메뉴 건너뛰기




Volumn 37, Issue 11, 2014, Pages 833-840

Apolipoprotein E in synaptic plasticity and alzheimer’s disease: Potential cellular and molecular mechanisms

Author keywords

Alzheimer s disease; ApoER2; Apolipoprotein E; HSPG; LRP1; Synaptic plasticity

Indexed keywords

APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SYNDECAN; AMYLOID BETA PROTEIN;

EID: 84983071309     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2014.0248     Document Type: Review
Times cited : (108)

References (96)
  • 2
    • 77950641320 scopus 로고    scopus 로고
    • Differential effects of ApoE isoforms on dendritic spines in vivo: Linking an Alzheimer’s disease risk factor with synaptic alterations
    • Basak, J.M., and Kim, J. (2010). Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer’s disease risk factor with synaptic alterations. J. Neurosci. 30, 4526-4527.
    • (2010) J. Neurosci. , vol.30 , pp. 4526-4527
    • Basak, J.M.1    Kim, J.2
  • 3
    • 84858423000 scopus 로고    scopus 로고
    • Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice
    • Bien-Ly, N., Gillespie, A.K., Walker, D., Yoon, S.Y., and Huang, Y. (2012). Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J. Neurosci. 32, 4803-4811.
    • (2012) J. Neurosci. , vol.32 , pp. 4803-4811
    • Bien-Ly, N.1    Gillespie, A.K.2    Walker, D.3    Yoon, S.Y.4    Huang, Y.5
  • 5
    • 43449117577 scopus 로고    scopus 로고
    • Balancing structure and function at hippocampal dendritic spines
    • Bourne, J.N., and Harris, K.M. (2008). Balancing structure and function at hippocampal dendritic spines. Annu. Rev. Neurosci. 31, 47-67.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 47-67
    • Bourne, J.N.1    Harris, K.M.2
  • 6
    • 0033564771 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration
    • Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R.E., Wyss-Coray, T., Mucke, L., and Mahley, R.W. (1999). Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J. Neurosci. 19, 4867-4880.
    • (1999) J. Neurosci. , vol.19 , pp. 4867-4880
    • Buttini, M.1    Orth, M.2    Bellosta, S.3    Akeefe, H.4    Pitas, R.E.5    Wyss-Coray, T.6    Mucke, L.7    Mahley, R.W.8
  • 7
    • 0034077821 scopus 로고    scopus 로고
    • Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice
    • Cambon, K., Davies, H.A., and Stewart, M.G. (2000). Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice. Neuroscience 97, 685-692.
    • (2000) Neuroscience , vol.97 , pp. 685-692
    • Cambon, K.1    Davies, H.A.2    Stewart, M.G.3
  • 9
    • 58149389019 scopus 로고    scopus 로고
    • Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3
    • Chai, X., Forster, E., Zhao, S., Bock, H.H., and Frotscher, M. (2009). Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J. Neurosci. 29, 288-299.
    • (2009) J. Neurosci. , vol.29 , pp. 288-299
    • Chai, X.1    Forster, E.2    Zhao, S.3    Bock, H.H.4    Frotscher, M.5
  • 10
    • 29444436680 scopus 로고    scopus 로고
    • Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
    • Chang, S., ran Ma, T., Miranda, R.D., Balestra, M.E., Mahley, R.W., and Huang, Y. (2005). Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc. Natl. Acad. Sci. USA 102, 18694-18699.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18694-18699
    • Chang, S.1    Ran Ma, T.2    Miranda, R.D.3    Balestra, M.E.4    Mahley, R.W.5    Huang, Y.6
  • 11
    • 77955350021 scopus 로고    scopus 로고
    • ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
    • Chen, Y., Durakoglugil, M.S., Xian, X. and Herz, J. (2010). ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc. Natl. Acad. Sci. USA 107, 12011-12016.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12011-12016
    • Chen, Y.1    Durakoglugil, M.S.2    Xian, X.3    Herz, J.4
  • 12
    • 42349091996 scopus 로고    scopus 로고
    • Actin in action: The interplay between the actin cytoskeleton and synaptic efficacy
    • Cingolani, L.A., and Goda, Y. (2008). Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. Nat. Rev. Neurosci. 9, 344-356.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 344-356
    • Cingolani, L.A.1    Goda, Y.2
  • 16
    • 0032512634 scopus 로고    scopus 로고
    • A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins
    • DeMattos, R.B., Curtiss, L.K., and Williams, D.L. (1998). A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins. J. Biol. Chem. 273, 4206-4212.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4206-4212
    • DeMattos, R.B.1    Curtiss, L.K.2    Williams, D.L.3
  • 17
    • 3543104951 scopus 로고    scopus 로고
    • Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • Dietschy, J.M., and Turley, S.D. (2004). Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397.
    • (2004) J. Lipid Res. , vol.45 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 19
    • 0033535040 scopus 로고    scopus 로고
    • Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons
    • Ethell, I.M., and Yamaguchi, Y. (1999). Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J. Cell Biol. 144, 575-586.
    • (1999) J. Cell Biol. , vol.144 , pp. 575-586
    • Ethell, I.M.1    Yamaguchi, Y.2
  • 21
    • 0029958248 scopus 로고    scopus 로고
    • Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
    • Fagan, A.M., Bu, G., Sun, Y., Daugherty, A., and Holtzman, D.M. (1996). Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271, 30121-30125.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30121-30125
    • Fagan, A.M.1    Bu, G.2    Sun, Y.3    Daugherty, A.4    Holtzman, D.M.5
  • 22
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer, L.A., Cupples, L.A., Haines, J.L., Hyman, B., Kukull, W.A., Mayeux, R., Myers, R.H., Pericak-Vance, M.A., Risch, N., and van Duijn, C.M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278, 1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    Van Duijn, C.M.10
  • 23
    • 77952549757 scopus 로고    scopus 로고
    • Targeting Abeta and tau in Alzheimer’s disease, an early interim report
    • Golde, T.E., Petrucelli, L., and Lewis, J. (2010). Targeting Abeta and tau in Alzheimer’s disease, an early interim report. Exp. Neurol. 223, 252-266.
    • (2010) Exp. Neurol. , vol.223 , pp. 252-266
    • Golde, T.E.1    Petrucelli, L.2    Lewis, J.3
  • 24
    • 0028790904 scopus 로고
    • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
    • Gordon, I., Grauer, E., Genis, I., Sehayek, E., and Michaelson, D.M. (1995). Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci. Lett. 199, 1-4.
    • (1995) Neurosci. Lett. , vol.199 , pp. 1-4
    • Gordon, I.1    Grauer, E.2    Genis, I.3    Sehayek, E.4    Michaelson, D.M.5
  • 25
    • 15744378392 scopus 로고    scopus 로고
    • Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
    • Grootendorst, J., Bour, A., Vogel, E., Kelche, C., Sullivan, P.M., Dodart, J.-C., Bales, K., and Mathis, C. (2005) Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav. Brain Res. 159, 1-14.
    • (2005) Behav. Brain Res. , vol.159 , pp. 1-14
    • Grootendorst, J.1    Bour, A.2    Vogel, E.3    Kelche, C.4    Sullivan, P.M.5    Dodart, J.-C.6    Bales, K.7    Mathis, C.8
  • 26
    • 58149225472 scopus 로고    scopus 로고
    • Microtubules in dendritic spine development
    • Gu, J., Firestein, B.L., and Zheng, J.Q. (2008). Microtubules in dendritic spine development. J. Neurosci. 28, 12120-12124.
    • (2008) J. Neurosci. , vol.28 , pp. 12120-12124
    • Gu, J.1    Firestein, B.L.2    Zheng, J.Q.3
  • 27
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer’s amyloid betapeptide
    • Haass, C., and Selkoe, D.J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid betapeptide. Nat. Rev. Mol. Cell Biol. 8, 101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 28
    • 0034870449 scopus 로고    scopus 로고
    • Behavioral phenotyping of GFAPApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer’s-like neuropathology
    • Hartman, R.E., Wozniak, D.F., Nardi, A., Olney, J.W., Sartorius, L., and Holtzman, D.M. (2001). Behavioral phenotyping of GFAPApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer’s-like neuropathology. Exp. Neurol. 170, 326-344.
    • (2001) Exp. Neurol. , vol.170 , pp. 326-344
    • Hartman, R.E.1    Wozniak, D.F.2    Nardi, A.3    Olney, J.W.4    Sartorius, L.5    Holtzman, D.M.6
  • 29
    • 34248232920 scopus 로고    scopus 로고
    • Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons
    • Hoe, H.S., Freeman, J., and Rebeck, G.W. (2006). Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons. Mol. Neurodegener. 1, 18.
    • (2006) Mol. Neurodegener. , vol.1 , pp. 18
    • Hoe, H.S.1    Freeman, J.2    Rebeck, G.W.3
  • 30
    • 0028822219 scopus 로고
    • Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
    • Holtzman, D.M., Pitas, R.E., Kilbridge, J., Nathan, B., Mahley, R.W., Bu, G., and Schwartz, A.L. (1995). Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA 92, 9480-9484.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3    Nathan, B.4    Mahley, R.W.5    Bu, G.6    Schwartz, A.L.7
  • 31
    • 58149272090 scopus 로고    scopus 로고
    • Activity-dependent dynamic microtubule invasion of dendritic spines
    • Hu, X., Viesselmann, C., Nam, S., Merriam, E., and Dent, E.W. (2008). Activity-dependent dynamic microtubule invasion of dendritic spines. J. Neurosci. 28, 13094-13105.
    • (2008) J. Neurosci. , vol.28 , pp. 13094-13105
    • Hu, X.1    Viesselmann, C.2    Nam, S.3    Merriam, E.4    Dent, E.W.5
  • 34
    • 0032577695 scopus 로고    scopus 로고
    • Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4
    • Ji, Z.S., Pitas, R.E., and Mahley, R.W. (1998). Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4. J. Biol. Chem. 273, 13452-13460.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13452-13460
    • Ji, Z.S.1    Pitas, R.E.2    Mahley, R.W.3
  • 35
    • 0242403213 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients
    • Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D.M., and Wisniewski, T. (2003). Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients. Neuro Sci. 122, 305-315.
    • (2003) Neuro Sci. , vol.122 , pp. 305-315
    • Ji, Y.1    Gong, Y.2    Gan, W.3    Beach, T.4    Holtzman, D.M.5    Wisniewski, T.6
  • 38
    • 68249134074 scopus 로고    scopus 로고
    • ). The role of apolipoprotein E in Alzheimer’s disease
    • Kim, J., Basak, J.M., and Holtzman, D.M. (2009a). The role of apolipoprotein E in Alzheimer’s disease. Neuron 63, 287-303.
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 39
    • 71449125786 scopus 로고    scopus 로고
    • Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A[beta] clearance
    • Kim, J., Castellano, J.M., Jiang, H., Basak, J.M., Parsadanian, M., Pham, V., Mason, S.M., Paul, S.M., and Holtzman, D.M. (2009b). Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A[beta] clearance. Neuron 64, 632-644.
    • (2009) Neuron , vol.64 , pp. 632-644
    • Kim, J.1    Castellano, J.M.2    Jiang, H.3    Basak, J.M.4    Parsadanian, M.5    Pham, V.6    Mason, S.M.7    Paul, S.M.8    Holtzman, D.M.9
  • 40
    • 83055160869 scopus 로고    scopus 로고
    • Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis
    • Kim, J., Jiang, H., Park, S., Eltorai, A., Stewart, F., Yoon, H., Basak, J.M., Finn, M.B., and Holtzman, D.M. (2011). Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. J. Neurosci. 31, 18007-18012.
    • (2011) J. Neurosci. , vol.31 , pp. 18007-18012
    • Kim, J.1    Jiang, H.2    Park, S.3    Eltorai, A.4    Stewart, F.5    Yoon, H.6    Basak, J.M.7    Finn, M.B.8    Holtzman, D.M.9
  • 42
    • 84860377430 scopus 로고    scopus 로고
    • MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
    • Kim, J., Yoon, H., Ramírez, C., Lee, S., Hoe, H., Fernández-Hernando, C., and Kim, J. (2012b). miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483.
    • (2012) Exp. Neurol. , vol.235 , pp. 476-483
    • Kim, J.1    Yoon, H.2    Ramírez, C.3    Lee, S.4    Hoe, H.5    Fernández-Hernando, C.6    Kim, J.7
  • 43
    • 0030050980 scopus 로고    scopus 로고
    • Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
    • Kinnunen, T., Raulo, E., Nolo, R., Maccarana, M., Lindahl, U., and Rauvala, H. (1996). Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. J. Biol. Chem. 271, 2243-2248.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2243-2248
    • Kinnunen, T.1    Raulo, E.2    Nolo, R.3    Maccarana, M.4    Lindahl, U.5    Rauvala, H.6
  • 44
    • 0032562591 scopus 로고    scopus 로고
    • Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth
    • Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H.B., and Rauvala, H. (1998). Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J. Biol. Chem. 273, 10702-10708.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10702-10708
    • Kinnunen, T.1    Kaksonen, M.2    Saarinen, J.3    Kalkkinen, N.4    Peng, H.B.5    Rauvala, H.6
  • 45
    • 4644298544 scopus 로고    scopus 로고
    • Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E
    • Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., and Nukina, N. (2004). Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. Neurosci. Lett. 369, 173-178.
    • (2004) Neurosci. Lett. , vol.369 , pp. 173-178
    • Kitamura, H.W.1    Hamanaka, H.2    Watanabe, M.3    Wada, K.4    Yamazaki, C.5    Fujita, S.C.6    Manabe, T.7    Nukina, N.8
  • 46
    • 77949399837 scopus 로고    scopus 로고
    • Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP
    • Kornecook, T.J., McKinney, A.P., Ferguson, M.T., and Dodart, J.C. (2010). Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP. Genes Brain Behav. 9, 182-192.
    • (2010) Genes Brain Behav. , vol.9 , pp. 182-192
    • Kornecook, T.J.1    McKinney, A.P.2    Ferguson, M.T.3    Dodart, J.C.4
  • 47
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal, R.C., Herz, J., Weisgraber, K.H., Mahley, R.W., Brown, M.S., and Goldstein, J.L. (1990). Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J. Biol. Chem. 265, 10771-10779.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10771-10779
    • Kowal, R.C.1    Herz, J.2    Weisgraber, K.H.3    Mahley, R.W.4    Brown, M.S.5    Goldstein, J.L.6
  • 48
    • 70350463625 scopus 로고    scopus 로고
    • Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity
    • Kramar, E.A., Chen, L.Y., Brandon, N.J., Rex, C.S., Liu, F., Gall, C.M., and Lynch, G. (2009). Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity. J. Neurosci. 29, 12982-12993.
    • (2009) J. Neurosci. , vol.29 , pp. 12982-12993
    • Kramar, E.A.1    Chen, L.Y.2    Brandon, N.J.3    Rex, C.S.4    Liu, F.5    Gall, C.M.6    Lynch, G.7
  • 50
    • 84907364703 scopus 로고    scopus 로고
    • More than cholesterol transporters: Lipoprotein receptors in CNS function and neurodegeneration
    • Lane-Donovan, C., Philips, Gary T., and Herz, J. (2014). More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83, 771-787.
    • (2014) Neuron , vol.83 , pp. 771-787
    • Lane-Donovan, C.1    Philips, G.T.2    Herz, J.3
  • 51
    • 0043095312 scopus 로고    scopus 로고
    • Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
    • Lanz, T.A., Carter, D.B., and Merchant, K.M. (2003). Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol. Dis. 13, 246-253.
    • (2003) Neurobiol. Dis. , vol.13 , pp. 246-253
    • Lanz, T.A.1    Carter, D.B.2    Merchant, K.M.3
  • 52
    • 84901008874 scopus 로고    scopus 로고
    • Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis
    • Liao, F., Hori, Y., Hudry, E., Bauer, A.Q., Jiang, H., Mahan, T.E., Lefton, K.B., Zhang, T.J., Dearborn, J.T., Kim, J., et al. (2014). Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis. J. Neurosci. 34, 7281-7292.
    • (2014) J. Neurosci. , vol.34 , pp. 7281-7292
    • Liao, F.1    Hori, Y.2    Hudry, E.3    Bauer, A.Q.4    Jiang, H.5    Mahan, T.E.6    Lefton, K.B.7    Zhang, T.J.8    Dearborn, J.T.9    Kim, J.10
  • 54
    • 84872713614 scopus 로고    scopus 로고
    • Apolipoprotein e sets the stage: Response to injury triggers neuropathology
    • Mahley, R.W., and Huang, Y. (2012). Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron 76, 871-885.
    • (2012) Neuron , vol.76 , pp. 871-885
    • Mahley, R.W.1    Huang, Y.2
  • 56
    • 4544310410 scopus 로고    scopus 로고
    • Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model
    • Mann, K.M., Thorngate, F.E., Katoh-Fukui, Y., Hamanaka, H., Williams, D.L., Fujita, S., and Lamb, B.T. (2004). Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Hum. Mol. Genet. 13, 1959-1968.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 1959-1968
    • Mann, K.M.1    Thorngate, F.E.2    Katoh-Fukui, Y.3    Hamanaka, H.4    Williams, D.L.5    Fujita, S.6    Lamb, B.T.7
  • 57
    • 0030948449 scopus 로고    scopus 로고
    • Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE
    • Masliah, E., Samuel, W., Veinbergs, I., Mallory, M., Mante, M., and Saitoh, T. (1997). Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE. Brain Res. 751, 307-314.
    • (1997) Brain Res. , vol.751 , pp. 307-314
    • Masliah, E.1    Samuel, W.2    Veinbergs, I.3    Mallory, M.4    Mante, M.5    Saitoh, T.6
  • 60
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., and Ikeda, K. (1991). Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541, 163-166.
    • (1991) Brain Res. , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 61
    • 0031030661 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development
    • Narita, M., Bu, G., Holtzman, D.M., and Schwartz, A.L. (1997). The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. J. Neurochem. 68, 587-595.
    • (1997) J. Neurochem. , vol.68 , pp. 587-595
    • Narita, M.1    Bu, G.2    Holtzman, D.M.3    Schwartz, A.L.4
  • 62
  • 63
    • 0037154858 scopus 로고    scopus 로고
    • Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
    • Nathan, B.P., Jiang, Y., Wong, G.K., Shen, F., Brewer, G.J., and Struble, R.G. (2002). Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 928, 96-105.
    • (2002) Brain Res. , vol.928 , pp. 96-105
    • Nathan, B.P.1    Jiang, Y.2    Wong, G.K.3    Shen, F.4    Brewer, G.J.5    Struble, R.G.6
  • 64
    • 67649774919 scopus 로고    scopus 로고
    • Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice
    • Nichol, K., Deeny, S.P., Seif, J., Camaclang, K., and Cotman, C.W. (2009). Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement 5, 287-294.
    • (2009) Alzheimers Dement , vol.5 , pp. 287-294
    • Nichol, K.1    Deeny, S.P.2    Seif, J.3    Camaclang, K.4    Cotman, C.W.5
  • 65
    • 55249114701 scopus 로고    scopus 로고
    • The reelin signaling pathway promotes dendritic spine development in hippocampal neurons
    • Niu, S., Yabut, O., and D’Arcangelo, G. (2008). The reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J. Neurosci. 28, 10339-10348.
    • (2008) J. Neurosci. , vol.28 , pp. 10339-10348
    • Niu, S.1    Yabut, O.2    D’Arcangelo, G.3
  • 66
    • 83055160677 scopus 로고    scopus 로고
    • The APOE4 conundrum
    • Osherovich, L. (2009). The APOE4 conundrum. SciBX 2, 1-3.
    • (2009) SciBX , vol.2 , pp. 1-3
    • Osherovich, L.1
  • 68
    • 47649093892 scopus 로고    scopus 로고
    • Dendritic spine dynamics--a key role for kalirin-7
    • Penzes, P., and Jones, K.A. (2008). Dendritic spine dynamics--a key role for kalirin-7. Trends Neurosci. 31, 419-427.
    • (2008) Trends Neurosci. , vol.31 , pp. 419-427
    • Penzes, P.1    Jones, K.A.2
  • 69
    • 0031013111 scopus 로고    scopus 로고
    • Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures
    • Puttfarcken, P.S., Manelli, A.M., Falduto, M.T., Getz, G.S., and LaDu, M.J. (1997). Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures. J. Neurochem. 68, 760-769.
    • (1997) J. Neurochem. , vol.68 , pp. 760-769
    • Puttfarcken, P.S.1    Manelli, A.M.2    Falduto, M.T.3    Getz, G.S.4    LaDu, M.J.5
  • 70
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R.E., Mahley, R.W., and Mucke, L. (1998). Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95, 10914-10919.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6    Mahley, R.W.7    Mucke, L.8
  • 72
    • 27944466636 scopus 로고    scopus 로고
    • Effect of domain interaction on apolipoprotein E levels in mouse brain
    • Ramaswamy, G., Xu, Q., Huang, Y., and Weisgraber, K.H. (2005). Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25, 10658-10663.
    • (2005) J. Neurosci. , vol.25 , pp. 10658-10663
    • Ramaswamy, G.1    Xu, Q.2    Huang, Y.3    Weisgraber, K.H.4
  • 76
    • 4344659648 scopus 로고    scopus 로고
    • A synthetic peptide blocking the Apolipoprotein E/{beta}-amyloid binding mitigates {beta}-amyloid toxicity and fibril formation in vitro and reduces {beta}-amyloid plaques in transgenic mice
    • Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J.A., Li, Y., Schmidt, S.D., Mathews, P.M., Fryer, J.D., Holtzman, D.M., Sigurdsson, E.M., et al. (2004). A synthetic peptide blocking the Apolipoprotein E/{beta}-amyloid binding mitigates {beta}-amyloid toxicity and fibril formation in vitro and reduces {beta}-amyloid plaques in transgenic mice. Am. J. Pathol. 165, 937-948.
    • (2004) Am. J. Pathol. , vol.165 , pp. 937-948
    • Sadowski, M.1    Pankiewicz, J.2    Scholtzova, H.3    Ripellino, J.A.4    Li, Y.5    Schmidt, S.D.6    Mathews, P.M.7    Fryer, J.D.8    Holtzman, D.M.9    Sigurdsson, E.M.10
  • 78
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer’s disease is a synaptic failure
    • Selkoe, D.J. (2002). Alzheimer’s disease is a synaptic failure. Science 298, 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 79
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J., and Sabatini, B.L. (2007). Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27, 2866-2875.
    • (2007) J. Neurosci. , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 80
    • 70349327570 scopus 로고    scopus 로고
    • Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway
    • Shi, Y., Mantuano, E., Inoue, G., Campana, W.M., and Gonias, S.L. (2009). Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci. Signal. 2, ra18.
    • (2009) Sci. Signal. , vol.2 , pp. 18
    • Shi, Y.1    Mantuano, E.2    Inoue, G.3    Campana, W.M.4    Gonias, S.L.5
  • 81
    • 82755174052 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
    • Siegel, J.A., Haley, G.E., and Raber, J. (2012). Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiol. Aging 33, 345-358.
    • (2012) Neurobiol. Aging , vol.33 , pp. 345-358
    • Siegel, J.A.1    Haley, G.E.2    Raber, J.3
  • 82
    • 70449408083 scopus 로고    scopus 로고
    • Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
    • Stanford, K.I., Bishop, J.R., Foley, E.M., Gonzales, J.C., Niesman, I.R., Witztum, J.L., and Esko, J.D. (2009). Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J. Clin. Invest. 119, 3236-3245.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3236-3245
    • Stanford, K.I.1    Bishop, J.R.2    Foley, E.M.3    Gonzales, J.C.4    Niesman, I.R.5    Witztum, J.L.6    Esko, J.D.7
  • 84
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocytespecific expression and differing biological effects of astrocytesecreted apoE3 and apoE4 lipoproteins
    • Sun, Y., Wu, S., Bu, G., Onifade, M.K., Patel, S.N., LaDu, M.J., Fagan, A.M., and Holtzman, D.M. (1998). Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocytespecific expression and differing biological effects of astrocytesecreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18, 3261-3272.
    • (1998) J. Neurosci. , vol.18 , pp. 3261-3272
    • Sun, Y.1    Wu, S.2    Bu, G.3    Onifade, M.K.4    Patel, S.N.5    LaDu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 85
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer’s disease: Synapse loss is the major correlate of cognitive impairment
    • Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A. and Katzman, R. (1991). Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30, 572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 86
    • 0032708306 scopus 로고    scopus 로고
    • Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture
    • Teter, B., Xu, P.T., Gilbert, J.R., Roses, A.D., Galasko, D., and Cole, G.M. (1999). Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. J. Neurochem. 73, 2613-2616.
    • (1999) J. Neurochem. , vol.73 , pp. 2613-2616
    • Teter, B.1    Xu, P.T.2    Gilbert, J.R.3    Roses, A.D.4    Galasko, D.5    Cole, G.M.6
  • 87
    • 0036570338 scopus 로고    scopus 로고
    • Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function
    • Teter, B., Xu, P.T., Gilbert, J.R., Roses, A.D., Galasko, D., and Cole, G.M. (2002). Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. J. Neurosci. Res. 68, 331-336.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 331-336
    • Teter, B.1    Xu, P.T.2    Gilbert, J.R.3    Roses, A.D.4    Galasko, D.5    Cole, G.M.6
  • 91
    • 67649104088 scopus 로고    scopus 로고
    • APOE genotypespecific differences in the innate immune response
    • Vitek, M.P., Brown, C.M., and Colton, C.A. (2007). APOE genotypespecific differences in the innate immune response. Neurobiol. Aging 30, 1350-1360.
    • (2007) Neurobiol. Aging , vol.30 , pp. 1350-1360
    • Vitek, M.P.1    Brown, C.M.2    Colton, C.A.3
  • 93
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer’s disease
    • Walsh, D.M., and Selkoe, D.J. (2004). Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 44, 181-193.
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 94
    • 15944410978 scopus 로고    scopus 로고
    • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
    • Wang, C., Wilson, W.A., Moore, S.D., Mace, B.E., Maeda, N., Schmechel, D.E., and Sullivan, P.M. (2005). Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol. Dis. 18, 390-398.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 390-398
    • Wang, C.1    Wilson, W.A.2    Moore, S.D.3    Mace, B.E.4    Maeda, N.5    Schmechel, D.E.6    Sullivan, P.M.7
  • 95
    • 0034864642 scopus 로고    scopus 로고
    • Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion
    • White, F., Nicoll, J.A., Roses, A.D., and Horsburgh, K. (2001). Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion. Neurobiol. Dis. 8, 611-625.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 611-625
    • White, F.1    Nicoll, J.A.2    Roses, A.D.3    Horsburgh, K.4
  • 96
    • 33749641662 scopus 로고    scopus 로고
    • Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, nonclathrin-mediated pathway
    • Wilsie, L.C., Gonzales, A.M., and Orlando, R.A. (2006). Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, nonclathrin-mediated pathway. Lipids Health Dis. 5, 23.
    • (2006) Lipids Health Dis. , vol.5 , pp. 23
    • Wilsie, L.C.1    Gonzales, A.M.2    Orlando, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.