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Volumn 37, Issue 2, 2016, Pages 114-125

Re-examining the Nature and Function of Self-Reactive T cells

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; CD1C ANTIGEN; CD5 ANTIGEN; CRE RECOMBINASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; T6 ANTIGEN; TETRAMER; TISSUE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; AUTOANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84983134471     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2015.12.005     Document Type: Review
Times cited : (64)

References (81)
  • 1
    • 84906243997 scopus 로고    scopus 로고
    • The self-obsession of T cells: how TCR signaling thresholds affect fate ‘decisions’ and effector function
    • 1 Hogquist, K.A., Jameson, S.C., The self-obsession of T cells: how TCR signaling thresholds affect fate ‘decisions’ and effector function. Nat. Immunol. 15 (2014), 815–823.
    • (2014) Nat. Immunol. , vol.15 , pp. 815-823
    • Hogquist, K.A.1    Jameson, S.C.2
  • 2
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    • 2 Klein, L., et al. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat. Rev. Immunol. 14 (2014), 377–391.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 377-391
    • Klein, L.1
  • 3
    • 84859388345 scopus 로고    scopus 로고
    • Selection of self-reactive T cells in the thymus
    • 3 Stritesky, G.L., et al. Selection of self-reactive T cells in the thymus. Annu. Rev. Immunol. 30 (2012), 95–114.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 95-114
    • Stritesky, G.L.1
  • 4
    • 74049160009 scopus 로고    scopus 로고
    • Mechanisms maintaining peripheral tolerance
    • 4 Mueller, D.L., Mechanisms maintaining peripheral tolerance. Nat. Immunol. 11 (2010), 21–27.
    • (2010) Nat. Immunol. , vol.11 , pp. 21-27
    • Mueller, D.L.1
  • 5
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • 5 Ota, K., et al. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346 (1990), 183–187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1
  • 6
    • 84930408029 scopus 로고    scopus 로고
    • Mechanisms of human autoimmunity
    • 6 Rosenblum, M.D., et al. Mechanisms of human autoimmunity. J. Clin. Invest. 125 (2015), 2228–2233.
    • (2015) J. Clin. Invest. , vol.125 , pp. 2228-2233
    • Rosenblum, M.D.1
  • 7
    • 84908072032 scopus 로고    scopus 로고
    • Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
    • 7 Ito, Y., et al. Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 346 (2014), 363–368.
    • (2014) Science , vol.346 , pp. 363-368
    • Ito, Y.1
  • 8
    • 84919665688 scopus 로고    scopus 로고
    • + T cells with an anergic phenotype in healthy individuals
    • + T cells with an anergic phenotype in healthy individuals. Science 346 (2014), 1536–1540.
    • (2014) Science , vol.346 , pp. 1536-1540
    • Maeda, Y.1
  • 9
    • 84929676377 scopus 로고    scopus 로고
    • + T lymphocytes
    • + T lymphocytes. Immunity 42 (2015), 929–941.
    • (2015) Immunity , vol.42 , pp. 929-941
    • Yu, W.1
  • 10
    • 84874253445 scopus 로고    scopus 로고
    • + memory-phenotype T cells are abundant in unexposed adults
    • + memory-phenotype T cells are abundant in unexposed adults. Immunity 38 (2013), 373–383.
    • (2013) Immunity , vol.38 , pp. 373-383
    • Su, L.F.1
  • 11
    • 84860346184 scopus 로고    scopus 로고
    • The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude
    • 11 Jenkins, M.K., Moon, J.J., The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J. Immunol. 188 (2012), 4135–4140.
    • (2012) J. Immunol. , vol.188 , pp. 4135-4140
    • Jenkins, M.K.1    Moon, J.J.2
  • 12
    • 65549087573 scopus 로고    scopus 로고
    • + T cell precursor frequency determines the quality of the antitumor immune response
    • + T cell precursor frequency determines the quality of the antitumor immune response. J. Exp. Med. 206 (2009), 849–866.
    • (2009) J. Exp. Med. , vol.206 , pp. 849-866
    • Rizzuto, G.A.1
  • 13
    • 34548038390 scopus 로고    scopus 로고
    • + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27 (2007), 203–213.
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1
  • 14
    • 78449298644 scopus 로고    scopus 로고
    • CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
    • 14 de Jong, A., et al. CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire. Nat. Immunol. 11 (2010), 1102–1109.
    • (2010) Nat. Immunol. , vol.11 , pp. 1102-1109
    • de Jong, A.1
  • 15
    • 79951796594 scopus 로고    scopus 로고
    • High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells
    • 15 de Lalla, C., et al. High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells. Eur. J. Immunol. 41 (2011), 602–610.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 602-610
    • de Lalla, C.1
  • 16
    • 84870266508 scopus 로고    scopus 로고
    • Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
    • 16 Taylor, J.J., et al. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J. Exp. Med. 209 (2012), 2065–2077.
    • (2012) J. Exp. Med. , vol.209 , pp. 2065-2077
    • Taylor, J.J.1
  • 17
    • 56349161598 scopus 로고    scopus 로고
    • B-cell tolerance checkpoints in health and autoimmunity
    • 17 Meffre, E., Wardemann, H., B-cell tolerance checkpoints in health and autoimmunity. Curr. Opin. Immunol. 20 (2008), 632–638.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 632-638
    • Meffre, E.1    Wardemann, H.2
  • 18
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • 18 Kim, J.M., et al. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8 (2007), 191–197.
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1
  • 19
    • 84920976294 scopus 로고    scopus 로고
    • + T-cell responses
    • + T-cell responses. Eur. J. Immunol. 44 (2014), 3621–3631.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 3621-3631
    • Nystrom, S.N.1
  • 20
    • 84940121598 scopus 로고    scopus 로고
    • The contained self-reactive peripheral T cell repertoire: size, diversity, and cellular composition
    • 20 Richards, D.M., et al. The contained self-reactive peripheral T cell repertoire: size, diversity, and cellular composition. J. Immunol. 195 (2015), 2067–2079.
    • (2015) J. Immunol. , vol.195 , pp. 2067-2079
    • Richards, D.M.1
  • 21
    • 0035863825 scopus 로고    scopus 로고
    • Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question
    • 21 Suchin, E.J., et al. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J. Immunol. 166 (2001), 973–981.
    • (2001) J. Immunol. , vol.166 , pp. 973-981
    • Suchin, E.J.1
  • 22
    • 0033008083 scopus 로고    scopus 로고
    • The structural basis of T cell activation by superantigens
    • 22 Li, H.M., et al. The structural basis of T cell activation by superantigens. Annu. Rev. Immunol. 17 (1999), 435–466.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 435-466
    • Li, H.M.1
  • 23
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • 23 Waterhouse, P., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 (1995), 985–988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 24
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
    • 24 Marie, J.C., et al. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25 (2006), 441–454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1
  • 25
    • 84947441287 scopus 로고    scopus 로고
    • + T cell tolerance to tissue-restricted self-antigens is mediated by antigen-specific regulatory T cells rather than deletion
    • + T cell tolerance to tissue-restricted self-antigens is mediated by antigen-specific regulatory T cells rather than deletion. Immunity 43 (2015), 896–908.
    • (2015) Immunity , vol.43 , pp. 896-908
    • Legoux, F.P.1
  • 26
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • 26 Zehn, D., Bevan, M.J., T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25 (2006), 261–270.
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 28
    • 84870280593 scopus 로고    scopus 로고
    • Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
    • 28 Enouz, S., et al. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J. Exp. Med. 209 (2012), 1769–1779.
    • (2012) J. Exp. Med. , vol.209 , pp. 1769-1779
    • Enouz, S.1
  • 29
    • 84867777146 scopus 로고    scopus 로고
    • + T cells specifically regulate the frequency of individual antigen-reactive T cells
    • + T cells specifically regulate the frequency of individual antigen-reactive T cells. Immunity 37 (2012), 735–746.
    • (2012) Immunity , vol.37 , pp. 735-746
    • Singh, N.J.1
  • 30
    • 84921278229 scopus 로고    scopus 로고
    • T cell receptor cross-reactivity between similar foreign and self-peptides influences naive cell population size and autoimmunity
    • 30 Nelson, R.W., et al. T cell receptor cross-reactivity between similar foreign and self-peptides influences naive cell population size and autoimmunity. Immunity 42 (2015), 95–107.
    • (2015) Immunity , vol.42 , pp. 95-107
    • Nelson, R.W.1
  • 31
    • 84901295133 scopus 로고    scopus 로고
    • Deconstructing the peptide-MHC specificity of T cell recognition
    • 31 Birnbaum, M.E., et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157 (2014), 1073–1087.
    • (2014) Cell , vol.157 , pp. 1073-1087
    • Birnbaum, M.E.1
  • 32
    • 84924610426 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Immunol. 194 (2015), 2531–2538.
    • (2015) J. Immunol. , vol.194 , pp. 2531-2538
    • Eugster, A.1
  • 33
    • 84855497162 scopus 로고    scopus 로고
    • A single autoimmune T cell receptor recognizes more than a million different peptides
    • 33 Wooldridge, L., et al. A single autoimmune T cell receptor recognizes more than a million different peptides. J. Biol. Chem. 287 (2012), 1168–1177.
    • (2012) J. Biol. Chem. , vol.287 , pp. 1168-1177
    • Wooldridge, L.1
  • 34
    • 84947444776 scopus 로고    scopus 로고
    • Crossreactive αβ T cell receptors are the predominant targets of thymocyte negative selection
    • 34 McDonald, B.D., et al. Crossreactive αβ T cell receptors are the predominant targets of thymocyte negative selection. Immunity 43 (2015), 859–869.
    • (2015) Immunity , vol.43 , pp. 859-869
    • McDonald, B.D.1
  • 35
    • 84927652023 scopus 로고    scopus 로고
    • Dynamic tuning of lymphocytes: physiological basis, mechanisms, and function
    • 35 Grossman, Z., Paul, W.E., Dynamic tuning of lymphocytes: physiological basis, mechanisms, and function. Annu. Rev. Immunol. 33 (2015), 677–713.
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 677-713
    • Grossman, Z.1    Paul, W.E.2
  • 36
    • 0034889233 scopus 로고    scopus 로고
    • + T cells without selection of higher affinity TCR
    • + T cells without selection of higher affinity TCR. Nat. Immunol. 2 (2001), 711–717.
    • (2001) Nat. Immunol. , vol.2 , pp. 711-717
    • Slifka, M.K.1    Whitton, J.L.2
  • 37
    • 84894447120 scopus 로고    scopus 로고
    • + T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self-peptide and MHC
    • + T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self-peptide and MHC. Nat. Immunol. 15 (2014), 266–274.
    • (2014) Nat. Immunol. , vol.15 , pp. 266-274
    • Persaud, S.P.1
  • 38
    • 84874244135 scopus 로고    scopus 로고
    • T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens
    • 38 Mandl, J.N., et al. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity 38 (2013), 263–274.
    • (2013) Immunity , vol.38 , pp. 263-274
    • Mandl, J.N.1
  • 39
    • 84924979971 scopus 로고    scopus 로고
    • + T cells to respond to foreign antigens
    • + T cells to respond to foreign antigens. Nat. Immunol. 16 (2015), 107–117.
    • (2015) Nat. Immunol. , vol.16 , pp. 107-117
    • Fulton, R.B.1
  • 40
    • 84915747866 scopus 로고    scopus 로고
    • Optimal T-cell receptor affinity for inducing autoimmunity
    • 40 Koehli, S., et al. Optimal T-cell receptor affinity for inducing autoimmunity. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 17248–17253.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 17248-17253
    • Koehli, S.1
  • 41
    • 84924988088 scopus 로고    scopus 로고
    • CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens
    • 41 Henderson, J.G., et al. CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. Immunity 42 (2015), 471–483.
    • (2015) Immunity , vol.42 , pp. 471-483
    • Henderson, J.G.1
  • 42
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in T-reg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • 42 Moran, A.E., et al. T cell receptor signal strength in T-reg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208 (2011), 1279–1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 43
    • 84875257845 scopus 로고    scopus 로고
    • Murine thymic selection quantified using a unique method to capture deleted T cells
    • 43 Stritesky, G.L., et al. Murine thymic selection quantified using a unique method to capture deleted T cells. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 4679–4684.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 4679-4684
    • Stritesky, G.L.1
  • 44
    • 84907228126 scopus 로고    scopus 로고
    • A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
    • 44 Au-Yeung, B.B., et al. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), E3679–E3688.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. E3679-E3688
    • Au-Yeung, B.B.1
  • 45
    • 58749109022 scopus 로고    scopus 로고
    • Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire
    • 45 Wolfl, M., et al. Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire. J. Immunol. 181 (2008), 6435–6446.
    • (2008) J. Immunol. , vol.181 , pp. 6435-6446
    • Wolfl, M.1
  • 46
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • 46 Stefanova, I., et al. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420 (2002), 429–434.
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanova, I.1
  • 47
    • 34247118771 scopus 로고    scopus 로고
    • Molecular mimicry and auto-immunity
    • 47 Blank, M., et al. Molecular mimicry and auto-immunity. Clin. Rev. Allergy Immunol. 32 (2007), 111–118.
    • (2007) Clin. Rev. Allergy Immunol. , vol.32 , pp. 111-118
    • Blank, M.1
  • 48
    • 84940930030 scopus 로고    scopus 로고
    • Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site
    • 48 Horai, R., et al. Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site. Immunity 43 (2015), 343–353.
    • (2015) Immunity , vol.43 , pp. 343-353
    • Horai, R.1
  • 49
    • 84885063645 scopus 로고    scopus 로고
    • CNS-specific T cells shape brain function via the choroid plexus
    • 49 Baruch, K., Schwartz, M., CNS-specific T cells shape brain function via the choroid plexus. Brain Behav. Immun. 34 (2013), 11–16.
    • (2013) Brain Behav. Immun. , vol.34 , pp. 11-16
    • Baruch, K.1    Schwartz, M.2
  • 50
    • 84866391516 scopus 로고    scopus 로고
    • Pro-cognitive properties of T cells
    • 50 Kipnis, J., et al. Pro-cognitive properties of T cells. Nat. Rev. Immunol. 12 (2012), 662–668.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 662-668
    • Kipnis, J.1
  • 51
    • 84904301649 scopus 로고    scopus 로고
    • Protective autoimmunity: a unifying model for the immune network involved in CNS repair
    • 51 Schwartz, M., Raposo, C., Protective autoimmunity: a unifying model for the immune network involved in CNS repair. Neuroscientist 20 (2014), 343–358.
    • (2014) Neuroscientist , vol.20 , pp. 343-358
    • Schwartz, M.1    Raposo, C.2
  • 52
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • 52 Moalem, G., et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5 (1999), 49–55.
    • (1999) Nat. Med. , vol.5 , pp. 49-55
    • Moalem, G.1
  • 53
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • 53 Zamvil, S.S., Steinman, L., The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8 (1990), 579–621.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 54
    • 13544261413 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Blood 105 (2005), 1484–1491.
    • (2005) Blood , vol.105 , pp. 1484-1491
    • Monteiro, J.P.1
  • 55
    • 65549105119 scopus 로고    scopus 로고
    • A role for human skin-resident T cells in wound healing
    • 55 Toulon, A., et al. A role for human skin-resident T cells in wound healing. J. Exp. Med. 206 (2009), 743–750.
    • (2009) J. Exp. Med. , vol.206 , pp. 743-750
    • Toulon, A.1
  • 56
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • 56 Feuerer, M., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15 (2009), 930–939.
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1
  • 57
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • 57 Cipolletta, D., et al. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486 (2012), 549–553.
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1
  • 58
    • 84890050252 scopus 로고    scopus 로고
    • A special population of regulatory T cells potentiates muscle repair
    • 58 Burzyn, D., et al. A special population of regulatory T cells potentiates muscle repair. Cell 155 (2013), 1282–1295.
    • (2013) Cell , vol.155 , pp. 1282-1295
    • Burzyn, D.1
  • 59
    • 84940380928 scopus 로고    scopus 로고
    • A distinct function of regulatory T cells in tissue protection
    • 59 Arpaia, N., et al. A distinct function of regulatory T cells in tissue protection. Cell 162 (2015), 1078–1089.
    • (2015) Cell , vol.162 , pp. 1078-1089
    • Arpaia, N.1
  • 60
    • 51149085208 scopus 로고    scopus 로고
    • Nature and functions of autoantibodies
    • 60 Elkon, K., Casali, P., Nature and functions of autoantibodies. Nat. Clin. Pract. Rheumatol. 4 (2008), 491–498.
    • (2008) Nat. Clin. Pract. Rheumatol. , vol.4 , pp. 491-498
    • Elkon, K.1    Casali, P.2
  • 61
    • 84856568116 scopus 로고    scopus 로고
    • Natural IgM in immune equilibrium and harnessing their therapeutic potential
    • 61 Kaveri, S.V., et al. Natural IgM in immune equilibrium and harnessing their therapeutic potential. J. Immunol. 188 (2012), 939–945.
    • (2012) J. Immunol. , vol.188 , pp. 939-945
    • Kaveri, S.V.1
  • 62
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • 62 Hsieh, C.S., et al. Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 12 (2012), 157–167.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 157-167
    • Hsieh, C.S.1
  • 63
    • 84907982768 scopus 로고    scopus 로고
    • Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
    • 63 Perry, J.S., et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 41 (2014), 414–426.
    • (2014) Immunity , vol.41 , pp. 414-426
    • Perry, J.S.1
  • 64
    • 36749031198 scopus 로고    scopus 로고
    • + regulatory T cells in the NOD mouse model of autoimmune diabetes
    • + regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 104 (2007), 18181–18186.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 18181-18186
    • Feuerer, M.1
  • 65
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • 65 Ohkura, N., et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37 (2012), 785–799.
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1
  • 66
    • 84921729777 scopus 로고    scopus 로고
    • Transcriptional control of regulatory T cells
    • 66 Delacher, M., et al. Transcriptional control of regulatory T cells. Curr. Top. Microbiol. Immunol. 381 (2014), 83–124.
    • (2014) Curr. Top. Microbiol. Immunol. , vol.381 , pp. 83-124
    • Delacher, M.1
  • 67
    • 84928581675 scopus 로고    scopus 로고
    • Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • 67 Yang, S., et al. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 348 (2015), 589–594.
    • (2015) Science , vol.348 , pp. 589-594
    • Yang, S.1
  • 68
    • 84947441940 scopus 로고    scopus 로고
    • A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes
    • 68 Scharschmidt, T.C., et al. A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes. Immunity 43 (2015), 1011–1021.
    • (2015) Immunity , vol.43 , pp. 1011-1021
    • Scharschmidt, T.C.1
  • 69
    • 84928407438 scopus 로고    scopus 로고
    • Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice
    • 69 Kolodin, D., et al. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 21 (2015), 543–557.
    • (2015) Cell Metab. , vol.21 , pp. 543-557
    • Kolodin, D.1
  • 70
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • 70 Hodi, F.S., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363 (2010), 711–723.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 71
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • 71 Topalian, S.L., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366 (2012), 2443–2454.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 72
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • 72 Wolchok, J.D., et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369 (2013), 122–133.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 73
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • 73 Rosenberg, S.A., Restifo, N.P., Adoptive cell transfer as personalized immunotherapy for human cancer. Science 348 (2015), 62–68.
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 74
    • 84937846973 scopus 로고    scopus 로고
    • Evolving synergistic combinations of targeted immunotherapies to combat cancer
    • 74 Melero, I., et al. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat. Rev. Cancer 15 (2015), 457–472.
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 457-472
    • Melero, I.1
  • 75
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • 75 Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 76
    • 84941343279 scopus 로고    scopus 로고
    • Releasing the brakes on cancer immunotherapy
    • 76 Littman, D.R., Releasing the brakes on cancer immunotherapy. Cell 162 (2015), 1186–1190.
    • (2015) Cell , vol.162 , pp. 1186-1190
    • Littman, D.R.1
  • 77
    • 84957836940 scopus 로고    scopus 로고
    • Immune response to cancer therapy: mounting an effective antitumor response and mechanisms of resistance
    • 77 Medler, T.R., et al. Immune response to cancer therapy: mounting an effective antitumor response and mechanisms of resistance. Trends Cancer 1 (2015), 66–75.
    • (2015) Trends Cancer , vol.1 , pp. 66-75
    • Medler, T.R.1
  • 78
    • 84905503399 scopus 로고    scopus 로고
    • Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1
    • 78 Kong, Y.C., Flynn, J.C., Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1. Front. Immunol., 5, 2014, 206.
    • (2014) Front. Immunol. , vol.5 , pp. 206
    • Kong, Y.C.1    Flynn, J.C.2
  • 79
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • 79 Josefowicz, S.Z., et al. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30 (2012), 531–564.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1
  • 80
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • 80 Klatzmann, D., Abbas, A.K., The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat. Rev. Immunol. 15 (2015), 283–294.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2


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