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Volumn 311, Issue 1, 2016, Pages H24-H35

Microcirculatory dysfunction in sepsis: Pathophysiology, clinical monitoring, and potential therapies

Author keywords

Microcirculation; Microcirculatory monitoring; Microvascular resuscitation; Sepsis

Indexed keywords

ANTICOAGULANT AGENT; BIOLOGICAL MARKER; HYPERTENSIVE FACTOR; INOTROPIC AGENT; NITRIC OXIDE SYNTHASE; SEDATIVE AGENT; VASODILATOR AGENT;

EID: 84983801357     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00034.2016     Document Type: Review
Times cited : (80)

References (115)
  • 1
    • 2942744464 scopus 로고    scopus 로고
    • Endothelium as an organ system
    • Aird WC. Endothelium as an organ system. Crit Care Med 32: S271–S279, 2004.
    • (2004) Crit Care Med , vol.32 , pp. 271-279
    • Aird, W.C.1
  • 3
    • 85132475528 scopus 로고    scopus 로고
    • Cytocam-IDF (Incident dark field illumination) imaging for bedside monitoring of the microcirculation
    • Aykut G, Veenstra G, Scorcella C, Ince C, Boerma C. Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation. Intensive Care Med Exp 3: 40, 2015.
    • (2015) Intensive Care Med Exp , vol.3 , pp. 40
    • Aykut, G.1    Veenstra, G.2    Scorcella, C.3    Ince, C.4    Boerma, C.5
  • 4
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34: 403–408, 2006.
    • (2006) Crit Care Med , vol.34 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3    Sakr, Y.4    Koch, M.5    Verdant, C.6    Vincent, J.L.7
  • 6
    • 68049100316 scopus 로고    scopus 로고
    • Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients
    • De Backer D, Donadello K, Favory R. Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients. Curr Opin Anaesthesiol 22: 150–154, 2009.
    • (2009) Curr Opin Anaesthesiol , vol.22 , pp. 150-154
    • De Backer, D.1    Donadello, K.2    Favory, R.3
  • 7
    • 84874934644 scopus 로고    scopus 로고
    • Microcirculatory alterations in patients with severe sepsis: Impact of time of assessment and relationship with outcome
    • De Backer D, Donadello K, Sakr Y, Ospina-Tascon G, Salgado D, Scolletta S, Vincent JL. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med 41: 791–799, 2013.
    • (2013) Crit Care Med , vol.41 , pp. 791-799
    • De Backer, D.1    Donadello, K.2    Sakr, Y.3    Ospina-Tascon, G.4    Salgado, D.5    Scolletta, S.6    Vincent, J.L.7
  • 10
    • 84891656914 scopus 로고    scopus 로고
    • Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock
    • De Backer D, Orbegozo Cortes D, Donadello K, Vincent JL. Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock. Virulence 5: 73–79, 2013.
    • (2013) Virulence , vol.5 , pp. 73-79
    • De Backer, D.1    Orbegozo Cortes, D.2    Donadello, K.3    Vincent, J.L.4
  • 12
    • 33745603201 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    • De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 34: 1918–1924, 2006.
    • (2006) Crit Care Med , vol.34 , pp. 1918-1924
    • De Backer, D.1    Verdant, C.2    Chierego, M.3    Koch, M.4    Gullo, A.5    Vincent, J.L.6
  • 14
    • 0141920370 scopus 로고    scopus 로고
    • Microvascular dysfunction in sepsis—hemodynamics, oxygen transport, and nitric oxide
    • Bateman RM, Sharpe MD, Ellis CG. Microvascular dysfunction in sepsis—hemodynamics, oxygen transport, and nitric oxide. Crit Care 7: 359–373, 2003.
    • (2003) Crit Care , vol.7 , pp. 359-373
    • Bateman, R.M.1    Sharpe, M.D.2    Ellis, C.G.3
  • 15
    • 84946045423 scopus 로고    scopus 로고
    • Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries
    • Bateman RM, Sharpe MD, Jagger JE, Ellis CG. Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries. Crit Care 19: 389, 2015.
    • (2015) Crit Care , vol.19 , pp. 389
    • Bateman, R.M.1    Sharpe, M.D.2    Jagger, J.E.3    Ellis, C.G.4
  • 16
    • 34547115685 scopus 로고    scopus 로고
    • Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    • Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol 293: H448–H456, 2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H448-H456
    • Bateman, R.M.1    Tokunaga, C.2    Kareco, T.3    Dorscheid, D.R.4    Walley, K.R.5
  • 17
    • 78649327189 scopus 로고    scopus 로고
    • The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients
    • Boerma EC, Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med 36: 2004–2018, 2010.
    • (2010) Intensive Care Med , vol.36 , pp. 2004-2018
    • Boerma, E.C.1    Ince, C.2
  • 21
    • 34447500485 scopus 로고    scopus 로고
    • Microvascular and capillary perfusion following glycocalyx degradation
    • Cabrales P, Vázquez BY, Tsai AG, Intaglietta M. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol 102: 2251–2259, 2007.
    • (2007) J Appl Physiol , vol.102 , pp. 2251-2259
    • Cabrales, P.1    Vázquez, B.Y.2    Tsai, A.G.3    Intaglietta, M.4
  • 22
    • 46349100429 scopus 로고    scopus 로고
    • Inflammatory response in microvascular endothelium in sepsis: Role of oxidants
    • Cepinskas G, Wilson JX. Inflammatory response in microvascular endothelium in sepsis: role of oxidants. J Clin Biochem Nutr 42: 175–184, 2008.
    • (2008) J Clin Biochem Nutr , vol.42 , pp. 175-184
    • Cepinskas, G.1    Wilson, J.X.2
  • 24
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J. The immunopathogenesis of sepsis. Nature 420: 885–891, 2002.
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 25
    • 0038104909 scopus 로고    scopus 로고
    • Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis
    • Condon MR, Kim JE, Deitch EA, Machiedo GW, Spolarics Z. Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis. Am J Physiol Heart Circ Physiol 284: H2177–H2184, 2003.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , pp. H2177-H2184
    • Condon, M.R.1    Kim, J.E.2    Deitch, E.A.3    Machiedo, G.W.4    Spolarics, Z.5
  • 26
    • 0042190645 scopus 로고    scopus 로고
    • Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface
    • Constantinescu AA, Vink H, Spaan JA. Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface. Arterioscler Thromb Vasc Biol 23: 1541–1547, 2003.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1541-1547
    • Constantinescu, A.A.1    Vink, H.2    Spaan, J.A.3
  • 27
    • 33645102148 scopus 로고    scopus 로고
    • Sublingual capnometry tracks microcirculatory changes in septic patients
    • Creteur J, De Backer D, Sakr Y, Koch M, Vincent JL. Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 32: 516–523, 2006.
    • (2006) Intensive Care Med , vol.32 , pp. 516-523
    • Creteur, J.1    De Backer, D.2    Sakr, Y.3    Koch, M.4    Vincent, J.L.5
  • 28
    • 0032711616 scopus 로고    scopus 로고
    • Does gastric tonometry monitor splanchnic perfusion?
    • Creteur J, De Backer D, Vincent JL. Does gastric tonometry monitor splanchnic perfusion? Crit Care Med 27: 2480–2484, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 2480-2484
    • Creteur, J.1    De Backer, D.2    Vincent, J.L.3
  • 30
    • 77955905942 scopus 로고    scopus 로고
    • Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation
    • Creteur J, Neves AP, Vincent JL. Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation. Crit Care 13 Suppl 5: S11, 2009.
    • (2009) Crit Care , vol.13 , pp. 11
    • Creteur, J.1    Neves, A.P.2    Vincent, J.L.3
  • 35
    • 78549257551 scopus 로고    scopus 로고
    • Comparison of 6% hydroxyethyl starch 130/04 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients
    • Dubin A, Pozo MO, Casabella CA, Murias G, Pálizas F, Moseinco MC, Kanoore Edul VS, Estenssoro E, Ince C. Comparison of 6% hydroxyethyl starch 130/04 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients. J Crit Care 25: 659, 2010.
    • (2010) J Crit Care , vol.25 , pp. 659
    • Dubin, A.1    Pozo, M.O.2    Casabella, C.A.3    Murias, G.4    Pálizas, F.5    Moseinco, M.C.6    Kanoore Edul, V.S.7    Estenssoro, E.8    Ince, C.9
  • 37
    • 84860240248 scopus 로고    scopus 로고
    • Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
    • Edul VS, Enrico C, Laviolle B, Vazquez AR, Ince C, Dubin A. Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med 40: 1443–1448, 2012.
    • (2012) Crit Care Med , vol.40 , pp. 1443-1448
    • Edul, V.S.1    Enrico, C.2    Laviolle, B.3    Vazquez, A.R.4    Ince, C.5    Dubin, A.6
  • 38
    • 0033943531 scopus 로고    scopus 로고
    • Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow
    • Eichelbrönner O, Sielenkämper A, Cepinskas G, Sibbald WJ, Chin-Yee IH. Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow. Crit Care Med 28: 1865–1870, 2000.
    • (2000) Crit Care Med , vol.28 , pp. 1865-1870
    • Eichelbrönner, O.1    Sielenkämper, A.2    Cepinskas, G.3    Sibbald, W.J.4    Chin-Yee, I.H.5
  • 39
    • 1942487804 scopus 로고    scopus 로고
    • Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia
    • Eipel C, Bordel R, Nickels RM, Menger MD, Vollmar B. Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 286: G769–G776, 2004.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286 , pp. G769-G776
    • Eipel, C.1    Bordel, R.2    Nickels, R.M.3    Menger, M.D.4    Vollmar, B.5
  • 41
    • 84941422119 scopus 로고    scopus 로고
    • Cutaneous microcirculation in preterm neonates: Comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging
    • van Elteren HA, Ince C, Tibboel D, Reiss IK, de Jonge RC. Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging. J Clin Monit Comput 29: 543–548, 2015.
    • (2015) J Clin Monit Comput , vol.29 , pp. 543-548
    • Van Elteren, H.A.1    Ince, C.2    Tibboel, D.3    Reiss, I.K.4    De Jonge, R.C.5
  • 42
    • 0030065143 scopus 로고    scopus 로고
    • Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis
    • Farquhar I, Martin CM, Lam C, Potter R, Ellis CG, Sibbald WJ. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 61: 190–196, 1996.
    • (1996) J Surg Res , vol.61 , pp. 190-196
    • Farquhar, I.1    Martin, C.M.2    Lam, C.3    Potter, R.4    Ellis, C.G.5    Sibbald, W.J.6
  • 43
    • 12344335535 scopus 로고    scopus 로고
    • Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages
    • Frost MT, Wang Q, Moncada S, Singer M. Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol 288: R394–R400, 2005.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288 , pp. 394-400
    • Frost, M.T.1    Wang, Q.2    Moncada, S.3    Singer, M.4
  • 44
    • 59649104743 scopus 로고    scopus 로고
    • Adverse outcomes associated with the use of drotrecogin alfa (Activated) in patients with severe sepsis and baseline bleeding precautions
    • Gentry CA, Gross KB, Sud B, Drevets DA. Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med 37: 19–25, 2009.
    • (2009) Crit Care Med , vol.37 , pp. 19-25
    • Gentry, C.A.1    Gross, K.B.2    Sud, B.3    Drevets, D.A.4
  • 45
    • 78650418818 scopus 로고    scopus 로고
    • Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients
    • Georger JF, Hamzaoui O, Chaari A, Maizel J, Richard C, Teboul JL. Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients. Intensive Care Med 36: 1882–1889, 2010.
    • (2010) Intensive Care Med , vol.36 , pp. 1882-1889
    • Georger, J.F.1    Hamzaoui, O.2    Chaari, A.3    Maizel, J.4    Richard, C.5    Teboul, J.L.6
  • 46
    • 84955511199 scopus 로고    scopus 로고
    • A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes
    • Gilbert-Kawai E, Coppel J, Bountziouka V, Ince C, Martin D. A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes. BMC Med Imaging 16: 10, 2016.
    • (2016) BMC Med Imaging , vol.16 , pp. 10
    • Gilbert-Kawai, E.1    Coppel, J.2    Bountziouka, V.3    Ince, C.4    Martin, D.5
  • 48
    • 9344267214 scopus 로고    scopus 로고
    • Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: Interpreting capillary oxygen transport data using a mathematical model
    • Goldman D, Bateman RM, Ellis CG. Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model. Am J Physiol Heart Circ Physiol 287: H2535–H2544, 2004.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. H2535-H2544
    • Goldman, D.1    Bateman, R.M.2    Ellis, C.G.3
  • 49
    • 33744941056 scopus 로고    scopus 로고
    • Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: Role of heterogeneous capillary spacing and blood flow
    • Goldman D, Bateman RM, Ellis CG. Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am J Physiol Heart Circ Physiol 290: H2277–H2285, 2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , pp. H2277-H2285
    • Goldman, D.1    Bateman, R.M.2    Ellis, C.G.3
  • 51
    • 0034533811 scopus 로고    scopus 로고
    • TNF-α increases entry of macromolecules into luminal endothelial cell glycocalyx
    • Henry CB, Duling BR. TNF-α increases entry of macromolecules into luminal endothelial cell glycocalyx. Am J Physiol Heart Circ Physiol 279: H2815–H2823, 2000.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279 , pp. H2815-H2823
    • Henry, C.B.1    Duling, B.R.2
  • 52
    • 84875362828 scopus 로고    scopus 로고
    • Microcirculation in sepsis: New perspectives
    • Hernandez G, Bruhn A, Ince C. Microcirculation in sepsis: new perspectives. Curr Vasc Pharmacol 11: 161–169, 2013.
    • (2013) Curr Vasc Pharmacol , vol.11 , pp. 161-169
    • Hernandez, G.1    Bruhn, A.2    Ince, C.3
  • 54
    • 0036155210 scopus 로고    scopus 로고
    • Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium
    • Hoffmann JN, Vollmar B, Römisch J, Inthorn D, Schildberg FW, Menger MD. Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium. Crit Care Med 30: 218–225, 2002.
    • (2002) Crit Care Med , vol.30 , pp. 218-225
    • Hoffmann, J.N.1    Vollmar, B.2    Römisch, J.3    Inthorn, D.4    Schildberg, F.W.5    Menger, M.D.6
  • 55
    • 28044471186 scopus 로고    scopus 로고
    • Monitoring oxygen delivery in the critically ill
    • Huang YC. Monitoring oxygen delivery in the critically ill. Chest 128: 554S–560S, 2005.
    • (2005) Chest , vol.128 , pp. 554S-560S
    • Huang, Y.C.1
  • 57
    • 0032790876 scopus 로고    scopus 로고
    • Microcirculatory oxygenation and shunting in sepsis and shock
    • Ince C, Sinaasappel M. Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 27: 1369–1377, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 1369-1377
    • Ince, C.1    Sinaasappel, M.2
  • 58
    • 0036644462 scopus 로고    scopus 로고
    • The microcirculation unveiled
    • Ince C. The microcirculation unveiled. Am J Respir Crit Care Med 166: 1–2, 2002.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1-2
    • Ince, C.1
  • 59
    • 27144553471 scopus 로고    scopus 로고
    • The microcirculation is the motor of sepsis
    • Ince C. The microcirculation is the motor of sepsis. Crit Care 9 Suppl 4: S13–S19, 2005.
    • (2005) Crit Care 9 Suppl , vol.4 , pp. 13-19
    • Ince, C.1
  • 60
    • 84978790887 scopus 로고    scopus 로고
    • Hemodynamic coherence and the rationale for monitoring the microcirculation
    • Ince C. Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care 19 Suppl 3: S8, 2015.
    • (2015) Crit Care 19 Suppl , vol.3 , pp. 8
    • Ince, C.1
  • 61
  • 62
    • 79961030348 scopus 로고    scopus 로고
    • A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    • Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg 254: 194–200, 2011.
    • (2011) Ann Surg , vol.254 , pp. 194-200
    • Johansson, P.I.1    Stensballe, J.2    Rasmussen, L.S.3    Ostrowski, S.R.4
  • 63
    • 77249162677 scopus 로고    scopus 로고
    • Lactate clearance vs. Central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial
    • Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs. central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303: 739–746, 2010.
    • (2010) JAMA , vol.303 , pp. 739-746
    • Jones, A.E.1    Shapiro, N.I.2    Trzeciak, S.3    Arnold, R.C.4    Claremont, H.A.5    Kline, J.A.6
  • 64
    • 80054078769 scopus 로고    scopus 로고
    • The microcirculation as a therapeutic target in the treatment of sepsis and shock
    • Kanoore Edul VS, Dubin A, Ince C. The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med 32: 558–568, 2011.
    • (2011) Semin Respir Crit Care Med , vol.32 , pp. 558-568
    • Kanoore Edul, V.S.1    Dubin, A.2    Ince, C.3
  • 65
    • 40749160044 scopus 로고    scopus 로고
    • Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model
    • Kao R, Xenocostas A, Rui T, Yu P, Huang W, Rose J, Martin CM. Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model. Crit Care 11: R58, 2007.
    • (2007) Crit Care , vol.11 , pp. 58
    • Kao, R.1    Xenocostas, A.2    Rui, T.3    Yu, P.4    Huang, W.5    Rose, J.6    Martin, C.M.7
  • 66
    • 0031945765 scopus 로고    scopus 로고
    • Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection
    • Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J. Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection. Am J Respir Crit Care Med 157: 776–784, 1998.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 776-784
    • Kayal, S.1    Jaïs, J.P.2    Aguini, N.3    Chaudière, J.4    Labrousse, J.5
  • 68
    • 0028053865 scopus 로고
    • Microvascular perfusion is impaired in a rat model of normotensive sepsis
    • Lam C, Tyml K, Martin C, Sibbald W. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94: 2077–2083, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 2077-2083
    • Lam, C.1    Tyml, K.2    Martin, C.3    Sibbald, W.4
  • 69
    • 77951204279 scopus 로고    scopus 로고
    • The response of the host microcirculation to bacterial sepsis: Does the pathogen matter?
    • Legrand M, Klijn E, Payen D, Ince C. The response of the host microcirculation to bacterial sepsis: does the pathogen matter? J Mol Med 88: 127–133, 2010.
    • (2010) J Mol Med , vol.88 , pp. 127-133
    • Legrand, M.1    Klijn, E.2    Payen, D.3    Ince, C.4
  • 70
    • 0038347425 scopus 로고    scopus 로고
    • Conducted vasoconstriction is reduced in a mouse model of sepsis
    • Lidington D, Ouellette Y, Li F, Tyml K. Conducted vasoconstriction is reduced in a mouse model of sepsis. J Vasc Res 40: 149–158, 2003.
    • (2003) J Vasc Res , vol.40 , pp. 149-158
    • Lidington, D.1    Ouellette, Y.2    Li, F.3    Tyml, K.4
  • 71
    • 0033843226 scopus 로고    scopus 로고
    • Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway
    • Lidington D, Ouellette Y, Tyml K. Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway. J Cell Physiol 185: 117–125, 2000.
    • (2000) J Cell Physiol , vol.185 , pp. 117-125
    • Lidington, D.1    Ouellette, Y.2    Tyml, K.3
  • 72
    • 84919627287 scopus 로고    scopus 로고
    • Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients
    • Lima A, Bakker J. Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients. Rev Bras Ter Intensiva 23: 341–351, 2011.
    • (2011) Rev Bras Ter Intensiva , vol.23 , pp. 341-351
    • Lima, A.1    Bakker, J.2
  • 73
    • 0029981670 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
    • Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 314: 877–880, 1996.
    • (1996) Biochem J , vol.314 , pp. 877-880
    • Lizasoain, I.1    Moro, M.A.2    Knowles, R.G.3    Darley-Usmar, V.4    Moncada, S.5
  • 75
    • 42149084524 scopus 로고    scopus 로고
    • Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress
    • Marechal X, Favory R, Joulin O, Montaigne D, Hassoun S, Decoster B, Zerimech F, Neviere R. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress. Shock 29: 572–576, 2008.
    • (2008) Shock , vol.29 , pp. 572-576
    • Marechal, X.1    Favory, R.2    Joulin, O.3    Montaigne, D.4    Hassoun, S.5    Decoster, B.6    Zerimech, F.7    Neviere, R.8
  • 78
    • 84924286492 scopus 로고    scopus 로고
    • Dexmedetomidine attenuates the microcirculatory derangements evoked by experimental sepsis
    • Miranda ML, Balarini MM, Bouskela E. Dexmedetomidine attenuates the microcirculatory derangements evoked by experimental sepsis. Anesthesiology 122: 619–630, 2015.
    • (2015) Anesthesiology , vol.122 , pp. 619-630
    • Miranda, M.L.1    Balarini, M.M.2    Bouskela, E.3
  • 82
    • 76249116054 scopus 로고    scopus 로고
    • The effects of vasoactive drugs on intestinal functional capillary density in endotoxemic rats: Intravital video-microscopy analysis
    • Nacul FE, Guia IL, Lessa MA, Tibiriçá E. The effects of vasoactive drugs on intestinal functional capillary density in endotoxemic rats: intravital video-microscopy analysis. Anesth Analg 110: 547–554, 2010.
    • (2010) Anesth Analg , vol.110 , pp. 547-554
    • Nacul, F.E.1    Guia, I.L.2    Lessa, M.A.3    Tibiriçá, E.4
  • 83
    • 0035888676 scopus 로고    scopus 로고
    • Microcirculation in intestinal villi: A comparison between hemorrhagic and endotoxin shock
    • Nakajima Y, Baudry N, Duranteau J, Vicaut E. Microcirculation in intestinal villi: a comparison between hemorrhagic and endotoxin shock. Am J Respir Crit Care Med 164: 1526–1530, 2001.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1526-1530
    • Nakajima, Y.1    Baudry, N.2    Duranteau, J.3    Vicaut, E.4
  • 84
    • 54849433850 scopus 로고    scopus 로고
    • Increased levels of glycosaminoglycans during septic shock: Relation to mortality and the antibacterial actions of plasma
    • Nelson A, Berkestedt I, Schmidtchen A, Ljunggren L, Bodelsson M. Increased levels of glycosaminoglycans during septic shock: relation to mortality and the antibacterial actions of plasma. Shock 30: 623–627, 2008.
    • (2008) Shock , vol.30 , pp. 623-627
    • Nelson, A.1    Berkestedt, I.2    Schmidtchen, A.3    Ljunggren, L.4    Bodelsson, M.5
  • 88
    • 0033134093 scopus 로고    scopus 로고
    • Subacute sepsis impairs vascular smooth muscle contractile machinery and alters vasoconstrictor and dilator mechanisms
    • Price SA, Spain DA, Wilson MA, Harris PD, Garrison RN. Subacute sepsis impairs vascular smooth muscle contractile machinery and alters vasoconstrictor and dilator mechanisms. J Surg Res 83: 75–80, 1999.
    • (1999) J Surg Res , vol.83 , pp. 75-80
    • Price, S.A.1    Spain, D.A.2    Wilson, M.A.3    Harris, P.D.4    Garrison, R.N.5
  • 90
    • 32844471203 scopus 로고    scopus 로고
    • Transcutaneous arterial carbon dioxide pressure monitoring in critically ill adult patients
    • Rodriguez P, Lellouche F, Aboab J, Buisson CB, Brochard L. Transcutaneous arterial carbon dioxide pressure monitoring in critically ill adult patients. Intensive Care Med 32: 309–312, 2006.
    • (2006) Intensive Care Med , vol.32 , pp. 309-312
    • Rodriguez, P.1    Lellouche, F.2    Aboab, J.3    Buisson, C.B.4    Brochard, L.5
  • 91
    • 33846918427 scopus 로고    scopus 로고
    • Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats
    • Rosengarten B, Hecht M, Auch D, Ghofrani HA, Schermuly RT, Grimminger F, Kaps M. Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats. Cerebrovasc Dis 23: 140–147, 2007.
    • (2007) Cerebrovasc Dis , vol.23 , pp. 140-147
    • Rosengarten, B.1    Hecht, M.2    Auch, D.3    Ghofrani, H.A.4    Schermuly, R.T.5    Grimminger, F.6    Kaps, M.7
  • 93
    • 4444233598 scopus 로고    scopus 로고
    • Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    • Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32: 1825–1831, 2004.
    • (2004) Crit Care Med , vol.32 , pp. 1825-1831
    • Sakr, Y.1    Dubois, M.J.2    De Backer, D.3    Creteur, J.4    Vincent, J.L.5
  • 95
    • 78650414437 scopus 로고    scopus 로고
    • Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries
    • Secor D, Li F, Ellis CG, Sharpe MD, Gross PL, Wilson JX, Tyml K. Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med 36: 1928–1934, 2010.
    • (2010) Intensive Care Med , vol.36 , pp. 1928-1934
    • Secor, D.1    Li, F.2    Ellis, C.G.3    Sharpe, M.D.4    Gross, P.L.5    Wilson, J.X.6    Tyml, K.7
  • 96
    • 80053175825 scopus 로고    scopus 로고
    • The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis
    • Shapiro NI, Arnold R, Sherwin R, O’Connor J, Najarro G, Singh S, Lundy D, Nelson T, Trzeciak SW, Jones AE. The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis. Crit Care 15: R223, 2011.
    • (2011) Crit Care , vol.15 , pp. 223
    • Shapiro, N.I.1    Arnold, R.2    Sherwin, R.3    O’Connor, J.4    Najarro, G.5    Singh, S.6    Lundy, D.7    Nelson, T.8    Trzeciak, S.W.9    Jones, A.E.10
  • 97
    • 11244316895 scopus 로고    scopus 로고
    • Chemical physiology of blood flow regulation by red blood cells: The role of nitric oxide and S-nitrosohemoglobin
    • Singel DJ, Stamler JS. Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. Annu Rev Physiol 67: 99–145, 2005.
    • (2005) Annu Rev Physiol , vol.67 , pp. 99-145
    • Singel, D.J.1    Stamler, J.S.2
  • 98
    • 4043128084 scopus 로고    scopus 로고
    • Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
    • Singer M, De Santis V, Vitale D, Jeffcoate W. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 364: 545–548, 2004.
    • (2004) Lancet , vol.364 , pp. 545-548
    • Singer, M.1    De Santis, V.2    Vitale, D.3    Jeffcoate, W.4
  • 102
    • 81255138173 scopus 로고    scopus 로고
    • SvO2 to monitor resuscitation of septic patients: Let’s just understand the basic physiology
    • Teboul JL, Hamzaoui O, Monnet X. SvO2 to monitor resuscitation of septic patients: let’s just understand the basic physiology. Crit Care 15: 1005, 2011.
    • (2011) Crit Care , vol.15 , pp. 1005
    • Teboul, J.L.1    Hamzaoui, O.2    Monnet, X.3
  • 104
    • 44049093984 scopus 로고    scopus 로고
    • Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    • Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 15: 399–413, 2008.
    • (2008) Acad Emerg Med , vol.15 , pp. 399-413
    • Trzeciak, S.1    Cinel, I.2    Phillip Dellinger, R.3    Shapiro, N.I.4    Arnold, R.C.5    Parrillo, J.E.6    Hollenberg, S.M.7
  • 108
    • 49949105606 scopus 로고    scopus 로고
    • Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism
    • Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism. Crit Care Med 36: 2355–2362, 2008.
    • (2008) Crit Care Med , vol.36 , pp. 2355-2362
    • Tyml, K.1    Li, F.2    Wilson, J.X.3
  • 109
    • 0034822793 scopus 로고    scopus 로고
    • Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo
    • Tyml K, Wang X, Lidington D, Ouellette Y. Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo. Am J Physiol Heart Circ Physiol 281: H1397–H1406, 2001.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , pp. H1397-H1406
    • Tyml, K.1    Wang, X.2    Lidington, D.3    Ouellette, Y.4
  • 110
    • 0024817150 scopus 로고
    • Differential response of the microvasculature in the liver during bacteremia
    • Unger LS, Cryer HM, Garrison RN. Differential response of the microvasculature in the liver during bacteremia. Circ Shock 29: 335–344, 1989.
    • (1989) Circ Shock , vol.29 , pp. 335-344
    • Unger, L.S.1    Cryer, H.M.2    Garrison, R.N.3
  • 112
    • 84906925627 scopus 로고    scopus 로고
    • Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide
    • Villela NR, Santos AO, Miranda ML, Bouskela E. Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide. J Transl Med 12: 232, 2014.
    • (2014) J Transl Med , vol.12 , pp. 232
    • Villela, N.R.1    Santos, A.O.2    Miranda, M.L.3    Bouskela, E.4
  • 113
    • 27144483559 scopus 로고    scopus 로고
    • Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
    • Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care 9 Suppl 4: S9–S12, 2005.
    • (2005) Crit Care , vol.9 , pp. S9-S12
    • Vincent, J.L.1    De Backer, D.2
  • 115
    • 0038311988 scopus 로고    scopus 로고
    • Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice
    • Wu F, Wilson JX, Tyml K. Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice. Am J Physiol Regul Integr Comp Physiol 285: R50–R56, 2003.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285 , pp. 50-56
    • Wu, F.1    Wilson, J.X.2    Tyml, K.3


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