메뉴 건너뛰기




Volumn 53, Issue 11, 2009, Pages 1419-1429

The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis

Author keywords

Anthocyanins; Apoptosis; Diabetes; Glucose transporter4; Insulin receptor phosphorylation

Indexed keywords

ANTHOCYANIN; ANTIDIABETIC AGENT; GLUCOSE TRANSPORTER 4; SLC2A4 PROTEIN, RAT; STREPTOZOCIN; TRIACYLGLYCEROL;

EID: 70449602358     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200800526     Document Type: Article
Times cited : (151)

References (44)
  • 1
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini, E., Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr. Rev. 1998, 19, 477-490.
    • (1998) Endocr. Rev , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 2
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • Kahn, S. E., The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003, 46, 3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 3
    • 0034457378 scopus 로고    scopus 로고
    • Insulin resistance is not necessarily an essential component of type 2 diabetes
    • Gerich, J. E., Insulin resistance is not necessarily an essential component of type 2 diabetes. J. Clin. Endocrinol.Metab. 2000, 85, 2113-2115.
    • (2000) J. Clin. Endocrinol.Metab , vol.85 , pp. 2113-2115
    • Gerich, J.E.1
  • 4
    • 44749085712 scopus 로고    scopus 로고
    • Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
    • Florez, J. C., Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 2008, 51,1100-1110.
    • (2008) Diabetologia , vol.51 , pp. 1100-1110
    • Florez, J.C.1
  • 5
    • 0025115342 scopus 로고
    • Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects
    • Thies, R. S., Molina, J. M., Ciaraldi, T. P., Freidenberg, G. R.Olefsky, J. M., Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes 1990,39,250-259.
    • (1990) Diabetes , vol.39 , pp. 250-259
    • Thies, R.S.1    Molina, J.M.2    Ciaraldi, T.P.3    Freidenberg, G.R.4    Olefsky, J.M.5
  • 6
    • 0033515429 scopus 로고    scopus 로고
    • Deconstructing type 2 diabetes
    • Taylor, S. I., Deconstructing type 2 diabetes. Cell 1999, 97,9-12.
    • (1999) Cell , vol.97 , pp. 9-12
    • Taylor, S.I.1
  • 7
    • 0033866831 scopus 로고    scopus 로고
    • New approaches in the treatment of type II diabetes
    • Zhang, B. B., Moller, D. E., New approaches in the treatment of type II diabetes. Curr. Opin. Chem. Biol. 2000, 4, 461-467
    • (2000) Curr. Opin. Chem. Biol , vol.4 , pp. 461-467
    • Zhang, B.B.1    Moller, D.E.2
  • 8
    • 0035787076 scopus 로고    scopus 로고
    • Discovery of a small molecule insulin receptor activator
    • Salituro, G. M., Pelaez, F., Zhang, B. B., Discovery of a small molecule insulin receptor activator. Rec. Prog. Horm. Res.2001,56,107-126.
    • (2001) Rec. Prog. Horm. Res , vol.56 , pp. 107-126
    • Salituro, G.M.1    Pelaez, F.2    Zhang, B.B.3
  • 9
    • 0028875678 scopus 로고
    • Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway
    • Haruta, T., Morris, A. J., Rose, D. W., Nelson, J. G. et al.Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J. Biol. Chem.1995,270,27991-27994.
    • (1995) J. Biol. Chem , vol.270 , pp. 27991-27994
    • Haruta, T.1    Morris, A.J.2    Rose, D.W.3    Nelson, J.G.4
  • 10
    • 0033524932 scopus 로고    scopus 로고
    • GLUT4 gene regulation and manipulation
    • Charron, M. J., Katz, E. B., Oslon, A. L., GLUT4 gene regulation and manipulation. J. Biol. Chem. 1999, 274, 3253-3256
    • (1999) J. Biol. Chem , vol.274 , pp. 3253-3256
    • Charron, M.J.1    Katz, E.B.2    Oslon, A.L.3
  • 11
    • 0033613830 scopus 로고    scopus 로고
    • Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location
    • Pessin, J. E., Thurmond, D. C., Elmendorf, J. S., Coker, K. J.Okada, S., Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location! J. Biol.Chem. 1999, 274, 2593-2596.
    • (1999) J. Biol.Chem , vol.274 , pp. 2593-2596
    • Pessin, J.E.1    Thurmond, D.C.2    Elmendorf, J.S.3    Coker, K.4    Okada, S.5
  • 12
    • 0036270751 scopus 로고    scopus 로고
    • Regulated transport of the glucose transporter GLUT4. Nature Rev
    • Bryant, N. J., Govers, R., James, D. E., Regulated transport of the glucose transporter GLUT4. Nature Rev. Mol. Cell Biol. 2002, 3, 267-277.
    • (2002) Mol. Cell Biol , vol.3 , pp. 267-277
    • Bryant, N.J.1    Govers, R.2    James, D.E.3
  • 13
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo, R. A., Pharmacologic therapy for type 2 diabetes mellitus. Ann. Intern. Med. 1999, 131, 281-303
    • (1999) Ann. Intern. Med , vol.131 , pp. 281-303
    • Defronzo, R.A.1
  • 14
    • 0042991484 scopus 로고    scopus 로고
    • Implications of the United Kingdom Prospective Diabetes Study
    • American Diabetes Association
    • American Diabetes Association. Implications of the United Kingdom Prospective Diabetes Study. Diabetes Care 2003,26, S28-S32.
    • (2003) Diabetes Care , vol.26
  • 15
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes
    • Inzucchi, S. E., Oral antihyperglycemic therapy for type 2 diabetes. J. Am. Med. Assoc. 2002, 287, 360-372.
    • (2002) J. Am. Med. Assoc , vol.287 , pp. 360-372
    • Inzucchi, S.E.1
  • 16
    • 0033499583 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity
    • Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T. et al.Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.Diabetes 1999, 48, 2398-2406.
    • (1999) Diabetes , vol.48 , pp. 2398-2406
    • Kaneto, H.1    Kajimoto, Y.2    Miyagawa, J.3    Matsuoka, T.4
  • 17
    • 0032403857 scopus 로고    scopus 로고
    • The crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation. Free Radic
    • Virag, L., Marmer, D. J., Szabo, C., The crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation. Free Radic. Biol. Med. 1998, 25, 1075-1082
    • (1998) Biol. Med , vol.25 , pp. 1075-1082
    • Virag, L.1    Marmer, D.J.2    Szabo, C.3
  • 18
    • 0019945886 scopus 로고
    • Preventive and therapeutic effects of large dose nicotina-mide injections on diabetes associated with insulitis
    • Yamada, K., Nonaka, K., Hanafusa, T., Miyazaki, A. et al.Preventive and therapeutic effects of large dose nicotina-mide injections on diabetes associated with insulitis.Diabetes 1982, 31, 749-753.
    • (1982) , vol.31 , pp. 749-753
    • Yamada, K.1    Nonaka, K.2    Hanafusa, T.3    Miyazaki, A.4
  • 20
    • 0001419018 scopus 로고    scopus 로고
    • Structural analysis and measurement of anthocyanins from colored seed coats of Vigna, Phaseolus, and Glycine Legumes.Biosci
    • Yoshida, K., Sato, Y., Okuno, R., Kameda, K. et al., Structural analysis and measurement of anthocyanins from colored seed coats of Vigna, Phaseolus, and Glycine Legumes.Biosci. Biotechnol. Biochem. 1996, 60, 589-593.
    • (1996) Biotechnol. Biochem , vol.60 , pp. 589-593
    • Yoshida, K.1    Sato, Y.2    Okuno, R.3    Kameda, K.4
  • 21
    • 0035543027 scopus 로고    scopus 로고
    • Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr)
    • Choung, M. G., Baek, I. Y., Kang, S. T., Han, W. Y. et al.Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr). J. Agric. Food Chem. 2001, 49, 5848-5851.
    • (2001) J. Agric. Food Chem , vol.49 , pp. 5848-5851
    • Choung, M.G.1    Baek, I.Y.2    Kang, S.T.3    Han, W.Y.4
  • 22
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets and the French paradox for coronary heart disease
    • Renaud, S., de Logeril, M., Wine, alcohol, platelets and the French paradox for coronary heart disease. Lancet 1992,339,1523-1526.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    de Logeril, M.2
  • 23
    • 32344437926 scopus 로고    scopus 로고
    • Antho-cyanins from soybean seed coat inhibit the expression of TNF-a-induced genes associated with iischemia/reperfusion in endothelial cell by NF-kB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reper-fusion in vivo
    • Kim, H. J., Tsoy, I., Park, J. M., Chung, J. I. et al., Antho-cyanins from soybean seed coat inhibit the expression of TNF-a-induced genes associated with iischemia/reperfusion in endothelial cell by NF-kB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reper-fusion in vivo. FEBS Lett. 2006, 580, 1391-1397
    • (2006) FEBS Lett , vol.580 , pp. 1391-1397
    • Kim, H.J.1    Tsoy, I.2    Park, J.M.3    Chung, J.I.4
  • 24
    • 0034003009 scopus 로고    scopus 로고
    • Relationship among antioxidant activity, vasodilation capacity and phenolic contents of red wines
    • Burns, J., Gardner, P. T., O'Neil, J., Crawford, S. et al.Relationship among antioxidant activity, vasodilation capacity and phenolic contents of red wines. J. Agric. Food Chem. 2000, 48, 220-230.
    • (2000) J. Agric. Food Chem , vol.48 , pp. 220-230
    • Burns, J.1    Gardner, P.T.2    O'neil, J.3    Crawford, S.4
  • 25
    • 11244279678 scopus 로고    scopus 로고
    • Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits
    • Jayaprakasam, B., Vareed, S. K., Olson, L. K., Nair, M. G., Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J. Agric. Food Chem. 2005, 53, 28-31
    • (2005) J. Agric. Food Chem , vol.53 , pp. 28-31
    • Jayaprakasam, B.1    Vareed, S.K.2    Olson, L.K.3    Nair, M.G.4
  • 26
    • 35348964129 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice
    • Sasaki, R., Nishimura, N., Hoshino, H., Isa, Y. et al., Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem. Pharmacol. 2007, 74,1619-1627.
    • (2007) Biochem. Pharmacol , vol.74 , pp. 1619-1627
    • Sasaki, R.1    Nishimura, N.2    Hoshino, H.3    Isa, Y.4
  • 27
    • 3042745184 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Electro-mechanical cellular alterations
    • Casis, O., Echevarria, E., Diabetic cardiomyopathy: electro-mechanical cellular alterations. Curr. Vasc. Pharmacol.2004,2,237-248.
    • (2004) Curr. Vasc. Pharmacol , vol.2 , pp. 237-248
    • Casis, O.1    Echevarria, E.2
  • 28
    • 43849100719 scopus 로고    scopus 로고
    • Type 1 diabetes, hyperglycaemia, and the heart
    • Retnakaran, R., Zinman, B., Type 1 diabetes, hyperglycaemia, and the heart. Lancet 2008, 371, 1790-1799
    • (2008) Lancet , vol.371 , pp. 1790-1799
    • Retnakaran, R.1    Zinman, B.2
  • 29
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Jarvinen, H., Glucose toxicity. Endocr. Rev. 1992, 13,415-431.
    • (1992) Endocr. Rev , vol.13 , pp. 415-431
    • Yki-Jarvinen, H.1
  • 30
    • 0027482889 scopus 로고
    • Serum cholesterol. Doing the right thing
    • Stamler, J., Stamler, R., Brown, W. V., Gotto, A. M. et al.Serum cholesterol. Doing the right thing. Circulation 1993,88,1954-1960.
    • (1993) Circulation , vol.88 , pp. 1954-1960
    • Stamler, J.1    Stamler, R.2    Brown, W.V.3    Gotto, A.4
  • 31
    • 38349169835 scopus 로고    scopus 로고
    • Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation
    • Palmieri, V., Capaldo, B., Russo, C., Iaccarino, M. et al.Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: insights from echocardiography and exercise cardiac performance evaluation.Diabetes Res. Clin. Pract. 2008, 79, 262-268.
    • (2008) , vol.79 , pp. 262-268
    • Palmieri, V.1    Capaldo, B.2    Russo, C.3    Iaccarino, M.4
  • 32
    • 36049039920 scopus 로고    scopus 로고
    • Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes
    • Griffin, K. A., Abu-Naser, M., Abu-Amarah, I., Pichen, M.et al.Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes. Am. J. Physiol.Renal Physiol. 2007, 293, 1605-1613.
    • (2007) Am. J. Physiol.Renal Physiol , vol.293 , pp. 1605-1613
    • Griffin, K.A.1    Abu-Naser, M.2    Abu-Amarah, I.3    Pichen, M.4
  • 33
    • 54349105227 scopus 로고    scopus 로고
    • Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
    • Tsoyi, K., Park, H. B., Kim, Y. M., Chung, J. I. et al., Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. J. Agric.Food Chem. 2008, 56, 8969-8974.
    • (2008) J. Agric.Food Chem , vol.56 , pp. 8969-8974
    • Tsoyi, K.1    Park, H.B.2    Kim, Y.M.3    Chung, J.I.4
  • 34
    • 0026757162 scopus 로고
    • Human GLUT4/muscle-fat glucose transporter gene. Characterization and genetic variation
    • Buse, J. B., Yasuda, K., Lay, T. P., Seo, T. S. et al., Human GLUT4/muscle-fat glucose transporter gene. Characterization and genetic variation. Diabetes 1992, 41, 1436-1445.
    • (1992) Diabetes , vol.41 , pp. 1436-1445
    • Buse, J.B.1    Yasuda, K.2    Lay, T.P.3    Seo, T.S.4
  • 35
    • 0031560431 scopus 로고    scopus 로고
    • Regulatory elements in the insulin-responsive glucose transporter (GLUT4) gene
    • Ezaki, O., Regulatory elements in the insulin-responsive glucose transporter (GLUT4) gene. Biochem. Biophys. Res.Commun. 1997, 241, 1-6.
    • (1997) Biochem. Biophys. Res.Commun , vol.241 , pp. 1-6
    • Ezaki, O.1
  • 36
    • 38049148308 scopus 로고    scopus 로고
    • FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
    • Ni. G., Wang, N., Cao, D. J., Sachan, N. et al., FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc. Natl.Acad. Sci. USA 2007, 104, 20517-20522.
    • (2007) Proc. Natl.Acad. Sci. USA , vol.104 , pp. 20517-20522
    • Ni, G.1    Wang, N.2    Cao, D.J.3    Sachan, N.4
  • 37
    • 0033834248 scopus 로고    scopus 로고
    • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    • Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D. et al.Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 2000, 6, 924-928.
    • (2000) Nat. Med , vol.6 , pp. 924-928
    • Zisman, A.1    Peroni, O.D.2    Abel, E.D.3    Michael, M.D.4
  • 38
    • 0036202197 scopus 로고    scopus 로고
    • Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus
    • Futura, M., Yano, Y Gabazza, E. C., Araki-Sasaki, R. et al.Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus.Diabetes Res. Clin. Pract. 2002, 56, 159-171.
    • (2002) , vol.56 , pp. 159-171
    • Futura, M.1    Yano, Y.2    Gabazza, E.C.3    Araki-Sasaki, R.4
  • 39
    • 0023392635 scopus 로고
    • The insulin receptor: Molecular biology and transmembrane signaling
    • Goldfine, I. D., The insulin receptor: molecular biology and transmembrane signaling. Endocrin. Rev. 1987, 8, 235-255.
    • (1987) Endocrin. Rev , vol.8 , pp. 235-255
    • Goldfine, I.D.1
  • 40
    • 0025945012 scopus 로고
    • Insulin resistance: Mechanisms,syndromes and implications. New Eng
    • Moller, D. E., Flier, J. S., Insulin resistance: Mechanisms,syndromes and implications. New Eng. J. Med. 1991, 325,938-948.
    • (1991) J. Med , vol.325 , pp. 938-948
    • Moller, D.E.1    Flier, J.S.2
  • 41
    • 0027953703 scopus 로고
    • Banting Lecture. Insulin action, diabetogenes,and the cause of type 2 diabetes
    • Kahn, C. R., Banting Lecture. Insulin action, diabetogenes,and the cause of type 2 diabetes. Diabetes 1994, 43,1066-1084.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 42
    • 1842579975 scopus 로고    scopus 로고
    • Oxidative stress impairs skeletal muscle repair in diabetic rats
    • Aragno, M., Mastrocola, R., Catalano, M. G., Brignardello, E.et al., Oxidative stress impairs skeletal muscle repair in diabetic rats. Diabetes 2004, 53, 1082-1088.
    • (2004) Diabetes , vol.53 , pp. 1082-1088
    • Aragno, M.1    Mastrocola, R.2    Catalano, M.G.3    Brignardello, E.4
  • 43
    • 0031739726 scopus 로고    scopus 로고
    • Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophospha mide-accelerated diabetes
    • Augstein, P., Elefanty, A. G., Allison, J., Harrison, L.C.Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophospha mide-accelerated diabetes. Diabetologia 1998, 41,1381-1388.
    • (1998) Diabetologia , vol.41 , pp. 1381-1388
    • Augstein, P.1    Elefanty, A.G.2    Allison, J.3    Harrison, L.C.4
  • 44
    • 33645241629 scopus 로고    scopus 로고
    • Chronic administration of stasuma mandarin fruit (Citrus unshiu MARC.) improves oxidative stress in streptozotocin-induced diabetic rat liver
    • Sigiura, M., Ohshima, M., Ogawa, K., Yano, M., Chronic administration of stasuma mandarin fruit (Citrus unshiu MARC.) improves oxidative stress in streptozotocin-induced diabetic rat liver. Biol. Pharm. Bull. 2006, 29, 588-591.
    • (2006) Biol. Pharm. Bull , vol.29 , pp. 588-591
    • Sigiura, M.1    Ohshima, M.2    Ogawa, K.3    Yano, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.