메뉴 건너뛰기




Volumn 254, Issue 2, 2011, Pages 194-200

A high admission syndecan-1 Level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANTITHROMBIN; CATECHOLAMINE; D DIMER; DNA FRAGMENT; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; HEMOGLOBIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; LACTIC ACID; NORADRENALIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; SYNDECAN 1; THROMBOMODULIN; TISSUE FACTOR PATHWAY INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; UROKINASE RECEPTOR; VON WILLEBRAND FACTOR;

EID: 79961030348     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e318226113d     Document Type: Article
Times cited : (448)

References (62)
  • 1
    • 0003547899 scopus 로고    scopus 로고
    • Peden M, McGee K, Krug E., Geneva, Switzerland, World Health Organization
    • Peden M, McGee K, Krug E. Injury: A leading cause of the global burden of disease, 2000. Peden M, McGee K, Krug E. Available at: http://whqlibdoc.who. int/publications/2002-9241562323.pdf. 2002. Geneva, Switzerland, World Health Organization.
    • (2000) Injury: A Leading Cause of the Global Burden of Disease
    • Peden, M.1    McGee, K.2    Krug, E.3
  • 2
    • 0028909841 scopus 로고
    • Epidemiology of trauma deaths: A reassessment
    • Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38:185-193.
    • (1995) J Trauma , vol.38 , pp. 185-193
    • Sauaia, A.1    Moore, F.A.2    Moore, E.E.3
  • 4
    • 19544365744 scopus 로고    scopus 로고
    • Pathophysiology of polytrauma
    • DOI 10.1016/j.injury.2004.12.037, PII S0020138304005522
    • Keel M, Trentz O. Pathophysiology of polytrauma. Injury. 2005;36:691-709. (Pubitemid 40732303)
    • (2005) Injury , vol.36 , Issue.6 , pp. 691-709
    • Keel, M.1    Trentz, O.2
  • 5
    • 36549073599 scopus 로고    scopus 로고
    • Role of biological modifiers regulating the immune response after trauma
    • DOI 10.1016/j.injury.2007.09.023, PII S0020138307004093, Immune Response to Trauma
    • Stahel PF, Smith WR, Moore EE. Role of biological modifiers regulating the immune response after trauma. Injury. 2007;38:1409-1422. (Pubitemid 350192403)
    • (2007) Injury , vol.38 , Issue.12 , pp. 1409-1422
    • Stahel, P.F.1    Smith, W.R.2    Moore, E.E.3
  • 6
    • 21744446231 scopus 로고    scopus 로고
    • Neurobiology of the stress response: Contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury
    • DOI 10.1097/01.shk.0000167112.18871.5c
    • Molina PE. Neurobiology of the stress response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury. Shock. 2005;24:3-10. (Pubitemid 40946588)
    • (2005) Shock , vol.24 , Issue.1 , pp. 3-10
    • Molina, P.E.1
  • 7
    • 33644801469 scopus 로고    scopus 로고
    • The interactions between inflammation and coagulation
    • DOI 10.1111/j.1365-2141.2005.05753.x
    • Esmon CT. The interactions between inflammation and coagulation. Br J Haematol. 2005;131:417-430. (Pubitemid 43899639)
    • (2005) British Journal of Haematology , vol.131 , Issue.4 , pp. 417-430
    • Esmon, C.T.1
  • 8
    • 74949117097 scopus 로고    scopus 로고
    • Inflammation and coagulation
    • Levi M, van der PT. Inflammation and coagulation. Crit Care Med. 2010;38:S26-S34.
    • (2010) Crit Care Med , vol.38
    • Levi, M.1    Van Der, P.T.2
  • 10
    • 0036912250 scopus 로고    scopus 로고
    • Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma
    • Gando S, Kameue T, Matsuda N, et al. Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma. Thromb Haemost. 2002;88:943-949. (Pubitemid 36018780)
    • (2002) Thrombosis and Haemostasis , vol.88 , Issue.6 , pp. 943-949
    • Gando, S.1    Kameue, T.2    Matsuda, N.3    Hayakawa, M.4    Ishitani, T.5    Morimoto, Y.6    Kemmotsu, O.7
  • 11
    • 36249024081 scopus 로고    scopus 로고
    • Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma
    • DOI 10.1097/shk.0b013e318123e64e
    • Maier B, Lefering R, Lehnert M, et al. Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma. Shock. 2007;28:668-674. (Pubitemid 350135471)
    • (2007) Shock , vol.28 , Issue.6 , pp. 668-674
    • Maier, B.1    Lefering, R.2    Lehnert, M.3    Laurer, H.L.4    Steudel, W.I.5    Neugebauer, E.A.6    Marzi, I.7
  • 12
    • 34250700510 scopus 로고    scopus 로고
    • Role of the alternative pathway in the early complement activation following major trauma
    • DOI 10.1097/shk.0b013e3180342439
    • Ganter MT, Brohi K, Cohen MJ, et al. Role of the alternative pathway in the early complement activation following major trauma. Shock. 2007;28:29-34. (Pubitemid 46956459)
    • (2007) Shock , vol.28 , Issue.1 , pp. 29-34
    • Ganter, M.T.1    Brohi, K.2    Cohen, M.J.3    Shaffer, L.A.4    Walsh, M.C.5    Stahl, G.L.6    Pittet, J.-F.7
  • 13
    • 77954717673 scopus 로고    scopus 로고
    • 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit
    • Cohen MJ, Serkova NJ, Wiener-Kronish J, et al. 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit. J Trauma. 2010;69:31-40.
    • (2010) J Trauma , vol.69 , pp. 31-40
    • Cohen, M.J.1    Serkova, N.J.2    Wiener-Kronish, J.3
  • 14
    • 0016611266 scopus 로고
    • Plasma catecholamines in severely injured patients: A prospective study on 45 patients with multiple injuries
    • Jaattela A, Alho A, Avikainen V, et al. Plasma catecholamines in severely injured patients: a prospective study on 45 patients with multiple injuries. Br J Surg. 1975;62:177-181.
    • (1975) Br J Surg , vol.62 , pp. 177-181
    • Jaattela, A.1    Alho, A.2    Avikainen, V.3
  • 15
  • 16
    • 0018971649 scopus 로고
    • Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system
    • Cryer PE. Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system. N Engl J Med. 1980;303:436-444. (Pubitemid 10043641)
    • (1980) New England Journal of Medicine , vol.303 , Issue.8 , pp. 436-444
    • Cryer, P.E.1
  • 17
    • 0020148444 scopus 로고
    • Endogenous and exogenous catecholamines in critical care medicine
    • Chernow B, Rainey TG, Lake CR. Endogenous and exogenous catecholamines in critical care medicine. Crit Care Med. 1982;10:409-416.
    • (1982) Crit Care Med , vol.10 , pp. 409-416
    • Chernow, B.1    Rainey, T.G.2    Lake, C.R.3
  • 18
    • 0033665898 scopus 로고    scopus 로고
    • Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo
    • von Kanel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol. 2000;65:357-369.
    • (2000) Eur J Haematol , vol.65 , pp. 357-369
    • Von Kanel, R.1    Dimsdale, J.E.2
  • 19
    • 70349331059 scopus 로고    scopus 로고
    • Sympathetic overstimulation during critical illness: Adverse effects of adrenergic stress
    • Dunser MW, Hasibeder WR. Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med. 2009;24:293-316.
    • (2009) J Intensive Care Med , vol.24 , pp. 293-316
    • Dunser, M.W.1    Hasibeder, W.R.2
  • 20
    • 77958477935 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation
    • doi:10.1016/j.mehy.2010.07.031
    • Johansson PI, Ostrowski SR. Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation. Med Hypotheses. 2010; doi:10.1016/j.mehy.2010.07.031.
    • (2010) Med Hypotheses
    • Johansson, P.I.1    Ostrowski, S.R.2
  • 21
    • 0022359950 scopus 로고
    • Catecholamine-mediated injury to endothelium in rabbit perfused aorta: A quantitative analysis by scanning electron microscopy
    • Makhmudov RM, Mamedov Y, Dolgov VV, et al. Catecholamine-mediated injury to endothelium in rabbit perfused aorta: a quantitative analysis by scanning electron microscopy. Cor Vasa. 1985;27:456-463. (Pubitemid 16207788)
    • (1985) Cor et Vasa , vol.27 , Issue.6 , pp. 456-463
    • Makhmudov, R.M.1    Mamedov Ya., D.2    Dolgov, V.V.3    Repin, V.S.4
  • 24
    • 0021740184 scopus 로고
    • Deleterious effect of adrenaline on the vascular endothelial lining
    • Dolgov VV, Makhmudov RM, Bondarenko MF, et al. [Deleterious action of adrenaline on the endothelial lining of the vessels]. Arkh Patol. 1984;46:31-36. (Pubitemid 15176270)
    • (1984) Arkhiv Patologii , vol.46 , Issue.10 , pp. 31-36
    • Dolgov, V.V.1    Makhmudov, R.M.2    Bondarenko, M.F.3    Repin, V.S.4
  • 25
    • 77950817867 scopus 로고    scopus 로고
    • Early release of high mobility group box nuclear protein 1 after severe trauma in humans: Role of injury severity and tissue hypoperfusion
    • Cohen MJ, Brohi K, Calfee CS, et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care. 2009;13:R174.
    • (2009) Crit Care , vol.13
    • Cohen, M.J.1    Brohi, K.2    Calfee, C.S.3
  • 26
    • 54049088538 scopus 로고    scopus 로고
    • Neutrophil-derived circulating free DNA (cf-DNA/NETs): A potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis
    • Margraf S, Logters T, Reipen J, et al. Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock. 2008;30:352-358.
    • (2008) Shock , vol.30 , pp. 352-358
    • Margraf, S.1    Logters, T.2    Reipen, J.3
  • 27
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104-107.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3
  • 28
    • 33750537772 scopus 로고    scopus 로고
    • The impact of endogenous triggers on trauma-associated inflammation
    • DOI 10.1097/MCC.0b013e3280106806, PII 0007519820061200000014
    • Zedler S, Faist E. The impact of endogenous triggers on trauma-associated inflammation. Curr Opin Crit Care. 2006;12:595-601. (Pubitemid 44673437)
    • (2006) Current Opinion in Critical Care , vol.12 , Issue.6 , pp. 595-601
    • Zedler, S.1    Faist, E.2
  • 29
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
    • DOI 10.1016/j.it.2007.08.004, PII S1471490607002074
    • Rubartelli A, Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol. 2007;28:429-436. (Pubitemid 47444554)
    • (2007) Trends in Immunology , vol.28 , Issue.10 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 30
    • 33745168975 scopus 로고    scopus 로고
    • The coagulopathy of trauma versus disseminated intravascular coagulation
    • Hess JR, Lawson JH. The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006;60:S12-S19.
    • (2006) J Trauma , vol.60
    • Hess, J.R.1    Lawson, J.H.2
  • 31
    • 67650645257 scopus 로고    scopus 로고
    • The coagulopathy of trauma: A review of mechanisms
    • Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65:748-754.
    • (2008) J Trauma , vol.65 , pp. 748-754
    • Hess, J.R.1    Brohi, K.2    Dutton, R.P.3
  • 32
    • 0035218409 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in trauma patients
    • DOI 10.1055/s-2001-18864
    • Gando S. Disseminated intravascular coagulation in trauma patients. Semin Thromb Hemost. 2001;27:585-592. (Pubitemid 33152571)
    • (2001) Seminars in Thrombosis and Hemostasis , vol.27 , Issue.6 , pp. 585-592
    • Gando, S.1
  • 33
    • 2942744464 scopus 로고    scopus 로고
    • Endothelium as an organ system
    • Aird WC. Endothelium as an organ system. Crit Care Med. 2004;32:S271-S279.
    • (2004) Crit Care Med , vol.32
    • Aird, W.C.1
  • 36
    • 2142763785 scopus 로고    scopus 로고
    • Endothelial Glycocalyx as an Additional Barrier Determining Extravasation of 6% Hydroxyethyl Starch or 5% Albumin Solutions in the Coronary Vascular Bed
    • DOI 10.1097/00000542-200405000-00025
    • Rehm M, Zahler S, Lotsch M, et al. Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed. Anesthesiology. 2004;100:1211-1223. (Pubitemid 38541978)
    • (2004) Anesthesiology , vol.100 , Issue.5 , pp. 1211-1223
    • Rehm, M.1    Zahler, S.2    Lotsch, M.3    Welsch, U.4    Conzen, P.5    Jacob, M.6    Becker, B.F.7
  • 37
    • 0034785698 scopus 로고    scopus 로고
    • Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    • Rehm M, Haller M, Orth V, et al. Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy. Anesthesiology. 2001;95:849-856. (Pubitemid 32939106)
    • (2001) Anesthesiology , vol.95 , Issue.4 , pp. 849-856
    • Rehm, M.1    Haller, M.2    Orth, V.3    Kreimeier, U.4    Jacob, M.5    Dressel, H.6    Mayer, S.7    Brechtelsbauer, H.8    Finsterer, U.9
  • 40
  • 41
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • DOI 10.1182/blood-2002-06-1887
    • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003;101:3765-3777. (Pubitemid 36857845)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3765-3777
    • Aird, W.C.1
  • 42
    • 77950864525 scopus 로고    scopus 로고
    • The acute coagulopathy of trauma shock: Clinical relevance
    • Frith D, Brohi K. The acute coagulopathy of trauma shock: Clinical relevance. Surgeon. 2010;8:159-163.
    • (2010) Surgeon , vol.8 , pp. 159-163
    • Frith, D.1    Brohi, K.2
  • 44
    • 63149101598 scopus 로고    scopus 로고
    • The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality
    • Stensballe J, Christiansen M, Tonnesen E, et al. The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality. Acta Anaesthesiol Scand. 2009;53:515-521.
    • (2009) Acta Anaesthesiol Scand , vol.53 , pp. 515-521
    • Stensballe, J.1    Christiansen, M.2    Tonnesen, E.3
  • 46
    • 73849096747 scopus 로고    scopus 로고
    • Increase in activated protein C mediates acute traumatic coagulopathy in mice
    • Chesebro BB, Rahn P, Carles M, et al. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock. 2009;32:659-695.
    • (2009) Shock , vol.32 , pp. 659-695
    • Chesebro, B.B.1    Rahn, P.2    Carles, M.3
  • 47
    • 34247568437 scopus 로고    scopus 로고
    • Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?
    • DOI 10.1097/01.sla.0000256862.79374.31, PII 0000065820070500000021
    • Brohi K, Cohen MJ, Ganter MT, et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245:812-818. (Pubitemid 46684113)
    • (2007) Annals of Surgery , vol.245 , Issue.5 , pp. 812-818
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Matthay, M.A.4    MacKersie, R.C.5    Pittet, J.-F.6
  • 48
    • 73949106835 scopus 로고    scopus 로고
    • Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia
    • Cohen MJ, Bir N, Rahn P, et al. Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia. J Trauma. 2009;67:1176-1181.
    • (2009) J Trauma , vol.67 , pp. 1176-1181
    • Cohen, M.J.1    Bir, N.2    Rahn, P.3
  • 50
    • 0034603747 scopus 로고    scopus 로고
    • Oxidized lipoproteins degrade the endothelial surface layer: Implications for platelet-endothelial cell adhesion
    • Vink H, Constantinescu AA, Spaan JA. Oxidized lipoproteins degrade the endothelial surface layer: implications for platelet-endothelial cell adhesion. Circulation. 2000;101:1500-1502. (Pubitemid 30180883)
    • (2000) Circulation , vol.101 , Issue.13 , pp. 1500-1502
    • Vink, H.1    Constantinescu, A.A.2    Spaan, J.A.E.3
  • 51
    • 77954997615 scopus 로고    scopus 로고
    • Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion
    • Chappell D, Dorfler N, Jacob M, et al. Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion. Shock. 2010;34:133-139.
    • (2010) Shock , vol.34 , pp. 133-139
    • Chappell, D.1    Dorfler, N.2    Jacob, M.3
  • 52
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT. The protein C pathway. Chest. 2003;124:26S-32S. (Pubitemid 37128433)
    • (2003) Chest , vol.124 , Issue.3 SUPPL.
    • Esmon, C.T.1
  • 53
    • 0030744179 scopus 로고    scopus 로고
    • Soluble markers of endothelial cell function
    • Blann A, Seigneur M. Soluble markers of endothelial cell function. Clin Hemorheol Microcirc. 1997;17:3-11. (Pubitemid 27334980)
    • (1997) Clinical Hemorheology and Microcirculation , vol.17 , Issue.1 , pp. 3-11
    • Blann, A.1
  • 54
    • 70449107044 scopus 로고    scopus 로고
    • Extracellular histones are major mediators of death in sepsis
    • Xu J, Zhang X, Pelayo R, et al. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009;15:1318-1321.
    • (2009) Nat Med , vol.15 , pp. 1318-1321
    • Xu, J.1    Zhang, X.2    Pelayo, R.3
  • 55
    • 76449114411 scopus 로고    scopus 로고
    • Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    • Johansson PI, Stissing T, Bochsen L, et al. Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med. 2009;17:45.
    • (2009) Scand J Trauma Resusc Emerg Med , vol.17 , pp. 45
    • Johansson, P.I.1    Stissing, T.2    Bochsen, L.3
  • 56
    • 77956201218 scopus 로고    scopus 로고
    • Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    • Kashuk JL, Moore EE, Sawyer M, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010;252:434-442.
    • (2010) Ann Surg , vol.252 , pp. 434-442
    • Kashuk, J.L.1    Moore, E.E.2    Sawyer, M.3
  • 57
    • 70350459505 scopus 로고    scopus 로고
    • Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    • Schochl H, Frietsch T, Pavelka M, et al. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma. 2009;67:125-131.
    • (2009) J Trauma , vol.67 , pp. 125-131
    • Schochl, H.1    Frietsch, T.2    Pavelka, M.3
  • 58
    • 3242699717 scopus 로고    scopus 로고
    • UPA and uPAR in fibrinolysis, immunity and pathology
    • DOI 10.1016/j.it.2004.06.004, PII S1471490604001851
    • Mondino A, Blasi F. uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol. 2004;25:450-455. (Pubitemid 38951087)
    • (2004) Trends in Immunology , vol.25 , Issue.8 , pp. 450-455
    • Mondino, A.1    Blasi, F.2
  • 59
    • 77950390898 scopus 로고    scopus 로고
    • Fibrinolytic cross-talk: A new mechanism for plasmin formation
    • Dejouvencel T, Doeuvre L, Lacroix R, et al. Fibrinolytic cross-talk: a new mechanism for plasmin formation. Blood. 2010;115:2048-2056.
    • (2010) Blood , vol.115 , pp. 2048-2056
    • Dejouvencel, T.1    Doeuvre, L.2    Lacroix, R.3
  • 60
    • 77956561594 scopus 로고    scopus 로고
    • Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
    • Connolly BM, Choi EY, Gardsvoll H, et al. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010;116:1593-1603.
    • (2010) Blood , vol.116 , pp. 1593-1603
    • Connolly, B.M.1    Choi, E.Y.2    Gardsvoll, H.3
  • 61
    • 70349658770 scopus 로고    scopus 로고
    • Personalized medicine: Genetic Variation and loss of physiologic complexity are associated with mortality in 644 trauma patients
    • Norris PR, Canter JA, Jenkins JM, et al. Personalized Medicine: Genetic Variation and Loss of Physiologic Complexity Are Associated With Mortality in 644 Trauma Patients. Ann Surg. 2009.
    • (2009) Ann Surg
    • Norris, P.R.1    Canter, J.A.2    Jenkins, J.M.3
  • 62
    • 64949109301 scopus 로고    scopus 로고
    • Genetic variation in the autonomic nervous system affects mortality: A study of 1, 095 trauma patients
    • Morris JA Jr., Norris PR, Moore JH, et al. Genetic variation in the autonomic nervous system affects mortality: a study of 1, 095 trauma patients. J Am Coll Surg. 2009;208:663-668.
    • (2009) J Am Coll Surg , vol.208 , pp. 663-668
    • Morris Jr., J.A.1    Norris, P.R.2    Moore, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.