Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate

Oncotarget

Volumn 7, Issue 30, 2016, Pages 47494-47510

  Yin, Chengqian ^a   He, Dan ^a   Chen, Shuyang ^a,d   Tan, Xiaoling ^b   Sang, Nianli ^a,c  

^a DREXEL UNIVERSITY   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP; Hypoxia; Metabolism; NAD+; Pyruvate

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; ALANINE; CITRATE SYNTHASE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR; LACTATE DEHYDROGENASE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXYGEN; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINIC ACID; ACETYL COENZYME A; MTOR PROTEIN, HUMAN; OXALOACETIC ACID; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CANCER CELL; CELL CULTURE; CELL METABOLISM; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; IN VIVO STUDY; METABOLITE; OXIDATIVE PHOSPHORYLATION; ADAPTATION; DRUG EFFECTS; ELECTRON TRANSPORT; METABOLISM; NEOPLASM; PHYSIOLOGY;

ACETYL COENZYME A; ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; CELL PROLIFERATION; ELECTRON TRANSPORT; GLYCOLYSIS; HUMANS; NAD; NEOPLASMS; OXALOACETIC ACID; OXYGEN; PYRUVIC ACID; TOR SERINE-THREONINE KINASES;

EID: 84982843550     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10202     Document Type: Article

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