Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

Journal of Nutritional Biochemistry

Volumn 36, Issue , 2016, Pages 68-80

  Yan, Fujie ^a,b   Dai, Guanhai ^c   Zheng, Xiaodong ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c Zhejiang Academy of Traditional Chinese Medicine   (China)

Author keywords

AKT; db db mice; Glucose metabolism; HepG2 cells; Mulberry anthocyanins

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADIPONECTIN; ANTHOCYANIN; CHOLESTEROL; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCATED SERUM PROTEIN; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE 2; GLYCOGEN SYNTHASE KINASE 3BETA; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; METFORMIN; MULBERRY ANTHOCYANIN EXTRACT; MULBERRY EXTRACT; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PLASMA PROTEIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; PLANT EXTRACT;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; GLYCOGEN ANALYSIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER; MALE; METABOLIC PARAMETERS; MORUS ALBA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SUPPLEMENTATION; UPREGULATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; DIET THERAPY; DIETARY SUPPLEMENT; ENZYMOLOGY; FRUIT; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; HEP-G2 CELL LINE; HYPERGLYCEMIA; ISOLATION AND PURIFICATION; METABOLISM; MORUS; MUTANT MOUSE STRAIN; RANDOMIZATION;

ANIMALS; ANTHOCYANINS; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; FRUIT; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIVER; MALE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MORUS; PHOSPHATIDYLINOSITOL 3-KINASE; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84983649252     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2016.07.004     Document Type: Article

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