메뉴 건너뛰기




Volumn 97, Issue 4, 2000, Pages 685-692

Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice

Author keywords

Alzheimer; ApoE; Electron microscopy; Hippocampus; Morphometry; Transgenic mice

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

EID: 0034077821     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00065-8     Document Type: Article
Times cited : (57)

References (81)
  • 1
    • 0023589151 scopus 로고
    • Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans
    • Adams I. Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans. Brain Res. 424:1987;343-351.
    • (1987) Brain Res. , vol.424 , pp. 343-351
    • Adams, I.1
  • 2
    • 0000968097 scopus 로고
    • The hippocampal formation
    • (ed. Paxinos G.), 2nd edn., Academic, New York
    • Amaral D. G. and Witter M. P. (1995) The hippocampal formation. In The Rat Nervous System (ed. Paxinos G.), 2nd edn., Academic, New York.
    • (1995) In the Rat Nervous System
    • Amaral, D.G.1    Witter, M.P.2
  • 4
    • 0031021296 scopus 로고    scopus 로고
    • Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele
    • Arendt T., Schindler C., Bruckner M.K., Eschrich K., Bigl V., Zedlick D., Marcova L. Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele. J. Neurosci. 17:1997;516-529.
    • (1997) J. Neurosci. , vol.17 , pp. 516-529
    • Arendt, T.1    Schindler, C.2    Bruckner, M.K.3    Eschrich, K.4    Bigl, V.5    Zedlick, D.6    Marcova, L.7
  • 5
    • 0028850374 scopus 로고
    • Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma-cells produces differential-effects on neurite outgrowth
    • Bellosta S., Nathan B.P., Orth M., Dong L.M., Mahley R.W., Pitas R.E. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma-cells produces differential-effects on neurite outgrowth. J. biol. Chem. 270:1995;27,063-27,071.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27
    • Bellosta, S.1    Nathan, B.P.2    Orth, M.3    Dong, L.M.4    Mahley, R.W.5    Pitas, R.E.6
  • 6
    • 0030601841 scopus 로고    scopus 로고
    • Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: The EVA study
    • Berr C., Dufouil C., Brousseau T., Richard F., Amouyel P., Marceteau E., Alperovitch A. Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: the EVA study. Neurosci. Lett. 218:1996;9-12.
    • (1996) Neurosci. Lett. , vol.218 , pp. 9-12
    • Berr, C.1    Dufouil, C.2    Brousseau, T.3    Richard, F.4    Amouyel, P.5    Marceteau, E.6    Alperovitch, A.7
  • 7
    • 0029119753 scopus 로고
    • Association of apolipoprotein-E genotype with brain levels of apolipoprotein-E and apolipoprotein-J (clusterin) in Alzheimer disease
    • Bertrand P., Poirier J., Oda T., Finch C.E., Pasinetti G.M. Association of apolipoprotein-E genotype with brain levels of apolipoprotein-E and apolipoprotein-J (clusterin) in Alzheimer disease. Molec. Brain Res. 33:1995;174-178.
    • (1995) Molec. Brain Res. , vol.33 , pp. 174-178
    • Bertrand, P.1    Poirier, J.2    Oda, T.3    Finch, C.E.4    Pasinetti, G.M.5
  • 8
    • 0029801332 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease - Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the apoE4 allele
    • Blennow K., Bogdanovic N., Alafuzoff I., Ekman R., Davidsson P. Synaptic pathology in Alzheimer's disease - relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the apoE4 allele. J. neural Transm. 103:1996;603-618.
    • (1996) J. Neural Transm. , vol.103 , pp. 603-618
    • Blennow, K.1    Bogdanovic, N.2    Alafuzoff, I.3    Ekman, R.4    Davidsson, P.5
  • 11
    • 0033564771 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E3 or E4 in the brains of Apoe(-/-) mice: Isoform-specific effects on neurodegeneration
    • Buttini M., Orth M., Bellosta S., Akeefe H., Pitas R.E., WyssCoray T., Mucke L., Mahley R.W. Expression of human apolipoprotein E3 or E4 in the brains of Apoe(-/-) mice: isoform-specific effects on neurodegeneration. J. Neurosci. 19:1999;4867-4880.
    • (1999) J. Neurosci. , vol.19 , pp. 4867-4880
    • Buttini, M.1    Orth, M.2    Bellosta, S.3    Akeefe, H.4    Pitas, R.E.5    Wysscoray, T.6    Mucke, L.7    Mahley, R.W.8
  • 12
    • 0026549426 scopus 로고
    • Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions
    • Cabalka L.M., Hyman B.T., Goodlett C.R., Ritchie T.C., Vanhoesen G.W. Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions. Neurobiol. Aging. 13:1992;283-291.
    • (1992) Neurobiol. Aging , vol.13 , pp. 283-291
    • Cabalka, L.M.1    Hyman, B.T.2    Goodlett, C.R.3    Ritchie, T.C.4    Vanhoesen, G.W.5
  • 17
    • 0029583882 scopus 로고
    • The 'disector' - A tool for quantitative assessment of synaptic plasticity: An example on hippocampal synapses and synapse-perforations in ageing rats
    • DeGroot D.M.G., Bierman E.P.B., Bruijnzeel P.L.B., Woutersen R.A. The 'disector' - a tool for quantitative assessment of synaptic plasticity: an example on hippocampal synapses and synapse-perforations in ageing rats. Eur. J. Morph. 33:1995;305-309.
    • (1995) Eur. J. Morph. , vol.33 , pp. 305-309
    • Degroot, D.M.G.1    Bierman, E.P.B.2    Bruijnzeel, P.L.B.3    Woutersen, R.A.4
  • 18
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky S.T., Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann. Neurol. 27:1990;457-464.
    • (1990) Ann. Neurol. , vol.27 , pp. 457-464
    • Dekosky, S.T.1    Scheff, S.W.2
  • 21
    • 0026938047 scopus 로고
    • Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique
    • Geinisman Y., Detoledomorrell L., Morrell F., Persina I.S., Rossi M. Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus. 2:1992;437-444.
    • (1992) Hippocampus , vol.2 , pp. 437-444
    • Geinisman, Y.1    Detoledomorrell, L.2    Morrell, F.3    Persina, I.S.4    Rossi, M.5
  • 22
    • 0029940557 scopus 로고    scopus 로고
    • Gene-targeting studies of mammalian behaviour: Is it the mutation or the background genotype?
    • Gerlai R. Gene-targeting studies of mammalian behaviour: is it the mutation or the background genotype? Trends Neurosci. 19:1996;177-181.
    • (1996) Trends Neurosci. , vol.19 , pp. 177-181
    • Gerlai, R.1
  • 23
    • 0024595972 scopus 로고
    • Synaptic loss in Alzheimer's disease and other dementias
    • Hamos J.E., De Gennaro L.J., Drachman D.A. Synaptic loss in Alzheimer's disease and other dementias. Neurology. 39:1989;355-361.
    • (1989) Neurology , vol.39 , pp. 355-361
    • Hamos, J.E.1    De Gennaro, L.J.2    Drachman, D.A.3
  • 26
    • 0022002899 scopus 로고
    • Giebt es nervenzellverluste wahrend der alterung in der menschlichen hirnrinde?
    • Haug H. Giebt es nervenzellverluste wahrend der alterung in der menschlichen hirnrinde? Nervenheilkunde. 4:1985;103-109.
    • (1985) Nervenheilkunde , vol.4 , pp. 103-109
    • Haug, H.1
  • 28
    • 0028801680 scopus 로고
    • Loss of synaptophysin-like immunoreactivity in the hippocampal-formation is an early phenomenon in Alzheimer's disease
    • Heinonen O., Soininen H., Sorvari H., Kosunen O., Paljarvi L., Koivisto E., Riekkinen P.J. Loss of synaptophysin-like immunoreactivity in the hippocampal-formation is an early phenomenon in Alzheimer's disease. Neuroscience. 64:1995;375-384.
    • (1995) Neuroscience , vol.64 , pp. 375-384
    • Heinonen, O.1    Soininen, H.2    Sorvari, H.3    Kosunen, O.4    Paljarvi, L.5    Koivisto, E.6    Riekkinen, P.J.7
  • 29
    • 0028822219 scopus 로고
    • Low-density-lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell-line
    • Holtzman D.M., Pitas R.E., Kilbridge J., Nathan B., Mahley R.W., Bu G.J., Schwartz A.L. Low-density-lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell-line. Proc. natn. Acad. Sci. U.S.A. 92:1995;9480-9484.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3    Nathan, B.4    Mahley, R.W.5    Bu, G.J.6    Schwartz, A.L.7
  • 31
    • 0033577169 scopus 로고    scopus 로고
    • Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia
    • Horsburgh K., Kelly S., McCulloch J., Higgins G.A., Roses A.D., Nicoll J. Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia. NeuroReport. 10:1999;837-841.
    • (1999) NeuroReport , vol.10 , pp. 837-841
    • Horsburgh, K.1    Kelly, S.2    McCulloch, J.3    Higgins, G.A.4    Roses, A.D.5    Nicoll, J.6
  • 32
    • 0029782194 scopus 로고    scopus 로고
    • Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat
    • Horsburgh K., Nicoll J.A.R. Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat. Neuropath. appl. Neurobiol. 22:1996;342-349.
    • (1996) Neuropath. Appl. Neurobiol. , vol.22 , pp. 342-349
    • Horsburgh, K.1    Nicoll, J.A.R.2
  • 33
    • 0004187685 scopus 로고    scopus 로고
    • Estimation of reference volume using the Cavalieri method
    • Oxford: Bios Scientific
    • Howard C.V., Reed M.G. Estimation of reference volume using the Cavalieri method. Unbiased Stereology. 1998;Bios Scientific, Oxford.
    • (1998) Unbiased Stereology
    • Howard, C.V.1    Reed, M.G.2
  • 34
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • Hyman B.T., Van Hoesen G.W., Kromer L.J., Damasio A.R. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann. Neurol. 20:1986;472-481.
    • (1986) Ann. Neurol. , vol.20 , pp. 472-481
    • Hyman, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 35
    • 0026597219 scopus 로고
    • Mr-based hippocampal volumetry in the diagnosis of Alzheimer's disease
    • Jack C.R., Petersen R.C., Obrien P.C., Tangalos E.G. Mr-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology. 42:1992;183-188.
    • (1992) Neurology , vol.42 , pp. 183-188
    • Jack, C.R.1    Petersen, R.C.2    Obrien, P.C.3    Tangalos, E.G.4
  • 37
    • 0031963852 scopus 로고    scopus 로고
    • Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
    • Jordan J., Galindo M.F., Miller R.J., Reardon C.A., Getz G.S., LaDu M.J. Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J. Neurosci. 18:1998;195-204.
    • (1998) J. Neurosci. , vol.18 , pp. 195-204
    • Jordan, J.1    Galindo, M.F.2    Miller, R.J.3    Reardon, C.A.4    Getz, G.S.5    Ladu, M.J.6
  • 38
    • 0021956436 scopus 로고
    • Sex differences in the dendritic branching of dentate granule cells following differential experience
    • Juraska J.M., Fitch J.M., Henderson C., Rivers N. Sex differences in the dendritic branching of dentate granule cells following differential experience. Brain Res. 333:1985;73-80.
    • (1985) Brain Res. , vol.333 , pp. 73-80
    • Juraska, J.M.1    Fitch, J.M.2    Henderson, C.3    Rivers, N.4
  • 44
    • 0024299370 scopus 로고
    • Apolipoprotein E - Cholesterol transport protein with expanding role in cell biology
    • Mahley R.W. Apolipoprotein E - cholesterol transport protein with expanding role in cell biology. Science. 240:1988;622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 47
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's-disease
    • Masliah E., Terry R.D., Alford M., Deteresa R., Hansen L.A. Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's-disease. Am. J. Path. 138:1991;235-246.
    • (1991) Am. J. Path. , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    Deteresa, R.4    Hansen, L.A.5
  • 48
    • 0011285428 scopus 로고
    • The expression of the ApoE4 allele in Alzheimer's disease accentuates the synaptic loss and the severity of the dementia (Abstract)
    • Miller A., Alford M., Katzman R., Thal L., Saitoh T., Masliah E. The expression of the ApoE4 allele in Alzheimer's disease accentuates the synaptic loss and the severity of the dementia (Abstract). Ann. Neurol. 36:1994;268-269.
    • (1994) Ann. Neurol. , vol.36 , pp. 268-269
    • Miller, A.1    Alford, M.2    Katzman, R.3    Thal, L.4    Saitoh, T.5    Masliah, E.6
  • 49
    • 0025971426 scopus 로고
    • Apolipoprotein-E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's-disease and Kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba Y., Tomonaga M., Kawasaki H., Otomo E., Ikeda K. Apolipoprotein-E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's-disease and Kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:1991;163-166.
    • (1991) Brain Res. , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 51
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
    • Nathan B.P., Chang K.C., Bellosta S., Brisch E., Ge N.F., Mahley R.W., Pitas R.E. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. biol. Chem. 270:1995;19,791-19,799.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19
    • Nathan, B.P.1    Chang, K.C.2    Bellosta, S.3    Brisch, E.4    Ge, N.F.5    Mahley, R.W.6    Pitas, R.E.7
  • 53
    • 0026536066 scopus 로고
    • Generation of mice carrying a mutant apolipoprotein-E gene inactivated by gene targeting in embryonic stem-cells
    • Piedrahita J.A., Zhang S.H., Hagaman J.R., Oliver P.M., Maeda N. Generation of mice carrying a mutant apolipoprotein-E gene inactivated by gene targeting in embryonic stem-cells. Proc. natn. Acad. Sci. U.S.A. 89:1992;4471-4475.
    • (1992) Proc. Natn. Acad. Sci. U.S.A. , vol.89 , pp. 4471-4475
    • Piedrahita, J.A.1    Zhang, S.H.2    Hagaman, J.R.3    Oliver, P.M.4    Maeda, N.5
  • 54
    • 0028172930 scopus 로고
    • Apolipoprotein-E in animal-models of CNS injury and in Alzheimer's-disease
    • Poirier J. Apolipoprotein-E in animal-models of CNS injury and in Alzheimer's-disease. Trends Neurosci. 17:1994;525-530.
    • (1994) Trends Neurosci. , vol.17 , pp. 525-530
    • Poirier, J.1
  • 55
    • 0027298061 scopus 로고
    • Cholesterol-synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult-rats
    • Poirier J., Baccichet A., Dea D., Gauthier S. Cholesterol-synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult-rats. Neuroscience. 55:1993;81-90.
    • (1993) Neuroscience , vol.55 , pp. 81-90
    • Poirier, J.1    Baccichet, A.2    Dea, D.3    Gauthier, S.4
  • 56
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein-E messenger-RNA and GFAP messenger-RNA in hippocampus after entorhinal cortex lesioning
    • Poirier J., Hess M., May P.C., Finch C.E. Astrocytic apolipoprotein-E messenger-RNA and GFAP messenger-RNA in hippocampus after entorhinal cortex lesioning. Molec. Brain Res. 11:1991;97-106.
    • (1991) Molec. Brain Res. , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.C.3    Finch, C.E.4
  • 57
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J., Wong D., Buttini M., Orth M., Bellosta S., Pitas R.E., Mahley R.W., Mucke L. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. natn. Acad. Sci. U.S.A. 95:1998;10,914-10,919.
    • (1998) Proc. Natn. Acad. Sci. U.S.A. , vol.95 , pp. 10
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6    Mahley, R.W.7    Mucke, L.8
  • 58
    • 0031780158 scopus 로고    scopus 로고
    • Synapses in hippocampus occupy only 1-2% of cell membranes and are spaced less than half-micron apart: A quantitative ultrastructural analysis with discussion of physiological implications
    • Rusakov D.A., Harrison E., Stewart M.G. Synapses in hippocampus occupy only 1-2% of cell membranes and are spaced less than half-micron apart: a quantitative ultrastructural analysis with discussion of physiological implications. Neuropharmacology. 37:1998;513-521.
    • (1998) Neuropharmacology , vol.37 , pp. 513-521
    • Rusakov, D.A.1    Harrison, E.2    Stewart, M.G.3
  • 59
    • 0027400026 scopus 로고
    • Synapse loss in the temporal lobe in Alzheimer's-disease
    • Scheff S.W., Price D.A. Synapse loss in the temporal lobe in Alzheimer's-disease. Ann. Neurol. 33:1993;190-199.
    • (1993) Ann. Neurol. , vol.33 , pp. 190-199
    • Scheff, S.W.1    Price, D.A.2
  • 60
    • 0029793008 scopus 로고    scopus 로고
    • Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease
    • Scheff S.W., Sparks D.L., Price D.A. Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease. Dementia. 7:1996;226-232.
    • (1996) Dementia , vol.7 , pp. 226-232
    • Scheff, S.W.1    Sparks, D.L.2    Price, D.A.3
  • 64
    • 0032901189 scopus 로고    scopus 로고
    • Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse
    • Sheng H.X., Laskowitz D.T., Mackensen G.B., Kudo M., Pearlstein R.D., Warner D.S. Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. Stroke. 30:1999;1118-1123.
    • (1999) Stroke , vol.30 , pp. 1118-1123
    • Sheng, H.X.1    Laskowitz, D.T.2    Mackensen, G.B.3    Kudo, M.4    Pearlstein, R.D.5    Warner, D.S.6
  • 66
    • 0029893405 scopus 로고    scopus 로고
    • Apolipoprotein E, memory and Alzheimer's disease
    • Soininen H.S., Riekkinen P.J. Sr. Apolipoprotein E, memory and Alzheimer's disease. Trends Neurosci. 19:1996;224-228.
    • (1996) Trends Neurosci. , vol.19 , pp. 224-228
    • Soininen, H.S.1    Riekkinen P.J., Sr.2
  • 67
    • 0021234096 scopus 로고
    • The unbiased estimation of the number and size of arbitrary particles using the disector
    • Sterio D.C. The unbiased estimation of the number and size of arbitrary particles using the disector. J. Microsc. 134:1984;127-136.
    • (1984) J. Microsc. , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 68
    • 0017200805 scopus 로고
    • Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat
    • Steward O., Scoville S.A. Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat. J. comp. Neurol. 169:1976;347-370.
    • (1976) J. Comp. Neurol. , vol.169 , pp. 347-370
    • Steward, O.1    Scoville, S.A.2
  • 69
    • 0032080001 scopus 로고    scopus 로고
    • Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: Implications for Alzheimer's disease
    • Stone D.J., Rozovsky I., Morgan T.E., Anderson C.P., Finch C.E. Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease. J. Neurosci. 18:1998;3180-3185.
    • (1998) J. Neurosci. , vol.18 , pp. 3180-3185
    • Stone, D.J.1    Rozovsky, I.2    Morgan, T.E.3    Anderson, C.P.4    Finch, C.E.5
  • 72
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (ApoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
    • Sun Y.L., Wu S., Bu G.J., Onifade M.K., Patel S.N., LaDu M.J., Fagan A.M., Holtzman D.M. Glial fibrillary acidic protein-apolipoprotein E (ApoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18:1998;3261-3272.
    • (1998) J. Neurosci. , vol.18 , pp. 3261-3272
    • Sun, Y.L.1    Wu, S.2    Bu, G.J.3    Onifade, M.K.4    Patel, S.N.5    Ladu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 73
    • 0030872413 scopus 로고    scopus 로고
    • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
    • Sze C.I., Troncoso J.C., Kawas C., Mouton P., Price D.L., Martin L.J. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J. Neuropath. exp. Neurol. 56:1997;933-944.
    • (1997) J. Neuropath. Exp. Neurol. , vol.56 , pp. 933-944
    • Sze, C.I.1    Troncoso, J.C.2    Kawas, C.3    Mouton, P.4    Price, D.L.5    Martin, L.J.6
  • 74
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:1991;572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 75
    • 0031585498 scopus 로고    scopus 로고
    • Reduced size of right hippocampus in 39- To 80-year-old normal subjects carrying the apolipoprotein E epsilon 4 allele
    • Tohgi H., Takahashi S., Kato E., Homma A., Niina R., Sasaki K., Yonezawa H., Sasaki M. Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E epsilon 4 allele. Neurosci. Lett. 236:1997;21-24.
    • (1997) Neurosci. Lett. , vol.236 , pp. 21-24
    • Tohgi, H.1    Takahashi, S.2    Kato, E.3    Homma, A.4    Niina, R.5    Sasaki, K.6    Yonezawa, H.7    Sasaki, M.8
  • 79
    • 0030175279 scopus 로고    scopus 로고
    • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: Human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice
    • Xu P.T., Schmechel D., RothrockChristian T., Burkhart D.S., Qiu H.L., Popko B., Sullivan P., Maeda N., Saunders A.M., Roses A.D., Gilbert J.R. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol. Dis. 3:1996;229-245.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 229-245
    • Xu, P.T.1    Schmechel, D.2    Rothrockchristian, T.3    Burkhart, D.S.4    Qiu, H.L.5    Popko, B.6    Sullivan, P.7    Maeda, N.8    Saunders, A.M.9    Roses, A.D.10    Gilbert, J.R.11
  • 81
    • 0031911126 scopus 로고    scopus 로고
    • Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning
    • Zarow C., Victoroff J. Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning. Expl Neurol. 149:1998;79-86.
    • (1998) Expl Neurol. , vol.149 , pp. 79-86
    • Zarow, C.1    Victoroff, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.