-
1
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
-
Bales, K.R., Verina, T., Dodel, R.C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E.M., Little, S.P., Cummins, D.J., et al. (1997). Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17, 263-264.
-
(1997)
Nat. Genet.
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
Du, Y.4
Altstiel, L.5
Bender, M.6
Hyslop, P.7
Johnstone, E.M.8
Little, S.P.9
Cummins, D.J.10
-
2
-
-
77950641320
-
Differential effects of ApoE isoforms on dendritic spines in vivo: Linking an Alzheimer’s disease risk factor with synaptic alterations
-
Basak, J.M., and Kim, J. (2010). Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer’s disease risk factor with synaptic alterations. J. Neurosci. 30, 4526-4527.
-
(2010)
J. Neurosci.
, vol.30
, pp. 4526-4527
-
-
Basak, J.M.1
Kim, J.2
-
3
-
-
84858423000
-
Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice
-
Bien-Ly, N., Gillespie, A.K., Walker, D., Yoon, S.Y., and Huang, Y. (2012). Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J. Neurosci. 32, 4803-4811.
-
(2012)
J. Neurosci.
, vol.32
, pp. 4803-4811
-
-
Bien-Ly, N.1
Gillespie, A.K.2
Walker, D.3
Yoon, S.Y.4
Huang, Y.5
-
4
-
-
48949099311
-
Middleaged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
-
Bour, A., Grootendorst, J., Vogel, E., Kelche, C., Dodart, J.C., Bales, K., Moreau, P.H., Sullivan, P.M., and Mathis, C. (2008). Middleaged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav. Brain Res. 193, 174-182.
-
(2008)
Behav. Brain Res.
, vol.193
, pp. 174-182
-
-
Bour, A.1
Grootendorst, J.2
Vogel, E.3
Kelche, C.4
Dodart, J.C.5
Bales, K.6
Moreau, P.H.7
Sullivan, P.M.8
Mathis, C.9
-
5
-
-
43449117577
-
Balancing structure and function at hippocampal dendritic spines
-
Bourne, J.N., and Harris, K.M. (2008). Balancing structure and function at hippocampal dendritic spines. Annu. Rev. Neurosci. 31, 47-67.
-
(2008)
Annu. Rev. Neurosci.
, vol.31
, pp. 47-67
-
-
Bourne, J.N.1
Harris, K.M.2
-
6
-
-
0033564771
-
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration
-
Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R.E., Wyss-Coray, T., Mucke, L., and Mahley, R.W. (1999). Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J. Neurosci. 19, 4867-4880.
-
(1999)
J. Neurosci.
, vol.19
, pp. 4867-4880
-
-
Buttini, M.1
Orth, M.2
Bellosta, S.3
Akeefe, H.4
Pitas, R.E.5
Wyss-Coray, T.6
Mucke, L.7
Mahley, R.W.8
-
7
-
-
0034077821
-
Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice
-
Cambon, K., Davies, H.A., and Stewart, M.G. (2000). Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice. Neuroscience 97, 685-692.
-
(2000)
Neuroscience
, vol.97
, pp. 685-692
-
-
Cambon, K.1
Davies, H.A.2
Stewart, M.G.3
-
8
-
-
79959772357
-
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
-
Castellano, J.M., Kim, J., Stewart, F.R., Jiang, H., DeMattos, R.B., Patterson, B.W., Fagan, A.M., Morris, J.C., Mawuenyega, K.G., Cruchaga, C., et al. (2011). Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med. 3, 89ra57.
-
(2011)
Sci. Transl. Med.
, vol.3
, pp. 89
-
-
Castellano, J.M.1
Kim, J.2
Stewart, F.R.3
Jiang, H.4
DeMattos, R.B.5
Patterson, B.W.6
Fagan, A.M.7
Morris, J.C.8
Mawuenyega, K.G.9
Cruchaga, C.10
-
9
-
-
58149389019
-
Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3
-
Chai, X., Forster, E., Zhao, S., Bock, H.H., and Frotscher, M. (2009). Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J. Neurosci. 29, 288-299.
-
(2009)
J. Neurosci.
, vol.29
, pp. 288-299
-
-
Chai, X.1
Forster, E.2
Zhao, S.3
Bock, H.H.4
Frotscher, M.5
-
10
-
-
29444436680
-
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
-
Chang, S., ran Ma, T., Miranda, R.D., Balestra, M.E., Mahley, R.W., and Huang, Y. (2005). Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc. Natl. Acad. Sci. USA 102, 18694-18699.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18694-18699
-
-
Chang, S.1
Ran Ma, T.2
Miranda, R.D.3
Balestra, M.E.4
Mahley, R.W.5
Huang, Y.6
-
11
-
-
77955350021
-
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
-
Chen, Y., Durakoglugil, M.S., Xian, X. and Herz, J. (2010). ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc. Natl. Acad. Sci. USA 107, 12011-12016.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 12011-12016
-
-
Chen, Y.1
Durakoglugil, M.S.2
Xian, X.3
Herz, J.4
-
12
-
-
42349091996
-
Actin in action: The interplay between the actin cytoskeleton and synaptic efficacy
-
Cingolani, L.A., and Goda, Y. (2008). Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. Nat. Rev. Neurosci. 9, 344-356.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 344-356
-
-
Cingolani, L.A.1
Goda, Y.2
-
13
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families
-
Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Small, G.W., Roses, A.D., Haines, J.L., and Pericak-Vance, M.A. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261, 921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
14
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear betaamyloid and reverse deficits in AD mouse models
-
Cramer, P.E., Cirrito, J.R., Wesson, D.W., Lee, C.Y., Karlo, J.C., Zinn, A.E., Casali, B.T., Restivo, J.L., Goebel, W.D., James, M.J., et al. (2012). ApoE-directed therapeutics rapidly clear betaamyloid and reverse deficits in AD mouse models. Science 335, 1503-1506.
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
Lee, C.Y.4
Karlo, J.C.5
Zinn, A.E.6
Casali, B.T.7
Restivo, J.L.8
Goebel, W.D.9
James, M.J.10
-
15
-
-
0033213256
-
Reelin is a ligand for lipoprotein receptors
-
D’Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D.S., Sheldon, M., and Curran, T. (1999). Reelin is a ligand for lipoprotein receptors. Neuron 24, 471-479.
-
(1999)
Neuron
, vol.24
, pp. 471-479
-
-
D’Arcangelo, G.1
Homayouni, R.2
Keshvara, L.3
Rice, D.S.4
Sheldon, M.5
Curran, T.6
-
16
-
-
0032512634
-
A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins
-
DeMattos, R.B., Curtiss, L.K., and Williams, D.L. (1998). A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins. J. Biol. Chem. 273, 4206-4212.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4206-4212
-
-
DeMattos, R.B.1
Curtiss, L.K.2
Williams, D.L.3
-
17
-
-
3543104951
-
Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
-
Dietschy, J.M., and Turley, S.D. (2004). Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397.
-
(2004)
J. Lipid Res.
, vol.45
, pp. 1375-1397
-
-
Dietschy, J.M.1
Turley, S.D.2
-
18
-
-
72849145019
-
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo
-
Dumanis, S.B., Tesoriero, J.A., Babus, L.W., Nguyen, M.T., Trotter, J.H., Ladu, M.J., Weeber, E.J., Turner, R.S., Xu, B., Rebeck, G.W., et al. (2009). ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J. Neurosci. 29, 15317-15322.
-
(2009)
J. Neurosci.
, vol.29
, pp. 15317-15322
-
-
Dumanis, S.B.1
Tesoriero, J.A.2
Babus, L.W.3
Nguyen, M.T.4
Trotter, J.H.5
Ladu, M.J.6
Weeber, E.J.7
Turner, R.S.8
Xu, B.9
Rebeck, G.W.10
-
19
-
-
0033535040
-
Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons
-
Ethell, I.M., and Yamaguchi, Y. (1999). Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J. Cell Biol. 144, 575-586.
-
(1999)
J. Cell Biol.
, vol.144
, pp. 575-586
-
-
Ethell, I.M.1
Yamaguchi, Y.2
-
20
-
-
0035959932
-
EphB/syndecan-2 signaling in dendritic spine morphogenesis
-
Ethell, I.M., Irie, F., Kalo, M.S., Couchman, J.R., Pasquale, E.B., and Yamaguchi, Y. (2001). EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31, 1001-1013.
-
(2001)
Neuron
, vol.31
, pp. 1001-1013
-
-
Ethell, I.M.1
Irie, F.2
Kalo, M.S.3
Couchman, J.R.4
Pasquale, E.B.5
Yamaguchi, Y.6
-
21
-
-
0029958248
-
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
-
Fagan, A.M., Bu, G., Sun, Y., Daugherty, A., and Holtzman, D.M. (1996). Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271, 30121-30125.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 30121-30125
-
-
Fagan, A.M.1
Bu, G.2
Sun, Y.3
Daugherty, A.4
Holtzman, D.M.5
-
22
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
Farrer, L.A., Cupples, L.A., Haines, J.L., Hyman, B., Kukull, W.A., Mayeux, R., Myers, R.H., Pericak-Vance, M.A., Risch, N., and van Duijn, C.M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278, 1349-1356.
-
(1997)
JAMA
, vol.278
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
Myers, R.H.7
Pericak-Vance, M.A.8
Risch, N.9
Van Duijn, C.M.10
-
23
-
-
77952549757
-
Targeting Abeta and tau in Alzheimer’s disease, an early interim report
-
Golde, T.E., Petrucelli, L., and Lewis, J. (2010). Targeting Abeta and tau in Alzheimer’s disease, an early interim report. Exp. Neurol. 223, 252-266.
-
(2010)
Exp. Neurol.
, vol.223
, pp. 252-266
-
-
Golde, T.E.1
Petrucelli, L.2
Lewis, J.3
-
24
-
-
0028790904
-
Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
-
Gordon, I., Grauer, E., Genis, I., Sehayek, E., and Michaelson, D.M. (1995). Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci. Lett. 199, 1-4.
-
(1995)
Neurosci. Lett.
, vol.199
, pp. 1-4
-
-
Gordon, I.1
Grauer, E.2
Genis, I.3
Sehayek, E.4
Michaelson, D.M.5
-
25
-
-
15744378392
-
Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
-
Grootendorst, J., Bour, A., Vogel, E., Kelche, C., Sullivan, P.M., Dodart, J.-C., Bales, K., and Mathis, C. (2005) Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav. Brain Res. 159, 1-14.
-
(2005)
Behav. Brain Res.
, vol.159
, pp. 1-14
-
-
Grootendorst, J.1
Bour, A.2
Vogel, E.3
Kelche, C.4
Sullivan, P.M.5
Dodart, J.-C.6
Bales, K.7
Mathis, C.8
-
26
-
-
58149225472
-
Microtubules in dendritic spine development
-
Gu, J., Firestein, B.L., and Zheng, J.Q. (2008). Microtubules in dendritic spine development. J. Neurosci. 28, 12120-12124.
-
(2008)
J. Neurosci.
, vol.28
, pp. 12120-12124
-
-
Gu, J.1
Firestein, B.L.2
Zheng, J.Q.3
-
27
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer’s amyloid betapeptide
-
Haass, C., and Selkoe, D.J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid betapeptide. Nat. Rev. Mol. Cell Biol. 8, 101-112.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
28
-
-
0034870449
-
Behavioral phenotyping of GFAPApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer’s-like neuropathology
-
Hartman, R.E., Wozniak, D.F., Nardi, A., Olney, J.W., Sartorius, L., and Holtzman, D.M. (2001). Behavioral phenotyping of GFAPApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer’s-like neuropathology. Exp. Neurol. 170, 326-344.
-
(2001)
Exp. Neurol.
, vol.170
, pp. 326-344
-
-
Hartman, R.E.1
Wozniak, D.F.2
Nardi, A.3
Olney, J.W.4
Sartorius, L.5
Holtzman, D.M.6
-
29
-
-
34248232920
-
Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons
-
Hoe, H.S., Freeman, J., and Rebeck, G.W. (2006). Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons. Mol. Neurodegener. 1, 18.
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 18
-
-
Hoe, H.S.1
Freeman, J.2
Rebeck, G.W.3
-
30
-
-
0028822219
-
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
-
Holtzman, D.M., Pitas, R.E., Kilbridge, J., Nathan, B., Mahley, R.W., Bu, G., and Schwartz, A.L. (1995). Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA 92, 9480-9484.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9480-9484
-
-
Holtzman, D.M.1
Pitas, R.E.2
Kilbridge, J.3
Nathan, B.4
Mahley, R.W.5
Bu, G.6
Schwartz, A.L.7
-
31
-
-
58149272090
-
Activity-dependent dynamic microtubule invasion of dendritic spines
-
Hu, X., Viesselmann, C., Nam, S., Merriam, E., and Dent, E.W. (2008). Activity-dependent dynamic microtubule invasion of dendritic spines. J. Neurosci. 28, 13094-13105.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13094-13105
-
-
Hu, X.1
Viesselmann, C.2
Nam, S.3
Merriam, E.4
Dent, E.W.5
-
32
-
-
84890365334
-
Gene transfer of human apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain
-
Hudry, E., Dashkoff, J., Roe, A.D., Takeda, S., Koffie, R.M., Hashimoto, T., Scheel, M., Spires-Jones, T., Arbel-Ornath, M., Betensky, R., et al. (2013). Gene transfer of human apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci. Transl. Med. 5, 212ra161.
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 212
-
-
Hudry, E.1
Dashkoff, J.2
Roe, A.D.3
Takeda, S.4
Koffie, R.M.5
Hashimoto, T.6
Scheel, M.7
Spires-Jones, T.8
Arbel-Ornath, M.9
Betensky, R.10
-
33
-
-
58149214025
-
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity
-
Jaworski, J., Kapitein, L.C., Gouveia, S.M., Dortland, B.R., Wulf, P.S., Grigoriev, I., Camera, P., Spangler, S.A., Di Stefano, P., Demmers, J., et al. (2009). Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron 61, 85-100.
-
(2009)
Neuron
, vol.61
, pp. 85-100
-
-
Jaworski, J.1
Kapitein, L.C.2
Gouveia, S.M.3
Dortland, B.R.4
Wulf, P.S.5
Grigoriev, I.6
Camera, P.7
Spangler, S.A.8
Di Stefano, P.9
Demmers, J.10
-
34
-
-
0032577695
-
Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4
-
Ji, Z.S., Pitas, R.E., and Mahley, R.W. (1998). Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4. J. Biol. Chem. 273, 13452-13460.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13452-13460
-
-
Ji, Z.S.1
Pitas, R.E.2
Mahley, R.W.3
-
35
-
-
0242403213
-
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients
-
Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D.M., and Wisniewski, T. (2003). Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients. Neuro Sci. 122, 305-315.
-
(2003)
Neuro Sci.
, vol.122
, pp. 305-315
-
-
Ji, Y.1
Gong, Y.2
Gan, W.3
Beach, T.4
Holtzman, D.M.5
Wisniewski, T.6
-
36
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang, Q., Lee, C.Y., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T.M., Collins, J.L., et al. (2008). ApoE promotes the proteolytic degradation of Abeta. Neuron 58, 681-693.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
Wilkinson, B.4
Cramer, P.5
Zelcer, N.6
Mann, K.7
Lamb, B.8
Willson, T.M.9
Collins, J.L.10
-
37
-
-
33846435323
-
Abeta40 inhibits amyloid deposition in vivo
-
Kim, J., Onstead, L., Randle, S., Price, R., Smithson, L., Zwizinski, C., Dickson, D.W., Golde, T., and McGowan, E. (2007). Abeta40 inhibits amyloid deposition in vivo. J. Neurosci. 27, 627-633.
-
(2007)
J. Neurosci.
, vol.27
, pp. 627-633
-
-
Kim, J.1
Onstead, L.2
Randle, S.3
Price, R.4
Smithson, L.5
Zwizinski, C.6
Dickson, D.W.7
Golde, T.8
McGowan, E.9
-
38
-
-
68249134074
-
). The role of apolipoprotein E in Alzheimer’s disease
-
Kim, J., Basak, J.M., and Holtzman, D.M. (2009a). The role of apolipoprotein E in Alzheimer’s disease. Neuron 63, 287-303.
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
39
-
-
71449125786
-
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A[beta] clearance
-
Kim, J., Castellano, J.M., Jiang, H., Basak, J.M., Parsadanian, M., Pham, V., Mason, S.M., Paul, S.M., and Holtzman, D.M. (2009b). Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A[beta] clearance. Neuron 64, 632-644.
-
(2009)
Neuron
, vol.64
, pp. 632-644
-
-
Kim, J.1
Castellano, J.M.2
Jiang, H.3
Basak, J.M.4
Parsadanian, M.5
Pham, V.6
Mason, S.M.7
Paul, S.M.8
Holtzman, D.M.9
-
40
-
-
83055160869
-
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis
-
Kim, J., Jiang, H., Park, S., Eltorai, A., Stewart, F., Yoon, H., Basak, J.M., Finn, M.B., and Holtzman, D.M. (2011). Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. J. Neurosci. 31, 18007-18012.
-
(2011)
J. Neurosci.
, vol.31
, pp. 18007-18012
-
-
Kim, J.1
Jiang, H.2
Park, S.3
Eltorai, A.4
Stewart, F.5
Yoon, H.6
Basak, J.M.7
Finn, M.B.8
Holtzman, D.M.9
-
41
-
-
84871887566
-
AntiapoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis
-
Kim, J., Eltorai, A.E., Jiang, H., Liao, F., Verghese, P.B., Kim, J., Stewart, F.R., Basak, J.M., and Holtzman, D.M. (2012a). AntiapoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis. J. Exp. Med. 209, 2149-2156.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2149-2156
-
-
Kim, J.1
Eltorai, A.E.2
Jiang, H.3
Liao, F.4
Verghese, P.B.5
Kim, J.6
Stewart, F.R.7
Basak, J.M.8
Holtzman, D.M.9
-
42
-
-
84860377430
-
MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
-
Kim, J., Yoon, H., Ramírez, C., Lee, S., Hoe, H., Fernández-Hernando, C., and Kim, J. (2012b). miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483.
-
(2012)
Exp. Neurol.
, vol.235
, pp. 476-483
-
-
Kim, J.1
Yoon, H.2
Ramírez, C.3
Lee, S.4
Hoe, H.5
Fernández-Hernando, C.6
Kim, J.7
-
43
-
-
0030050980
-
Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
-
Kinnunen, T., Raulo, E., Nolo, R., Maccarana, M., Lindahl, U., and Rauvala, H. (1996). Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. J. Biol. Chem. 271, 2243-2248.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2243-2248
-
-
Kinnunen, T.1
Raulo, E.2
Nolo, R.3
Maccarana, M.4
Lindahl, U.5
Rauvala, H.6
-
44
-
-
0032562591
-
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth
-
Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H.B., and Rauvala, H. (1998). Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J. Biol. Chem. 273, 10702-10708.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10702-10708
-
-
Kinnunen, T.1
Kaksonen, M.2
Saarinen, J.3
Kalkkinen, N.4
Peng, H.B.5
Rauvala, H.6
-
45
-
-
4644298544
-
Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E
-
Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., and Nukina, N. (2004). Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. Neurosci. Lett. 369, 173-178.
-
(2004)
Neurosci. Lett.
, vol.369
, pp. 173-178
-
-
Kitamura, H.W.1
Hamanaka, H.2
Watanabe, M.3
Wada, K.4
Yamazaki, C.5
Fujita, S.C.6
Manabe, T.7
Nukina, N.8
-
46
-
-
77949399837
-
Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP
-
Kornecook, T.J., McKinney, A.P., Ferguson, M.T., and Dodart, J.C. (2010). Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP. Genes Brain Behav. 9, 182-192.
-
(2010)
Genes Brain Behav.
, vol.9
, pp. 182-192
-
-
Kornecook, T.J.1
McKinney, A.P.2
Ferguson, M.T.3
Dodart, J.C.4
-
47
-
-
0025302165
-
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
-
Kowal, R.C., Herz, J., Weisgraber, K.H., Mahley, R.W., Brown, M.S., and Goldstein, J.L. (1990). Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J. Biol. Chem. 265, 10771-10779.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 10771-10779
-
-
Kowal, R.C.1
Herz, J.2
Weisgraber, K.H.3
Mahley, R.W.4
Brown, M.S.5
Goldstein, J.L.6
-
48
-
-
70350463625
-
Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity
-
Kramar, E.A., Chen, L.Y., Brandon, N.J., Rex, C.S., Liu, F., Gall, C.M., and Lynch, G. (2009). Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity. J. Neurosci. 29, 12982-12993.
-
(2009)
J. Neurosci.
, vol.29
, pp. 12982-12993
-
-
Kramar, E.A.1
Chen, L.Y.2
Brandon, N.J.3
Rex, C.S.4
Liu, F.5
Gall, C.M.6
Lynch, G.7
-
49
-
-
84876569513
-
Blocking the interaction between apolipoprotein E and Abeta reduces intraneuronal accumulation of Abeta and inhibits synaptic degeneration
-
Kuszczyk, M.A., Sanchez, S., Pankiewicz, J., Kim, J., Duszczyk, M., Guridi, M., Asuni, A.A., Sullivan, P.M., Holtzman, D.M., and Sadowski, M.J. (2013). Blocking the interaction between apolipoprotein E and Abeta reduces intraneuronal accumulation of Abeta and inhibits synaptic degeneration. Am. J. Pathol. 182, 1750-1768.
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 1750-1768
-
-
Kuszczyk, M.A.1
Sanchez, S.2
Pankiewicz, J.3
Kim, J.4
Duszczyk, M.5
Guridi, M.6
Asuni, A.A.7
Sullivan, P.M.8
Holtzman, D.M.9
Sadowski, M.J.10
-
50
-
-
84907364703
-
More than cholesterol transporters: Lipoprotein receptors in CNS function and neurodegeneration
-
Lane-Donovan, C., Philips, Gary T., and Herz, J. (2014). More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83, 771-787.
-
(2014)
Neuron
, vol.83
, pp. 771-787
-
-
Lane-Donovan, C.1
Philips, G.T.2
Herz, J.3
-
51
-
-
0043095312
-
Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
-
Lanz, T.A., Carter, D.B., and Merchant, K.M. (2003). Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol. Dis. 13, 246-253.
-
(2003)
Neurobiol. Dis.
, vol.13
, pp. 246-253
-
-
Lanz, T.A.1
Carter, D.B.2
Merchant, K.M.3
-
52
-
-
84901008874
-
Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis
-
Liao, F., Hori, Y., Hudry, E., Bauer, A.Q., Jiang, H., Mahan, T.E., Lefton, K.B., Zhang, T.J., Dearborn, J.T., Kim, J., et al. (2014). Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis. J. Neurosci. 34, 7281-7292.
-
(2014)
J. Neurosci.
, vol.34
, pp. 7281-7292
-
-
Liao, F.1
Hori, Y.2
Hudry, E.3
Bauer, A.Q.4
Jiang, H.5
Mahan, T.E.6
Lefton, K.B.7
Zhang, T.J.8
Dearborn, J.T.9
Kim, J.10
-
53
-
-
0035914385
-
New insights into the heparan sulfate proteoglycanbinding activity of apolipoprotein E
-
Libeu, C.P., Lund-Katz, S., Phillips, M.C., Wehrli, S., Hernaiz, M.J., Capila, I., Linhardt, R.J., Raffai, R.L., Newhouse, Y.M., Zhou, F., et al. (2001). New insights into the heparan sulfate proteoglycanbinding activity of apolipoprotein E. J. Biol. Chem. 276, 39138-39144.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39138-39144
-
-
Libeu, C.P.1
Lund-Katz, S.2
Phillips, M.C.3
Wehrli, S.4
Hernaiz, M.J.5
Capila, I.6
Linhardt, R.J.7
Raffai, R.L.8
Newhouse, Y.M.9
Zhou, F.10
-
54
-
-
84872713614
-
Apolipoprotein e sets the stage: Response to injury triggers neuropathology
-
Mahley, R.W., and Huang, Y. (2012). Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron 76, 871-885.
-
(2012)
Neuron
, vol.76
, pp. 871-885
-
-
Mahley, R.W.1
Huang, Y.2
-
55
-
-
84907970354
-
Effects of the absence of apolipoprotein E on lipoproteins, neurocognitive function, and retinal runction
-
press
-
Mak, A.C., Pullinger, C.R., Tang, L.F., Wong, J.S., Deo, R.C., Schwarz, J.M., Gugliucci, A., Movsesyan, I., Ishida, B.Y., Chu, C., et al. (2014). Effects of the absence of apolipoprotein E on lipoproteins, neurocognitive function, and retinal runction. JAMA Neurol. (in press).
-
(2014)
JAMA Neurol.
-
-
Mak, A.C.1
Pullinger, C.R.2
Tang, L.F.3
Wong, J.S.4
Deo, R.C.5
Schwarz, J.M.6
Gugliucci, A.7
Movsesyan, I.8
Ishida, B.Y.9
Chu, C.10
-
56
-
-
4544310410
-
Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model
-
Mann, K.M., Thorngate, F.E., Katoh-Fukui, Y., Hamanaka, H., Williams, D.L., Fujita, S., and Lamb, B.T. (2004). Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Hum. Mol. Genet. 13, 1959-1968.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1959-1968
-
-
Mann, K.M.1
Thorngate, F.E.2
Katoh-Fukui, Y.3
Hamanaka, H.4
Williams, D.L.5
Fujita, S.6
Lamb, B.T.7
-
57
-
-
0030948449
-
Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE
-
Masliah, E., Samuel, W., Veinbergs, I., Mallory, M., Mante, M., and Saitoh, T. (1997). Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE. Brain Res. 751, 307-314.
-
(1997)
Brain Res.
, vol.751
, pp. 307-314
-
-
Masliah, E.1
Samuel, W.2
Veinbergs, I.3
Mallory, M.4
Mante, M.5
Saitoh, T.6
-
58
-
-
22544482926
-
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
-
McGowan, E., Pickford, F., Kim, J., Onstead, L., Eriksen, J., Yu, C., Skipper, L., Murphy, M.P., Beard, J., Das, P., et al. (2005). Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191-199.
-
(2005)
Neuron
, vol.47
, pp. 191-199
-
-
McGowan, E.1
Pickford, F.2
Kim, J.3
Onstead, L.4
Eriksen, J.5
Yu, C.6
Skipper, L.7
Murphy, M.P.8
Beard, J.9
Das, P.10
-
59
-
-
77950929102
-
ApoE mimetic peptide decreases Abeta production in vitro and in vivo
-
Minami, S.S., Cordova, A., Cirrito, J.R., Tesoriero, J.A., Babus, L.W., Davis, G.C., Dakshanamurthy, S., Turner, R.S., Pak, D.T., Rebeck, G.W., et al. (2010). ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol. Neurodegener. 5, 16.
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 16
-
-
Minami, S.S.1
Cordova, A.2
Cirrito, J.R.3
Tesoriero, J.A.4
Babus, L.W.5
Davis, G.C.6
Dakshanamurthy, S.7
Turner, R.S.8
Pak, D.T.9
Rebeck, G.W.10
-
60
-
-
0025971426
-
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
-
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., and Ikeda, K. (1991). Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541, 163-166.
-
(1991)
Brain Res.
, vol.541
, pp. 163-166
-
-
Namba, Y.1
Tomonaga, M.2
Kawasaki, H.3
Otomo, E.4
Ikeda, K.5
-
61
-
-
0031030661
-
The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development
-
Narita, M., Bu, G., Holtzman, D.M., and Schwartz, A.L. (1997). The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. J. Neurochem. 68, 587-595.
-
(1997)
J. Neurochem.
, vol.68
, pp. 587-595
-
-
Narita, M.1
Bu, G.2
Holtzman, D.M.3
Schwartz, A.L.4
-
62
-
-
0028232662
-
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
-
Nathan, B.P., Bellosta, S., Sanan, D.A., Weisgraber, K.H., Mahley, R.W., and Pitas, R.E. (1994). Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264, 850-852.
-
(1994)
Science
, vol.264
, pp. 850-852
-
-
Nathan, B.P.1
Bellosta, S.2
Sanan, D.A.3
Weisgraber, K.H.4
Mahley, R.W.5
Pitas, R.E.6
-
63
-
-
0037154858
-
Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
-
Nathan, B.P., Jiang, Y., Wong, G.K., Shen, F., Brewer, G.J., and Struble, R.G. (2002). Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 928, 96-105.
-
(2002)
Brain Res.
, vol.928
, pp. 96-105
-
-
Nathan, B.P.1
Jiang, Y.2
Wong, G.K.3
Shen, F.4
Brewer, G.J.5
Struble, R.G.6
-
64
-
-
67649774919
-
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice
-
Nichol, K., Deeny, S.P., Seif, J., Camaclang, K., and Cotman, C.W. (2009). Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement 5, 287-294.
-
(2009)
Alzheimers Dement
, vol.5
, pp. 287-294
-
-
Nichol, K.1
Deeny, S.P.2
Seif, J.3
Camaclang, K.4
Cotman, C.W.5
-
65
-
-
55249114701
-
The reelin signaling pathway promotes dendritic spine development in hippocampal neurons
-
Niu, S., Yabut, O., and D’Arcangelo, G. (2008). The reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J. Neurosci. 28, 10339-10348.
-
(2008)
J. Neurosci.
, vol.28
, pp. 10339-10348
-
-
Niu, S.1
Yabut, O.2
D’Arcangelo, G.3
-
66
-
-
83055160677
-
The APOE4 conundrum
-
Osherovich, L. (2009). The APOE4 conundrum. SciBX 2, 1-3.
-
(2009)
SciBX
, vol.2
, pp. 1-3
-
-
Osherovich, L.1
-
67
-
-
84927547425
-
Blocking the apoE/Abeta interaction ameliorates Abeta-related pathology in APOE2 and 4 targeted replacement Alzheimer model mice
-
Pankiewicz, J.E., Guridi, M., Kim, J., Asuni, A.A., Sanchez, S., Sullivan, P.M., Holtzman, D.M., and Sadowski, M.J. (2014). Blocking the apoE/Abeta interaction ameliorates Abeta-related pathology in APOE2 and 4 targeted replacement Alzheimer model mice. Acta Neuropathol. Commun. 2, 75.
-
(2014)
Acta Neuropathol. Commun.
, vol.2
, pp. 75
-
-
Pankiewicz, J.E.1
Guridi, M.2
Kim, J.3
Asuni, A.A.4
Sanchez, S.5
Sullivan, P.M.6
Holtzman, D.M.7
Sadowski, M.J.8
-
68
-
-
47649093892
-
Dendritic spine dynamics--a key role for kalirin-7
-
Penzes, P., and Jones, K.A. (2008). Dendritic spine dynamics--a key role for kalirin-7. Trends Neurosci. 31, 419-427.
-
(2008)
Trends Neurosci.
, vol.31
, pp. 419-427
-
-
Penzes, P.1
Jones, K.A.2
-
69
-
-
0031013111
-
Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures
-
Puttfarcken, P.S., Manelli, A.M., Falduto, M.T., Getz, G.S., and LaDu, M.J. (1997). Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures. J. Neurochem. 68, 760-769.
-
(1997)
J. Neurochem.
, vol.68
, pp. 760-769
-
-
Puttfarcken, P.S.1
Manelli, A.M.2
Falduto, M.T.3
Getz, G.S.4
LaDu, M.J.5
-
70
-
-
0032168460
-
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
-
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R.E., Mahley, R.W., and Mucke, L. (1998). Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95, 10914-10919.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10914-10919
-
-
Raber, J.1
Wong, D.2
Buttini, M.3
Orth, M.4
Bellosta, S.5
Pitas, R.E.6
Mahley, R.W.7
Mucke, L.8
-
71
-
-
0034704816
-
Apolipoprotein E and cognitive performance
-
Raber, J., Wong, D., Yu, G.Q., Buttini, M., Mahley, R.W., Pitas, R.E., and Mucke, L. (2000). Apolipoprotein E and cognitive performance. Nature 404, 352-354.
-
(2000)
Nature
, vol.404
, pp. 352-354
-
-
Raber, J.1
Wong, D.2
Yu, G.Q.3
Buttini, M.4
Mahley, R.W.5
Pitas, R.E.6
Mucke, L.7
-
72
-
-
27944466636
-
Effect of domain interaction on apolipoprotein E levels in mouse brain
-
Ramaswamy, G., Xu, Q., Huang, Y., and Weisgraber, K.H. (2005). Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25, 10658-10663.
-
(2005)
J. Neurosci.
, vol.25
, pp. 10658-10663
-
-
Ramaswamy, G.1
Xu, Q.2
Huang, Y.3
Weisgraber, K.H.4
-
73
-
-
77955951903
-
Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation
-
Rex, C.S., Gavin, C.F., Rubio, M.D., Kramar, E.A., Chen, L.Y., Jia, Y., Huganir, R.L., Muzyczka, N., Gall, C.M., and Miller, C.A. (2010). Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Neuron 67, 603-617.
-
(2010)
Neuron
, vol.67
, pp. 603-617
-
-
Rex, C.S.1
Gavin, C.F.2
Rubio, M.D.3
Kramar, E.A.4
Chen, L.Y.5
Jia, Y.6
Huganir, R.L.7
Muzyczka, N.8
Gall, C.M.9
Miller, C.A.10
-
74
-
-
58149251844
-
Impact of Apolipoprotein E (ApoE) polymorphism on brain ApoE levels
-
Riddell, D.R., Zhou, H., Atchison, K., Warwick, H.K., Atkinson, P.J., Jefferson, J., Xu, L., Aschmies, S., Kirksey, Y., Hu, Y., et al. (2008). Impact of Apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J. Neurosci. 28, 11445-11453.
-
(2008)
J. Neurosci.
, vol.28
, pp. 11445-11453
-
-
Riddell, D.R.1
Zhou, H.2
Atchison, K.3
Warwick, H.K.4
Atkinson, P.J.5
Jefferson, J.6
Xu, L.7
Aschmies, S.8
Kirksey, Y.9
Hu, Y.10
-
75
-
-
23244454385
-
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
-
Ruiz, J., Kouiavskaia, D., Migliorini, M., Robinson, S., Saenko, E.L., Gorlatova, N., Li, D., Lawrence, D., Hyman, B.T., Weisgraber, K.H., et al. (2005). The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J. Lipid Res. 46, 1721-1731.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 1721-1731
-
-
Ruiz, J.1
Kouiavskaia, D.2
Migliorini, M.3
Robinson, S.4
Saenko, E.L.5
Gorlatova, N.6
Li, D.7
Lawrence, D.8
Hyman, B.T.9
Weisgraber, K.H.10
-
76
-
-
4344659648
-
A synthetic peptide blocking the Apolipoprotein E/{beta}-amyloid binding mitigates {beta}-amyloid toxicity and fibril formation in vitro and reduces {beta}-amyloid plaques in transgenic mice
-
Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J.A., Li, Y., Schmidt, S.D., Mathews, P.M., Fryer, J.D., Holtzman, D.M., Sigurdsson, E.M., et al. (2004). A synthetic peptide blocking the Apolipoprotein E/{beta}-amyloid binding mitigates {beta}-amyloid toxicity and fibril formation in vitro and reduces {beta}-amyloid plaques in transgenic mice. Am. J. Pathol. 165, 937-948.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 937-948
-
-
Sadowski, M.1
Pankiewicz, J.2
Scholtzova, H.3
Ripellino, J.A.4
Li, Y.5
Schmidt, S.D.6
Mathews, P.M.7
Fryer, J.D.8
Holtzman, D.M.9
Sigurdsson, E.M.10
-
77
-
-
33845484383
-
Blocking the apolipoprotein E/amyloid-{beta} interaction as a potential therapeutic approach for Alzheimer’s disease
-
Sadowski, M.J., Pankiewicz, J., Scholtzova, H., Mehta, P.D., Prelli, F., Quartermain, D., and Wisniewski, T. (2006). Blocking the apolipoprotein E/amyloid-{beta} interaction as a potential therapeutic approach for Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 103, 18787-18792.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18787-18792
-
-
Sadowski, M.J.1
Pankiewicz, J.2
Scholtzova, H.3
Mehta, P.D.4
Prelli, F.5
Quartermain, D.6
Wisniewski, T.7
-
78
-
-
0037174618
-
Alzheimer’s disease is a synaptic failure
-
Selkoe, D.J. (2002). Alzheimer’s disease is a synaptic failure. Science 298, 789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
79
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J., and Sabatini, B.L. (2007). Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27, 2866-2875.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
80
-
-
70349327570
-
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway
-
Shi, Y., Mantuano, E., Inoue, G., Campana, W.M., and Gonias, S.L. (2009). Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci. Signal. 2, ra18.
-
(2009)
Sci. Signal.
, vol.2
, pp. 18
-
-
Shi, Y.1
Mantuano, E.2
Inoue, G.3
Campana, W.M.4
Gonias, S.L.5
-
81
-
-
82755174052
-
Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
-
Siegel, J.A., Haley, G.E., and Raber, J. (2012). Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiol. Aging 33, 345-358.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 345-358
-
-
Siegel, J.A.1
Haley, G.E.2
Raber, J.3
-
82
-
-
70449408083
-
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
-
Stanford, K.I., Bishop, J.R., Foley, E.M., Gonzales, J.C., Niesman, I.R., Witztum, J.L., and Esko, J.D. (2009). Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J. Clin. Invest. 119, 3236-3245.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3236-3245
-
-
Stanford, K.I.1
Bishop, J.R.2
Foley, E.M.3
Gonzales, J.C.4
Niesman, I.R.5
Witztum, J.L.6
Esko, J.D.7
-
83
-
-
0028035306
-
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease
-
Strittmatter, W.J., Saunders, A.M., Goedert, M., Weisgraber, K.H., Dong, L.M., Jakes, R., Huang, D.Y., Pericak-Vance, M., Schmechel, D., and Roses, A.D. (1994). Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 11183-11186.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11183-11186
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Goedert, M.3
Weisgraber, K.H.4
Dong, L.M.5
Jakes, R.6
Huang, D.Y.7
Pericak-Vance, M.8
Schmechel, D.9
Roses, A.D.10
-
84
-
-
0032080231
-
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocytespecific expression and differing biological effects of astrocytesecreted apoE3 and apoE4 lipoproteins
-
Sun, Y., Wu, S., Bu, G., Onifade, M.K., Patel, S.N., LaDu, M.J., Fagan, A.M., and Holtzman, D.M. (1998). Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocytespecific expression and differing biological effects of astrocytesecreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18, 3261-3272.
-
(1998)
J. Neurosci.
, vol.18
, pp. 3261-3272
-
-
Sun, Y.1
Wu, S.2
Bu, G.3
Onifade, M.K.4
Patel, S.N.5
LaDu, M.J.6
Fagan, A.M.7
Holtzman, D.M.8
-
85
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer’s disease: Synapse loss is the major correlate of cognitive impairment
-
Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A. and Katzman, R. (1991). Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30, 572-580.
-
(1991)
Ann. Neurol.
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
86
-
-
0032708306
-
Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture
-
Teter, B., Xu, P.T., Gilbert, J.R., Roses, A.D., Galasko, D., and Cole, G.M. (1999). Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. J. Neurochem. 73, 2613-2616.
-
(1999)
J. Neurochem.
, vol.73
, pp. 2613-2616
-
-
Teter, B.1
Xu, P.T.2
Gilbert, J.R.3
Roses, A.D.4
Galasko, D.5
Cole, G.M.6
-
87
-
-
0036570338
-
Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function
-
Teter, B., Xu, P.T., Gilbert, J.R., Roses, A.D., Galasko, D., and Cole, G.M. (2002). Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. J. Neurosci. Res. 68, 331-336.
-
(2002)
J. Neurosci. Res.
, vol.68
, pp. 331-336
-
-
Teter, B.1
Xu, P.T.2
Gilbert, J.R.3
Roses, A.D.4
Galasko, D.5
Cole, G.M.6
-
88
-
-
19944426892
-
ApoE isoform affects LTP in human targeted replacement mice
-
Trommer, B.L., Shah, C., Yun, S.H., Gamkrelidze, G., Pasternak, E.S., Ye, G.L., Sotak, M., Sullivan, P.M., Pasternak, J.F., and LaDu, M.J. (2004). ApoE isoform affects LTP in human targeted replacement mice. Neuroreport 15, 2655-2658.
-
(2004)
Neuroreport
, vol.15
, pp. 2655-2658
-
-
Trommer, B.L.1
Shah, C.2
Yun, S.H.3
Gamkrelidze, G.4
Pasternak, E.S.5
Ye, G.L.6
Sotak, M.7
Sullivan, P.M.8
Pasternak, J.F.9
LaDu, M.J.10
-
89
-
-
19944429503
-
ApoE isoform-specific effects on LTP: Blockade by oligomeric amyloid-beta1-42
-
Trommer, B.L., Shah, C., Yun, S.H., Gamkrelidze, G., Pasternak, E.S., Stine, W.B., Manelli, A., Sullivan, P., Pasternak, J.F., and LaDu, M.J. (2005). ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. Neurobiol. Dis. 18, 75-82.
-
(2005)
Neurobiol. Dis.
, vol.18
, pp. 75-82
-
-
Trommer, B.L.1
Shah, C.2
Yun, S.H.3
Gamkrelidze, G.4
Pasternak, E.S.5
Stine, W.B.6
Manelli, A.7
Sullivan, P.8
Pasternak, J.F.9
LaDu, M.J.10
-
90
-
-
0033597195
-
Differential neurotrophic effects of apolipoprotein E in aged transgenic mice
-
Veinbergs, I., Mallory, M., Mante, M., Rockenstein, E., Gilbert, J.R., and Masliah, E. (1999). Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. Neurosci. Lett. 265, 218-222.
-
(1999)
Neurosci. Lett.
, vol.265
, pp. 218-222
-
-
Veinbergs, I.1
Mallory, M.2
Mante, M.3
Rockenstein, E.4
Gilbert, J.R.5
Masliah, E.6
-
91
-
-
67649104088
-
APOE genotypespecific differences in the innate immune response
-
Vitek, M.P., Brown, C.M., and Colton, C.A. (2007). APOE genotypespecific differences in the innate immune response. Neurobiol. Aging 30, 1350-1360.
-
(2007)
Neurobiol. Aging
, vol.30
, pp. 1350-1360
-
-
Vitek, M.P.1
Brown, C.M.2
Colton, C.A.3
-
92
-
-
38849086036
-
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
-
Wahrle, S.E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., Jain, S., Hirsch-Reinshagen, V., Wellington, C.L., Bales, K.R., et al. (2008). Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 118, 671-682.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 671-682
-
-
Wahrle, S.E.1
Jiang, H.2
Parsadanian, M.3
Kim, J.4
Li, A.5
Knoten, A.6
Jain, S.7
Hirsch-Reinshagen, V.8
Wellington, C.L.9
Bales, K.R.10
-
93
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer’s disease
-
Walsh, D.M., and Selkoe, D.J. (2004). Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 44, 181-193.
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
94
-
-
15944410978
-
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
-
Wang, C., Wilson, W.A., Moore, S.D., Mace, B.E., Maeda, N., Schmechel, D.E., and Sullivan, P.M. (2005). Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol. Dis. 18, 390-398.
-
(2005)
Neurobiol. Dis.
, vol.18
, pp. 390-398
-
-
Wang, C.1
Wilson, W.A.2
Moore, S.D.3
Mace, B.E.4
Maeda, N.5
Schmechel, D.E.6
Sullivan, P.M.7
-
95
-
-
0034864642
-
Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion
-
White, F., Nicoll, J.A., Roses, A.D., and Horsburgh, K. (2001). Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion. Neurobiol. Dis. 8, 611-625.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 611-625
-
-
White, F.1
Nicoll, J.A.2
Roses, A.D.3
Horsburgh, K.4
-
96
-
-
33749641662
-
Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, nonclathrin-mediated pathway
-
Wilsie, L.C., Gonzales, A.M., and Orlando, R.A. (2006). Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, nonclathrin-mediated pathway. Lipids Health Dis. 5, 23.
-
(2006)
Lipids Health Dis.
, vol.5
, pp. 23
-
-
Wilsie, L.C.1
Gonzales, A.M.2
Orlando, R.A.3
|