The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

Nature Structural and Molecular Biology

Volumn 23, Issue 10, 2016, Pages 933-939

  Wu, Ying ^a,b   Zhou, Xiaohong ^a,b   Barnes, Christopher O ^b   DeLucia, Maria ^a,b   Cohen, Aina E ^c   Gronenborn, Angela M ^a,b   Ahn, Jinwoo ^a,b   Calero, Guillermo ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DCAF1 PROTEIN; DDB1 PROTEIN; HELIX LOOP HELIX PROTEIN; STERILE ALPHA MOTIF AND HISTIDINE ASPARTATE CONTAINING PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; UNG2 PROTEIN; VIRAL PROTEIN; VIRAL PROTEIN X; VPR PROTEIN; CARRIER PROTEIN; CCNO PROTEIN, HUMAN; DDB1 PROTEIN, HUMAN; DNA BINDING PROTEIN; DNA GLYCOSYLTRANSFERASE; PROTEIN BINDING; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VPRBP PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HYDROGEN BOND; IMMUNOPRECIPITATION; MOLECULAR MIMICRY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; CELL LINE; CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

CARRIER PROTEINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DNA GLYCOSYLASES; DNA-BINDING PROTEINS; HIV INFECTIONS; HIV-1; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84984622710     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3284     Document Type: Article

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