Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice

Journal of Ethnopharmacology

Volumn 134, Issue 3, 2011, Pages 961-970

  Li, You Gui ^a   Ji, Dong Feng ^a   Zhong, Shi ^a   Lv, Zhi Qiang ^a   Lin, Tian Bao ^a   Chen, Shi ^a   Hu, Gui Yan ^a  

^a INSTITUTE OF PLANT PROTECTION AND MICROBIOLOGY   (China)

Author keywords

1 Deoxynojirimycin; Diabetes mellitus; Mulberry leaves; Polysaccharide

Indexed keywords

1 DEOXYNOJIRIMYCIN; ACARBOSE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOSYLATED HEMOGLOBIN; HYDROXYL RADICAL; INSULIN; INSULIN 1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYSACCHARIDE; SUPEROXIDE; TRANSCRIPTION FACTOR PDX 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; GASTROINTESTINAL MUCOSA; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; MALE; MOUSE; MULBERRY; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PLANT LEAF;

1-DEOXYNOJIRIMYCIN; ALLOXAN; ANIMALS; BASE SEQUENCE; DIABETES MELLITUS, EXPERIMENTAL; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOKINASE; GLUCOSE TOLERANCE TEST; GLUCOSE-6-PHOSPHATASE; HOMEODOMAIN PROTEINS; INSULIN; MALE; MICE; MICE, INBRED ICR; MORUS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PLANT LEAVES; POLYSACCHARIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

MORUS (ANGIOSPERM); MUS;

EID: 79954423419     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.02.009     Document Type: Article

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