Effect of chirality of small molecule organofluorine inhibitors of amyloid self-assembly on inhibitor potency

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6931-6934

  Sood, Abha ^a   Abid, Mohammed ^a   Hailemichael, Samson ^a   Foster, Michelle ^a   Török, Béla ^a   Török, Marianna ^a  

^a UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

Author keywords

Amyloid beta peptide; Chiral; Fibrillogenesis; Organofluorine; Small molecule inhibitor

Indexed keywords

AMYLOID BETA PROTEIN; ORGANOFLUORINE DERIVATIVE; THIOFLAVINE; TRIFLUOROMETHYL INDOLYL HYDROXY PROPIONIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ATOMIC FORCE MICROSCOPY; CHIRALITY; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; ENANTIOMER; FLUORESCENCE SPECTROSCOPY; IN VITRO STUDY; RACEMIZATION; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; FLUORINE; HUMANS; MICROSCOPY, ATOMIC FORCE; PROPIONIC ACIDS; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM;

EID: 71849120435     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.066     Document Type: Article

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