Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 14280-14288

  Kennedy, Edward M ^a   Amie, Sarah M ^a   Bambara, Robert A ^a   Kim, Baek ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL SIMULATIONS; DNA POLYMERASE; DNA SYNTHESISS; DNA-TEMPLATE; HIV-1 REVERSE TRANSCRIPTASE; LOW LEVEL; MILLIMOLAR RANGE; MONOPHOSPHATES; REPLICATIVE POLYMERASE; REVERSE TRANSCRIPTION; RIBONUCLEOSIDES; RIBONUCLEOTIDES; T CELLS; TARGET CELLS; TRIPHOSPHATE;

CYTOLOGY; DNA; MACROPHAGES; TRANSCRIPTION; VIRUSES; YEAST;

DISEASES;

2' DEOXYNUCLEOSIDE TRIPHOSPHATE; DOUBLE STRANDED DNA; FLAP ENDONUCLEASE; FLAP ENDONUCLEASE 1; NUCLEOSIDE TRIPHOSPHATE; RIBONUCLEASE H; RIBONUCLEASE H2; RIBONUCLEOSIDE MONOPHOSPHATE; RIBONUCLEOTIDE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS DNA;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DNA REPAIR; DNA SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; SIMULATION; T LYMPHOCYTE ACTIVATION;

BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; DNA REPAIR; DNA REPLICATION; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; HYDROLYSIS; JURKAT CELLS; KINETICS; MACROPHAGES; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; REVERSE TRANSCRIPTION; RIBONUCLEASE H; RIBONUCLEOTIDES; TIME FACTORS;

EID: 84859990184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348482     Document Type: Article

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