Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis

International Journal of Molecular Medicine

Volumn 35, Issue 2, 2015, Pages 405-412

  Lee, Jong Seok ^a,b   Kim, Young Rae ^b   Song, In Gyu ^b   Ha, Suk Jin ^b   Kim, Young Eon ^c   Baek, Nam In ^d   Hong, Eock Kee ^b  

^a National Institute of Biological Resources   (South Korea)

^b Kangwon National University   (South Korea)

^c Korea Food Research Institute   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Anthocyanin; Apoptosis; Diabetes; Mulberry; Oxidative stress

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CYANIDIN 3 GLUCOSIDE; CYTOCHROME C; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTHOCYANIN; CASP3 PROTEIN, MOUSE; CYANIDIN 3-O-GLUCOSIDE; GLUCOSIDE; OXIDIZING AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; INSULIN RELEASE; LIPID PEROXIDATION; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; MTT ASSAY; MULBERRY; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FRUIT; ISOLATION AND PURIFICATION; METABOLISM; MORUS; SIGNAL TRANSDUCTION;

ANIMALS; ANTHOCYANINS; APOPTOSIS; CASPASE 3; CELL LINE; DNA FRAGMENTATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FRUIT; GLUCOSIDES; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; LIPID PEROXIDATION; MAP KINASE SIGNALING SYSTEM; MICE; MORUS; OXIDANTS; OXIDATIVE STRESS;

EID: 84919702968     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.2013     Document Type: Article

References (31)

1. Gray H and O'Rahilly S: Beta cell dysfunction in non-insulin-dependent diabetes mellitus. Transplant Proc 26: 366-370, 1994.
2. Demirseren DD, Emre S, Akoglu G, Arpaci D, Arman A, Metin A and Cakir B: Relationship between skin diseases and extracutaneous complications of diabetes mellitus: clinical analysis of 750 patients. Am J Clin Dermatol 15: 65-70, 2014.
3. Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y, Qi Y, Han X and Peng J: Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. Food Chem Toxicol 59: 657-669, 2013.
4. Ni Q, Xu G, Gao Q, Yang D and Zhang Y: Evaluation of reactive oxygen species scavenging activities and DNA damage prevention effect of Pleioblastus kongosanensis f. Aureostriatus leaf extract by chemiluminescence assay. J Photochem PhotobiolB 128: 115-121, 2013.
5. Gutierrez RM: Effect of the hexane extract of Piper auritum on insulin release from beta-cell and oxidative stress in streptozotocin-induced diabetic rat. Pharmacogn Mag 8: 308-313, 2012.
6. Mane C, Loonis M, Juhel C, Dufour C and Malien-Aubert C: Food grade lingonberry extract: polyphenolic composition and invivo protective effect against oxidative stress. J Agric Food Chem 59: 3330-3339, 2011.
7. Martin MA, Fernández-Millán E, Ramos S, Bravo L and Goya L: Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress. Mol Nutr Food Res 58: 447-456, 2014.
8. Aramwit P, Petcharat K and Supasyndh O: Efficacy of mulberry leaf tablets in patients with mild dyslipidemia. Phytother Res 25: 365-369, 2011.
9. Song N, Pang W, Yang H, Tan L, Fu J, Li H and Jiang Y: Primary study on protective effect of mulberry extracts on Abeta25-35-induced PC12 cells injury. Wei Sheng Yan Jiu 41: 925-929, 2012 (In Chinese).
10. Stefənuţ MN, Cəta A, Pop R, Tanasie C, Boc D, Ienascu I and Ordodi V: Anti-hyperglycemic effect of bilberry, blackberry and mulberry ultrasonic extracts on diabetic rats. Plant Foods Hum Nutr 68: 378-384, 2013.
11. Chang JJ, Hsu MJ, Huang HP, Chung DJ, Chang YC and Wang CJ: Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance. J Agric Food Chem 61: 6069-6076, 2013.
12. Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL and Hsieh YS: Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235: 248-259, 2006.
13. Jiang Y: Effects of anthocyanins derived from Xinjiang black mulberry fruit on delaying aging. Wei Sheng Yan Jiu 39: 451-453, 2010 (In Chinese).
14. Liu LK, Lee HJ, Shih YW, Chyau CC and Wang CJ: Mulberry anthocyanin extracts inhibit LDL oxidation and macrophage-derived foam cell formation induced by oxidative LDL. J Food Sci 73: H113-H121, 2008.
15. Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358, 1979.
16. Lee JH, Lee JS, Kim YR, Jung WC, Lee KE, Lee SY and Hong EK: Hispidin isolated from Phellinus linteus protects against hydrogen peroxide-induced oxidative stress in pancreatic MIN6N β-cells. J Med Food 14: 1431-1438, 2011.
17. Bian J, Wang K, Kong X, Liu H, Chen F, Hu M, Zhang X, Jiao X, Ge B, Wu Y and Meng S: Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus. Arch Virol 156: 1335-1344, 2011.
18. Haddad JJ: The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK(ERK): discordant proteomic effect of MAPK(p38). Protein Pept Lett 14: 361-371, 2007.
19. Ravindran J, Gupta N, Agrawal M, Bala Bhaskar AS and LakshmanaRao PV: Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 16: 145-161, 2011.
20. Brayman KL, Nakai I, Field J, Lloveras JJ, Farney A, Najarian JS and Sutherland DE: Intrathymic islet allografts prevent hyperglycemia and autoimmune beta-cell destruction in BB rats following transplantation in the prediabetic period. Transplant Proc 25: 284-285, 1993.
21. Nakanishi K and Watanabe C: 2008. Rate of beta-cell destruction in type 1 diabetes influences the development of diabetic retinopathy: protective effect of residual beta-cell function for more than 10 years. J Clin Endocrinol Metab 93: 4759-4766, 2008.
22. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S and Andersen ME: ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol 244: 77-83, 2010.
23. Sasaki T, Unno K, Tahara S and Kaneko T: Age-related increase of reactive oxygen generation in the brains of mammals and birds: is reactive oxygen a signaling molecule to determine the aging process and life span? Geriatr Gerontol Int 10 (Suppl1): S10-S24, 2010.
24. Liu Z, Celotto AM, Romero G, Wipf P and Palladino MJ: Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. Neurobiol Dis 45: 362-368, 2012.
25. Tsedensodnom O and Sadler KC: ROS: redux and paradox in fatty liver disease. Hepatology 58: 1210-1212, 2013.
26. Zhang C, Liu J, Pan H, Yang X and Bian K: Mitochondrial dysfunction induced by excessive ROS/RNS-metabolic cardiovascular disease and traditional Chinese medicines intervention. Zhongguo Zhong Yao Za Zhi 36: 2423-2428, 2011 (In Chinese).
27. Pervaiz S and Clément MV: Hydrogen peroxide-induced apoptosis: oxidative or reductive stress? Methods Enzymol 352: 150-159, 2002.
28. Chen CH, Chen SJ, Su CC, Yen CC, Tseng TJ, Jinn TR, Tang FC, Chen KL, Su YC, Lee KI, Hung DZ and Huang CF: Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. Toxicology 303: 72-82, 2013.
29. Supanji, Shimomachi M, Hasan MZ, Kawaichi M and Oka C: HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res 112: 79-92, 2013.
30. Cargnello M and Roux PP: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75: 50-83, 2011.
31. Fu YC, Yin SC, Chi CS, Hwang B and Hsu SL: Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway. Apoptosis 11: 2053-2063, 2006.