-
1
-
-
84866985855
-
Targeting the TGFb signalling pathway in disease
-
Akhurst RJ, Hata A. (2012). Targeting the TGFb signalling pathway in disease. Nat Rev Drug Discov 11: 790-811
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 790-811
-
-
Akhurst, R.J.1
Hata, A.2
-
2
-
-
79959863770
-
TGFb/TNFa-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
-
Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL. (2011). TGFb/TNFa-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res 71: 4707-4719
-
(2011)
Cancer Res
, vol.71
, pp. 4707-4719
-
-
Asiedu, M.K.1
Ingle, J.N.2
Behrens, M.D.3
Radisky, D.C.4
Knutson, K.L.5
-
3
-
-
84870276714
-
Identification of Axl as a downstream effector of TGF-b1 during Langerhans cell differentiation and epidermal homeostasis
-
Bauer T, Zagorska A, Jurkin J, Yasmin N, Koffel R, Richter S, Gesslbauer B, Lemke G, Strobl H. (2012). Identification of Axl as a downstream effector of TGF-b1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med 209: 2033-2047
-
(2012)
J Exp Med
, vol.209
, pp. 2033-2047
-
-
Bauer, T.1
Zagorska, A.2
Jurkin, J.3
Yasmin, N.4
Koffel, R.5
Richter, S.6
Gesslbauer, B.7
Lemke, G.8
Strobl, H.9
-
4
-
-
84874607100
-
TGF-b inhibition enhances chemotherapy action against triple-negative breast cancer
-
Bhola NE, Balko JM, Dugger TC, Kuba MG, Sanchez V, Sanders M, Stanford J, Cook RS, Arteaga CL. (2013). TGF-b inhibition enhances chemotherapy action against triple-negative breast cancer. J Clin Invest 123: 1348-1358
-
(2013)
J Clin Invest
, vol.123
, pp. 1348-1358
-
-
Bhola, N.E.1
Balko, J.M.2
Dugger, T.C.3
Kuba, M.G.4
Sanchez, V.5
Sanders, M.6
Stanford, J.7
Cook, R.S.8
Arteaga, C.L.9
-
5
-
-
0842288323
-
TGF-b signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL. (2004). TGF-b signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303: 848-851
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
Washington, M.K.7
Neilson, E.G.8
Moses, H.L.9
-
6
-
-
84867027347
-
TGFb induces the formation of tumour-initiating cells in claudin low breast cancer
-
Bruna A, Greenwood W, Le Quesne J, Teschendorff A, Miranda-Saavedra D, Rueda OM, Sandoval JL, Vidakovic AT, Saadi A, Pharoah P, Stingl J, Caldas C. (2012). TGFb induces the formation of tumour-initiating cells in claudin low breast cancer. Nat Commun 3: 1055
-
(2012)
Nat Commun
, vol.3
, pp. 1055
-
-
Bruna, A.1
Greenwood, W.2
Le Quesne, J.3
Teschendorff, A.4
Miranda-Saavedra, D.5
Rueda, O.M.6
Sandoval, J.L.7
Vidakovic, A.T.8
Saadi, A.9
Pharoah, P.10
Stingl, J.11
Caldas, C.12
-
7
-
-
84928151672
-
MiR-1269 promotes metastasis and forms a positive feedback loop with TGF-b.
-
Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gumus ZH, Shen X. (2015). miR-1269 promotes metastasis and forms a positive feedback loop with TGF-b. Nat Commun 6: 6879
-
(2015)
Nat Commun
, vol.6
, pp. 6879
-
-
Bu, P.1
Wang, L.2
Chen, K.Y.3
Rakhilin, N.4
Sun, J.5
Closa, A.6
Tung, K.L.7
King, S.8
Kristine Varanko, A.9
Xu, Y.10
Huan Chen, J.11
Zessin, A.S.12
Shealy, J.13
Cummings, B.14
Hsu, D.15
Lipkin, S.M.16
Moreno, V.17
Gumus, Z.H.18
Shen, X.19
-
8
-
-
38849160275
-
Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer
-
Buess M, Nuyten DS, Hastie T, Nielsen T, Pesich R, Brown PO. (2007). Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Genome Biol 8: R191
-
(2007)
Genome Biol
, vol.8
, pp. R191
-
-
Buess, M.1
Nuyten, D.S.2
Hastie, T.3
Nielsen, T.4
Pesich, R.5
Brown, P.O.6
-
9
-
-
84869021181
-
Dependency of colorectal cancer on a TGF-b-driven program in stromal cells for metastasis initiation
-
Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Cespedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E, Batlle E. (2012). Dependency of colorectal cancer on a TGF-b-driven program in stromal cells for metastasis initiation. Cancer Cell 22: 571-584
-
(2012)
Cancer Cell
, vol.22
, pp. 571-584
-
-
Calon, A.1
Espinet, E.2
Palomo-Ponce, S.3
Tauriello, D.V.4
Iglesias, M.5
Cespedes, M.V.6
Sevillano, M.7
Nadal, C.8
Jung, P.9
Zhang, X.H.10
Byrom, D.11
Riera, A.12
Rossell, D.13
Mangues, R.14
Massagué, J.15
Sancho, E.16
Batlle, E.17
-
10
-
-
84925818452
-
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
-
Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello DV, Byrom D, Cortina C, Morral C, Barcelo C, Tosi S, Riera A, Attolini CS, Rossell D, Sancho E, Batlle E. (2015). Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nat Genet 47: 320-329
-
(2015)
Nat Genet
, vol.47
, pp. 320-329
-
-
Calon, A.1
Lonardo, E.2
Berenguer-Llergo, A.3
Espinet, E.4
Hernando-Momblona, X.5
Iglesias, M.6
Sevillano, M.7
Palomo-Ponce, S.8
Tauriello, D.V.9
Byrom, D.10
Cortina, C.11
Morral, C.12
Barcelo, C.13
Tosi, S.14
Riera, A.15
Attolini, C.S.16
Rossell, D.17
Sancho, E.18
Batlle, E.19
-
12
-
-
84921709757
-
Cancer exosomes trigger mesenchymal stem cell differentiation into pro-Angiogenic and pro-invasive myofibroblasts
-
Chowdhury R, Webber JP, Gurney M, Mason MD, Tabi Z, Clayton A. (2015). Cancer exosomes trigger mesenchymal stem cell differentiation into pro-Angiogenic and pro-invasive myofibroblasts. Oncotarget 6: 715-731
-
(2015)
Oncotarget
, vol.6
, pp. 715-731
-
-
Chowdhury, R.1
Webber, J.P.2
Gurney, M.3
Mason, M.D.4
Tabi, Z.5
Clayton, A.6
-
13
-
-
84857640591
-
Cancer associated fibroblasts: The dark side of the coin
-
Cirri P, Chiarugi P. (2011). Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res 1: 482-497
-
(2011)
Am J Cancer Res
, vol.1
, pp. 482-497
-
-
Cirri, P.1
Chiarugi, P.2
-
14
-
-
84973575250
-
Repurposed drug screen identifies cardiac glycosides as inhibitors of TGFb-induced cancer-Associated fibroblast differentiation
-
e-pub ahead of print 6 April 2016
-
Coleman DT, Gray AL, Stephens CA, Scott ML, Cardelli JA. (2016). Repurposed drug screen identifies cardiac glycosides as inhibitors of TGFb-induced cancer-Associated fibroblast differentiation. Oncotarget; e-pub ahead of print 6 April 2016; doi: 10.18632/oncotarget.8609
-
(2016)
Oncotarget
-
-
Coleman, D.T.1
Gray, A.L.2
Stephens, C.A.3
Scott, M.L.4
Cardelli, J.A.5
-
15
-
-
79953788906
-
Transforming growth factor-b decreases the cancer-initiating cell population within diffuse-Type gastric carcinoma cells
-
Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K. (2011). Transforming growth factor-b decreases the cancer-initiating cell population within diffuse-Type gastric carcinoma cells. Oncogene 30: 1693-1705
-
(2011)
Oncogene
, vol.30
, pp. 1693-1705
-
-
Ehata, S.1
Johansson, E.2
Katayama, R.3
Koike, S.4
Watanabe, A.5
Hoshino, Y.6
Katsuno, Y.7
Komuro, A.8
Koinuma, D.9
Kano, M.R.10
Yashiro, M.11
Hirakawa, K.12
Aburatani, H.13
Fujita, N.14
Miyazono, K.15
-
16
-
-
84858004513
-
USP15 stabilizes TGFb receptor i and promotes oncogenesis through the activation of TGF-b signaling in glioblastoma
-
Eichhorn PJ, Rodon L, Gonzalez-Junca A, Dirac A, Gili M, Martinez-Saez E, Aura C, Barba I, Peg V, Prat A, Cuartas I, Jimenez J, Garcia-Dorado D, Sahuquillo J, Bernards R, Baselga J, Seoane J. (2012). USP15 stabilizes TGFb receptor I and promotes oncogenesis through the activation of TGF-b signaling in glioblastoma. Nat Med 18: 429-435
-
(2012)
Nat Med
, vol.18
, pp. 429-435
-
-
Eichhorn, P.J.1
Rodon, L.2
Gonzalez-Junca, A.3
Dirac, A.4
Gili, M.5
Martinez-Saez, E.6
Aura, C.7
Barba, I.8
Peg, V.9
Prat, A.10
Cuartas, I.11
Jimenez, J.12
Garcia-Dorado, D.13
Sahuquillo, J.14
Bernards, R.15
Baselga, J.16
Seoane, J.17
-
17
-
-
0037437371
-
TGF-b 1-mediated fibroblast-myofibroblast terminal differentiation-The role of Smad proteins
-
Evans RA, Tian YC, Steadman R, Phillips AO. (2003). TGF-b 1-mediated fibroblast-myofibroblast terminal differentiation-The role of Smad proteins. Exp Cell Res 282: 90-100
-
(2003)
Exp Cell Res
, vol.282
, pp. 90-100
-
-
Evans, R.A.1
Tian, Y.C.2
Steadman, R.3
Phillips, A.O.4
-
18
-
-
84906053870
-
Tumor-Associated macrophages promote cancer stem cell-like properties via transforming growth factor-b1-induced epithelial-mesenchymal transition in hepatocellular carcinoma
-
Fan QM, Jing YY, Yu GF, Kou XR, Ye F, Gao L, Li R, Zhao QD, Yang Y, Lu ZH, Wei LX (2014a) Tumor-Associated macrophages promote cancer stem cell-like properties via transforming growth factor-b1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett 352: 160-168
-
(2014)
Cancer Lett
, vol.352
, pp. 160-168
-
-
Fan, Q.M.1
Jing, Y.Y.2
Yu, G.F.3
Kou, X.R.4
Ye, F.5
Gao, L.6
Li, R.7
Zhao, Q.D.8
Yang, Y.9
Lu, Z.H.10
Wei, L.X.11
-
19
-
-
84896505509
-
TGF-b-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12
-
Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F, Liu Y (2014b) TGF-b-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clin Cancer Res 20: 1531-1541
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1531-1541
-
-
Fan, Y.1
Shen, B.2
Tan, M.3
Mu, X.4
Qin, Y.5
Zhang, F.6
Liu, Y.7
-
21
-
-
84930573987
-
The TGF-b Signaling regulator PMEPA1 suppresses prostate cancer metastases to bone
-
Fournier PG, Juarez P, Jiang G, Clines GA, NiewolnaM, Kim HS, Walton HW, Peng XH, Liu Y, Mohammad KS, Wells CD, Chirgwin JM, Guise TA. (2015). The TGF-b Signaling regulator PMEPA1 suppresses prostate cancer metastases to bone. Cancer Cell 27: 809-821
-
(2015)
Cancer Cell
, vol.27
, pp. 809-821
-
-
Fournier, P.G.1
Juarez, P.2
Jiang, G.3
Clines, G.A.4
NiewolnaM Kim, H.S.5
Walton, H.W.6
Peng, X.H.7
Liu, Y.8
Mohammad, K.S.9
Wells, C.D.10
Chirgwin, J.M.11
Guise, T.A.12
-
22
-
-
77951728283
-
Intravital imaging illuminates transforming growth factor b signaling switches during metastasis
-
Giampieri S, Pinner S, Sahai E. (2010). Intravital imaging illuminates transforming growth factor b signaling switches during metastasis. Cancer Res 70: 3435-3439
-
(2010)
Cancer Res
, vol.70
, pp. 3435-3439
-
-
Giampieri, S.1
Pinner, S.2
Sahai, E.3
-
23
-
-
84862180623
-
TGFb signaling plays a critical role in promoting alternative macrophage activation
-
Gong D, Shi W, Yi SJ, Chen H, Groffen J, Heisterkamp N. (2012). TGFb signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol 13: 31
-
(2012)
BMC Immunol
, vol.13
, pp. 31
-
-
Gong, D.1
Shi, W.2
Yi, S.J.3
Chen, H.4
Groffen, J.5
Heisterkamp, N.6
-
24
-
-
84925484149
-
Co-migration of colon cancer cells and CAFs induced by TGFb enhances liver metastasis
-
Gonzalez-Zubeldia I, Dotor J, Redrado M, Bleau AM, Manrique I, De Aberasturi AL, Villalba M, Calvo A. (2015). Co-migration of colon cancer cells and CAFs induced by TGFb enhances liver metastasis. Cell Tissue Res 359: 829-839
-
(2015)
Cell Tissue Res
, vol.359
, pp. 829-839
-
-
Gonzalez-Zubeldia, I.1
Dotor, J.2
Redrado, M.3
Bleau, A.M.4
Manrique, I.5
De Aberasturi, A.L.6
Villalba, M.7
Calvo, A.8
-
25
-
-
40849133772
-
Role of transforming growth factor-b superfamily signaling pathways in human disease
-
Gordon KJ, Blobe GC. (2008). Role of transforming growth factor-b superfamily signaling pathways in human disease. Biochim Biophys Acta 1782: 197-228
-
(2008)
Biochim Biophys Acta
, vol.1782
, pp. 197-228
-
-
Gordon, K.J.1
Blobe, G.C.2
-
26
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-b signaling in T cells
-
Gorelik L, Flavell RA. (2001). Immune-mediated eradication of tumors through the blockade of transforming growth factor-b signaling in T cells. Nat Med 7: 1118-1122
-
(2001)
Nat Med
, vol.7
, pp. 1118-1122
-
-
Gorelik, L.1
Flavell, R.A.2
-
27
-
-
84865335195
-
Metabolic reprogramming of cancer-Associated fibroblasts by TGFb drives tumor growth connecting TGF-b signaling with Warburg-like cancer metabolism and L-lactate production
-
Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Ando S, Martinez-Outschoorn U, Sotgia F, Lisanti MP. (2012). Metabolic reprogramming of cancer-Associated fibroblasts by TGFb drives tumor growth connecting TGF-b signaling with Warburg-like cancer metabolism and L-lactate production. Cell Cycle 11: 3019-3035
-
(2012)
Cell Cycle
, vol.11
, pp. 3019-3035
-
-
Guido, C.1
Whitaker-Menezes, D.2
Capparelli, C.3
Balliet, R.4
Lin, Z.5
Pestell, R.G.6
Howell, A.7
Aquila, S.8
Ando, S.9
Martinez-Outschoorn, U.10
Sotgia, F.11
Lisanti, M.P.12
-
28
-
-
84955485418
-
TGFb treatment enhances glioblastoma virotherapy by inhibiting the innate immune response
-
Han J, Chen X, Chu J, Xu B, Meisen WH, Chen L, Zhang L, Zhang J, He X, Wang QE, Chiocca EA, Kaur B, Caligiuri MA, Yu J. (2015). TGFb treatment enhances glioblastoma virotherapy by inhibiting the innate immune response. Cancer Res 75: 5273-5282
-
(2015)
Cancer Res
, vol.75
, pp. 5273-5282
-
-
Han, J.1
Chen, X.2
Chu, J.3
Xu, B.4
Meisen, W.H.5
Chen, L.6
Zhang, L.7
Zhang, J.8
He, X.9
Wang, Q.E.10
Chiocca, E.A.11
Kaur, B.12
Caligiuri, M.A.13
Yu, J.14
-
29
-
-
84896526311
-
ALCAM/CD166 is a TGF-b-responsive marker and functional regulator of prostate cancer metastasis to bone
-
Hansen AG, Arnold SA, Jiang M, Palmer TD, Ketova T, Merkel A, Pickup M, Samaras S, Shyr Y, Moses HL, Hayward SW, Sterling JA, Zijlstra A. (2014). ALCAM/CD166 is a TGF-b-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res 74: 1404-1415
-
(2014)
Cancer Res
, vol.74
, pp. 1404-1415
-
-
Hansen, A.G.1
Arnold, S.A.2
Jiang, M.3
Palmer, T.D.4
Ketova, T.5
Merkel, A.6
Pickup, M.7
Samaras, S.8
Shyr, Y.9
Moses, H.L.10
Hayward, S.W.11
Sterling, J.A.12
Zijlstra, A.13
-
30
-
-
84893760814
-
Cancerassociated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-b signaling
-
Hasegawa T, Yashiro M, Nishii T, Matsuoka J, Fuyuhiro Y, Morisaki T, Fukuoka T, Shimizu K, Shimizu T, Miwa A, Hirakawa K. (2014). Cancerassociated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-b signaling. Int J Cancer 134: 1785-1795
-
(2014)
Int J Cancer
, vol.134
, pp. 1785-1795
-
-
Hasegawa, T.1
Yashiro, M.2
Nishii, T.3
Matsuoka, J.4
Fuyuhiro, Y.5
Morisaki, T.6
Fukuoka, T.7
Shimizu, K.8
Shimizu, T.9
Miwa, A.10
Hirakawa, K.11
-
31
-
-
84891748444
-
Interaction with colon cancer cells hyperactivates TGF-b signaling in cancer-Associated fibroblasts
-
Hawinkels LJAC, Paauwe M, Verspaget HW, Wiercinska E, Van Der Zon JM, Van Der Ploeg K, Koelink PJ, Lindeman JHN, Mesker W, ten Dijke P, Sier CFM. (2014). Interaction with colon cancer cells hyperactivates TGF-b signaling in cancer-Associated fibroblasts. Oncogene 33: 97-107
-
(2014)
Oncogene
, vol.33
, pp. 97-107
-
-
Hawinkels, L.J.A.C.1
Paauwe, M.2
Verspaget, H.W.3
Wiercinska, E.4
Van Der Zon, J.M.5
Van Der Ploeg, K.6
Koelink, P.J.7
Lindeman, J.H.N.8
Mesker, W.9
Ten Dijke, P.10
Sier, C.F.M.11
-
32
-
-
70350497349
-
Autocrine TGF-b signaling maintains tumorigenicity of gliomainitiating cells through Sry-related HMG-box factors
-
Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K. (2009). Autocrine TGF-b signaling maintains tumorigenicity of gliomainitiating cells through Sry-related HMG-box factors. Cell Stem Cell 5: 504-514
-
(2009)
Cell Stem Cell
, vol.5
, pp. 504-514
-
-
Ikushima, H.1
Todo, T.2
Ino, Y.3
Takahashi, M.4
Miyazawa, K.5
Miyazono, K.6
-
33
-
-
82355164166
-
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein
-
Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K. (2011). Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein. J Biol Chem 286: 41434-41441
-
(2011)
J Biol Chem
, vol.286
, pp. 41434-41441
-
-
Ikushima, H.1
Todo, T.2
Ino, Y.3
Takahashi, M.4
Saito, N.5
Miyazawa, K.6
Miyazono, K.7
-
34
-
-
84883246046
-
TGFb signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin
-
James JM, Nalbandian A, Mukouyama YS. (2013). TGFb signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin. Development 140: 3903-3914
-
(2013)
Development
, vol.140
, pp. 3903-3914
-
-
James, J.M.1
Nalbandian, A.2
Mukouyama, Y.S.3
-
35
-
-
84890572219
-
MiR-155-mediated loss of C/EBPb shifts the TGF-b response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer
-
Johansson J, Berg T, Kurzejamska E, Pang MF, Tabor V, Jansson M, Roswall P, Pietras K, Sund M, Religa P, Fuxe J. (2013). MiR-155-mediated loss of C/EBPb shifts the TGF-b response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 32: 5614-5624
-
(2013)
Oncogene
, vol.32
, pp. 5614-5624
-
-
Johansson, J.1
Berg, T.2
Kurzejamska, E.3
Pang, M.F.4
Tabor, V.5
Jansson, M.6
Roswall, P.7
Pietras, K.8
Sund, M.9
Religa, P.10
Fuxe, J.11
-
36
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, Guise TA, Massagué J. (2003). A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537-549
-
(2003)
Cancer Cell
, vol.3
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
Drobnjak, M.4
Kakonen, S.M.5
Cordon-Cardo, C.6
Guise, T.A.7
Massagué, J.8
-
37
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. (2007). Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
Sullivan, A.4
Brooks, M.W.5
Bell, G.W.6
Richardson, A.L.7
Polyak, K.8
Tubo, R.9
Weinberg, R.A.10
-
38
-
-
84867575420
-
Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-Type gastric carcinomainitiating cells is inhibited by TGF-b.
-
Katsuno Y, Ehata S, Yashiro M, Yanagihara K, Hirakawa K, Miyazono K. (2012). Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-Type gastric carcinomainitiating cells is inhibited by TGF-b. J Pathol 228: 391-404
-
(2012)
J Pathol
, vol.228
, pp. 391-404
-
-
Katsuno, Y.1
Ehata, S.2
Yashiro, M.3
Yanagihara, K.4
Hirakawa, K.5
Miyazono, K.6
-
39
-
-
33745578957
-
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
-
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ. (2006). Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441: 1015-1019
-
(2006)
Nature
, vol.441
, pp. 1015-1019
-
-
Kim, B.G.1
Li, C.2
Qiao, W.3
Mamura, M.4
Kasprzak, B.5
Anver, M.6
Wolfraim, L.7
Hong, S.8
Mushinski, E.9
Potter, M.10
Kim, S.J.11
Fu, X.Y.12
Deng, C.13
Letterio, J.J.14
-
40
-
-
78650563018
-
Autocrine TGF-b and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
-
Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA, Orimo A. (2010). Autocrine TGF-b and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 107: 20009-20014
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20009-20014
-
-
Kojima, Y.1
Acar, A.2
Eaton, E.N.3
Mellody, K.T.4
Scheel, C.5
Ben-Porath, I.6
Onder, T.T.7
Wang, Z.C.8
Richardson, A.L.9
Weinberg, R.A.10
Orimo, A.11
-
41
-
-
84975698737
-
Musashi-2 (MSI2) supports TGF-b signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis
-
Kudinov AE, Deneka A, Nikonova AS, Beck TN, Ahn YH, Liu X, Martinez CF, Schultz FA, Reynolds S, Yang DH, Cai KQ, Yaghmour KM, Baker KA, Egleston BL, Nicolas E, Chikwem A, Andrianov G, Singh S, Borghaei H, Serebriiskii IG, Gibbons DL, Kurie JM, Golemis EA, Boumber Y. (2016). Musashi-2 (MSI2) supports TGF-b signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis. Proc Natl Acad Sci USA 113: 6955-6960
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. 6955-6960
-
-
Kudinov, A.E.1
Deneka, A.2
Nikonova, A.S.3
Beck, T.N.4
Ahn, Y.H.5
Liu, X.6
Martinez, C.F.7
Schultz, F.A.8
Reynolds, S.9
Yang, D.H.10
Cai, K.Q.11
Yaghmour, K.M.12
Baker, K.A.13
Egleston, B.L.14
Nicolas, E.15
Chikwem, A.16
Andrianov, G.17
Singh, S.18
Borghaei, H.19
Serebriiskii, I.G.20
Gibbons, D.L.21
Kurie, J.M.22
Golemis, E.A.23
Boumber, Y.24
more..
-
42
-
-
81255205399
-
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
-
Labelle M, Begum S, Hynes RO. (2011). Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20: 576-590
-
(2011)
Cancer Cell
, vol.20
, pp. 576-590
-
-
Labelle, M.1
Begum, S.2
Hynes, R.O.3
-
43
-
-
84925533612
-
Axl as a downstream effector of TGF-b1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma
-
Li Y, Jia L, Liu C, Gong Y, Ren D, Wang N, Zhang X, Zhao Y. (2015). Axl as a downstream effector of TGF-b1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma. Tumour Biol 36: 1115-1127
-
(2015)
Tumour Biol
, vol.36
, pp. 1115-1127
-
-
Li, Y.1
Jia, L.2
Liu, C.3
Gong, Y.4
Ren, D.5
Wang, N.6
Zhang, X.7
Zhao, Y.8
-
44
-
-
84977103924
-
Conditional ablation of TGF-b signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
-
Liang Y, Zhu F, Zhang H, Chen D, Zhang X, Gao Q, Li Y. (2016). Conditional ablation of TGF-b signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model. Sci Rep 6: 29479
-
(2016)
Sci Rep
, vol.6
, pp. 29479
-
-
Liang, Y.1
Zhu, F.2
Zhang, H.3
Chen, D.4
Zhang, X.5
Gao, Q.6
Li, Y.7
-
45
-
-
84907502240
-
SIX1 promotes tumor lymphangiogenesis by coordinating TGFb signals that increase expression of VEGF-C.
-
Liu D, Li L, Zhang XX, Wan DY, Xi BX, Hu Z, Ding WC, Zhu D, Wang XL, Wang W, Feng ZH, Wang H, Ma D, Gao QL. (2014). SIX1 promotes tumor lymphangiogenesis by coordinating TGFb signals that increase expression of VEGF-C. Cancer Res 74: 5597-5607
-
(2014)
Cancer Res
, vol.74
, pp. 5597-5607
-
-
Liu, D.1
Li, L.2
Zhang, X.X.3
Wan, D.Y.4
Xi, B.X.5
Hu, Z.6
Ding, W.C.7
Zhu, D.8
Wang, X.L.9
Wang, W.10
Feng, Z.H.11
Wang, H.12
Ma, D.13
Gao, Q.L.14
-
46
-
-
84958012934
-
Autophagy is involved in TGF-b1-induced protective mechanisms and formation of cancer-Associated fibroblasts phenotype in tumor microenvironment
-
Liu FL, Mo EP, Yang L, Du J, Wang HS, Zhang H, Kurihara H, Xu J, Cai SH. (2016). Autophagy is involved in TGF-b1-induced protective mechanisms and formation of cancer-Associated fibroblasts phenotype in tumor microenvironment. Oncotarget 7: 4122-4141
-
(2016)
Oncotarget
, vol.7
, pp. 4122-4141
-
-
Liu, F.L.1
Mo, E.P.2
Yang, L.3
Du, J.4
Wang, H.S.5
Zhang, H.6
Kurihara, H.7
Xu, J.8
Cai, S.H.9
-
47
-
-
84861514155
-
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFb signaling
-
Lo PK, Kanojia D, Liu X, Singh UP, Berger FG, Wang Q, Chen H. (2012). CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFb signaling. Oncogene 31: 2614-2626
-
(2012)
Oncogene
, vol.31
, pp. 2614-2626
-
-
Lo, P.K.1
Kanojia, D.2
Liu, X.3
Singh, U.P.4
Berger, F.G.5
Wang, Q.6
Chen, H.7
-
48
-
-
84947560004
-
Mesenchymal stem ells induce directional migration of invasive breast cancer cells through TGF-b
-
McAndrews KM, McGrail DJ, Ravikumar N, Dawson MR. (2015). Mesenchymal stem ells induce directional migration of invasive breast cancer cells through TGF-b. Sci Rep 5: 16941
-
(2015)
Sci Rep
, vol.5
, pp. 16941
-
-
McAndrews, K.M.1
McGrail, D.J.2
Ravikumar, N.3
Dawson, M.R.4
-
49
-
-
84939445272
-
Myeloid-specific TGF-b signaling in bone promotes basic-FGF and breast cancer bone metastasis
-
Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. (2016). Myeloid-specific TGF-b signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene 35: 2370-2378
-
(2016)
Oncogene
, vol.35
, pp. 2370-2378
-
-
Meng, X.1
Vander Ark, A.2
Lee, P.3
Hostetter, G.4
Bhowmick, N.A.5
Matrisian, L.M.6
Williams, B.O.7
Miranti, C.K.8
Li, X.9
-
50
-
-
84863603551
-
CD44s regulates the TGF-b-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma
-
Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Watanabe M, Beppu T, Tamada M, Nagano O, Saya H, Baba H. (2012). CD44s regulates the TGF-b-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res 72: 3414-3423
-
(2012)
Cancer Res
, vol.72
, pp. 3414-3423
-
-
Mima, K.1
Okabe, H.2
Ishimoto, T.3
Hayashi, H.4
Nakagawa, S.5
Kuroki, H.6
Watanabe, M.7
Beppu, T.8
Tamada, M.9
Nagano, O.10
Saya, H.11
Baba, H.12
-
51
-
-
49249120549
-
Carcinoma-Associated fibroblastlike differentiation of human mesenchymal stem cells
-
Mishra PJ, Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP, Ganesan S, Glod JW, Banerjee D. (2008). Carcinoma-Associated fibroblastlike differentiation of human mesenchymal stem cells. Cancer Res 68: 4331-4339
-
(2008)
Cancer Res
, vol.68
, pp. 4331-4339
-
-
Mishra, P.J.1
Mishra, P.J.2
Humeniuk, R.3
Medina, D.J.4
Alexe, G.5
Mesirov, J.P.6
Ganesan, S.7
Glod, J.W.8
Banerjee, D.9
-
52
-
-
84959105586
-
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-b.
-
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyarto BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. (2016). Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-b. Nat Immunol 17: 414-421
-
(2016)
Nat Immunol
, vol.17
, pp. 414-421
-
-
Mohammed, J.1
Beura, L.K.2
Bobr, A.3
Astry, B.4
Chicoine, B.5
Kashem, S.W.6
Welty, N.E.7
Igyarto, B.Z.8
Wijeyesinghe, S.9
Thompson, E.A.10
Matte, C.11
Bartholin, L.12
Kaplan, A.13
Sheppard, D.14
Bridges, A.G.15
Shlomchik, W.D.16
Masopust, D.17
Kaplan, D.H.18
-
53
-
-
84977475925
-
The discovery and early days of TGF-b: A historical perspective
-
e-pub ahead of print 1 July 2016
-
Moses HL, Roberts AB, Derynck R. (2016). The discovery and early days of TGF-b: a historical perspective. Cold Spring Harb Perspect Biol; e-pub ahead of print 1 July 2016; doi: 10.1101/cshperspect.a021865
-
(2016)
Cold Spring Harb Perspect Biol
-
-
Moses, H.L.1
Roberts, A.B.2
Derynck, R.3
-
54
-
-
76249087423
-
TGF-b-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A. (2010). TGF-b-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463: 676-680
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
Tadokoro, Y.4
Ooshio, T.5
Kondo, Y.6
Nakao, S.7
Motoyama, N.8
Hirao, A.9
-
55
-
-
47149083462
-
Inhibition of endogenous TGF-b signaling enhances lymphangiogenesis
-
Oka M, Iwata C, Suzuki HI, Kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyazono K. (2008). Inhibition of endogenous TGF-b signaling enhances lymphangiogenesis. Blood 111: 4571-4579
-
(2008)
Blood
, vol.111
, pp. 4571-4579
-
-
Oka, M.1
Iwata, C.2
Suzuki, H.I.3
Kiyono, K.4
Morishita, Y.5
Watabe, T.6
Komuro, A.7
Kano, M.R.8
Miyazono, K.9
-
56
-
-
84923329516
-
TGF-b promotes heterogeneity and drug resistance in squamous cell carcinoma
-
Oshimori N, Oristian D, Fuchs E. (2015). TGF-b promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell 160: 963-976
-
(2015)
Cell
, vol.160
, pp. 963-976
-
-
Oshimori, N.1
Oristian, D.2
Fuchs, E.3
-
57
-
-
58149236744
-
Roles of TGFb in metastasis
-
Padua D, Massagué J. (2009). Roles of TGFb in metastasis. Cell Res 19: 89-102
-
(2009)
Cell Res
, vol.19
, pp. 89-102
-
-
Padua, D.1
Massagué, J.2
-
58
-
-
41149157649
-
TGFb primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagué J. (2008). TGFb primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massagué, J.7
-
59
-
-
84958039742
-
TGF-b1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
-
PangMF, Georgoudaki AM, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander JS, Nelson CM, Jakobsson L, Betsholtz C, Sund M, Karlsson MC, Fuxe J. (2016). TGF-b1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis. Oncogene 35: 748-760
-
(2016)
Oncogene
, vol.35
, pp. 748-760
-
-
Pang, M.F.1
Georgoudaki, A.M.2
Lambut, L.3
Johansson, J.4
Tabor, V.5
Hagikura, K.6
Jin, Y.7
Jansson, M.8
Alexander, J.S.9
Nelson, C.M.10
Jakobsson, L.11
Betsholtz, C.12
Sund, M.13
Karlsson, M.C.14
Fuxe, J.15
-
60
-
-
69149094674
-
Transforming growth factor-b signaling and tumor angiogenesis
-
Pardali E, ten Dijke P. (2009). Transforming growth factor-b signaling and tumor angiogenesis. Front Biosci 14: 4848-4861
-
(2009)
Front Biosci
, vol.14
, pp. 4848-4861
-
-
Pardali, E.1
Ten Dijke, P.2
-
61
-
-
63249123273
-
TGF-b increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
-
Pen'uelas S, Anido J, Prieto-Sanchez RM, Folch G, Barba I, Cuartas I, Garcia-Dorado D, Poca MA, Sahuquillo J, Baselga J, Seoane J. (2009). TGF-b increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 15: 315-327
-
(2009)
Cancer Cell
, vol.15
, pp. 315-327
-
-
Pen'uelas, S.1
Anido, J.2
Prieto-Sanchez, R.M.3
Folch, G.4
Barba, I.5
Cuartas, I.6
Garcia-Dorado, D.7
Poca, M.A.8
Sahuquillo, J.9
Baselga, J.10
Seoane, J.11
-
62
-
-
84888639681
-
The roles of TGF b in the tumour microenvironment
-
Pickup M, Novitskiy S, Moses HL. (2013). The roles of TGF b in the tumour microenvironment. Nat Rev Cancer 13: 788-799
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 788-799
-
-
Pickup, M.1
Novitskiy, S.2
Moses, H.L.3
-
63
-
-
79751501829
-
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
-
Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, ShibataW, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC. (2011). Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19: 257-272
-
(2011)
Cancer Cell
, vol.19
, pp. 257-272
-
-
Quante, M.1
Tu, S.P.2
Tomita, H.3
Gonda, T.4
Wang, S.S.5
Takashi, S.6
Baik, G.H.7
ShibataW Diprete, B.8
Betz, K.S.9
Friedman, R.10
Varro, A.11
Tycko, B.12
Wang, T.C.13
-
64
-
-
84923296070
-
Axl activates autocrine transforming growth factor-b signaling in hepatocellular carcinoma
-
Reichl P, Dengler M, Van Zijl F, Huber H, Fuhrlinger G, Reichel C, SieghartW, Peck-Radosavljevic M, Grubinger M, Mikulits W. (2015). Axl activates autocrine transforming growth factor-b signaling in hepatocellular carcinoma. Hepatology 61: 930-941
-
(2015)
Hepatology
, vol.61
, pp. 930-941
-
-
Reichl, P.1
Dengler, M.2
Van Zijl, F.3
Huber, H.4
Fuhrlinger, G.5
Reichel, C.6
SieghartW Peck-Radosavljevic, M.7
Grubinger, M.8
Mikulits, W.9
-
65
-
-
0042307513
-
The two faces of transforming growth factor b in carcinogenesis
-
Roberts AB, Wakefield LM. (2003). The two faces of transforming growth factor b in carcinogenesis. Proc Natl Acad Sci USA 100: 8621-8623
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
66
-
-
84961288435
-
First-in-Human Dose Study of the novel transforming growth factor-b receptor i kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma
-
Rodon J, Carducci MA, Sepulveda-Sanchez JM, Azaro A, Calvo E, Seoane J, Brana I, Sicart E, Gueorguieva I, Cleverly AL, Pillay NS, Desaiah D, Estrem ST, Paz-Ares L, Holdhoff M, Blakeley J, Lahn MM, Baselga J. (2015). First-in-Human Dose Study of the novel transforming growth factor-b receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma. Clin Cancer Res 21: 553-560
-
(2015)
Clin Cancer Res
, vol.21
, pp. 553-560
-
-
Rodon, J.1
Carducci, M.A.2
Sepulveda-Sanchez, J.M.3
Azaro, A.4
Calvo, E.5
Seoane, J.6
Brana, I.7
Sicart, E.8
Gueorguieva, I.9
Cleverly, A.L.10
Pillay, N.S.11
Desaiah, D.12
Estrem, S.T.13
Paz-Ares, L.14
Holdhoff, M.15
Blakeley, J.16
Lahn, M.M.17
Baselga, J.18
-
67
-
-
79958265710
-
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
-
Scheel C, Eaton EN, Li SHJ, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA. (2011). Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145: 926-940
-
(2011)
Cell
, vol.145
, pp. 926-940
-
-
Scheel, C.1
Eaton, E.N.2
Li, S.H.J.3
Chaffer, C.L.4
Reinhardt, F.5
Kah, K.J.6
Bell, G.7
Guo, W.8
Rubin, J.9
Richardson, A.L.10
Weinberg, R.A.11
-
68
-
-
84908015217
-
Transforming growth factor b-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression
-
Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J, Conejo-Garcia JR. (2014). Transforming growth factor b-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity 41: 427-439
-
(2014)
Immunity
, vol.41
, pp. 427-439
-
-
Stephen, T.L.1
Rutkowski, M.R.2
Allegrezza, M.J.3
Perales-Puchalt, A.4
Tesone, A.J.5
Svoronos, N.6
Nguyen, J.M.7
Sarmin, F.8
Borowsky, M.E.9
Tchou, J.10
Conejo-Garcia, J.R.11
-
69
-
-
34548706039
-
Transforming growth factor-b can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model
-
Tang B, Yoo N, Vu M, Mamura M, Nam JS, Ooshima A, Du Z, Desprez PY, Anver MR, Michalowska AM, Shih J, Parks WT, Wakefield LM. (2007). Transforming growth factor-b can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. Cancer Res 67: 8643-8652
-
(2007)
Cancer Res
, vol.67
, pp. 8643-8652
-
-
Tang, B.1
Yoo, N.2
Vu, M.3
Mamura, M.4
Nam, J.S.5
Ooshima, A.6
Du, Z.7
Desprez, P.Y.8
Anver, M.R.9
Michalowska, A.M.10
Shih, J.11
Parks, W.T.12
Wakefield, L.M.13
-
70
-
-
84941595668
-
Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis
-
Tang YN, Ding WQ, Guo XJ, Yuan XW, Wang DM, Song JG. (2015). Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. Nat Commun 6: 8230
-
(2015)
Nat Commun
, vol.6
, pp. 8230
-
-
Tang, Y.N.1
Ding, W.Q.2
Guo, X.J.3
Yuan, X.W.4
Wang, D.M.5
Song, J.G.6
-
71
-
-
84962821750
-
MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3
-
Wang C, Liu P, Wu H, Cui P, Li Y, Liu Y, Liu Z, Gou S. (2016). MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3. Oncotarget 7: 14912-14924
-
(2016)
Oncotarget
, vol.7
, pp. 14912-14924
-
-
Wang, C.1
Liu, P.2
Wu, H.3
Cui, P.4
Li, Y.5
Liu, Y.6
Liu, Z.7
Gou, S.8
-
72
-
-
84946203483
-
Excess TGF-b mediates muscle weakness associated with bone metastases in mice
-
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA. (2015). Excess TGF-b mediates muscle weakness associated with bone metastases in mice. Nat Med 21: 1262-1271
-
(2015)
Nat Med
, vol.21
, pp. 1262-1271
-
-
Waning, D.L.1
Mohammad, K.S.2
Reiken, S.3
Xie, W.4
Andersson, D.C.5
John, S.6
Chiechi, A.7
Wright, L.E.8
Umanskaya, A.9
Niewolna, M.10
Trivedi, T.11
Charkhzarrin, S.12
Khatiwada, P.13
Wronska, A.14
Haynes, A.15
Benassi, M.S.16
Witzmann, F.A.17
Zhen, G.18
Wang, X.19
Cao, X.20
Roodman, G.D.21
Marks, A.R.22
Guise, T.A.23
more..
-
73
-
-
84941316326
-
Osteopontin mediates an MZF1-TGF-b1-dependent transformation of mesenchymal stem cells into cancer-Associated fibroblasts in breast cancer
-
Weber CE, Kothari AN, Wai PY, Li NY, Driver J, Zapf MA, Franzen CA, Gupta GN, Osipo C, Zlobin A, Syn WK, Zhang J, Kuo PC, Mi Z. (2014). Osteopontin mediates an MZF1-TGF-b1-dependent transformation of mesenchymal stem cells into cancer-Associated fibroblasts in breast cancer. Oncogene 34: 4821-4833
-
(2014)
Oncogene
, vol.34
, pp. 4821-4833
-
-
Weber, C.E.1
Kothari, A.N.2
Wai, P.Y.3
Li, N.Y.4
Driver, J.5
Zapf, M.A.6
Franzen, C.A.7
Gupta, G.N.8
Osipo, C.9
Zlobin, A.10
Syn, W.K.11
Zhang, J.12
Kuo, P.C.13
Mi, Z.14
-
74
-
-
84955450515
-
CCL9 induced by TGFb signaling in myeloid cells enhances tumor cell survival in the premetastatic organ
-
Yan HH, Jiang J, Pang Y, Achyut BR, Lizardo M, Liang X, Hunter K, Khanna C, Hollander C, Yang L. (2015). CCL9 induced by TGFb signaling in myeloid cells enhances tumor cell survival in the premetastatic organ. Cancer Res 75: 5283-5298
-
(2015)
Cancer Res
, vol.75
, pp. 5283-5298
-
-
Yan, H.H.1
Jiang, J.2
Pang, Y.3
Achyut, B.R.4
Lizardo, M.5
Liang, X.6
Hunter, K.7
Khanna, C.8
Hollander, C.9
Yang, L.10
-
75
-
-
77955384579
-
Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung
-
Yan HH, Pickup M, Pang YL, Gorska AE, Li ZY, Chytil A, Geng YP, Gray JW, Moses HL, Yang L. (2010). Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res 70: 6139-6149
-
(2010)
Cancer Res
, vol.70
, pp. 6139-6149
-
-
Yan, H.H.1
Pickup, M.2
Pang, Y.L.3
Gorska, A.E.4
Li, Z.Y.5
Chytil, A.6
Geng, Y.P.7
Gray, J.W.8
Moses, H.L.9
Yang, L.10
-
76
-
-
37349100945
-
Abrogation of TGF b signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
-
Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL. (2008). Abrogation of TGF b signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13: 23-35
-
(2008)
Cancer Cell
, vol.13
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
Gorska, A.E.4
Chytil, A.5
Aakre, M.6
Carbone, D.P.7
Matrisian, L.M.8
Richmond, A.9
Lin, P.C.10
Moses, H.L.11
-
77
-
-
77953023274
-
TGF-b and immune cells: An important regulatory axis in the tumor microenvironment and progression
-
Yang L, Pang Y, Moses HL. (2010). TGF-b and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 31: 220-227
-
(2010)
Trends Immunol
, vol.31
, pp. 220-227
-
-
Yang, L.1
Pang, Y.2
Moses, H.L.3
-
78
-
-
77951460399
-
Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-b.
-
You HN, Ding W, Rountree CB. (2010). Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-b. Hepatology 51: 1635-1644
-
(2010)
Hepatology
, vol.51
, pp. 1635-1644
-
-
You, H.N.1
Ding, W.2
Rountree, C.B.3
-
79
-
-
84900316922
-
A long noncoding RNA activated by TGF-b promotes the invasion-metastasis cascade in hepatocellular carcinoma
-
Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, Wang SB, Wang YZ, Yang Y, Yang N, Zhou WP, Yang GS, Sun SH. (2014). A long noncoding RNA activated by TGF-b promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 25: 666-681
-
(2014)
Cancer Cell
, vol.25
, pp. 666-681
-
-
Yuan, J.H.1
Yang, F.2
Wang, F.3
Ma, J.Z.4
Guo, Y.J.5
Tao, Q.F.6
Liu, F.7
Pan, W.8
Wang, T.T.9
Zhou, C.C.10
Wang, S.B.11
Wang, Y.Z.12
Yang, Y.13
Yang, N.14
Zhou, W.P.15
Yang, G.S.16
Sun, S.H.17
-
80
-
-
35948945337
-
Discovery of endothelial to mesenchymal transition as a source for carcinomaassociated fibroblasts
-
Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. (2007). Discovery of endothelial to mesenchymal transition as a source for carcinomaassociated fibroblasts. Cancer Res 67: 10123-10128
-
(2007)
Cancer Res
, vol.67
, pp. 10123-10128
-
-
Zeisberg, E.M.1
Potenta, S.2
Xie, L.3
Zeisberg, M.4
Kalluri, R.5
-
81
-
-
84900434811
-
Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-b signalling
-
Zhou F, Drabsch Y, Dekker TJ, De Vinuesa AG, Li Y, Hawinkels LJ, Sheppard KA, Goumans MJ, Luwor RB, De Vries CJ, Mesker WE, Tollenaar RA, Devilee P, Lu CX, Zhu H, Zhang L, Dijke PT. (2014). Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-b signalling. Nat Commun 5: 3388
-
(2014)
Nat Commun
, vol.5
, pp. 3388
-
-
Zhou, F.1
Drabsch, Y.2
Dekker, T.J.3
De Vinuesa, A.G.4
Li, Y.5
Hawinkels, L.J.6
Sheppard, K.A.7
Goumans, M.J.8
Luwor, R.B.9
De Vries, C.J.10
Mesker, W.E.11
Tollenaar, R.A.12
Devilee, P.13
Lu, C.X.14
Zhu, H.15
Zhang, L.16
Dijke, P.T.17
-
82
-
-
84936971662
-
TGFb1 secreted by cancer-Associated fibroblasts induces epithelialmesenchymal transition of bladder cancer cells through lncRNAZEB2NAT
-
Zhuang J, Lu Q, Shen B, Huang X, Shen L, Zheng X, Huang R, Yan J, Guo H. (2015). TGFb1 secreted by cancer-Associated fibroblasts induces epithelialmesenchymal transition of bladder cancer cells through lncRNAZEB2NAT. Sci Rep 5: 11924
-
(2015)
Sci Rep
, vol.5
, pp. 11924
-
-
Zhuang, J.1
Lu, Q.2
Shen, B.3
Huang, X.4
Shen, L.5
Zheng, X.6
Huang, R.7
Yan, J.8
Guo, H.9
|