Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries

Intensive Care Medicine

Volumn 36, Issue 11, 2010, Pages 1928-1934

  Secor, Dan ^a,b   Li, Fuyan ^a,b   Ellis, Christopher G ^a,b   Sharpe, Michael D ^b   Gross, Peter L ^c   Wilson, John X ^d   Tyml, Karel ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

Ascorbate; Fibrin; Microcirculation; Nitric oxide; Platelets

Indexed keywords

ASCORBIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N ACETYL S NITROSOPENICILLAMINE; PADGEM PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CAPILLARY; CONTROLLED STUDY; DRUG EFFECT; FIBRIN DEPOSITION; HINDLIMB; IMAGE ANALYSIS; LEG MUSCLE; MICROANGIOPATHY; MICROSCOPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; SEPSIS; THROMBOCYTE ADHESION;

ANIMALS; BLOOD COAGULATION; CAPILLARIES; EXTREMITIES; MICE; P-SELECTIN; PLATELET ADHESIVENESS; SEPSIS;

EID: 78650414437     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1969-3     Document Type: Article

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