2563
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury Jr., P.T.3
-
32
-
-
0033771793
-
Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson's disease?
-
Goldberg, M. S. & Lansbury, P. T. Jr. Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson's disease? Nature Cell Biol. 2, E115-E119 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
-
-
Goldberg, M.S.1
Lansbury Jr., P.T.2
-
33
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
Bruijn, L. I. et al. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 281, 1851-1854 (1998).
-
(1998)
Science
, vol.281
, pp. 1851-1854
-
-
Bruijn, L.I.1
-
34
-
-
0033913783
-
Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads?
-
Caughey, B. Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads? Nature Med. 6, 751-754 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 751-754
-
-
Caughey, B.1
-
35
-
-
0029104733
-
Prion protein amyloid and neurodegeneration
-
Prusiner, S. B. & DeArmond, S. J. Prion protein amyloid and neurodegeneration. Amyloid 2, 39-65 (1995).
-
(1995)
Amyloid
, vol.2
, pp. 39-65
-
-
Prusiner, S.B.1
DeArmond, S.J.2
-
36
-
-
0035964955
-
Transsuppression of misfolding in an amyloid disease
-
Hammarstrom, P., Schneider, F. & Kelly, J. W. Transsuppression of misfolding in an amyloid disease. Science 293, 2459-2461 (2001).
-
(2001)
Science
, vol.293
, pp. 2459-2461
-
-
Hammarstrom, P.1
Schneider, F.2
Kelly, J.W.3
-
37
-
-
0029784838
-
Amyloid β-protein and the genetics of Alzheimer's disease
-
Selkoe, D. J. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271, 18295-18298 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18295-18298
-
-
Selkoe, D.J.1
-
38
-
-
0030638760
-
Amyloid hypothesis of Alzheimer's rides high - For now
-
Schehr, R. S. Amyloid hypothesis of Alzheimer's rides high - for now. Nature Biotechnol. 15, 19-20 (1997).
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 19-20
-
-
Schehr, R.S.1
-
39
-
-
0035818516
-
Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro
-
White, J. T. & Kelly, J. W. Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro. Proc. Natl Acad. Sci. USA 98, 13019-13024 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13019-13024
-
-
White, J.T.1
Kelly, J.W.2
-
40
-
-
0031820439
-
APOE genotype predicts when - Not whether - One is predisposed to develop Alzheimer disease
-
Meyer, M. R. et al. APOE genotype predicts when - not whether - one is predisposed to develop Alzheimer disease. Nature Genet. 19, 321-322 (1998).
-
(1998)
Nature Genet.
, vol.19
, pp. 321-322
-
-
Meyer, M.R.1
-
41
-
-
0028585824
-
APOE is a major susceptibility gene for Alzheimer's disease
-
Roses, A. D. & Saunders, A. M. APOE is a major susceptibility gene for Alzheimer's disease. Curr. Opin. Biotechnol. 5, 663-667 (1994).
-
(1994)
Curr. Opin. Biotechnol.
, vol.5
, pp. 663-667
-
-
Roses, A.D.1
Saunders, A.M.2
-
42
-
-
0035949632
-
Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy
-
Hammarstrom, P., Jiang, X., Deechongkit, S. & Kelly, J. W. Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry 40, 11453-11459 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 11453-11459
-
-
Hammarstrom, P.1
Jiang, X.2
Deechongkit, S.3
Kelly, J.W.4
-
43
-
-
0042847751
-
Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing
-
Jimenez, J. L. et al. Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing. EMBO J. 18, 815-821 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 815-821
-
-
Jimenez, J.L.1
-
44
-
-
0030586945
-
Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix
-
Blake, C. & Serpell, L. Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix. Structure 4, 989-998 (1996).
-
(1996)
Structure
, vol.4
, pp. 989-998
-
-
Blake, C.1
Serpell, L.2
-
45
-
-
0028845988
-
Examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs
-
Serpell, L. C. et al. Examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs. J. Mol. Biol. 254, 113-118 (1995).
-
(1995)
J. Mol. Biol.
, vol.254
, pp. 113-118
-
-
Serpell, L.C.1
-
46
-
-
0034725535
-
The protofilament substructure of amyloid fibirls
-
Serpell, L. C. et al. The protofilament substructure of amyloid fibirls. J. Mol. Biol. 300, 1033-1039 (2000).
-
(2000)
J. Mol. Biol.
, vol.300
, pp. 1033-1039
-
-
Serpell, L.C.1
-
47
-
-
0031592945
-
Common core structure of amyloid fibrils by synchrotron X-ray diffraction
-
Sunde, M. et al. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J. Mol. Biol. 273, 729-739 (1997).
-
(1997)
J. Mol. Biol.
, vol.273
, pp. 729-739
-
-
Sunde, M.1
-
48
-
-
0242357566
-
-
(eds Kyle, R. A. & Gertz, M. A.) (Parthenon Publishing, New York) Proc. 8th Int. Symp. Amyloidosis
-
Lovat, L. B., Hohenester, E., Westermark, P., Wood, S. P. & Pepys, M. B. in Amyloid Amyloidosis 1998, Proc. 8th Int. Symp. Amyloidosis (eds Kyle, R. A. & Gertz, M. A.) 29-31 (Parthenon Publishing, New York, 1999).
-
(1999)
Amyloid Amyloidosis 1998
, pp. 29-31
-
-
Lovat, L.B.1
Hohenester, E.2
Westermark, P.3
Wood, S.P.4
Pepys, M.B.5
-
49
-
-
0031815275
-
Serum amyloid P component scintigraphy in familial amyloid polyneuropathy: Regression of visceral amyloid following liver transplantation
-
Rydh, A. et al. Serum amyloid P component scintigraphy in familial amyloid polyneuropathy: regression of visceral amyloid following liver transplantation. Eur. J. Nucl. Med. 25, 709-713 (1998).
-
(1998)
Eur. J. Nucl. Med.
, vol.25
, pp. 709-713
-
-
Rydh, A.1
-
50
-
-
0035297712
-
Targeting small Aβ oligomers: The solution to an Alzheimer's disease conundrum?
-
Klein, W. L., Krafft, G. A. & Finch, C. E. Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci. 24, 219-224 (2001).
-
(2001)
Trends Neurosci.
, vol.24
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
51
-
-
0035800097
-
Vesicle permeabilization by protofibrillar α-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease
-
Volles, M. J. et al. Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40, 7812-7819 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 7812-7819
-
-
Volles, M.J.1
-
52
-
-
0026675307
-
Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro
-
Colon, W. & Kelly, J. W. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry 31, 8654-8660 (1992).
-
(1992)
Biochemistry
, vol.31
, pp. 8654-8660
-
-
Colon, W.1
Kelly, J.W.2
-
53
-
-
0030004644
-
The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate which can self-assemble into amyloid
-
Lai, Z., Colon, W. & Kelly, J. W. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate which can self-assemble into amyloid. Biochemistry 35, 6470-6482 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 6470-6482
-
-
Lai, Z.1
Colon, W.2
Kelly, J.W.3
-
54
-
-
0028839438
-
Comparison of lethal and non-lethal transthyretin variants and their relationship to amyloid disease
-
McCutchen, S. F., Lai, Z., Miroy, G., Kelly, J. W. & Colon, W. Comparison of lethal and non-lethal transthyretin variants and their relationship to amyloid disease. Biochemistry 34, 13527-13536 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 13527-13536
-
-
McCutchen, S.F.1
Lai, Z.2
Miroy, G.3
Kelly, J.W.4
Colon, W.5
-
55
-
-
0035949432
-
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured
-
Jiang, X. et al. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry 40, 11442-11452 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 11442-11452
-
-
Jiang, X.1
-
56
-
-
0032558978
-
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: Implications for wild-type, V30M, and L55P amyloid fibril formation
-
Lashuel, H. A., Lai, Z. & Kelly, J. W. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry 37, 17851-17864 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 17851-17864
-
-
Lashuel, H.A.1
Lai, Z.2
Kelly, J.W.3
-
57
-
-
0033813424
-
A glimpse of a possible amyloidogenic intermediate of transthyretin
-
Liu, K., Cho, H. S., Lashuel, H. A., Kelly, J. W. & Wemmer, D. E. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Struct. Biol. 7, 754-757 (2000).
-
(2000)
Nature Struct. Biol.
, vol.7
, pp. 754-757
-
-
Liu, K.1
Cho, H.S.2
Lashuel, H.A.3
Kelly, J.W.4
Wemmer, D.E.5
-
58
-
-
0031056829
-
Instability, unfolding and aggregation of human lysosozyme variants underlying amyloid fibrillogenesis
-
Booth, D. R. et al. Instability, unfolding and aggregation of human lysosozyme variants underlying amyloid fibrillogenesis. Nature 385, 787-793 (1997).
-
(1997)
Nature
, vol.385
, pp. 787-793
-
-
Booth, D.R.1
-
59
-
-
0028298127
-
Mutations and off-pathway aggregation of proteins
-
Wetzel, R. Mutations and off-pathway aggregation of proteins. Trends Biotechnol. 12, 193-198 (1994).
-
(1994)
Trends Biotechnol.
, vol.12
, pp. 193-198
-
-
Wetzel, R.1
-
60
-
-
0033200063
-
Protein misfolding, evolution and disease
-
Dobson, C. M. Protein misfolding, evolution and disease. Trends Biochem. Sci. 24, 329-332 (1999).
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
61
-
-
0030447882
-
Inhibiting transthyretin amyloid fibril formation via protein stabilization
-
Miroy, G. J. et al. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proc. Natl Acad. Sci. USA 93, 15051-15056 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 15051-15056
-
-
Miroy, G.J.1
-
62
-
-
0032573082
-
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
-
Peterson, S. A. et al. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proc. Natl Acad. Sci. USA 95, 12956-12960 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12956-12960
-
-
Peterson, S.A.1
-
63
-
-
0034127176
-
Rational design of potent human transthyretin amyloid disease inhibitors
-
Klabunde, T. et al. Rational design of potent human transthyretin amyloid disease inhibitors. Nature Struct. Biol. 7, 312-321 (2000).
-
(2000)
Nature Struct. Biol.
, vol.7
, pp. 312-321
-
-
Klabunde, T.1
-
64
-
-
0034654494
-
Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors
-
Petrassi, H. M., Klabunde, T., Sacchettini, J. & Kelly, J. W. Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors. J. Am. Chem. Soc. 122, 2178-2192 (2000).
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 2178-2192
-
-
Petrassi, H.M.1
Klabunde, T.2
Sacchettini, J.3
Kelly, J.W.4
-
65
-
-
0032945924
-
Synthesis and evaluation of anthranilic acid-based transthyretin amyloid febril inhibitors
-
Oza, V. B., Petrassi, H. M., Purkey, H. E. & Kelly, J. W. Synthesis and evaluation of anthranilic acid-based transthyretin amyloid febril inhibitors, Bioorg. Med. Chem. Lett. 9, 1-6 (1999).
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 1-6
-
-
Oza, V.B.1
Petrassi, H.M.2
Purkey, H.E.3
Kelly, J.W.4
-
66
-
-
0031684499
-
Discovering transthyretin amyloid fibril inhibitors by limited screening
-
Baures, P. W., Peterson, S. A. & Kelly, J. W. Discovering transthyretin amyloid fibril inhibitors by limited screening. Bioorg. Med. Chem. 6, 1389-1401 (1998).
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1389-1401
-
-
Baures, P.W.1
Peterson, S.A.2
Kelly, J.W.3
-
67
-
-
0032970177
-
Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the nonsteroidal anti-inflammatory drug flufenamic acid
-
Baures, P. W., Oza, V. B., Peterson, S. A. & Kelly, J. W. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the nonsteroidal anti-inflammatory drug flufenamic acid. Bioorg. Med. Chem. 7, 1339-1347 (1999).
-
(1999)
Bioorg. Med. Chem.
, vol.7
, pp. 1339-1347
-
-
Baures, P.W.1
Oza, V.B.2
Peterson, S.A.3
Kelly, J.W.4
-
68
-
-
0030830019
-
Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid
-
Kelly, J. W. et al. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Adv. Protein Chem. 50, 161-181 (1997).
-
(1997)
Adv. Protein Chem.
, vol.50
, pp. 161-181
-
-
Kelly, J.W.1
-
69
-
-
0034647438
-
Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the β-domain
-
Krebs, M. R. H. et al. Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the β-domain. J. Mol. Biol. 300, 541-549 (2000).
-
(2000)
J. Mol. Biol.
, vol.300
, pp. 541-549
-
-
Krebs, M.R.H.1
-
70
-
-
0033616575
-
Designing conditions for in vitro formation of amyloid protofilaments and fibrils
-
Chiti, F. et al. Designing conditions for in vitro formation of amyloid protofilaments and fibrils. Proc. Natl Acad. Sci. USA 96, 3590-3594 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3590-3594
-
-
Chiti, F.1
-
71
-
-
0035812658
-
Identification and characterization of key kinetic Intermediates in amyloid-β-protein fibrillogenesis
-
Kirkitadze, M. D., Condron, M. M. & Teplow, D. B. Identification and characterization of key kinetic Intermediates in amyloid-β-protein fibrillogenesis. J. Mol. Biol. 312, 1103-1119 (2001).
-
(2001)
J. Mol. Biol.
, vol.312
, pp. 1103-1119
-
-
Kirkitadze, M.D.1
Condron, M.M.2
Teplow, D.B.3
-
72
-
-
0035235477
-
Modulation of β-amyloid production and fibrillization
-
Allsop, D. et al. Modulation of β-amyloid production and fibrillization. Biochem. Soc. Symp. 67, 1-14 (2001).
-
(2001)
Biochem. Soc. Symp.
, vol.67
, pp. 1-14
-
-
Allsop, D.1
-
73
-
-
0242326154
-
Aβ Oligomerization: A therapeutic target for Alzheimer's disease
-
Howlett, D. R. Aβ Oligomerization: a therapeutic target for Alzheimer's disease. Curr. Med. Chem. Immunol. Endocr. Metab. Agents 1, 25-38 (2001).
-
(2001)
Curr. Med. Chem. Immunol. Endocr. Metab. Agents
, vol.1
, pp. 25-38
-
-
Howlett, D.R.1
-
74
-
-
0033855433
-
Self-assembly of β-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates
-
Bohrmann, B. et al. Self-assembly of β-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J. Struct. Biol. 130, 232-246 (2000).
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 232-246
-
-
Bohrmann, B.1
-
75
-
-
0032866410
-
Design and testing of inhibitors of fibril formation
-
Findeis, M. A. & Molineaux, S. M. Design and testing of inhibitors of fibril formation. Methods Enzymol. 309, 476-488 (1999).
-
(1999)
Methods Enzymol.
, vol.309
, pp. 476-488
-
-
Findeis, M.A.1
Molineaux, S.M.2
-
76
-
-
0032867537
-
Screening for pharmacologic inhibitors of amyloid fibril formation
-
LeVine, H. & Scholten, J. D. Screening for pharmacologic inhibitors of amyloid fibril formation. Methods Enzymol. 309, 467-476 (1999).
-
(1999)
Methods Enzymol.
, vol.309
, pp. 467-476
-
-
LeVine, H.1
Scholten, J.D.2
-
77
-
-
0032930444
-
Inhibition of β-amyloid formation as a therapeutic strategy
-
Moore, C. L. & Wolfe, M. S. Inhibition of β-amyloid formation as a therapeutic strategy. Expert Opin. Ther. Pat. 9, 135-146 (1999).
-
(1999)
Expert Opin. Ther. Pat.
, vol.9
, pp. 135-146
-
-
Moore, C.L.1
Wolfe, M.S.2
-
78
-
-
0030801497
-
Inhibitors of Aβ peptide aggregation as potential anti-Alzheimer agents
-
Bandiera, T., Lansen, J., Post, C. & Varasi, M. Inhibitors of Aβ peptide aggregation as potential anti-Alzheimer agents. Curr. Med. Chem. 4, 159-170 (1997).
-
(1997)
Curr. Med. Chem.
, vol.4
, pp. 159-170
-
-
Bandiera, T.1
Lansen, J.2
Post, C.3
Varasi, M.4
-
79
-
-
0015150725
-
Creation of amyloid fibrils from Bence Jones proteins in vitro
-
Glenner, G. G. et al. Creation of amyloid fibrils from Bence Jones proteins in vitro. Science 174, 712-714 (1971).
-
(1971)
Science
, vol.174
, pp. 712-714
-
-
Glenner, G.G.1
-
80
-
-
0016803424
-
Intralysosomal formation of amyloid fibrils
-
Shirahama, T. & Cohen, A. S. Intralysosomal formation of amyloid fibrils. Am. J. Pathol. 81, 101-116 (1975).
-
(1975)
Am. J. Pathol.
, vol.81
, pp. 101-116
-
-
Shirahama, T.1
Cohen, A.S.2
-
81
-
-
0025037933
-
Amyloid enhancing factor loaded macrophages in amyloid fibril formation
-
Shirahama, T. et al. Amyloid enhancing factor loaded macrophages in amyloid fibril formation. Lab. Inv. 62, 61-68 (1990).
-
(1990)
Lab. Inv.
, vol.62
, pp. 61-68
-
-
Shirahama, T.1
-
82
-
-
0029934134
-
Trafficking of cell-surface amyloid β-protein precursor II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization
-
Yamazaki, T., Koo, E. H. & Selkoe, D. J. Trafficking of cell-surface amyloid β-protein precursor II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization. J. Cell Sci. 109, 999-1008 (1996).
-
(1996)
J. Cell Sci.
, vol.109
, pp. 999-1008
-
-
Yamazaki, T.1
Koo, E.H.2
Selkoe, D.J.3
-
83
-
-
0033575336
-
Intracellular accumulation of insoluble, newly synthesized Aβ n-42 in amyloid precursor protein-transfected cells that have been treated with Aβ 1-42
-
Yang, A. J., Chandswangbhuvana, D., Shu, T., Henschen, A. & Glabe, C. G. Intracellular accumulation of insoluble, newly synthesized Aβ n-42 in amyloid precursor protein-transfected cells that have been treated with Aβ 1-42. J. Biol. Chem. 274, 20650-20656 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20650-20656
-
-
Yang, A.J.1
Chandswangbhuvana, D.2
Shu, T.3
Henschen, A.4
Glabe, C.G.5
-
84
-
-
0035909981
-
The V122I cardiac variant of transthyretin increases the velocity of rate-limiting tetramer dissociation resulting in accelerated amyloidosis
-
Jiang, X., Buxbaum, J. N. & Kelly, J. W. The V122I cardiac variant of transthyretin increases the velocity of rate-limiting tetramer dissociation resulting in accelerated amyloidosis. Proc. Natl Acad. Sci. USA 98, 14943-14948 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14943-14948
-
-
Jiang, X.1
Buxbaum, J.N.2
Kelly, J.W.3
-
85
-
-
0034602241
-
Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface
-
Liu, K. et al. Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface. J. Mol. Biol. 303, 555-565 (2000).
-
(2000)
J. Mol. Biol.
, vol.303
, pp. 555-565
-
-
Liu, K.1
-
86
-
-
0035826761
-
Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
-
Purkey H. E., Derrell, M. I. & Kelly, J. W. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proc. Natl Acad. Sci. USA 98, 5566-5571 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5566-5571
-
-
Purkey, H.E.1
Derrell, M.I.2
Kelly, J.W.3
-
87
-
-
0037122698
-
Synthesis, structure and activity of diclofenac analogs as transthyretin amyloid fibril inhibitors
-
Oza, V. B. et al. Synthesis, structure and activity of diclofenac analogs as transthyretin amyloid fibril inhibitors. J. Med. Chem. 45, 321-332 (2002).
-
(2002)
J. Med. Chem.
, vol.45
, pp. 321-332
-
-
Oza, V.B.1
-
88
-
-
0034168709
-
Transplantation for amyloidosis
-
Suhr, O. B. Transplantation for amyloidosis. Rinsho Byori 48, 329-335 (2000).
-
(2000)
Rinsho Byori
, vol.48
, pp. 329-335
-
-
Suhr, O.B.1
-
90
-
-
0035823391
-
Disruption of protein-protein interactions: Design of a synthetic receptor that blocks the binding of cytochrorne c to cytochrome c peroxidase
-
Wei, Y. et al. Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrorne c to cytochrome c peroxidase. J. Chem. Soc. Chem. Commun. 1580-1581 (2001).
-
(2001)
J. Chem. Soc. Chem. Commun.
, pp. 1580-1581
-
-
Wei, Y.1
-
91
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
-
Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
-
92
-
-
0035979145
-
Aβ immunization: Moving Aβ peptide from brain to blood
-
Lee, V. M. Y. Aβ immunization: moving Aβ peptide from brain to blood. Proc. Natl Acad. Sci. USA 98, 8931-8932 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8931-8932
-
-
Lee, V.M.Y.1
-
93
-
-
0001189971
-
A strikingly benign evolution of FAP in an individual found to be a compound heterozygote for two TTR mutations: TTR Met30 and TTR Met119
-
Coelho, T. et al. A strikingly benign evolution of FAP in an individual found to be a compound heterozygote for two TTR mutations: TTR Met30 and TTR Met119. J. Rheumatol. 20, 179 (1993).
-
(1993)
J. Rheumatol.
, vol.20
, pp. 179
-
-
Coelho, T.1
-
94
-
-
0002270675
-
Compound heterozygotes of transthyretin Met30 and transthyretin Met119 are protected from the devastating effects of familial amyloid polyneuropathy
-
[AU:1 pge OK?]
-
Coelho, T. et al. Compound heterozygotes of transthyretin Met30 and transthyretin Met119 are protected from the devastating effects of familial amyloid polyneuropathy. Neuromusc. Disord. 6, 27 [AU:1 pge OK?] (1996).
-
(1996)
Neuromusc. Disord.
, vol.6
, pp. 27
-
-
Coelho, T.1
-
95
-
-
0033607151
-
Characterization of the structure and function of W to F WW domain variants: Identification of a natively unnfolded protein that folds upon ligand binding
-
Koepf, E. K. et al. Characterization of the structure and function of W to F WW domain variants: identification of a natively unnfolded protein that folds upon ligand binding. Biochemistry 38, 14338-14351 (1999).
-
(1999)
Biochemistry
, vol.38
, pp. 14338-14351
-
-
Koepf, E.K.1
-
96
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen, S. et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414, 212-216 (2001).
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
-
97
-
-
0033352083
-
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
-
Kim, S.-H. et al. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nature Neurosci. 2, 984-988 (1999).
-
(1999)
Nature Neurosci.
, vol.2
, pp. 984-988
-
-
Kim, S.-H.1
-
98
-
-
0242326157
-
Potential drug therapies for lysosomal storage disorders
-
Fan, J.-Q. Potential drug therapies for lysosomal storage disorders. Front. Biotechnol. Pharmacol. 2, 275-291 (2001).
-
(2001)
Front. Biotechnol. Pharmacol.
, vol.2
, pp. 275-291
-
-
Fan, J.-Q.1
-
99
-
-
0033018496
-
Accelerated transport and maturation of lysosomal α-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor
-
Fan, J. -Q., Ishii, S., Asano, N. & Suzuki, Y. Accelerated transport and maturation of lysosomal α-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor. Nature Med. 5, 112-115 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 112-115
-
-
Fan, J.-Q.1
Ishii, S.2
Asano, N.3
Suzuki, Y.4
-
100
-
-
0034705043
-
Mimicking dominant negative inhibition of prion replication through structure-based drug design
-
Perrier, V. et al. Mimicking dominant negative inhibition of prion replication through structure-based drug design. Proc. Natl Acad. Sci. USA 97, 6073-6078 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6073-6078
-
-
Perrier, V.1
-
101
-
-
0028913416
-
Arresting amyloidosis in vivo using small molecule anionic sulfates or sulfonates: Implications for Alzheimer's disease
-
Kisislevsky, R. et al. Arresting amyloidosis in vivo using small molecule anionic sulfates or sulfonates: implications for Alzheimer's disease, Nature Med. 1, 143-148 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 143-148
-
-
Kisislevsky, R.1
-
102
-
-
0033548474
-
The heparin/heparan sulfate-binding site on APO-serum amyloid A. Implications for the therapeutic intervention of amyloidosis
-
Ancsin, J. B. & Kisilevsky, R. The heparin/heparan sulfate-binding site on APO-serum amyloid A. Implications for the therapeutic intervention of amyloidosis. J. Biol. Chem. 274, 7172-7181 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7172-7181
-
-
Ancsin, J.B.1
Kisilevsky, R.2
-
103
-
-
0242294640
-
-
(eds Kyle, R. A. & Gertz, M. A.) (Parthenon Publishing, New York) Proc. 8th Int. Symp. Amyloidosis
-
Ancsin, J. B. & Kisilevsky, R. in Amyloid Amyloidosis 1998, Proc. 8th Int. Symp. Amyloidosis (eds Kyle, R. A. & Gertz, M. A.) 77-79 (Parthenon Publishing, New York 1999).
-
(1999)
Amyloid Amyloidosis 1998
, pp. 77-79
-
-
Ancsin, J.B.1
Kisilevsky, R.2
-
104
-
-
84984755327
-
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan, D. et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982-985 (2000).
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
-
105
-
-
0035899413
-
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity
-
Peretz, D. at al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 412, 739-743 (2001).
-
(2001)
Nature
, vol.412
, pp. 739-743
-
-
Peretz, D.1
|