Blocking the interaction between apolipoprotein e and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

American Journal of Pathology

Volumn 182, Issue 5, 2013, Pages 1750-1768

  Kuszczyk, Magdalena A ^a   Sanchez, Sandrine ^a   Pankiewicz, Joanna ^a   Kim, Jungsu ^b   Duszczyk, Malgorzata ^a   Guridi, Maitea ^a   Asuni, Ayodeji A ^a   Sullivan, Patrick M ^c,d   Holtzman, David M ^b   Sadowski, Martin J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN ABETA; APOLIPOPROTEIN E; OLIGOMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; COCULTURE; CONTROLLED STUDY; DEGENERATION; DOWN REGULATION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SYNAPTIC DEGENERATION;

AMYLOID BETA-PEPTIDES; ANIMALS; APOLIPOPROTEINS E; ASTROCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOCYTOSIS; EXTRACELLULAR SPACE; FEMALE; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HUMANS; MICE; MICE, KNOCKOUT; NERVE DEGENERATION; NEURONS; PROTEIN BINDING; PROTEIN ISOFORMS; SUBCELLULAR FRACTIONS; SYNAPSES;

EID: 84876569513     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.01.034     Document Type: Article

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