Alteration of the sublingual microvascular glycocalyx in critically ill patients

Microvascular Research

Volumn 90, Issue , 2013, Pages 86-89

  Donati, Abele ^a,b   Damiani, Elisa ^a   Domizi, Roberta ^a   Romano, Rocco ^a   Adrario, Erica ^a   Pelaia, Paolo ^a   Ince, Can ^b   Singer, Mervyn ^c  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; NORADRENALIN;

ADULT; AGED; ARTICLE; CELL INTERACTION; CLINICAL ARTICLE; COLLOID; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CRYSTALLOID; ENDOTHELIAL DYSFUNCTION; ERYTHROCYTE; FEMALE; GLYCOCALYX; HEART RATE; HUMAN; LEUKOCYTE ROLLING; MALE; MICROVASCULATURE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SEPSIS; SUBLINGUAL GLAND; VENULE;

ACUTE PHYSIOLOGY AND CHRONIC HEALTH EVALUATION II; APACHE II; HEART RATE; HR; ICU; INTENSIVE CARE UNIT; NOT SIGNIFICANT; NS; PBR; PERFUSED BOUNDARY REGION; RECEIVER OPERATING CHARACTERISTIC CURVE; RL; ROC CURVE; ROLLING LEUKOCYTES; SDF; SIDESTREAM DARK FIELD;

AGED; AREA UNDER CURVE; BLOOD FLOW VELOCITY; CASE-CONTROL STUDIES; CRITICAL ILLNESS; ENDOTHELIAL CELLS; FEMALE; GLYCOCALYX; HEART RATE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INTENSIVE CARE UNITS; LEUKOCYTE ROLLING; MALE; MICROCIRCULATION; MICROSCOPY, VIDEO; MICROVESSELS; MIDDLE AGED; POINT-OF-CARE SYSTEMS; PREDICTIVE VALUE OF TESTS; ROC CURVE; SEPSIS; SOFTWARE; TIME FACTORS; TONGUE;

EID: 84888428063     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2013.08.007     Document Type: Article

References (14)

1. Donati A., Domizi R., Damiani E., Adrario E., Pelaia P., Ince C. From macrohemodynamic to the microcirculation. Crit. Care Res. Pract 2013, (art. ID 892710). 10.1155/2013/892710.
2. Ince C. The microcirculation is the motor of sepsis. Crit. Care 2005, 9:S13-S19.
3. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., Cohen J., Opal S.M., Vincent J.L., Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med. 2003, 31:1250-1256.
4. Marechal X., Favory R., Joulin O., Montaigne D., Hassoun S., Decoster B., Zerimech F., Neviere R. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress. Shock 2008, 29:572-576.
5. Martens R.J., Vink H., van Oostrenbrugge R.J., Staals J. Sublingual microvascular glycocalyx dimensions in lacunar stroke patients. Cerebrovasc. Dis. 2013, 35:451-454.
6. Morelli A., Donati A., Ertmer C., Rehberg S., Kampmeier T., Orecchioni A., D'Egidio A., Cecchini V., Landoni G., Pietropaoli P., Westphal M., Venditti M., Mebazaa A., Singer M. Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study. Crit. Care Med. 2013, 41. 10.1097/CCM.0b013e31828a678d.
7. Mulivor A.W., Lipowsky H.H. Role of glycocalyx in leukocyte-endothelial cell adhesion. Am. J. Physiol. Heart Circ. Physiol. 2002, 283:H1282-H1291.
8. Nieuwdorp M., Holleman F., de Groot E., Vink H., Gort J., Kontush A., Chapman M.J., Hutten B.A., Brouwer C.B., Hoekstra J.B., Kastelein J.J., Stroes E.S. Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis. Diabetologia 2007, 50:1288-1293.
9. Ostrowski S.R., Johansson P.I. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J. Trauma Acute Care Surg. 2012, 73:60-66.
10. Schouten M., Wiersinga W.J., Levi M., van der Poll T. Inflammation, endothelium, and coagulation in sepsis. J. Leukoc. Biol. 2008, 83:536-545.
11. Van den Berg B.M., Nieuwdorp M., Stroes E.S., Vink H. Glycocalyx and endothelial (dys) function: from mice to men. Pharmacol. Rep. 2006, 58:S75-S80.
12. Vink H., Duling B.R. Identification of distinct luminal domains for macromolecules, erythrocytes and leukocytes within mammalian capillaries. Circ. Res. 1996, 79:581-589.
13. Vlahu C.A., Lemkes B.A., Struijk D.G., Koopman M.G., Krediet R.T., Vink H. Damage of the endothelial glycocalyx in dialysis patients. J. Am. Soc. Nephrol. 2012, 23:1900-1908.
14. Woodcock T.E., Woodcock T.M. Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br. J. Anaesth. 2012, 108:384-394.