-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-10
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-54
-
(2003)
N Engl J Med
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
Mannino, D.M.2
Eaton, S.3
Moss, M.4
-
3
-
-
44049093984
-
Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
-
Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM; Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators: Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008; 15:399-413
-
(2008)
Acad Emerg Med
, vol.15
, pp. 399-413
-
-
Trzeciak, S.1
Cinel, I.2
Phillip Dellinger, R.3
Shapiro, N.I.4
Arnold, R.C.5
Parrillo, J.E.6
Hollenberg, S.M.7
-
4
-
-
84863585302
-
Dexmedetomidine and clonidine: From second- to first-line sedative agents in the critical care setting?
-
Pichot C, Ghignone M, Quintin L: Dexmedetomidine and clonidine: From second- to first-line sedative agents in the critical care setting? J Intensive Care Med 2012; 27:219-37
-
(2012)
J Intensive Care Med
, vol.27
, pp. 219-237
-
-
Pichot, C.1
Ghignone, M.2
Quintin, L.3
-
5
-
-
0033803263
-
Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care
-
Venn RM, Hell J, Grounds RM: Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000; 4:302-8
-
(2000)
Crit Care
, vol.4
, pp. 302-308
-
-
Venn, R.M.1
Hell, J.2
Grounds, R.M.3
-
6
-
-
77953076612
-
Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: An a priori-designed analysis of the MENDS randomized controlled trial
-
Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW; MENDS Investigators: Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: An a priori-designed analysis of the MENDS randomized controlled trial. Crit Care 2010; 14:R38
-
(2010)
Crit Care
, vol.14
, pp. R38
-
-
Pandharipande, P.P.1
Sanders, R.D.2
Girard, T.D.3
McGrane, S.4
Thompson, J.L.5
Shintani, A.K.6
Herr, D.L.7
Maze, M.8
Ely, E.W.9
-
7
-
-
84889261274
-
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: A pilot study
-
Geloen A, Chapelier K, Cividjian A, Dantony E, Rabilloud M, May CN, Quintin L: Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: A pilot study. Crit Care Med 2013; 41:e431-8
-
(2013)
Crit Care Med
, vol.41
, pp. e431-e438
-
-
Geloen, A.1
Chapelier, K.2
Cividjian, A.3
Dantony, E.4
Rabilloud, M.5
May, C.N.6
Quintin, L.7
-
8
-
-
1642541830
-
Hypothermia attenuates the vasodilator effects of dexmedetomidine on pial vessels in rabbits in vivo
-
Iida H, Iida M, Ohata H, Nagase K, Dohi S: Hypothermia attenuates the vasodilator effects of dexmedetomidine on pial vessels in rabbits in vivo. Anesth Analg 2004; 98:477-82
-
(2004)
Anesth Analg
, vol.98
, pp. 477-482
-
-
Iida, H.1
Iida, M.2
Ohata, H.3
Nagase, K.4
Dohi, S.5
-
10
-
-
0344443276
-
Effects of dexmedetomidine on blood coagulation evaluated by thromboelastography
-
Martins CR, Tardelli MA, Amaral JL: [Effects of dexmedetomidine on blood coagulation evaluated by thromboelastography]. Rev Bras Anestesiol 2003; 53:705-19
-
(2003)
Rev Bras Anestesiol
, vol.53
, pp. 705-719
-
-
Martins, C.R.1
Tardelli, M.A.2
Amaral, J.L.3
-
11
-
-
84862994957
-
Dexmedetomidine prevents alterations of intestinal microcirculation that are induced by surgical stress and pain in a novel rat model
-
Yeh YC, Sun WZ, Ko WJ, Chan WS, Fan SZ, Tsai JC, Lin TY: Dexmedetomidine prevents alterations of intestinal microcirculation that are induced by surgical stress and pain in a novel rat model. Anesth Analg 2012; 115:46-53
-
(2012)
Anesth Analg
, vol.115
, pp. 46-53
-
-
Yeh, Y.C.1
Sun, W.Z.2
Ko, W.J.3
Chan, W.S.4
Fan, S.Z.5
Tsai, J.C.6
Lin, T.Y.7
-
12
-
-
34248196922
-
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients
-
Memiş D, Hekimoʇlu S, Vatan I, Yandim T, Yüksel M, Süt N: Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth 2007; 98:550-2
-
(2007)
Br J Anaesth
, vol.98
, pp. 550-552
-
-
Memiş, D.1
Hekimoʇlu, S.2
Vatan, I.3
Yandim, T.4
Yüksel, M.5
Süt, N.6
-
13
-
-
0344683235
-
-
Washington, D.C., National Academies Press
-
Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals, 8th edition. Washington, D.C., National Academies Press, 2011, pp 1-220
-
(2011)
Guide for the Care and Use of Laboratory Animals, 8th Edition
, pp. 1-220
-
-
-
14
-
-
0019122176
-
Technical report - A new chamber technique for microvascular studies in unanesthetized hamsters
-
Endrich B, Asaishi K, Götz A, Messmer K: Technical report - A new chamber technique for microvascular studies in unanesthetized hamsters. Res Exp Med (Berl) 1980; 177:125-34
-
(1980)
Res Exp Med (Berl)
, vol.177
, pp. 125-134
-
-
Endrich, B.1
Asaishi, K.2
Götz, A.3
Messmer, K.4
-
15
-
-
0031171594
-
Cap image - A new kind of computer-assisted video image analysis system for dynamic capillary microscopy
-
Klyscz T, Jünger M, Jung F, Zeintl H: [Cap image - A new kind of computer-assisted video image analysis system for dynamic capillary microscopy]. Biomed Tech (Berl) 1997; 42:168-75
-
(1997)
Biomed Tech (Berl)
, vol.42
, pp. 168-175
-
-
Klyscz, T.1
Jünger, M.2
Jung, F.3
Zeintl, H.4
-
16
-
-
60449086833
-
Systemic and microcirculatory responses to progressive hemorrhage
-
Dubin A, Pozo MO, Ferrara G, Murias G, Martins E, Canullán C, Canales HS, Kanoore Edul VS, Estenssoro E, Ince C: Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 2009; 35:556-64
-
(2009)
Intensive Care Med
, vol.35
, pp. 556-564
-
-
Dubin, A.1
Pozo, M.O.2
Ferrara, G.3
Murias, G.4
Martins, E.5
Canullán, C.6
Canales, H.S.7
Kanoore Edul, V.S.8
Estenssoro, E.9
Ince, C.10
-
17
-
-
2942565800
-
Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats
-
Taniguchi T, Kidani Y, Kanakura H, Takemoto Y, Yamamoto K: Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Crit Care Med 2004; 32:1322-6
-
(2004)
Crit Care Med
, vol.32
, pp. 1322-1326
-
-
Taniguchi, T.1
Kidani, Y.2
Kanakura, H.3
Takemoto, Y.4
Yamamoto, K.5
-
18
-
-
49649085558
-
Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats
-
Taniguchi T, Kurita A, Kobayashi K, Yamamoto K, Inaba H: Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. J Anesth 2008; 22:221-8
-
(2008)
J Anesth
, vol.22
, pp. 221-228
-
-
Taniguchi, T.1
Kurita, A.2
Kobayashi, K.3
Yamamoto, K.4
Inaba, H.5
-
19
-
-
75549088112
-
Sedation improves early outcome in severely septic Sprague Dawley rats
-
Qiao H, Sanders RD, Ma D, Wu X, Maze M: Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care 2009; 13:R136
-
(2009)
Crit Care
, vol.13
, pp. R136
-
-
Qiao, H.1
Sanders, R.D.2
Ma, D.3
Wu, X.4
Maze, M.5
-
20
-
-
70350348642
-
To scale or not to scale: The principles of dose extrapolation
-
Sharma V, McNeill JH: To scale or not to scale: The principles of dose extrapolation. Br J Pharmacol 2009; 157:907-21
-
(2009)
Br J Pharmacol
, vol.157
, pp. 907-921
-
-
Sharma, V.1
McNeill, J.H.2
-
21
-
-
33646707532
-
Comparison between multiple behavioral effects of peripheral ethanol administration in rats: Sedation, ataxia, and bradykinesia
-
Chuck TL, McLaughlin PJ, Arizzi-LaFrance MN, Salamone JD, Correa M: Comparison between multiple behavioral effects of peripheral ethanol administration in rats: Sedation, ataxia, and bradykinesia. Life Sci 2006; 79:154-61
-
(2006)
Life Sci
, vol.79
, pp. 154-161
-
-
Chuck, T.L.1
McLaughlin, P.J.2
Arizzi-LaFrance, M.N.3
Salamone, J.D.4
Correa, M.5
-
22
-
-
0037302179
-
A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit
-
Venn M, Newman J, Grounds M: A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med 2003; 29:201-7
-
(2003)
Intensive Care Med
, vol.29
, pp. 201-207
-
-
Venn, M.1
Newman, J.2
Grounds, M.3
-
23
-
-
59649127447
-
Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial
-
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group: Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial. JAMA 2009; 301:489-99
-
(2009)
JAMA
, vol.301
, pp. 489-499
-
-
Riker, R.R.1
Shehabi, Y.2
Bokesch, P.M.3
Ceraso, D.4
Wisemandle, W.5
Koura, F.6
Whitten, P.7
Margolis, B.D.8
Byrne, D.W.9
Ely, E.W.10
Rocha, M.G.11
-
24
-
-
37149040245
-
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial
-
Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW: Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. JAMA 2007; 298:2644-53
-
(2007)
JAMA
, vol.298
, pp. 2644-2653
-
-
Pandharipande, P.P.1
Pun, B.T.2
Herr, D.L.3
Maze, M.4
Girard, T.D.5
Miller, R.R.6
Shintani, A.K.7
Thompson, J.L.8
Jackson, J.C.9
Deppen, S.A.10
Stiles, R.A.11
Dittus, R.S.12
Bernard, G.R.13
Ely, E.W.14
-
25
-
-
77954459092
-
Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: A meta-analysis
-
Tan JA, Ho KM: Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: A meta-analysis. Intensive Care Med 2010; 36:926-39
-
(2010)
Intensive Care Med
, vol.36
, pp. 926-939
-
-
Tan, J.A.1
Ho, K.M.2
-
28
-
-
79951837349
-
Microcirculatory effects of fluid therapy and dopamine, associated or not to fluid therapy, in endotoxemic hamsters
-
Santos AO, Furtado ES, Villela NR, Bouskela E: Microcirculatory effects of fluid therapy and dopamine, associated or not to fluid therapy, in endotoxemic hamsters. Clin Hemorheol Microcirc 2011; 47:1-13
-
(2011)
Clin Hemorheol Microcirc
, vol.47
, pp. 1-13
-
-
Santos, A.O.1
Furtado, E.S.2
Villela, N.R.3
Bouskela, E.4
-
29
-
-
1842637573
-
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia
-
Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Fertmann J, Schildberg FW, Menger MD: Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia. Crit Care Med 2004; 32:1011-7
-
(2004)
Crit Care Med
, vol.32
, pp. 1011-1017
-
-
Hoffmann, J.N.1
Vollmar, B.2
Laschke, M.W.3
Inthorn, D.4
Fertmann, J.5
Schildberg, F.W.6
Menger, M.D.7
-
30
-
-
0033227938
-
A chronic model for intravital microscopic study of microcirculatory disorders and leukocyte/endothelial cell interaction during normotensive endotoxemia
-
Hoffmann JN, Vollmar B, Inthorn D, Schildberg FW, Menger MD: A chronic model for intravital microscopic study of microcirculatory disorders and leukocyte/endothelial cell interaction during normotensive endotoxemia. Shock 1999; 12:355-64
-
(1999)
Shock
, vol.12
, pp. 355-364
-
-
Hoffmann, J.N.1
Vollmar, B.2
Inthorn, D.3
Schildberg, F.W.4
Menger, M.D.5
-
31
-
-
0029781690
-
Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III
-
Uchiba M, Okajima K, Murakami K, Okabe H, Takatsuki K: Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III. Am J Physiol 1996; 270(6 Pt 1): L921-30
-
(1996)
Am J Physiol
, vol.270
, Issue.6
, pp. L921-L930
-
-
Uchiba, M.1
Okajima, K.2
Murakami, K.3
Okabe, H.4
Takatsuki, K.5
-
32
-
-
44649105672
-
Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory
-
Sud R, Spengler RN, Nader ND, Ignatowski TA: Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory. Eur J Pharmacol 2008; 588:217-31 33.
-
(2008)
Eur J Pharmacol
, vol.588
, pp. 217-231
-
-
Sud, R.1
Spengler, R.N.2
Nader, N.D.3
Ignatowski, T.A.4
-
33
-
-
33750044882
-
Spies CD: Clonidine attenuated early proinflammatory response in T-cell subsets after cardiac surgery
-
von Dossow V, Baehr N, Moshirzadeh M, von Heymann C, Braun JP, Hein OV, Sander M, Wernecke KD, Konertz W, Spies CD: Clonidine attenuated early proinflammatory response in T-cell subsets after cardiac surgery. Anesth Analg 2006; 103:809-14
-
(2006)
Anesth Analg
, vol.103
, pp. 809-814
-
-
Von Dossow, V.1
Baehr, N.2
Moshirzadeh, M.3
Von Heymann, C.4
Braun, J.P.5
Hein, O.V.6
Sander, M.7
Wernecke, K.D.8
Konertz, W.9
-
34
-
-
34548862295
-
Noninvasive hemodynamic monitoring in the intensive care unit
-
Marik PE, Baram M: Noninvasive hemodynamic monitoring in the intensive care unit. Crit Care Clin 2007; 23:383-400
-
(2007)
Crit Care Clin
, vol.23
, pp. 383-400
-
-
Marik, P.E.1
Baram, M.2
-
35
-
-
51849153406
-
Effects of propofol on human microcirculation
-
Koch M, De Backer D, Vincent JL, Barvais L, Hennart D, Schmartz D: Effects of propofol on human microcirculation. Br J Anaesth 2008; 101:473-8
-
(2008)
Br J Anaesth
, vol.101
, pp. 473-478
-
-
Koch, M.1
De Backer, D.2
Vincent, J.L.3
Barvais, L.4
Hennart, D.5
Schmartz, D.6
-
36
-
-
33846844721
-
Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil
-
Lamblin V, Favory R, Boulo M, Mathieu D: Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil. Crit Care 2006; 10:R176
-
(2006)
Crit Care
, vol.10
, pp. R176
-
-
Lamblin, V.1
Favory, R.2
Boulo, M.3
Mathieu, D.4
-
37
-
-
0034330430
-
The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure
-
Hoffmann JN, Vollmar B, Inthorn D, Schildberg FW, Menger MD: The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure. Shock 2000; 14:528-34
-
(2000)
Shock
, vol.14
, pp. 528-534
-
-
Hoffmann, J.N.1
Vollmar, B.2
Inthorn, D.3
Schildberg, F.W.4
Menger, M.D.5
-
38
-
-
0036321888
-
Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
-
Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Schildberg FW, Menger MD: Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia. Anesthesiology 2002; 97:460-70
-
(2002)
Anesthesiology
, vol.97
, pp. 460-470
-
-
Hoffmann, J.N.1
Vollmar, B.2
Laschke, M.W.3
Inthorn, D.4
Schildberg, F.W.5
Menger, M.D.6
-
39
-
-
0033653471
-
Intravenous anaesthesia and the rat microcirculation: The dorsal microcirculatory chamber
-
Brookes ZL, Brown NJ, Reilly CS: Intravenous anaesthesia and the rat microcirculation: The dorsal microcirculatory chamber. Br J Anaesth 2000; 85:901-3
-
(2000)
Br J Anaesth
, vol.85
, pp. 901-903
-
-
Brookes, Z.L.1
Brown, N.J.2
Reilly, C.S.3
-
40
-
-
33846817498
-
Physiology and immunology of the cholinergic anti-inflammatory pathway
-
Tracey KJ: Physiology and immunology of the cholinergic anti-inflammatory pathway. J Clin Invest 2007; 117:289-96
-
(2007)
J Clin Invest
, vol.117
, pp. 289-296
-
-
Tracey, K.J.1
-
41
-
-
84898858078
-
The cholinergic anti-inflammatory pathway: A critical review
-
Martelli D, McKinley MJ, McAllen RM: The cholinergic anti-inflammatory pathway: A critical review. Auton Neurosci 2014; 182:65-9
-
(2014)
Auton Neurosci
, vol.182
, pp. 65-69
-
-
Martelli, D.1
McKinley, M.J.2
McAllen, R.M.3
-
42
-
-
61649119660
-
Central sympatholytics prolong survival in experimental sepsis
-
Hofer S, Steppan J, Wagner T, Funke B, Lichtenstern C, Martin E, Graf BM, Bierhaus A, Weigand MA: Central sympatholytics prolong survival in experimental sepsis. Crit Care 2009; 13:R11
-
(2009)
Crit Care
, vol.13
, pp. R11
-
-
Hofer, S.1
Steppan, J.2
Wagner, T.3
Funke, B.4
Lichtenstern, C.5
Martin, E.6
Graf, B.M.7
Bierhaus, A.8
Weigand, M.A.9
|