HIV-1 Vpr protein enhances proteasomal degradation of MCM10 DNA replication factor through the Cul4-DDB1[VprBP] E3 ubiquitin ligase to induce G2/M cell cycle arrest

Journal of Biological Chemistry

Volumn 290, Issue 28, 2015, Pages 17380-17389

  Romani, Bizhan ^a,b   Baygloo, Nima Shaykh ^a   Aghasadeghi, Mohammad Reza ^c   Allahbakhshi, Elham ^b  

^a UNIVERSITY OF ISFAHAN   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; VIRUSES;

BINDING PROTEINS; DNA REPLICATIONS; G2/M CELL CYCLE ARREST; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; NATURAL SUBSTRATES; PROTEASOMAL DEGRADATION; UBIQUITIN LIGASES; UBIQUITINATION;

DISEASES;

CUL4 DDB[VPRBP] E3 UBIQUITIN LIGASE; MINICHROMOSOME MAINTENANCE PROTEIN; MINICHROMOSOME MAINTENANCE PROTEIN 10; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VPR PROTEIN; CARRIER PROTEIN; CULLIN; DDB1 PROTEIN, HUMAN; DNA BINDING PROTEIN; MCM10 PROTEIN, HUMAN; PROTEASOME; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VPRBP PROTEIN, HUMAN;

ARTICLE; CHROMATIN; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; DNA REPLICATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; PHYSIOLOGY;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1;

CARRIER PROTEINS; CULLIN PROTEINS; DNA REPLICATION; DNA-BINDING PROTEINS; G2 PHASE CELL CYCLE CHECKPOINTS; HEK293 CELLS; HELA CELLS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MINICHROMOSOME MAINTENANCE PROTEINS; MODELS, BIOLOGICAL; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, SMALL INTERFERING; UBIQUITIN-PROTEIN LIGASES; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84940069344     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.641522     Document Type: Article

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