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Volumn 285, Issue 1 54-1, 2003, Pages

Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice

Author keywords

Arterial pressure; Cecal ligation and puncture; Inducible nitric oxide synthase; Oxidative stress

Indexed keywords

ASCORBIC ACID; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; NORADRENALIN; UNCLASSIFIED DRUG;

EID: 0038311988     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00564.2002     Document Type: Article
Times cited : (91)

References (47)
  • 1
    • 0035104547 scopus 로고    scopus 로고
    • Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat
    • Armour J, Tyml K, Lidington D, and Wilson JX. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat. J Appl Physiol 90: 795-803, 2001.
    • (2001) J Appl Physiol , vol.90 , pp. 795-803
    • Armour, J.1    Tyml, K.2    Lidington, D.3    Wilson, J.X.4
  • 3
    • 0032508594 scopus 로고    scopus 로고
    • Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells
    • Beck KF, Eberhardt W, Walpen S, Apel M, and Pfeilschifter J. Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells. FEBS Lett 435: 35-38, 1998.
    • (1998) FEBS Lett , vol.435 , pp. 35-38
    • Beck, K.F.1    Eberhardt, W.2    Walpen, S.3    Apel, M.4    Pfeilschifter, J.5
  • 4
    • 0029997657 scopus 로고    scopus 로고
    • Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
    • Borrelli E, Roux-Lombard P, Grau GE, Girardin E, Ricou B, Dayer J, and Suter PM. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med 24: 392-397, 1996.
    • (1996) Crit Care Med , vol.24 , pp. 392-397
    • Borrelli, E.1    Roux-Lombard, P.2    Grau, G.E.3    Girardin, E.4    Ricou, B.5    Dayer, J.6    Suter, P.M.7
  • 5
    • 0027396814 scopus 로고
    • Approach to the molecular basis of nephron heterogeneity: Application of reverse transcription-polymerase chain reaction to dissected tubule segments
    • Briggs JP, Todd-Turla K, Schnermann JB, and Killen PD. Approach to the molecular basis of nephron heterogeneity: application of reverse transcription-polymerase chain reaction to dissected tubule segments. Semin Nephrol 13: 2-12, 1993.
    • (1993) Semin Nephrol , vol.13 , pp. 2-12
    • Briggs, J.P.1    Todd-Turla, K.2    Schnermann, J.B.3    Killen, P.D.4
  • 7
    • 0023722960 scopus 로고
    • Effect of scavengers of oxygen-derived free radicals on mortality in endotoxin-challenged mice
    • Broner CW, Shenep JL, Stidham GL, Stokes DC, and Hildner WK. Effect of scavengers of oxygen-derived free radicals on mortality in endotoxin-challenged mice. Crit Care Med 16: 848-851, 1988.
    • (1988) Crit Care Med , vol.16 , pp. 848-851
    • Broner, C.W.1    Shenep, J.L.2    Stidham, G.L.3    Stokes, D.C.4    Hildner, W.K.5
  • 8
    • 0033040739 scopus 로고    scopus 로고
    • Does vitamin C act as a pro-oxidant under physiological conditions?
    • Carr A and Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 13: 1007-1024, 1999.
    • (1999) FASEB J , vol.13 , pp. 1007-1024
    • Carr, A.1    Frei, B.2
  • 10
    • 0035668193 scopus 로고    scopus 로고
    • Is nitric oxide overproduction the target of choice for the management of septic shock?
    • Feihl F, Waeber B, and Liaudet L. Is nitric oxide overproduction the target of choice for the management of septic shock? Pharmacol Ther 91: 179-213, 2001.
    • (2001) Pharmacol Ther , vol.91 , pp. 179-213
    • Feihl, F.1    Waeber, B.2    Liaudet, L.3
  • 12
    • 0030024893 scopus 로고    scopus 로고
    • Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading
    • Galley HF, Davies MJ, and Webster NR. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radic Biol Med 20: 139-143, 1996.
    • (1996) Free Radic Biol Med , vol.20 , pp. 139-143
    • Galley, H.F.1    Davies, M.J.2    Webster, N.R.3
  • 13
    • 0030013115 scopus 로고    scopus 로고
    • Regulation of nitric oxide synthase activity in cultured human endothelial cells: Effect of antioxidants
    • Galley HF, Walker BE, Howdle PD, and Webster NR. Regulation of nitric oxide synthase activity in cultured human endothelial cells: effect of antioxidants. Free Radic Biol Med 21: 97-101, 1996.
    • (1996) Free Radic Biol Med , vol.21 , pp. 97-101
    • Galley, H.F.1    Walker, B.E.2    Howdle, P.D.3    Webster, N.R.4
  • 14
    • 0032696185 scopus 로고    scopus 로고
    • The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections
    • Gorton HC and Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther 22: 530-533, 1999.
    • (1999) J Manipulative Physiol Ther , vol.22 , pp. 530-533
    • Gorton, H.C.1    Jarvis, K.2
  • 15
    • 0027383809 scopus 로고
    • Free radicals and antioxidants in sepsis
    • Goode HF and Webster NR. Free radicals and antioxidants in sepsis. Crit Care Med 21: 1770-1776, 1993.
    • (1993) Crit Care Med , vol.21 , pp. 1770-1776
    • Goode, H.F.1    Webster, N.R.2
  • 16
    • 0032036428 scopus 로고    scopus 로고
    • Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages
    • Gross A, Spiesser S, Terraza A, Rouot B, Caron E, and Dornand J. Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Infect Immun 66: 1309-1316, 1998.
    • (1998) Infect Immun , vol.66 , pp. 1309-1316
    • Gross, A.1    Spiesser, S.2    Terraza, A.3    Rouot, B.4    Caron, E.5    Dornand, J.6
  • 17
    • 0033052884 scopus 로고    scopus 로고
    • Redox imbalance in the critically ill
    • Gutteridge JM and Mitchell J. Redox imbalance in the critically ill. Br Med Bull 55: 49-75, 1999.
    • (1999) Br Med Bull , vol.55 , pp. 49-75
    • Gutteridge, J.M.1    Mitchell, J.2
  • 19
    • 0026581074 scopus 로고
    • Vitamin C the common cold
    • Hemila H. Vitamin C and the common cold. Br J Nutr 67: 3-16, 1992.
    • (1992) Br J Nutr , vol.67 , pp. 3-16
    • Hemila, H.1
  • 20
    • 0035808310 scopus 로고    scopus 로고
    • L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
    • Heller R, Unbehaun A, Schellenberg B, Mayer B, WernerFelmayer G, and Werner ER. L-Ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 276: 40-47, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 40-47
    • Heller, R.1    Unbehaun, A.2    Schellenberg, B.3    Mayer, B.4    WernerFelmayer, G.5    Werner, E.R.6
  • 21
    • 0034647013 scopus 로고    scopus 로고
    • Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase
    • Hollenberg SM, Broussard M, Osman J, and Parrillo JE. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86: 774-778, 2000.
    • (2000) Circ Res , vol.86 , pp. 774-778
    • Hollenberg, S.M.1    Broussard, M.2    Osman, J.3    Parrillo, J.E.4
  • 22
    • 0027477592 scopus 로고
    • Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats
    • Hollenberg SM, Cunnion RE, and Zimmerberg J. Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol Heart Circ Physiol 264: H660-H663, 1993.
    • (1993) Am J Physiol Heart Circ Physiol , vol.264
    • Hollenberg, S.M.1    Cunnion, R.E.2    Zimmerberg, J.3
  • 23
    • 0036071854 scopus 로고    scopus 로고
    • Sepsis inhibits reduction of dehydroascorbic acid and accumulation of ascorbate in astroglial cultures: Intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake inhibition
    • Korcok J, Wu F, Tyml K, Hammond RR, and Wilson JX. Sepsis inhibits reduction of dehydroascorbic acid and accumulation of ascorbate in astroglial cultures: intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake inhibition. J Neurochem 81: 185-193, 2002.
    • (2002) J Neurochem , vol.81 , pp. 185-193
    • Korcok, J.1    Wu, F.2    Tyml, K.3    Hammond, R.R.4    Wilson, J.X.5
  • 24
    • 0034102272 scopus 로고    scopus 로고
    • Superoxide enhances interleukin 1β-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene
    • Kuo PC, Abe K, and Schroeder RA. Superoxide enhances interleukin 1β-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. Gastroenterology 118: 608-618, 2000.
    • (2000) Gastroenterology , vol.118 , pp. 608-618
    • Kuo, P.C.1    Abe, K.2    Schroeder, R.A.3
  • 25
    • 0028843127 scopus 로고
    • Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo
    • Laszlo F, Evans SM, and Whittle BJ. Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur J Pharmacol 272: 169-175, 1995.
    • (1995) Eur J Pharmacol , vol.272 , pp. 169-175
    • Laszlo, F.1    Evans, S.M.2    Whittle, B.J.3
  • 26
    • 0030935693 scopus 로고    scopus 로고
    • Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo
    • Liu SF, Barnes PJ, and Evans TW. Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo. Crit Care Med 25: 512-518, 1997.
    • (1997) Crit Care Med , vol.25 , pp. 512-518
    • Liu, S.F.1    Barnes, P.J.2    Evans, T.W.3
  • 28
    • 0026744830 scopus 로고
    • Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
    • Lyons CR, Orloff GJ, and Cunningham JM. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 267: 6370-6374, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 6370-6374
    • Lyons, C.R.1    Orloff, G.J.2    Cunningham, J.M.3
  • 29
    • 0034662864 scopus 로고    scopus 로고
    • Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock
    • Macarthur H, Westfall TC, Riley DP, Misko TP, and Salvemini D. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc Natl Acad Sci USA 97: 9753-9758, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9753-9758
    • Macarthur, H.1    Westfall, T.C.2    Riley, D.P.3    Misko, T.P.4    Salvemini, D.5
  • 30
    • 0034190373 scopus 로고    scopus 로고
    • How does ascorbic acid prevent endothelial dysfunction?
    • May JM. How does ascorbic acid prevent endothelial dysfunction? Free Radic Biol Med 28: 1421-4129, 2000.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1421-4129
    • May, J.M.1
  • 32
    • 0031973672 scopus 로고    scopus 로고
    • Nacetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes
    • Pahan K, Sheikh FG, Namboodiri AM, and Singh I. Nacetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radic Biol Med 24: 39-48, 1998.
    • (1998) Free Radic Biol Med , vol.24 , pp. 39-48
    • Pahan, K.1    Sheikh, F.G.2    Namboodiri, A.M.3    Singh, I.4
  • 33
    • 0031976068 scopus 로고    scopus 로고
    • Nitric oxide in sepsis and endotoxaemia
    • Parratt JR. Nitric oxide in sepsis and endotoxaemia. J Antimicrob Chemother 41, Suppl A: 31-39, 1998.
    • (1998) J Antimicrob Chemother , vol.41 , Issue.SUPPL. A , pp. 31-39
    • Parratt, J.R.1
  • 34
    • 0036583710 scopus 로고    scopus 로고
    • Hypotension during septic shock does not correlate with exhaled nitric oxide in anesthetized rat
    • Pedoto A, Wang J, Tassiopoulos AK, Hakim TS, Yang ZJ, and Camporesi EM. Hypotension during septic shock does not correlate with exhaled nitric oxide in anesthetized rat. Shock 17: 427-432, 2002.
    • (2002) Shock , vol.17 , pp. 427-432
    • Pedoto, A.1    Wang, J.2    Tassiopoulos, A.K.3    Hakim, T.S.4    Yang, Z.J.5    Camporesi, E.M.6
  • 36
    • 0028821595 scopus 로고
    • Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in reversible endotoxic shock studied by a novel monoclonal antibody against rat iNOS
    • Sato K, Miyakawa K, Takeya M, Hattori R, Yui Y, Sunamoto M, Ichimori Y, Ushio Y, and Takahashi K. Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in reversible endotoxic shock studied by a novel monoclonal antibody against rat iNOS. J Leukoc Biol 57: 36-44, 1995.
    • (1995) J Leukoc Biol , vol.57 , pp. 36-44
    • Sato, K.1    Miyakawa, K.2    Takeya, M.3    Hattori, R.4    Yui, Y.5    Sunamoto, M.6    Ichimori, Y.7    Ushio, Y.8    Takahashi, K.9
  • 37
    • 0033847308 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition increases venular leukocyte rolling and adhesion in septic rats
    • Sundrani R, Easington CR, Mattoo A, Parrillo JE, and Hollenberg SM. Nitric oxide synthase inhibition increases venular leukocyte rolling and adhesion in septic rats. Crit Care Med 28: 2898-2903, 2000.
    • (2000) Crit Care Med , vol.28 , pp. 2898-2903
    • Sundrani, R.1    Easington, C.R.2    Mattoo, A.3    Parrillo, J.E.4    Hollenberg, S.M.5
  • 38
    • 0027331622 scopus 로고
    • Effect of free radical scavengers on endotoxin-induced respiratory muscle dysfunction
    • Supinski G, Nethery D, and DiMarco A. Effect of free radical scavengers on endotoxin-induced respiratory muscle dysfunction. Am Rev Respir Dis 148: 1318-1324, 1993.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1318-1324
    • Supinski, G.1    Nethery, D.2    DiMarco, A.3
  • 39
    • 0022749279 scopus 로고
    • Effect of allopurinol and superoxide dismutase on survival rate in rats with sepsis
    • Warner BW, Hasselgren PO, and Fischer JE. Effect of allopurinol and superoxide dismutase on survival rate in rats with sepsis. Curr Surg 43: 292-293, 1986.
    • (1986) Curr Surg , vol.43 , pp. 292-293
    • Warner, B.W.1    Hasselgren, P.O.2    Fischer, J.E.3
  • 41
    • 0030154883 scopus 로고    scopus 로고
    • Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle
    • Wilson JX, Dixon SJ, Yu J, Nees S, and Tyml K. Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle. Microcirculation 3: 211-221, 1996.
    • (1996) Microcirculation , vol.3 , pp. 211-221
    • Wilson, J.X.1    Dixon, S.J.2    Yu, J.3    Nees, S.4    Tyml, K.5
  • 42
    • 0033019515 scopus 로고    scopus 로고
    • The role of the endothelium in modulating vascular control in sepsis and related conditions
    • Wort SJ and Evans T. The role of the endothelium in modulating vascular control in sepsis and related conditions. Br Med Bull 55: 30-48, 1999.
    • (1999) Br Med Bull , vol.55 , pp. 30-48
    • Wort, S.J.1    Evans, T.2
  • 43
    • 0028911559 scopus 로고
    • Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock
    • Wu CC, Chen SJ, Szabo C, Thiemermann C, and Vane JR. Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br J Pharmacol 114: 1666-1672, 1995.
    • (1995) Br J Pharmacol , vol.114 , pp. 1666-1672
    • Wu, C.C.1    Chen, S.J.2    Szabo, C.3    Thiemermann, C.4    Vane, J.R.5
  • 44
    • 0000171092 scopus 로고    scopus 로고
    • Nitric oxide attenuates but superoxide enhances iNOS expression in endotoxin- and IFNγ-stimulated skeletal muscle endothelial cells
    • Wu F, Cepinskas G, Wilson JX, and Tyml K. Nitric oxide attenuates but superoxide enhances iNOS expression in endotoxin- and IFNγ-stimulated skeletal muscle endothelial cells. Microcirculation 8: 415-425, 2001.
    • (2001) Microcirculation , vol.8 , pp. 415-425
    • Wu, F.1    Cepinskas, G.2    Wilson, J.X.3    Tyml, K.4
  • 45
    • 0037024337 scopus 로고    scopus 로고
    • Ascorbate inhibits iNOS expression in endotoxin- and IFNγ-stimulated rat skeletal muscle endothelial cells
    • Wu F, Tyml K, and Wilson JX. Ascorbate inhibits iNOS expression in endotoxin- and IFNγ-stimulated rat skeletal muscle endothelial cells. FEBS Lett 520: 122-126, 2002.
    • (2002) FEBS Lett , vol.520 , pp. 122-126
    • Wu, F.1    Tyml, K.2    Wilson, J.X.3
  • 46
    • 0037005876 scopus 로고    scopus 로고
    • Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection
    • Zhou X, Potoka DA, Boyle P, Nadler EP, McGinnis K, and Ford HR. Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection. FEMS Microbiol Lett 206: 93-97, 2002.
    • (2002) FEMS Microbiol Lett , vol.206 , pp. 93-97
    • Zhou, X.1    Potoka, D.A.2    Boyle, P.3    Nadler, E.P.4    McGinnis, K.5    Ford, H.R.6
  • 47
    • 0028946802 scopus 로고
    • Defining the role of oxyradicals in the pathogenesis of sepsis
    • Zimmerman JJ. Defining the role of oxyradicals in the pathogenesis of sepsis. Crit Care Med 23: 616-617, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 616-617
    • Zimmerman, J.J.1


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